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[Optimal management of the flux of patients during mass screening].

The article entitled "The optimization of technological flows of patients at the department of automated mass medical check-ups of workers (DAMMCHW)" sets forth the issues related to the activities of the department providing computer-based dispensarization of workers at industrial enterprises. The specific character of medical check-up organization under the conditions of DAMMCHW is described. A functional scheme of technological flows of patients is provided.

Ambulatory Care↗

Coeliac disease: is it time for mass screening?

Screening studies indicate a prevalence of coeliac disease (CD) of up to 1% in populations of European ancestry, yet the majority of cases remain undiagnosed. Serological markers for CD now available have high sensitivity and specificity, offering the option of mass population screening. The principles of disease screening as set out by Wilson and Jugner can be applied to CD to predict whether this is appropriate. CD is an important health problem for the individual and the community because of high prevalence, associated specific and non-specific morbidity, and long-term complications of which the most important are gut malignancy and osteoporosis. However, recent studies indicate that the prevalence of malignancy and the health impact of osteoporosis are much less than previously supposed, so the prophylactic benefits of early diagnosis through screening may be low. While CD has an accepted and effective treatment, dietary gluten exclusion, this is difficult for the individual and asymptomatic cases may be poorly motivated to comply. Diagnosis of CD is by histological confirmation on duodenal biopsy. We now recognise milder degrees of gluten sensitive enteropathy without villous atrophy (Marsh I, II lesions) and the benefits to the individual by identifying these early lesions through screening is unknown: whether to treat such individuals needs to be agreed before programmes commence. Screening with serum antibodies is relatively non-invasive but may have to be repeated during each individual's lifetime. HLA typing beforehand to identify the 30% of the population with DQ2 or DQ8, who are at potential risk of CD, will allow one-off exclusion of a large percentage of the population but like all genetic testing has ethical implications. The economic costs of screening and treatment versus morbidity prevented have not been calculated.

Celiac Disease↗

[Bicycle ergometry test results in persons with ischemic heart disease detected in mass screening].

Bicycle ergometry in 40-59 year-old male patients with coronary heart disease, identified during mass prophylactic examination on the basis of epidemiological criteria, has shown that in patients with angina pectoris of effort and no myocardial infarction in history positive exercise tests are observed in 20,8% of cases, while in patients with painless CHD forms positive results are observed in 15.4% of cases. Positive exercise tests are the most often in patients with daily anginal attacks and in those with ST depression and flat negative T waves.

Adult↗

[Outcome and future of mass screening for uterine cervical cancer].

Recent effort in the field of gynecologic malignancy has been most concentrated on an early diagnosis and early treatment for them, resulting in the brilliant fruits, that is, an apparent decrease in the mortality of patients with uterine cervical cancer. However, from the standpoint of efficacy, several problems still remain in the present mass population screening system for cervical cancer. Each problem should be resolved in the near future, and a further efficient and effective cancer detection system must be contributed. For this purpose, first of all, population screening at the clinical office must be promoted in order to increase the total number of examinees and to strengthen its system. Secondly, the systematic screening preventing the compliance of examinees should be carried out. Thirdly, increased capability of cytologic examination and adequate control for its diagnostic accuracy must be assured, and lastly, precise detection and follow-up system must be provided.

Cost-Benefit Analysis↗