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[Evaluation tests of computer systems concerning tri-dimensional dose calculations].

The development of irradiation techniques in radiotherapy shows a clear tendency towards the systematic use of three-dimensional (3D) information. Great efforts are being made to set up 3D conformal radiotherapy. Consequently, in the aim of greater coherence and accuracy, "the dosimetric tool" must also meet the requirements of 3D radiotherapy, as it plays a role in the treatment chain. To know if the treatment planning system is a "3D", "2D" or even "1D" system, one should not be satisfied with reading the technical documentation and the program algorithm description nor entirely trust the constructor's assertions. It is essential to clearly and precisely evaluate the possibilities of the treatment planning system. Even if it is proved not to satisfy perfectly all the tests which would qualify it as a real 3D calculation system, the study of the test results helps to give clear explanations of the dosimetric results. Two series of test cases are proposed. The first series allows us to understand in which conditions the treatment planning system takes into account the scatter influence in a volume. The second series is designed to inform us about the capability of the dose calculation algorithm when the medium encloses non-homogeneities. These test cases do not constitute an exhaustive "check-list" able to tackle completely the question of 3D calculation. They are submitted as examples and should be considered as an evaluation methodology for the software implanted in the treatment planning system.

Computer Simulation↗
PubMed1984

Platelet function testing: an improved approach utilizing lumi-aggregation and an interactive computer system.

An approach to laboratory testing of platelet function is described that uses an interactive, computer-assisted lumi-aggregation technic. Use of this approach over the past 18 months in the clinical laboratory has improved significantly not only the procurement but also the analysis of aggregation and secretion data. All calculations are printed out automatically following the completion of each run, permitting an entire study to be completed in 60-90 minutes following the preparation of platelet-rich plasma. An internal ATP standard used in each run helps minimize apparent variations in platelet ATP secretion resulting from variations in the luciferin-luciferase measuring system itself. The simultaneous monitoring of platelet aggregation and secretion provides a much-improved opportunity for the assessment of secretory defects than does study of aggregation curves alone. The present work provides a simple, efficient approach to platelet lumi-aggregation testing in the clinical laboratory.

Blood Platelets↗
PubMed2004

Cellware--a multi-algorithmic software for computational systems biology.

UNLABELLED: The intracellular environment of a cell hosts a wide variety of enzymatic reactions, diffusion events, molecular binding, polymerization and metabolic channeling. To transform these biological events into a computational framework, distinct modeling strategies are required. While currently no tool is capable of capturing all these events, progress is being made to create an integrated environment for the modeling community. To address this niche requirement, Cellware has been developed to offer a multi-algorithmic environment for modeling and simulating both deterministic and stochastic events in the cell. AVAILABILITY: The software is available for free and can be downloaded from http://www.bii.a-star.edu.sg/sbg/cellware

Algorithms↗
PubMed1988

The development of an expert computer system on medical consulation.

In order to master fuzziness and uncertainty in solving human problems, an expert system shell SYSTEM Z-II which can handle both exact and inexact reasoning has been successfully developed. This paper describes how the Z-II system shell works in building a medical consultation expert system which accepts fuzzy human concepts and uncertain factors. This expert system ABVAB in the domain of "Abnormal Vaginal Bleeding" is described to demonstrate the power and flexibility of such system. The methods of approach in the development and testing of this system are presented together with the results.

Diagnosis, Computer-Assisted↗
PubMed1991

A high-resolution networked computer system for radiologic instruction of medical students.

A network of 18 Macintosh II-based workstations (Apple Computer Corp, Cupertino, CA) having high-resolution 1,024-line monitors is used for the radiologic instruction of medical students in our institution. Although this is an expensive system, it is time-shared with the Departments of Pathology, Physiology, Neuroscience, Biochemistry, Parasitology, and Microanatomy. The number of workstations available allows the entire class to access the system simultaneously by working in small groups. Because of its high resolution, medical imaging studies and text may be displayed on the same monitor side by side. We have chosen a question-and-answer format (Carousel). Forty-one radiologists in our affiliated medical institutions contributed cases. These cases in question-and-answer form supplement the lectures and film-based tutorials given as part of our mandatory third year radiology clerkship.

Computer Communication Networks↗