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At least 685 records · Page 38Linked to original sources
PubMed1989

[Correlation of arteriosclerosis obliterans of the lower extremity with coronary artery disease].

To ascertain the correlation between arteriosclerosis obliterans (ASO) of the lower extremities and coronary artery disease (CAD), 69 patients with lower extremity ASO were observed. Based on clinical symptoms, the patients were categorized as group A: 52 with intermittent claudication and group B: 17 with angina pectoris. All patients underwent angiography of both lower extremities and the heart. Results were as follows: 1. In group A, 33 patients had significant coronary stenosis with single (16 cases), double (12 cases) and triple (five cases) vessel disease. Sixteen patients had histories of myocardial infarction and two had vasospastic angina. In group B, 15 patients had significant coronary stenosis with single (five cases), double (six cases) and triple (four cases) vessel disease including two cases involving the left main trunk. Six patients had histories of myocardial infarction and two had vasospastic angina. 2. Electrocardiography revealed that 37 patients in group A and 14 patients in group B had abnormal ECGs as abnormal Q waves and ST-T changes. However, 10 patients in group A and three patients in group B had significant coronary stenosis despite their normal ECGs. 3. According to the sites of stenotic lesions, all 69 patients with ASO were classified in four types; as diffuse, pelvic, ilio-femoral and femoral. The incidence of CAD did not differ among these four types. 4. In group A, 38 patients experienced revascularization of ASO; 36 cases by bypass grafting, and two by percutaneous transluminal angioplasty (PTA). Ten patients received cardiac revascularization including three cases with coronary artery bypass graft (CABG) and seven cases with percutaneous transluminal coronary angioplasty (PTCA). In group B, 13 patients received revascularization of ASO with bypass grafting. Eleven patients had coronary revascularization including seven cases with CABG and four cases with PTCA. 5. Fourteen of the 69 patients received revascularization for both ASO and CAD. In conclusion, there is a highly significant coincidence of CAD in patients with ASO, and CAD is often silent. These data indicate that routine coronary angiography is necessary for detecting and preventing CAD in all patients with ASO. Coronary artery revascularization, especially PTCA, can be indicated prior to lower extremity revascularization.

Aged↗
PubMed1986

Effects of ketanserin on blood pressure, peripheral circulation and haemocoagulative parameters in essential hypertensives with or without arteriosclerosis obliterans of the lower limbs.

Ketanserin is a new strong antiserotoninergic drug that, unlike the previous ones, is selective for 5-hydroxytryptamine receptors. This drug has been employed successfully in the treatment of arterial hypertension and of some peripheral vascular diseases. The authors are carrying out a trial on medium term treatment with ketanserin (K) or propranolol (P) in comparison with placebo, to evaluate their effects on blood pressure, haemocoagulative parameters and peripheral circulation. The trial is a double-blind cross-over random trial on subjects with mild or moderate hypertension. Until now 13 patients have ended the study; six of them are suffering from arteriosclerosis obliterans of the lower limbs at 1st or 2nd stage according to Fontaine. Both propranolol and ketanserin significantly reduced the blood pressure, although the decrease in systolic blood pressure was more evident after propranolol. Heart rate diminished significantly only after propranolol administration. The noninvasive, intermittent (every 30 min) monitoring of blood pressure showed a significant 24-hour reduction of blood pressure after administration of propranolol or ketanserin without significant changes of circadian behaviour of the blood pressure. After administration of ketanserin a slight improvement in peripheral circulation was demonstrated, evaluated by using strain-gauge plethysmography. As regards the results obtained for platelet function and other haemocoagulative parameters examined, adenosine diphosphate-induced platelet aggregation, adenosine diphosphate slope, collagen lag period, antithrombin III biological activity, and serum fibrinogen did not show noticeable modifications after treatment, while beta-thromboglobulin levels decreased slightly after ketanserin administration.

Adult↗
PubMed1987

[Effect of the time of day on the EEG in cerebral arteriosclerosis].

UNLABELLED: The study was conducted with three men and seven women, 72-84 years old, characterized by psychopathological and clinical signs of cerebral arteriosclerosis (A). All patients suffered from disorder of sleep-waking rhythm. With one exception every experiment ran for five days during which closed-eye-EEGs were registered at 8 a.m., 12 noon, 4 p.m., and 8 p.m. of the alert but relaxed patients and recorded on tape for computer processing. Simultaneously with every EEG registration the body temperature was measured. The findings were compared statistically with corresponding data of a former study conducted with ten healthy aged volunteers (G). RESULTS: The dominant peak-frequency of the patients turned out significantly slower than that of the volunteers.--While in healthy persons the peak frequency increased corresponding with the body temperature from the morning to the late afternoon or the early evening respectively, the patients lacked such a correlation, although their temperatures rose gradually in the normal way. In most of the patients the peak-frequency had a remarkable small variety from day to day as well as from scalp-position, and its circadian shift was poor. Psychopathologically these subjects manifested primarily memory loss, general intellectual decline, and in four cases disorientation. On the other hand the EEGs of three women showed substantial greater variety of the peak-frequency from day to day and from scalp-position to scalp-position. Besides the alterations during the day were rather excessive, but lacking any appreciable correspondence with the undisturbed circadian variations of the body temperature. In these three cases psychopathologically personality changes preponderated.

Aged↗
PubMed1988

Homocysteine thiolactone in arteriosclerosis and cancer.

Homocysteine thiolactone was isolated from normal human plasma, sera of patients with acute myocardial infarction, and human neoplastic tissue. The compound was identified by ninhydrin reaction and by nitroprusside reaction following alkaline hydrolysis. Thin layer and ion exchange chromatography demonstrated a single uniform peak which co-chromatographed with authentic homocysteine thiolactone. The substance was isolated by extraction of plasma, serum or tissue with chloroform:methanol, re-extraction of the chloroform layer with dilue HCl, and evaporation of the resulting aqueous acid layer. The amount of homocysteine thiolactone was found to be 1,670 mumol/L in normal human serum and 12,500 mumol/L in sera of coronary heart disease patients. Although there is variability and overlap of values between groups, the difference between the two groups is significant (P = 0.025). The amount of homocysteine thiolactone in three human neoplasms was 17-123 mumol/kg. Only trace amounts were found in normal tissues, and none was detected in two other human neoplasms. The findings support the previous demonstration of abnormal homocysteine thiolactone metabolism in arteriosclerosis and cancer.

Adenocarcinoma↗
PubMed1987

Cerebral infarction due to radiation accelerated arteriosclerosis.

Radiation therapy may cause accelerated arteriosclerosis of carotid and vertebral vessels which can cause cerebral infarction. This is a late complication which usually occurs several years after therapy and often affects vessels in locations where severe arteriosclerotic change is uncommon.

Adult↗
PubMedDate not supplied

Enhanced endothelial permeability and invasion of leukocytes into the artery wall as initial events in experimental arteriosclerosis.

The temporal sequence of the very early events in arteriosclerosis, as induced by electrical stimulation in carotid arteries of rabbits, was examined by combined light microscopy and transmission electron microscopy. After one session (30 min) of DC impulses, the endothelial permeability to horse-radish peroxidase was increased mainly beneath the anode, judging from the massive accumulation of reaction products of peroxidase in the subendothelium. After a further stimulation period, some of the endothelial cells displayed alterations in pattern and size and heavy cytoplasmic deposition of silver salt. However, the endothelium was maintained as a continuous lining. During this initial phase, a considerable number of granulocytes and monocytes was found adhering to the endothelium of the stimulated region and also within the subendothelial space. The invasion of the leukocytes preceded the migration of smooth muscle cells from the media into the intima, a process which began after two days of the electrical stimulation schedule. These initial phases of plaque development may represent a special form of an inflammatory response.

Animals↗
PubMed1985

Testis, epididymis, and spermatic cord in elderly men. Correlation of angiographic and histologic studies with systemic arteriosclerosis.

Autopsy specimens of the testes, epididymides, and spermatic cords from 20 adult young and 60 elderly men were studied by angiographic and histologic techniques. Testicular alterations in elderly men were correlated to the degree of aortic atheromatosis. Elderly men without manifest atheromatosis showed no lesions. Elderly men with slight atheromatosis showed a spiculated outline of the testicular artery and intraparenchymatous zones with scarce filling of small arteries. These zones exhibited peritubular and interstitial fibrosis. Elderly men with severe atheromatosis showed large zones of the testicular parenchyma with scarce filling of centrifugal and centripetal arteries that exhibited fibrosis of the tunica intima and lumen reduction; the testicular parenchyma appeared fibrosed with sclerosed tubules. Epididymal lesions were parallel to testicular lesions. These results suggest that systemic arteriosclerosis is involved in the decline of testicular function with age.

Adult↗
PubMed1985

Screening of children with high familial risk of arteriosclerosis.

Serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C) and total triglyceride levels were determined in children with high risk arteriosclerotic family history. Significantly higher TC and lower HDL-C levels were found in children whose parents' first arteriosclerotic sign had appeared before 40 years of age. There were no similar significant alterations observed in children whose parents' first arteriosclerotic symptom appeared after the forties. Screening therefore seems to be necessary in the offsprings of patients if the first sign of arteriosclerosis has been detected before 40 years of age.

Adolescent↗
PubMed1985

[Experimental immune arteriosclerosis in the rabbit. Immunogenic and pathogenic properties of glycoproteins and elastins in arterial tissue].

Rabbits immunized with kappa elastin produced arteriosclerosis and antibodies that bound to target-structures (elastic fiber sheaths, endothelial and smooth muscle cells). These antibodies were cytotoxic for cultured rabbit or rat arterial smooth muscle cells. Absorption of the antielastin antiserum with pig aorta or human serum glycoproteins inhibited its binding to target-structures and suppressed its in vitro cytotoxicity. These data are discussed.

Animals↗
PubMed1985

[Arteriosclerosis of the aortic arch branches. An analysis of 43 cases].

During 2 years and 8 months (1980.9.-1983.4), 100 patients of arteriosclerosis were admitted to our hospital. Of these patients, 43 who had clinical symptoms of TIA, RIND, or bruits on the neck or supraclavicular fossa, were reviewed. Ages ranged from 46 to 81 years (mean: 66.3). Male to female ratio was 1.9:1. Of the 43 patients, 33 were submitted to arteriography of the branches of the aortic arch. Thirty-two but one had arteriosclerotic lesions on the 62 arteries: 32 carotid, 18 vertebral, and 12 subclavian arteries, respectively. Morphologically there were 42 stenoses, 13 occlusions, 7 aneurysmal dilatations, and three other lesions. Seven patients were involved only one artery and 25 were involved more than two arteries. Eight patients were involved other regions such as lower extremities, too. Of the 43 patients, 12 were operated upon and there were no operative deaths and complications. Three of 31 who were treated conservatively, died of malignancies and heart failure. Although operative indications for TIA or RIND have been defined, those for asymptomatic lesions have not been established. Once stroke occurred, however, it would become difficult to recover from it. It is hoped that operative indications for asymptomatic lesions are established as soon as possible.

Aged↗
PubMed1985

Hemodynamic effect of cilostazol on increasing peripheral blood flow in arteriosclerosis obliterans.

The novel synthetic antithrombotic drug, cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-qui nolinone, OPC-13013) was orally administered in a dose of 200 mg/day to 4 patients with arteriosclerosis obliterans (ASO) in the lower extremities to evaluate the hemodynamic effects of the drug. After 2 weeks of treatment, tissue blood flow through the pedal vessels was measured in 8 legs by the venous occlusion method using a strain-gauge plethysmograph. The flow measured during reactive hyperemia was shown to have significantly increased from 5.04 +/- 1.90 to 9.05 +/- 4.77 ml/min/100 g tissue (p less than 0.05, t-test), the rate being 80.68 +/- 66.61% of the initial level. The drug was, therefore, considered to have high clinical potential in the treatment of chronic arterial occlusion such as ASO and Buerger's disease (thromboangiitis obliterans). The drug was also shown to be of value in supporting the reconstruction of circulation in the lower extremities.

Aged↗
PubMedDate not supplied

[Treatment of carotid artery arteriosclerosis 1966 to 1976. Early and late results (author's transl)].

Early and late results of surgery for carotid arteriosclerosis between 1966 and 1976 were reviewed in 154 patients (192 operations). The percentages of excellent and good early results were 96.7% (stage 0), 91.3% (stage I), 46.6 (stage II) and 51.6% (stage III). Overall mortality was 9.1% within the month (3.8% as neurovascular risk). In late results, out of 140 survivors, the percentages of excellent and good results were 69% in stage 0, 59.7% in stage I, 45.5% in stage II and 56.7% in stage III, the mean delay being 40.5 months. There were 3.6% cases of neurological disorders (0.7% corresponding to the side of the operated carotid artery), 7.1% of vertigo and arterial hypertension, 33 (new) deaths (23.6%) occurred after a mean 31.3 months, of which 16 resulted from some cardiovascular trouble. The cumulative survival curves parallel those of the normal population showing the protection yielded by the operation and the decrease in neurovascular risk.

Adult↗
PubMed1979

[Fundus changes due to arteriosclerosis and chronic-arterial hypertension (author's transl)].

The authors report on difficulties in ophthalmoscopac differential diagnosis of fundus changes due to arteriosclerosis and hypertension. An attempt is made to present a classification of hypertensive alterations which -- in close association with the scheme published by Keith, Wagner and Neubauer -- uses the same descriptive terms but restricts itself to distinguish between changes of the vascular system on the one hand and changes of the parenchym as a consequence of the vascular changes on the other hand.

Adult↗
PubMed1979

[Inhibitors of platelet aggregation in the therapy of arteriosclerosis obliterans].

The central role of the thrombocytes in the initial atherogenesis and the secondary formation of the thrombus on sclerotically changed walls of the vessels is the basis of all experiments to perform a primary or secondary prevention of the atherosclerosis with thrombocyte aggregation inhibitors. Of the numerous thrombocyte-inhibiting substances acetyl salicylic acid, dipyridamol and sulfinpyrazone proved most suitable for clinical purposes. Apparantly for methodical reasons experiments of a primary prevention of the atherosclerosis with aggregation inhibitors have hitherto not be performed. On the other hand, in numerous quantitatively very different studies on patients with manifest cerebral, coronary and peripheral arteriosclerosis the influencibility of the course of the disease was tested by thrombocyte inhibitors. Since correct prospective studies are connected with enormous organisational expenditure and must extend for a longer period many extensive examinations have not yet finished. In the present survey the hitherto existing reports from literature are critically summarized, taking into particular consideration the per ipheral angioorganopathies and first informations on an own study concerning the prophylaxis of the diabetic angiopathy with Micristin are given. The present state of knowledge allows the conclusion that the well founded theoretical concept is apparantly confirmed by practice. However, the successes observed could be statistically ascertained only in individual cases, so that at present a final estimation of the prophylactic value of these preparations is not yet possible.

Arteriosclerosis Obliterans↗
PubMed1979

[Autoantibodies in arteriosclerosi and endangiitis obliterans].

10 of 14 patients with obliterating endangiitis and 2 of 17 patients with obliterating arteriosclerosis had in the serum immunoflorescence-optically provable low titre antibodies against different constituents of smooth musculature (once cross-reacting with transverse and cross striation of the myocardium). Further antibodiies against brush border of proximal renal tubuli, parietal cells, cardiac sarcolemma, cytoplasm of the liver and distal renal tubuli were found. Antibodies against nuclear material, skeletal musculature, further typical antibodies against mitochondria, ribosomes and membranes of the endoplasmatic reticulum as well as so-called pemphigus and pemphigoid antibodies could not be proved. The proof of low titre antibodies against constituents of smooth musculature is in this case regarded as an unspecific marker of an (often) viral inflammation.

Arteriosclerosis Obliterans↗
PubMed1979

[Conservative treatment of arteriosclerosis obliterans].

The conservative therapy of the arteriosclerotic obstructive disease demands a complex approach. The basis therapy, the symptomatic treatment of the haemodynamics of the extremity with ill vessels, the pathogenetically oriented therapy as well as the treatment of other localisations of the arteriosclerosis should be used combined. At stage III and IV additional measures, such as combat against pain, therapy with antibiotics and local treatment of tissue lesions are necessary. The results of the therapy should be critically tested not only on the basis of the clinical picture, but also on the basis of the course of the vascular processes.

Anti-Bacterial Agents↗
PubMed1977

[Relations between athero-arteriosclerosis and chronic liver diseases. Anatomopathological and statistical studies].

Starting from well known anatomopathological premises and on the basis of relative physiopathological concepts, particularly lipid metabolism and the lipidaemic fractions in patients suffering from chronic hepatopathy and athero-arteriosclerosis, a statistical investigation was carried out into the relations between the two disease conditions on the basis of the anatomopathological material collected over a period of six years in the S. Giovanni and S. Giacomo Hospitals in Rome. The conclusion is that there is a smaller incidence of athero-arteriosclerotic pathology in patients suffering from chronic hepatopathy up to the sixth decade of life.

Adult↗
PubMed1982

Platelet malondialdehyde and plasma thromboxane B2 formation in patients with obliterative arteriosclerosis of the lower limbs.

The platelet MDA and plasma TXB2 formation was studied in normal subjects and in patients with obliterative arteriosclerosis of the lower limbs. The increase in platelet MDA and plasma TXB2 formation could be found in these patients. It is concluded that these factors as well as the decrease in plasma cAMP level previously reported may play decisive role in the pathogenesis of occlusive arterial disease.

Adult↗