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At least 685 records · Page 38Linked to original sources
PubMed2001

[The influence of type I collagen on the cell behavior of human embryonic periosteous osteoblasts].

OBJECTIVE: To study the influence of type I collagen (COL I) on the cell behavior of human periosteous osteoblasts (OB) and the application of type I collagen in constructing bioactive artifical bone. METHODS: OB were cultured on dishes coated with bovine type I collagen in different final concentrations. The cell adhesion was examined by the methods of cell count, the proliferation of OB was studied by 3H-TdR, and the osteoblastic ability was assessed by the synthesis of collagen, osteocalcin and alkaline phosphatase (ALP). RESULTS: OB cultured on type I collagen layer had the following characteristics: 1. The amounts of adhesive cells were maximal top in 25 micrograms/ml final concentration; 2. The proliferation of OB was decreased above 12.5 micrograms/ml final concentration (P < 0.05); 3. The synthesis of type I collagen was reduced slightly (above 25 micrograms/ml, P < 0.05); 4. The secretion of osteocalcin was increased markedly (above 6.25 micrograms/ml, P < 0.05, which reached maximally in 25 micrograms/ml); 5. The ALP activity was also increased (above 12.5 micrograms/ml, P < 0.05). CONCLUSION: Type I collagen promotes the expression of osteoblastic phenotype and cell adhesion. When the scaffold materials for bone tissue engineering are coated with type I collagen, the osteogenesis of OB is enhanced to accelerate the transformation course from artificial bone to biological bone, the best final concentration is 25 micrograms/ml.

Alkaline Phosphatase↗
PubMed1992

Quantitative and morphological observations on the ultrastructure of articular tissue generated from free periosteal grafts.

This study investigates the ultrastructure of articular tissue generated on osteochondral defects in skeletally immature rabbits from free reversed periosteal allografts after 50 and 100 days of post-operative intermittent active motion. Tissue samples prepared for transmission electron microscopy were compared with normal cartilage and periosteum in terms of cell morphology and the pattern of intercellular collagen deposition. Well-differentiated tissue demonstrated many ultrastructural features of normal articular cartilage while poorly differentiated samples contained cells and intercellular collagen profiles which were somewhat similar to those observed in periosteum.

Animals↗
PubMed2005

Periosteal Ewing's sarcoma treated by photodynamic therapy with acridine orange.

We recently encountered a very rare case of periosteal Ewing's sarcoma (PES), which was treated by surgery followed by photodynamic therapy using acridine orange with radiodynamic therapy. No more than 15 cases of PES have been reported previously in literature. In our case, MRI revealed the tumor to be localized on the cortical surface of the proximal humerus. Histopathological examination of biopsy specimens revealed a small round cell sarcoma suggestive of Ewing's sarcoma or PNET, and immunohistochemistry showed positive staining for MIC2. Although fusion genes EWS-FLI1 and EWS-ERG were undetectable, PES was still considered to be the most likely diagnosis. Therefore, we administered preoperative chemotherapy, as a result of which the tumor shrank to 48% of its original volume. With a view to preserve excellent shoulder and upper limb function, we attempted intralesional tumor resection supported by photodynamic therapy using acridine orange with radiodynamic therapy. After surgery followed by postoperative chemotherapy, the patient has, until the time of writing, had no local tumor recurrence and no evidence of metastatic disease, and can move his shoulder fully and throw a ball well. Since it has been reported that PES has a better prognosis and responsiveness to chemotherapy than intramedullary Ewing's sarcoma, we believe that such reduction surgery with photodynamic therapy might be the strategy of choice to obtain satisfactory limb function in cases of PES.

Acridine Orange↗
PubMed2005

Intramuscular angiomatous tumors associated with periosteal changes and pain.

This case report discusses two cases in which patients present with the uncommon triad of extremity pain, focal periosteal reaction on imaging studies, and intramuscular hemangioma on pathologic examination. Both patients presented in this article were older than those previously reported in the literature. Neither patient reported complete resolution of pain following excision, although there was marked improvement.

Female↗
PubMedDate not supplied

Periosteal chondroma of the proximal radius: a case report.

When a chondroma is localized in the superficial region of the bone it is defined periosteal or juxtacortical chondroma. This is a rare and benign cartilaginous lesion that more frequently affects males, and is generally observed in the tubular bones of the hand; it may, however, affect the other major bones, particularly the proximal end of the humerus. Age of onset is the second or third decade of life. Symptoms include moderate local pain. The clinical case presented here has two special features: the first is the site; based on an analysis of the international literature it seems that an analogous lesion at the level of the radial neck has not as yet been described; the second is the symptomatology that brought the patient to our attention.

Adult↗
PubMed2006

Periosteal chondroma of the proximal humerus: a case report and review of the literature.

Periosteal chondroma is a slow growing benign cartilaginous tumor of bone. It is rarely reported among Thai people. The authors present a case ofperiosteal chondroma of the proximal humerus. A 14-year-old girl was admitted with a painless mass around her left shoulder On magnetic resonance images, a subcutaneous lesion with hypointensity on TI-weighted images and marked hyperintensity on T2-weighted images, eroded the underlying cortical bone of the proximal humerus. The patient underwent marginal excision. There was no recurrence of the lesion during 3 years of follow-up.

Adolescent↗
PubMed1992

Pericytes as a supplementary source of osteoblasts in periosteal osteogenesis.

In the adult rat femur, lifting a periosteum strip with microscopic bone flakes on its deep surface, if performed without damaging the surrounding microcirculation, rapidly leads to new bone formation and angiogenesis. Using vascular labeling, the pericytes and endothelial cells (ECs) were labeled with monastral blue (MB) in the preformed, preexisting postcapillary venules of the periosteal microcirculation. MB was detectable by light and electron microscopy and it persisted in some of the daughter cells. Between one and 21 hours, the MB labeling was restricted to the pericytes and ECs of postcapillary venules. Immediately afterward, both pericytes and ECs of these vessels were activated and continued to show MB. The phenomenon of pericyte activation includes enlargement, disruption of their basal lamina, separation from the walls of the preformed vessels, and the presence of mitotic figures. At this stage, activated pericytes with MB in their cytoplasm, fibroblast-like cells, and transitional cell forms between them were seen in interstitial areas. After 27 hours, vascular buds appeared and MB was detected in some ECs and pericytes. Between three and six days, when bone-tissue development was observed, some osteoblasts were MB labeled. Previous findings support the hypothesis that when the periosteum is activated, the process of bone formation from cells already present in the periosteum is augmented by proliferation and differentiation of pericytes, which contribute a supplementary population of osteoprogenitor cells.

Animals↗
PubMedDate not supplied

[A cortico-cancellous graft with a periosteal pedicle for the treatment of deep single-walled bone pockets].

The treatment of single-walled bone pockets involves a number of problems. Conventional treatment methods fail to bring about permanent success, particularly in the more advanced stages. A new method has been developed and described using a cortico-cancellous graft harvested from the apical region of the teeth with a periosteal pedicle that can be inserted into the highly infection-prone area of a bone pocket. The advantage of this procedure is that the transplant is perfused and thus not subjected to necrosis but highly resistant to infections. Indications, practical procedure and success rates are discussed and illustrated in one example.

Bone Transplantation↗
PubMed1991

[Cranioplasties using free femoral osteo-periostal flaps].

Injuries, osteomyelitis, tumors are responsible of large skull defects. Their management is difficult. Three post traumatic and post infectious defects were repaired with an osteoperiostic flap taken from the internal face of the femur. A large defect due to the removal of a metastatic tumor was repaired with an iliac osseous flap. The choice of the donor site depends on the defect size (the femur provides a flap of 13 cm x 8 cm, the iliac bone a flap of 17 x 17 cm). The three head injured patients had a range of six previous unsuccessful surgical attempts using polymerised material or bone grafts. The post operative course in the post traumatic patients was uneventful, the domestic result good, the periostic consolidation less than three months. The free flap seems a good method for the management of risky cases.

Bone Transplantation↗
PubMed1991

Biochemical study of repair of induced osteochondral defects of the distal portion of the radial carpal bone in horses by use of periosteal autografts.

Periosteal autografts were used for repair of large osteochondral defects in 10 horses aged 2 to 3 years old. In each horse, osteochondral defects measuring 1.0 x 1.0 cm2 were induced bilaterally on the distal articular surface of each radial carpal bone. Control and experimental defects were drilled. Periosteum was harvested from the proximal portion of the tibia and was glued into the principal defects, using a fibrin adhesive. Control defects were glued, but were not grafted. Sixteen weeks after the grafting procedure, the quality of the repair tissue of control and grafted defects was assessed biochemically. Total collagen content and the proportion of type-II collagen were determined. Galactosamine and glucosamine contents also were determined. From these measurements, contents of chondroitin and keratan sulfate and total glycosaminoglycan, and galactosamine-to-glucosamine ratio were calculated. All biochemical variables were compared with those of normal equine articular cartilage taken from the same site in another group of clinically normal horses. Total collagen content was determined on the basis of 4-hydroxyproline content, using a colorimetric method. The proportions of collagen types I and II in the repair tissue were assessed by electrophoresis of their cyanogen bromide-cleaved peptides on sodium dodecyl sulfate slab gels. Peptide ratios were computed and compared with those of standard mixtures of type-I and type-II collagens. Galactosamine and glucosamine contents were determined by use of ion chromatography. In general, the biochemical composition of repair tissue of grafted and nongrafted defects was similar, but clearly differed from that of normal articular cartilage.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1991

Radiologic study of endosteal, intracortical, and periosteal surfaces of hand bones in metabolic bone diseases.

In metabolic bone diseases, subtle abnormalities occur on the three surfaces of bone, the recognition of which is important for diagnosis, as well as in follow-up studies, to recognize progression or regression. These resorptive and formative changes are best studied in fine-detail hand radiographs under 6 to 8 times magnification by a relatively simple radiologic method (microradioscopy). The periosteal resorption of hyperparathyroidism is thus recognized earlier than by regular radiography, and intracortical resorption, not detectable by the naked eye, can be visualized. The latter is also seen frequently in nutritional osteomalcia, renal osteodystrophy, and thyrotoxicosis, and sometimes in acromegaly. Endosteal resorption in developing involutional osteoporosis can also be recognized more efficiently by microradioscopy than by ordinary radiographs without magnification. Fine-detail hand radiographs may thus be used as an inexpensive preliminary measurement for diagnosis of osteoporosis.

Bone Diseases, Metabolic↗
PubMed1990

[Two unusual periosteal exotoses].

After maceration of the skeleton of 2 persons we found 2 different solitary exostoses; one at the sciatic tuber, in the other at the sciatic tuber, in the other at the ventral side of the distal fibula. The exostoses reach a length of 2 cm. Prescher (1987) described a cartilaginous exostosis with a length of 2 cm at the proximal tibia. In our cases the exostoses belong to the periosteal form. We consider them to be bony origins of ligaments: at the sciatic tuber--the bony origin of the sacrotuberal ligament, at the distal fibula--the bony origin of the peroneal compartment of the retinaculum mm extensorum inferius.

Fibula↗
PubMed1990

Mooren's ulcer treated with a periosteal graft.

We report a case of recurrent Mooren's ulcer treated with an autogenous periosteal graft. The eye responded well to this therapy. Final visual acuity was 20/40 with spectacle correction of +2.00 + 2.50 X 165.

Aged↗
PubMedDate not supplied

Treatment of chronic, two-plane instability of the ankle joint: syndesmoplasty versus periosteal flap versus tenodesis.

Repair of chronic ankle instability is recommended by a step-to-step approach. Anatomic repair with ligamentoplasty or periosteal flap will result in complete range of motion of the foot, but with less stability (7.1 degrees talar tilt). The more unphysiologic tenodesis procedure should be done in long-standing cases and gross instability, with the risk of loss of motion (10 degrees supination in one third of the cases), but with the advantage of best mechanical stability (3.5 degrees talar tilt).

Adolescent↗
PubMed1990

[Periosteal chondroma].

Ten cases of periosteal (juxtacortical) chondroma were observed in a series of 234 benign cartilaginous tumors of the hand recorded in the Bone Tumor Register of the Orthopaedic Department of the Semmelweis Medical School, Budapest. The X-rays and histology of this slowly growing, juxtacortical, locally active tumor may simulate a chondrosarcoma and may often lead to difficulties in the differential diagnosis. The adequate assessment of the X-ray and histological finding prevents overdiagnosis and unjustified radical surgical therapy.

Adolescent↗
PubMed1989

[Periosteal vacuum-stimulation as a method of acupuncture in the treatment of lumbosacral pain syndromes].

A new technique is offered to treat the vertebrogenic lumboischialgies and lumbosacral radicular syndromes with periosteal vacuum application through tubular needles to the diseased vertebrae and sclerotomic zones. In a majority of 134 patients that underwent the combined therapy involving this technique improvement or substantial improvement was attained and documented with parametric tests (Lasseg symptom, the volume of vertebral motility, pain thresholds). The technique allowed a shortened average hospital stay of the patients and the duration of their sick leave. Some considerations are presented as to the possible mechanisms of therapeutic effect of the inttrvention.

Acupuncture Therapy↗
PubMed1989

[Congenital sternal cleft. Closed with a periosteal graft].

Three cases of sternal cleft are treated. In two cases direct approximation of the two sternal halves have been possible in neonatal period. The third case was seen later at 11 months: the cleft was 5 cm wide, we used autogenous periostal graft in two layers, the first in depth, the second above the sternal halves. This technique have given a good clinical and radiological result for two years. She must be reserved for the wide and "old" sternal cleft.

Humans↗