Contact dermatitis on the hands.
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Pathological changes in the skin, of allergic type, have been detected in 35 of 131 weavers, employed in the production of primarily texas textiles. Patch tests yielded in 21 patients positive results with cotton and texas textiles. Approximately 50% of positive results of dermal tests have been found to be induced by naphthol compounds added to dyes in the process of preliminary dying. Moreover, 2 cases of extensive hyperchromatism in persons concerned with the above mentioned textiles have been observed which, due to the treatment procedures and removed from work in exposure have partly subsided.
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Two machinists were seen whose chronic hand dermatitis was explained by allergic sensitivity to a biocide, Tris Nitro (2-[hydroxymethyl]-2-nitro-1,3-propanediol), which was added to their metalworking fluids (cutting oils) to prevent rancidity. The cause of the men's difficulty was first suspected when they had positive patch test reactions to a related biocide, Bronopol (2-bromo-2-nitropropane-1,3-diol), which we added to our standard screening tray because of its presence in more than 500 cosmetic formulations. The detective skills of the patients uncovered the chemical, Tris Nitro, related to Bronopol in their work environment. Most cases of dermatitis seen in machinists are irritant in origin. As we achieve better cooperation from the metalworking fluid industry, perhaps an increasing number of allergens will be identified. When this occurs, a cooperative manufacturer can be invaluable in directing a machinist to a replacement--a well-preserved cutting fluid free of the allergen.
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The following report describes a patient who had both an immediate and a delayed reaction to paraphenylenediamine (PPDA).
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