Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Orgasm”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 685 records · Page 38Linked to original sources
PubMed1999

[Effect of aging and diseases on male sexual function assessed by the International Index of Erectile Function].

PURPOSE: Many epidemiological factors contribute to erectile dysfunction (ED). The objective of the present research was to investigate the risk factors of ED and the influence of aging on male sexual function, to obtain some insight into prevention of ED. METHODS: The study sample consisted of employees, aged from 22 to 59 years old of ten companies in Japan, who responded to the International Index of Erectile Function (IIEF) questionnaire and a survey of health status and related variables. The IIEF sexual activity questionnaire includes 15 items related to male sexual activity organized into five domains (that is erectile function, orgasmic function, sexual desire, intercourse satisfaction, overall satisfaction) to which 967 of the 1,020 subjects (94.8%) provided complete responses. These 967 men constitute the present study sample. For statistical analysis, ANOVA with Scheffe's (post hoc) test was conducted, and statistical significance was set at p < 0.05. RESULTS: Presence of hypertension, heart disease, diabetes and hyperlipidemia was associated with a significantly decreased score for erectile function in subjects in their fifties (p < 0.05), however, it was not significant in the other age groups. In subjects, who were free from risk factors for sexual function, there was significant correlation between age and the scores for erectile function, orgasmic function, sexual desire and intercourse satisfaction. CONCLUSIONS: Aging and chronic disorders that have been considered to be putative risk factors for ED, therefore affect male sexual function in the elderly. The IIEF was suggested to be suited for use in studies assessing epidemiology of ED.

Adult↗
PubMed2005

[Analysis of mailed questionnaire for female sexual dysfunction after intra-pelvic surgery].

OBJECTIVE: Female sexual dysfunction is an unfavorable complication for women after intra-pelvic surgery. However, there has not been enough data obtained to analyze the inconvenience to female patients of intra-pelvic surgery. To clarify the categories of female sexual dysfunction after intra-pelvic surgery, we analyzed mailed questionnaires obtained from female patients who had undergone mono-therapy of intra-pelvic surgery. MATERIALS AND METHODS: A mailed questionnaire regarding female sexual dysfunction was sent to 174 patients, including 118 that had undergone a hysterectomy (Group A) and 56 ostomates (Group B) and the results were analyzed. These patients had received only intra-pelvic surgery, without radiation or chemotherapy. Of the 56 patients in Group B, 50 with rectal cancer had received a colostomy, and 6 with bladder cancer had received ileal conduits. The content of the questionnaire was as follows: age; with or without a male partner; key person for consultation in regard to sexual dysfunction; importance of sex life. Also, a before and after operation comparison was made regarding sexual frequency, sexual desire, genital response, genital transformation, dyspareunia, genital pain and itching, and orgasm. RESULTS: Seventy-eight of 174 (45%) patients returned the questionnaire. Nineteen patients without a male partner and 18 patients with a male partner had no sexual intercourse, very low sexual desire, and did not consider their sex life of importance. Twenty-five patients with a male partner (18 in Group A and 7 in Group B) had no trouble in their sexual activity after the operations. However, the other 16 patients (5 in Group A and 11 in Group B) had unsatisfactory sexual intercourse after their operations because of a decrease in sexual desire, poor genital response, and/or decrease of orgasms. Furthermore, the patients in Group B suffered significantly from sexual trouble compared with the patients in Group A. Especially, all the patients in Group B complained that their stoma prevented satisfactory sexual intercourse. CONCLUSIONS: Based on this data, we do not need to worry about female sexual dysfunction for patients without a male partner and patients with a partner but who are not sexually active before their operations. More than 60% of patients who had been sexually active before their operations maintained fair sexual activity after intra-pelvic surgery. However, we have to take care of the approximately 40% of patients who suffer from female sexual dysfunction after their operation, especially the ostomate patients.

Female↗
PubMed1980

Physiology of male sexual function.

The male sexual response cycle consists of excitement, plateau, orgasm, and resolution. The initial event, penile erection, is produced by arteriolar dilatation and increased blood flow to the erectile tissue of the penis. Erection is a reflex response initiated by visual, olfactory, or imaginative stimuli impinging upon supraspinal centers or by genital stimulation that in turn activates spinal reflex mechanisms. Sacral parasympathetic and thoracolumbar sympathetic nerves provide the efferent vasodilator input to the penis. Parasympathetic nerves also stimulate secretion from the seminal vesicles and prostate and Cowper's glands during the plateau phase. The orgasmic phase is characterized by seminal emission and ejaculation and the accompanying sensations. Emission of semen into the urethra depends on sympathetic nerves that elicit contractions of smooth muscles in the vas deferens, seminal vesicles, and prostate. Rhythmic contractions of striated muscle (bulbocavernosus and ischiocavernosus) generated by efferent pathways in the pudendal nerve eject semen from the urethra.

Animals↗
PubMed2000

Human middle cerebral artery blood velocity during sexual intercourse.

Although the augmentation of central hemodynamics during human sexual intercourse is well established, dynamic changes in human regional cerebral blood flow have not been reported. Noninvasive transcranial Doppler ultrasonography has been well validated and allows direct, continuous measurement of phasic blood velocity in the human middle cerebral artery (a linear index of regional cerebral blood flow). The middle cerebral artery supplies the premotor and primary sensorimotor cortical regions for the arms, upper and lower trunk, and head. Blood velocities in this vessel have been shown to increase significantly with sensory stimuli and physical stresses. Accordingly, we tested the hypothesis that human sexual intercourse increases middle cerebral artery blood velocity. We used noninvasive, transcranial Doppler ultrasonography (95% confidence limits for precision +/- 7%) to measure blood velocity in the left middle cerebral artery of 10 male and 10 female, sexually acquainted, healthy adults (age range, 23 to 47 years; mean, 30 years). To eliminate signal artifacts and allow complete freedom of motion, a modified low profile, temporal fossa transducer was secured by minimal unobtrusive forehead strapping. Continuous measurements of phasic blood velocity and heart rate were made in a private bedroom setting during rest (control), preexcitement, excitation, prepenetration, penetration, preorgasm, orgasm, and resolution with the untethered instrumented subject in the supine missionary position. Heart rate and blood velocity responses were similar in both sexes. During orgasm, the maximal heart rate increased significantly (P < 0.05): 49 +/- 44% in women, 65 +/- 32% in men, and 58 +/- 38% combined from a combined resting value of 77 +/- 11 standard deviations SD beats per minute. Importantly, blood velocity in the middle cerebral artery of the 20 subjects remained unchanged (P > 0.10) from a resting value of 56 +/- 15 cm/s. In conclusion, in both sexes, human middle cerebral artery blood velocity, a linear index of human regional cerebral blood flow, does not increase significantly (P > 0.10) during human sexual intercourse.

Adult↗
PubMed1999

[Primary absolute anorgasmy in the male. Report of three clinical cases].

Primary absolute anorgasmia is the impossibility to have orgasm and ejaculation during wake or every kind of sexual activity, in men with normal erectile function and nocturnal emission. In this syndrome the nervous system is unimpaired; the frequency is very low, with a very small number of reported cases in literature. Andrologists are generally requested by the patients for the first clinical approach. They should collaborate with sexologists for the diagnosis and treatment. Personal experience in 3 cases of anejaculatory men aged between 28 and 34, observed in the years 1995-1996, is presented and the clinical features of the patients and therapeutic strategy described. In two cases a sexual behavioral therapy was performed with success; in the third an electrovibration was employed to obtain the first orgasmic sensation.

Adult↗
PubMed1999

Sildenafil in the treatment of female sexual dysfunction induced by selective serotonin reuptake inhibitors.

OBJECTIVE: To review the literature describing female orgasmic disorder and impaired sexual desire disorder by selective serotonin reuptake inhibitors (SSRIs) and their treatment, including the use of sildenafil. STUDY DESIGN: Literature reviews of all available published articles on this topic from 1989 to 1996 were done. This paper also includes a sample case of a 38-year old woman who suffers from fluoxetine-induced arousal and orgasmic disturbance. RESULTS: Treatment approaches include the use of "antidotes," such as cyproheptadine, yohimbine, amantadine, granisetron and ginkgo biloba. This article also reports a case of successful female use of sildenafil, which was released by the Food and Drug Administration in March 1998 for erectile dysfunction in men. CONCLUSION: Sildenafil is beneficial in reversing female sexual dysfunction induced by SSRIs. This paper also discusses sildenafil's action in the background of nitric oxide and cyclic guaninosine monophosphate in penile/clitoral erection.

Adult↗
PubMed2000

Perceptions about female sexuality among young Pakistani men presenting to family physicians at a teaching hospital in Karachi.

OBJECTIVE: To study the perceptions about female sexuality among young Pakistani men, presenting to family physicians at a teaching hospital in Karachi, Pakistan. STUDY DESIGN: A questionnaire based prevalence study. SETTING: Questionnaire administered to 188 young Pakistani men, between the ages 18-30 years, who presented to family physicians, at the outpatient department of the Aga Khan University Hospital, Karachi, Pakistan. MAIN OUTCOME MEASURES: Perception among Pakistani young men about enjoyment of sexual experiences in women, whether women stop to enjoy sexual experiences during stress, menstruation, pregnancy and after menopause. Whether they are aware about "orgasm" in women and their belief in who can initiate sexual experiences, husband, wife or both. RESULTS: The age of the study population was uniformly distributed between 18-30 years. The majority of the respondents were professionals, with a high school or a higher level education and belonged to the middle socioeconomic group. Well over 40% of the respondents thought that sexual experiences in women in comparison to men are less enjoyable. 22% believed that women cannot enjoy sex during pregnancy while 20% thought they can't enjoy after menopause. 58% of the respondents were aware of the phenomenon of orgasm in women. 6.4% believed that the initiation of sexual experience lies with husband only. CONCLUSION: We have found a high prevalence of misconceptions about female sexuality among Pakistani young men in our study sample. We expect the situation to be more adverse in the society where education is less and people belong to the lower socio-economic class. We strongly recommend sex education of our youth.

Adolescent↗
PubMed2000

Cortical evoked potentials of the dorsal nerve of the clitoris and female sexual dysfunction in multiple sclerosis.

PURPOSE: We evaluated whether disrupting genital central nervous system pathways is associated with subjective reports of sexual dysfunction in women with multiple sclerosis. MATERIALS AND METHODS: We performed pudendal somatosensory evoked potential testing in and had sexual questionnaires completed by 14 women with a mean age of 47 years who had multiple sclerosis. RESULTS: The mean expanded disability status score was 5. All but 1 woman reported the desire for sexual intercourse. There was a high rate of dissatisfaction with their sex life and all study participants had concomitant bladder and bowel function problems. The most common sexual complaint was difficult or no orgasm, which was statistically associated with abnormalities or absence of 1 or both pudendal cortical evoked potentials. Fatigue and arousal disorders were also common. CONCLUSIONS: Women with multiple sclerosis have a high self-reported rate of sexual dysfunction, which decreases quality of life. Electrodiagnostic data imply that pudendal somatosensory innervation is necessary for normal female orgasmic function. More study is needed to confirm these findings.

Adult↗
PubMed2000

Infertility and psychosexual disorders: relationship in infertile couples.

175 consecutive infertile couples were interviewed together and individually in accordance with a 25 point questionnaire. Amongst the males, premature ejaculations 66% was most common problem followed by erectile dysfunction 15%, decreased libido 11% and orgasmic failure 8%. Amongst females dyspareunia 58%, decreased libido 28% and orgasmic failure 14% were most common problems. Various type of misconceptions were also observed in the infertile couples. Lack of sexual awareness and education formed an important part of observations. Psychosexual dysfunction and infertility was found to occur, in a large number of couples, together in association. Most common cause for this problem seems to be ignorance and lack of sex education.

Adult↗
PubMed2003

[Headache caused by sexual activity].

Headache caused by sexual activity, or coital headache, is included in International headache classification (1988). The paper presents 19 cases (15 males, 4 females, mean age 34 years) examined by the authors. In 58% of the cases, headache developed before orgasm, in 26%--during orgasm and in 16%--after it. Duration of severe headache was from several to 15 min and of moderate one--up to 7 h. In total, disease lasted from 1 week to 8 years. Focal neurological symptoms were absent; magnetic resonance tomography did not reveal any changes in 68% of the patients, while the others had mild hydrocephalia. However, there was a tension of jugular, trapeziform and, less often, of temporal muscles, and, in some of the patients, an increase of arterial pressure. Among psychological features, hypochondria in men and emotional lability in women were detected. According to the clinico-pathophysiological results obtained, different pathogenetic mechanisms of coital headache were suggested: (1) disturbance of venous outflow and dysfunction of antinociceptive systems; (2) increase of arterial pressure combined with tonic tension of pericranial muscles on the background of vertebrogenic disturbances.

Adult↗
PubMed2004

Female sexual function and response.

Although female sexual dysfunction is a problem with low priority, it can have a profound impact on quality of life. In women, the cycle of sexual response begins in the brain, where a memory, an image, a scent, music, or a fantasy acts as a trigger to prompt sexual arousal. Thus, the brain is really the key and starting place for treatment of sexual dysfunction. Decreased libido, altered arousal, inability to achieve orgasm, and dyspareunia are the four broad types of sexual dysfunction in women. Decreased libido, thought to be related to androgenic hormones, results in delayed or altered arousal, decreased vaginal lubrication and dilation, delayed or absent orgasm, and pain or dyspareunia, which can lead to an aversion to sexual experiences.

Adult↗
PubMedDate not supplied

Sexual dysfunction, Part I: Classification, etiology, and pathogenesis.

BACKGROUND: The sexual dysfunctions are extremely common but are rarely recognized by primary care physicians. They represent inhibitions in the appetitive or psychophysiologic changes that characterize the complete adult sexual response and are classified into four major categories: (1) sexual desire disorders (hypoactive sexual desire, sexual aversion disorder), (2) sexual arousal disorders (female sexual arousal disorder, male erectile dysfunction), (3) orgasmic disorders (inhibited male or female orgasm, premature ejaculation), and (4) sexual pain disorders (dyspareunia, vaginismus). METHODS: Articles about the sexual dysfunctions were obtained from a search of MEDLINE files from 1966 to the present using the categories as key words, along with the general key word "sexual dysfunction." Additional articles came from the reference lists of dysfunction-specific reviews. RESULTS AND CONCLUSIONS: Cause and pathogenesis span a continuum from organic to psychogenic and most often include a mosaic of factors. Organic factors include chronic illness, pregnancy, pharmacologic agents, endocrine alterations, and a host of other medical, surgical, and traumatic factors. Psychogenic factors include an array of individual factors (e.g., depression, anxiety, fear, frustration, guilt hypochondria, intrapsychic conflict), interpersonal and relationship factors (e.g., poor communication, relationship conflict, diminished trust, fear of intimacy, poor relationship models, family system conflict), psychosexual factors (e.g., negative learning and attitudes, performance anxiety, prior sexual trauma, restrictive religiosity, intellectual defenses), and sexual enactment factors (e.g., skill and knowledge deficits, unrealistic performance expectations). Understanding the cause and pathophysiology of sexual disorders will help primary care physicians diagnose these problems accurately and manage them effectively.

Humans↗
PubMed2004

Premature ejaculation. 2. Classification and diagnosis.

A classification of premature ejaculation must distinguish between hyper-orgasmic or hypo-orgasmic, between situational or global; furthermore, it must define whether it occurs during vaginal penetration only or also in masturbation, and must study its latency periods and its relationships to the erectile dysfunction, with which it is often associated. Tests with local anesthetics, biothesiometry and penile vibrotactile stimulation, integrated with a thorough study of the general and psycho-sexual history, provide a good diagnostic classification that makes the therapeutic approach appropriate.

Ejaculation↗
PubMed2004

Premature ejaculation. 3. Therapy.

Serotonergic drugs (SSRIs) are the most commonly used, but they are characterized by relapse some time after medication interruption as well as by sexual side effects. The efficacy of phosphodiesterase-5 inhibitors seems excellent, but the risk of tachyphylaxis has been reported. The former (fluoxetine, paroxetine, sertraline, clomipramine) should be used in young patients with hyper-orgasmic forms, while the latter (sildenafil, tadalafil, vardenafil) should be used in hypo-orgasmic forms, in old age or when PE is associated with erectile dysfunction. Topical anesthetics provide satisfactory results in premature ejaculation due to hypersensitivity of the glans, and physiotherapy of the pelvic floor muscles proves successful in cases associated with pelvic floor dysfunction. Therapeutic associations and psycho-sexual therapy techniques may improve results, particularly in the long term.

Ejaculation↗
PubMed2005

[Evaluating the treatment satisfaction of vardenafil in men with erectile dysfunction and female partners by the Treatment Satisfaction Scale].

The Treatment Satisfaction Scale (TSS) has been developed to assess various concepts related to erectile dysfunction (ED) treatment satisfaction in patients and their partners. The self-report questionnaire consists of 4 modules: unmedicated patient, medicated patient, unmedicated partner, and medicated partner modules, measuring a range of sexuality concepts considered important by ED patients and their partners including six domains: "Confidence", "Ease with Erection", "Erectile Function Satisfaction", "Pleasure from Sexual Activity", "Satisfaction with Orgasms", and "Satisfaction with Medication". The TSS is an internationally valid, psychometrically sound instrument to assess patient and partner satisfaction with ED therapy. In a recent double-blind, multicenter, parallel arms, flexible dose clinical trial, the TSS was used to compare patient and partner's satisfaction with vardenafil and placebo therapy. The results demonstrated that vardenafil significantly improved not only erectile function, but also confidence, ease of erection, pleasure, and satisfaction with erectile function, orgasm and medication in men ED and their partners. These attributes are considered to be essential in the acceptance and continued use of PDE5 inhibitor therapy for ED.

Double-Blind Method↗
PubMed2006

Modulation of uterine contractility and peristalsis by oxytocin in estrogen-primed non-pregnant swine uteri.

Oxytocin is one of the most potent uterotonic agents and is known to fluctuate throughout the menstrual cycle, showing an increase during sexual stimulation and arousal, with a peak during orgasm in women. To date, limited data are available on the effects of oxytocin on the regulation of uterine contractility and transport mechanisms in human reproduction. The goal of this study was to evaluate the effects of oxytocin on uterine contractility and peristalsis in estrogen-primed non-pregnant uteri. In an extracorporeal perfusion model of the swine uterus the effect of dynamic changes in uterine contractility and peristalsis in response to oxytocin and estrogen administration was observed. Spontaneous uterine contractility and oxytocin-induced uterine contractility and peristalsis with and without estrogen perfusion were assessed using an intrauterine double-chip microcatheter. Spontaneous peristalsis and oxytocin induced contraction waves without estrogen perfusion resulted in a slightly higher intrauterine pressure in the isthmus uteri in comparison with the corpus uteri, while the peristaltic waves were seen to start mostly in the corpus uteri, moving in the direction of the cervix. While after estrogen perfusion oxytocin produced a significant increase in intrauterine pressure in the isthmus uteri compared to the corpus uteri, and 80% of the peristaltic waves started in the isthmus uteri, moving in the direction of the corpus uteri. This observation strengthens the view that oxytocin is able to support directed transport mechanism in the female genital tract only in the presence of estrogens. The biological role of oxytocin increase during sexual stimulation and arousal with a peak during orgasm for the mechanisms of reproduction may be to stimulate directed uterine transport mechanisms in the presence of estrogens.

Animals↗
PubMed1984

[Towards an integrated sexuality for the couple : pre-orgasmy groups.].

This article deals with the treatment of pre-orgasmic women. Following a short description of the evolution of therapies, the authors define pre-orgasm and its treatment. The authors then present the sequence of treatment sessions and the results obtained in relation to the following aspects: respect for rules and assiduity, age groups, reactions to exercises, relation to partner, methods of undermining, group climate, use of personal creativity and, finally, the effects of therapy on the life of the couple. In conclusion, the authors underline the generalizing effect, produced by improvement in sexual relations on several other aspects of the lives of participants, and on their couple relationship.

English Abstract↗
PubMed2006

Current concepts in ejaculatory dysfunction.

Although erectile dysfunction has recently become the most well-known aspect of male sexual dysfunction, the most prevalent male sexual disorders are ejaculatory dysfunctions. Ejaculatory disorders are divided into 4 categories: premature ejaculation (PE), delayed ejaculation, retrograde ejaculation, and anejaculation/anorgasmia. Pharmacologic treatment for certain ejaculatory disorders exists, for example the off-label use of selective serotonin reuptake inhibitors for PE. Unfortunately, the other ejaculatory disorders are less studied and not as well understood. This review revisits the physiology of the normal ejaculatory response, specifically explores the mechanisms of anejaculation, and presents emerging data. The neurophysiology of the ejaculatory reflex is complex, making classification of the role of individual neurotransmitters extremely difficult. However, recent research has elucidated more about the role of serotonin and dopamine at the central level in the physiology of both arousal and orgasm. Other recent studies that look at differing pharmacokinetic profiles and binding affinities of the alpha(1)-antagonists serve as an indication of the centrally mediated role of ejaculation and orgasm. As our understanding of the interaction between central and peripheral modulations and regulation of the process of ejaculation increases, the probability of developing centrally acting pharmaceutical agents for the treatment of sexual dysfunction approaches reality.

Journal Article↗