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PubMed1993

Presentation of the rifle project risk factors and life expectancy. The RIFLE Research Group.

Plans are presented for conducting an epidemiological observational project which will pool the data from nine Italian field studies covering over 70,000 men and women aged 20 to 69 years, belonging to 52 population samples distributed in 13 different regions of the country. The main objective is to produce multivariate models for the prediction of all-cause mortality, life expectancy and selected causes of death as a function of some baseline characteristics. The entry examinations of the population samples were performed between 1978 and 1987 with the measurements of risk factors and other personal characteristics mainly related to cardiovascular diseases and other chronic conditions. They include a large number of anthropometric, social, biochemical, biophysical, clinical, nutritional and behavioural measurements, although only a limited subset of them is common to all the studies. The collection of data on life status, mortality and causes of death has already been completed for 45 out of the 52 samples, although for lengths of follow-up varying from 4 to 12 years. The systematic analysis of this data bank will be started in 1993.

Adult↗
PubMed1984

Prognostic factors for life expectancy after penetrating head injury.

Survival curves were made for 190 World War II veterans with penetrating head injuries, and for 106 WW II veterans with peripheral nerve injuries who matched the subjects with head injuries with respect to age at injury, years of formal education, and preinjury intelligence-test score. The results indicated that penetrating head injury coupled with posttraumatic epilepsy shortened life expectancy in subjects who survived the early postinjury period, but that head injury alone did not. Educational level was also a significant variable independent of seizures: subjects with more education survived longer than those with less education. Age at injury and the difference between preinjury and postinjury intelligence-test scores did not predict survival status.

Adolescent↗
PubMed1993

Protein oxidative damage is associated with life expectancy of houseflies.

The objective of this study was to test some of the predictions of the oxidative-stress hypothesis of aging, which postulates that aging is causally associated with the molecular damage inflicted by reactive oxygen species. Protein carbonyl content was used as an index of molecular oxidative modifications. The carbonyl content was found to be associated with the physiological age or life expectancy of flies rather than with their chronological age. Exposure of flies to sublethal hyperoxia (100% oxygen) irreversibly enhanced the carbonyl content of the flies and decreased their rate of oxygen consumption. Results of this study indicate that protein carbonyl content may be a biomarker of aging and support the general concept that oxidative stress may be a causal factor in the aging process.

Animals↗
PubMedDate not supplied

[Avoidable causes of death and their effects on life expectancy. A socio-demographic interpretation. The case of the northern frontier, 1980-1990].

"This study forms part of [a] research project on the health-disease-death process along the [Mexican] Northern Frontier--a by-product of the socio-economic structure of a specific social formation that determines disease and death--to support regional and sectorial design of policies and actions for the improvement of health conditions for its population.... An important finding is a 4.1 year increase of life expectancy due, among other causes, to a slight decrease in avoidable death causes, although these still produce about 50% of deaths." (SUMMARY IN ENG)

Americas↗
PubMed2003

[Low dose exposure to cadmium and its health effects. (4) Body burden, critical concentration and life expectancy].

As the last manuscript in our series of review articles on cadmium (Cd) and health effects, we reviewed research articles on epidemiologic and experimental studies on exposure levels of Cd in occupational and environmental settings in various countries, disposition and body burden of Cd, critical concentrations of Cd in the kidney of humans and animals with a focus on biomarkers for renal dysfunction, and life expectancy in Cd-polluted areas and reference areas. After this manuscript was compiled, cadmium levels in rice crops received significant attention, since the risk assessment of cadmium is now under review and discussion by the Joint Expert Committee of Food Additives and Contaminants organized by the Food Agricultural Organization and World Health Organization in 2003. We hope that the information compiled in this review may provide directions for future studies on the health risk assessment of Cd.

Animals↗
PubMed2004

Deleterious effects of increased body weight associated with intensive insulin therapy for type 1 diabetes: increased blood pressure and worsened lipid profile partially negate improvements in life expectancy.

OBJECTIVE: Weight gain is an unwanted side effect of improved glycaemic control in type 1 diabetes, associated with increased blood pressure (BP) and worsening lipid profiles. While improved glycaemic control per se should improve long-term patient outcomes, increases in BP and worsening lipid profiles may counteract these benefits. The aim of this modelling study was to assess whether the increased body weight and associated worsening of lipid profile and blood pressure would negate the improvements in glycaemic control seen with intensive therapy in patients with type 1 diabetes. METHODS: A validated diabetes model projected life expectancy (LE), quality-adjusted LE (QALE) and total lifetime costs of complications in type 1 diabetes cohorts with the characteristics of patients from the Diabetes Control and Complications Trial (DCCT). The following four cohorts (A-D) were created based on increased body weight under either conventional or intensive therapy: A) conventional glycaemic control in the subgroup with lowest weight-gain quartile after 6.5 years (HbA1c increased by 11% from baseline); B) conventional control in the highest weight-gain quartile (no change in HbA1c from baseline); C) intensive control in the lowest quartile of weight gain (with 16.1% decrease in HbA1c, but no increase in weight or associated BP, and improved lipid profile); D) intensive control in the highest quartile of weight gain (with 21% decrease in HbA1c, increased systolic BP of 6 mmHg, and worsened lipid profile). Data were derived from DCCT and other published sources. RESULTS: Intensive control, even with weight gain, led to major improvements in LE and QALE, and reduction in costs of complications versus conventional therapy. Intensive therapy with no weight increase led to a higher LE (increased by 0.57 years) and higher QALE (increased by 0.28 years) and lower costs of complications (reduced by 523 dollars/patient), compared to intensive therapy with the highest quartile of weight gain. CONCLUSIONS: Concerns about weight gain should not deter intensive insulin therapy. However, the value of improving glycaemic control without increasing body weight (and associated increased BP and worsening of lipid profile) has been confirmed.

Blood Pressure↗
PubMed1981

Predictive value of symptom-limited exercise testing for life expectancy in inoperable coronary patients with disabling angina.

100 inoperable coronary patients defined by severe angina, multistenosed vessels and narrowed or thrombosed distal beds performed a symptom-limited exercise test before coronary angiogram. During a 46 +/- 30 month period of follow-up 29 died, 25 of whom by cardiac cause. Among the exercise test data, the most discriminant for long-term survival was the exercise capacity, in spite of a poor correlation parameter for prediction of life expectancy.

Adult↗
PubMed1989

Analysis of life expectancy and living status of elderly patients surviving a burn injury.

This study evaluates the long-term outcome of elderly patients discharged from hospital after a burn injury. Ninety-three patients over the age of 60 years, admitted to a regional burn center, were included in the study from January 1981 to January 1986. The in-hospital mortality rate was 49.4%. Patients' living status was graded according to dependency: 47% of patients were reduced to a more dependent living status on discharge, and 36% of the survivors were followed up for between 1 and 5 years. During this time seven (19.4%) patients died, three (8.3%) became more independent, four (11.1%) less independent. Life table analysis of discharged patients showed no accelerated death rate in comparison with the normal population. The high mortality associated with burns in the elderly was confirmed. Half the survivors were at least temporarily less independent. Projected life expectancy for the elderly surviving a burn is comparable with his/her uninjured counterpart.

Activities of Daily Living↗
PubMed2004

Subjective life expectancy predicts offspring sex in a contemporary British population.

There is evidence that women who are in poor physical condition or who reside in deprived environments are more likely to give birth to daughters than to sons. Under deprived environmental conditions, or when in poor physical health, it has been hypothesized that parents should take into account the available resources and manipulate the sex of any children born. Using subjective life expectancy (SLE) as a measure of how an individual views their future health and environment, I demonstrate that there is an association between the sex of the first child and SLE in a sample of mothers from a contemporary British population (Gloucestershire, UK). SLE was a significant predictor of offspring sex: women who believed that they had longer to live were more likely to have had a male birth than women who thought they would die earlier. Detection of such a bias among the children of British mothers may provide evidence that the sex ratio under relatively affluent Western conditions can still be influenced by adverse environmental or poor maternal condition.

Adolescent↗
PubMed2005

Reorganization of cytoskeletal proteins and prolonged life expectancy caused by hepatocyte growth factor in a hamster model of late-phase dilated cardiomyopathy.

OBJECTIVE: It has been postulated recently that changes in cytoskeletal and sarcolemmal proteins initiate a final common pathway for contractile dysfunction in dilated cardiomyopathy. In ischemic cardiomyopathy, hepatocyte growth factor plays an important role in reorganizing the impaired cytoskeletal proteins in several cell types. We have tested the hypothesis that hepatocyte growth factor might improve life expectancy through modification of the molecular process that contributes to impairment in dilated cardiomyopathy. METHODS: Adult male 27-week-old BIO TO-2 hamsters, which show moderate cardiac remodeling, were divided into treatment groups that received (1) hemagglutinating virus of Japan liposomes containing human hepatocyte growth factor cDNA (H group), (2) culture medium (C group), or (3) sham operation (S group). RESULTS: After the operation, echocardiography demonstrated that the enlarged left ventricular end-systolic dimension and decreased fractional shortening were significantly attenuated in the H group compared with the C group. There was significantly less myocardial fibrosis in the H group compared with the C group. Immunohistochemical analysis showed alpha-dystroglycan and alpha- and beta-sarcoglycan expression in the basement membrane beneath the cardiomyocytes in the H group, whereas no expression of these proteins was seen in the C group. The 40-week survival was significantly better in the H group than in the C and S groups. CONCLUSION: An improved survival associated with transient reorganization of the cytoskeletal proteins and reduction in myocardial fibrosis was achieved by hepatocyte growth factor treatment in an adult hamster model of dilated cardiomyopathy. The results suggest a therapeutic potential of hepatocyte growth factor in the treatment of dilated cardiomyopathy.

Animals↗
PubMed2004

Impact of nursing home deaths on life expectancy calculations in small areas.

STUDY OBJECTIVE: The drive to tackle health inequalities at the local level has increased interest in mortality data for small populations. There is some concern that nursing homes may affect measures of mortality for small populations, but there has been little in depth analysis of this. DESIGN AND SETTING: Deaths between 1997 and 2001 and population figures from the GP register (Exeter) database and census 2001 were used to produce life expectancy (LE) figures for all electoral wards in West Sussex. The proportion of those dying within each ward that had been residents of nursing homes was calculated and the relation between these variables and deprivation investigated. RESULTS: There was a significant linear relation between nursing home deaths and LE (p<0.0001), which explained 36% of variation in LE between wards. Deprivation accounted for around 35% of the variation in LE (p<0.0001) but was not correlated with nursing home deaths (p> or =0.0982). Multiple linear regression shows that over 60% of the variation in LE at ward level can be explained by both nursing home deaths and deprivation (p<0.0001) and that the two variables explain similar proportions of this variation. The relation between LE and nursing home deaths within wards grouped by deprivation suggests that the impact of nursing homes is strongest in deprived wards. CONCLUSIONS: This finding has important implications for LE calculations in small populations. Further investigation is now needed to examine the impact of nursing homes in other areas, on other mortality measures, and in larger populations.

Aged↗
PubMed2006

Life expectancy and health care expenditures: a new calculation for Germany using the costs of dying.

Some people believe that the impact of population ageing on future health care expenditures will be quite moderate due to the high costs of dying. If not age per se but proximity to death determines the bulk of expenditures, a shift in the mortality risk to higher ages will not affect lifetime health care expenditures as death occurs only once in every life. We attempt to take this effect into account when we calculate the demographic impact on health care expenditures in Germany. From a Swiss data set, we derive age-expenditure profiles for both genders, separately for persons in their last 4 years of life and for survivors, which we apply to the projections of the age structure and mortality rates for the German population between 2002 and 2050 as published by the Statistische Bundesamt. In the extreme case, we assume that morbidity is compressed at the end of life in such a way that a 60-year old in 2050 is as healthy as a 56-year old today if his life expectancy is 4 years higher. We calculate that at constant prices, per-capita health expenditures of Social Health Insurance would rise from 2596 Euro in 2002 to between 2959 Euro and 3102 Euro in 2050 when only the age structure of the population changes and everything else remains constant at the present level, and to between 5232 Euro and 5485 Euro with a technology-driven exogenous cost increase of 1% per annum. A "naïve" projection based only on the age distribution of health care expenditures, but not distinguishing between survivors and decedents, yields values of 3217 Euro and 5688 Euro for 2050, respectively. Thus, the error of excluding the "costs of dying" effect is small compared with the error of underestimating the financial consequences of expanding medical technology.

Aged↗
PubMed1977

[Life expectancy in penile carcinoma (statistical evaluation of 150 penile carcinomas in the period 1912-1970)].

In the period 1912-1970 in the Göttingen area, 150 patients suffering from penis carcinoma were investigated and/or treated. With regard to method of treatment, three periods can be distinguished: 1912-1930, 1931-1948, and 1949-1970. During the first period, treatment was chiefly radiotherapy, in the second chiefly surgery, and in the third combined radiotherapy and surgery. Independent of the type of therapy and period of observation, the 3-, 5-, and 10-year survival rates were 52.5%, 46.7%, and 31.4%, respectively. The greatest life expectancy was that following combined surgical and high-voltage therapy. The importance of lymphography is emphasized.

Adult↗
PubMed2006

Causes of death behind low life expectancy of Danish women.

AIMS: The authors examined causes of death contributing to the relatively high mortality of Danish women born 1915-45, and evaluated the impact of smoking related causes of death. METHODS: Age-period-cohort analysis of mortality of Danish women aged 40-89 in 1960-98. Estimate of the negative curvature in parabola patterns for 50 causes of death. RESULTS: A total of 34 causes of death contributed to the relatively high mortality for women born 1915-45. The main contribution came from smoking-related causes of death. CONCLUSION: The results indicate a high smoking prevalence to be the main explanation behind the relatively low life expectancy of Danish women born 1915-45.

Aged↗
PubMed1978

Natural history and life expectancy in severe alpha1-antitrypsin deficiency, Pi Z.

Clinical data from 246 adult Swedish individuals with severe alpha1-antitrypsin deficiency, Pi Z, diagnosed in 1963--77, were analyzed. Primary emphysema was present in 109 cases. Of 75 Pi Z patients with other types of chronic obstructive pulmonary disease (COPD), all but 7 showed signs of emphysema. Median age at onset of dyspnoea in Pi Z smokers was 40 years, compared to 53 in non-smokers (p less than 0.001). Of the Pi Z individuals over the age of 50, 19% had a diagnosis of liver cirrhosis and 15% signs of glomerular renal damage. Of 91 deceased patients, 56 died from COPD and 12 from liver disease. A greatly reduced survival was demonstrated in Pi Z individuals, regardless of sex. Smoking Pi Z individuals had a significantly lower life expectancy than Pi Z non-smokers (p less than 0.01).

Adult↗
PubMed1980

Mortality and life expectancy after hip fractures.

Follow-up data for at least 4 years was collected for 675 patients treated for hip fractures in the period 1961--1970. Compared with a series from the same hospital for the years 1948--1957 the number of patients had more than doubled and a higher hospital mortality was encountered, but the 4-year survival rate was unchanged. The mortality after hip fracture was found to be related to the age and sex of the patient and to the nature and number of associated diseases. The mortality rate was found to be high in the first 2 months following the fracture, but patients surviving the second month showed no excess mortality during the following 4 years, having the same life expectancy as the general population.

Adolescent↗