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PubMed2004

Family, friend or foe? Critical reflections on the relevance and role of social capital in health promotion and community development.

Social capital has been the focus of considerable academic and policy interest in recent years. Despite this interest, the concept remains undertheorized: there is an urgent need for a critical engagement with this literature that goes beyond summary. This paper lays a foundation for a critical dialogue between social capital and health promotion, by examining problematics in the conceptualization and practice of social capital building and linking these to models of community development, a cornerstone health promotion strategy. In so doing, the paper contributes to the existing literature by providing a theoretical exposition and critique of various threads in social capital discourse, and linking these threads explicitly to community development practice. Distinctions between communitarian, institutional and critical approaches to social capital are elaborated, and the relationships between these three approaches and three models of community development-social planning, locality development, and social action-are discussed. The existing social capital literature is then critically examined in relation to three key themes common to both literatures: community integration, public participation, and power relations. This examination suggests that social capital cannot be conceived in isolation from economic and political structures, since social connections are contingent on, and structured by, access to material resources. This runs counter to many current policy discourses, which focus on the importance of connection and cohesion without addressing fundamental inequities in access to resources. This paper posits that approaches to community development and social capital should emphasise the importance of a conscious concern with social justice. A construction of social capital which explicitly endorses the importance of transformative social engagement, while at the same time recognising the potential negative consequences of social capital development, could help community organizers build communities in ways that truly promote health.

Canada↗

PubMed2001

The EC4 quality manual model.

One of the priorities of the European Confederation of Clinical Chemistry (EC4) is the harmonisation of the clinical laboratory profession in Europe. One of the first steps is to try to harmonise the quality systems, that is, the clinical laboratory organisational structure, responsibilities, procedures, processes and resources involved in quality management. The "EC4 Essential Criteria" were published by the Working Group on Harmonisation of Quality Systems in order to facilitate the development or the update of a quality system in a clinical laboratory, and to encourage international bodies to produce specific Standards for the clinical laboratory. Furthermore, the EC4 Working Group has produced a Quality Manual Model, which includes a sample of quality policy documents and some operational directions for an imaginary laboratory. This Quality Manual Model was prepared following the "EC4 Essential Criteria." Its purpose is that any quality system developed following the Manual could be accredited or certified against any Standard. The EC4 Quality Manual Model will be available, free of charge, to clinical laboratory professionals.

Accreditation↗

PubMed2001

Reforming the Israeli health system: findings of a 3-year evaluation.

Israel, like many other European countries, has recently reformed its health care system. The regulated market created by the National Health Insurance (NHI) law embodies many of the principles of managed competition. The purpose of this paper is to present initial findings from an evaluation of the first 3 years of the reform (1995-1997) regarding the implementation of the reform and the extent to which it has achieved its main goals. The evaluation was conducted using multiple quantitative and qualitative research tools: interviews with key informants; analysis of documents and sick fund financial statements; analysis of trends in sick fund membership; and population surveys conducted in 1995 and 1997 to assess the impact of the reform on outcome measures related to level of services to the public. Data from the evaluation show that the NHI law achieved a considerable number of its goals: to provide insurance coverage for the entire population, to ensure freedom of movement among sick funds, and to standardize the way resources are allocated to sick funds. The incentives that are embodied in the law have encouraged the sick funds to improve the level of services provided to the average insuree, and to develop services in the periphery and for some of the weaker populations. From the financial perspective, concerns that NHI would lead to a rise in the national health expenditure were not realized as of 1997. In the wake of NHI, there has been a decline in the age adjusted per capita expenditure in three sick funds, with no reports by insurees, at least through 1997, on a decline in satisfaction or level of service. However, the Israeli experience shows that regulating competition does not necessarily lead to economic stability and equality. Regulating the competition also did not solve some of the major policy issues in the Israeli health system including level of resources allocated to health, organizational structure of the hospital system, manpower planning and the extent of government involvement in system. Additional policy changes may be needed to resolve these issues. Up-to-date information is essential in helping policymakers track the process of reform implementation and results, and identify problems which need to be addressed in the future.

Consumer Behavior↗

PubMed2005

When opportunity knocks twice: two-year-olds' repetition of sentence subjects.

Why are young children's utterances short? This elicited imitation study used a new task--double imitation--to investigate the factors that contribute to children's failure to lexicalize sentence subjects. Two-year-olds heard a triad of sentences singly and attempted to imitate each; they then again heard the same triad singly and again attempted to imitate each. Comparisons between the two attempts showed that children's second passes were more accurate than their first. In addition, independent of sentence length, children increased their inclusion of pronominal and expletive but not lexical subjects. Children included verbs more often from sentences with pronominal than lexical subjects, suggesting a trade-off. Children included subjects more often in short sentences than long ones, and increased subject inclusion only in short sentences. The results suggest that children's language production is similar to adults': a complex interaction of syntactic knowledge, limited cognitive resources, communicative goals, and conversational structure.

Arousal↗

PubMed2004

The reality of glycaemic control in insulin treated diabetes: defining the clinical challenges.

The benefits of good glycaemic control in both type I and type II diabetes mellitus are undoubtedly proven. Most national bodies have recommended glycaemic targets, with an HbA(1c) to achieve between 6.5 and 7.5%. However, it is well known that even in clinical trials, and routinely in clinical practice, the majority of patients fail to achieve optimal glycaemic control. The reasons for this failure are complex and multifactorial. Healthcare providers often delay the initiation and intensification of insulin unnecessarily. This stems from a fear of causing hypoglycaemia or weight gain in patients, from doubts about patients' self-care abilities and/or from inadequate resources to provide the necessary structured education to support patient self-management. Patients may be poorly adherent to treatment advice-particularly behavioural aspects such as self-monitoring, diet and exercise-although this may itself derive from inadequate access to effective diabetes education. There is, however, a limit to what can be achieved with existing exogenous insulin therapies due to their imperfect pharmacokinetic and pharmacodynamic profiles. Prominent among these imperfections is the problem of variability of effect from injection to injection with basal insulin formulations. Improvements in this area should benefit control and tolerability.

Blood Glucose↗

PubMed1998

Changes in patterns of risk.

Against the background of debate about the nature of risk in relation to HIV transmission, and resultant changes in risk discourse from risk group to risk behaviour to risk situation, declines in the velocity of HIV spread are being documented in countries with high levels of political commitment and multi-sectoral approaches. Biological markers of sexual activity such as sexually transmitted disease incidence and HIV prevalence corroborate reports that young adults in Uganda and Thailand are increasingly adopting preventive behaviours. Risk perception, perceived social and community norms and self-efficacy influence behavioural change, but structural and contextual factors, including resource constraints affecting HIV prevention programmes and the treatment of sexually transmitted diseases, and social marginalization and stigmatization affecting access of vulnerable populations to the means of prevention play determinant roles. Both patterns of risk for HIV infection and our understanding of them are evolving. More research is required to gain knowledge and understanding of factors such as partner concurrency as well as cultural and socio-economic determinants and contextual underpinnings of sexual and drug injecting networks. This is an essential first step to mobilizing communities to take action at the individual, partnership and community levels to reduce risk.

Adult↗

PubMed1997

Medical informatics training in pathology residency programs.

Computers and information technology are increasingly used by pathologists, necessitating training in such technology in pathology residency programs. We surveyed 176 programs in the United States and Canada to assess informatics training in terms of instructional methods used, computer availability, and type of training offered. Eighty-four programs replied, for a response rate of 48%. Ninety percent of programs reported offering formal informatics training, but only 68% of programs required it. A rotation dedicated to teaching informatics was provided in 24% of the programs; in 44% of programs, informatics was integrated with other rotations. The most common instructional methods used were hands-on experience with microcomputers and the use of tutors. In 94% of programs, computers were available for resident use; in 60%, residents had individual computers assigned to them. Five programs offered a dedicated informatics rotation but did not provide residents with individual computers, and 22 programs required informatics training but did not provide residents with individual computers. Comparison of these data with data from 1993 shows an increase in programs offering (90% vs 84%) or requiring (68% vs 59%) informatics. Fewer programs offer a dedicated rotation (24% vs 31%) or integrate informatics training with other rotations (44% vs 69%). These data suggest that although informatics training is considered important by most training programs, inadequate resources and lack of formal, structured programs may limit training.

Canada↗

PubMed2006

OMIA (Online Mendelian Inheritance in Animals): an enhanced platform and integration into the Entrez search interface at NCBI.

Online Mendelian Inheritance in Animals (OMIA) is a comprehensive, annotated catalogue of inherited disorders and other familial traits in animals other than humans and mice. Structured as a comparative biology resource, OMIA is a comprehensive resource of phenotypic information on heritable animal traits and genes in a strongly comparative context, relating traits to genes where possible. OMIA is modelled on and is complementary to Online Mendelian Inheritance in Man (OMIM). OMIA has been moved to a MySQL database at the Australian National Genomic Information Service (ANGIS) and can be accessed at http://omia.angis.org.au/. It has also been integrated into the Entrez search interface at the National Center for Biotechnology Information (NCBI; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=omia). Curation of OMIA data by researchers working on particular species and disorders has also been enabled.

Animals↗

PubMed2006

Pseudogene.org: a comprehensive database and comparison platform for pseudogene annotation.

The Pseudogene.org knowledgebase serves as a comprehensive repository for pseudogene annotation. The definition of a pseudogene varies within the literature, resulting in significantly different approaches to the problem of identification. Consequently, it is difficult to maintain a consistent collection of pseudogenes in detail necessary for their effective use. Our database is designed to address this issue. It integrates a variety of heterogeneous resources and supports a subset structure that highlights specific groups of pseudogenes that are of interest to the research community. Tools are provided for the comparison of sets and the creation of layered set unions, enabling researchers to derive a current 'consensus' set of pseudogenes. Additional features include versatile search, the capacity for robust interaction with other databases, the ability to reconstruct older versions of the database (accounting for changing genome builds) and an underlying object-oriented interface designed for researchers with a minimal knowledge of programming. At the present time, the database contains more than 100,000 pseudogenes spanning 64 prokaryote and 11 eukaryote genomes, including a collection of human annotations compiled from 16 sources.

Databases, Genetic↗

PubMed2006

The ASAP II database: analysis and comparative genomics of alternative splicing in 15 animal species.

We have greatly expanded the Alternative Splicing Annotation Project (ASAP) database: (i) its human alternative splicing data are expanded approximately 3-fold over the previous ASAP database, to nearly 90,000 distinct alternative splicing events; (ii) it now provides genome-wide alternative splicing analyses for 15 vertebrate, insect and other animal species; (iii) it provides comprehensive comparative genomics information for comparing alternative splicing and splice site conservation across 17 aligned genomes, based on UCSC multigenome alignments; (iv) it provides an approximately 2- to 3-fold expansion in detection of tissue-specific alternative splicing events, and of cancer versus normal specific alternative splicing events. We have also constructed a novel database linking orthologous exons and orthologous introns between genomes, based on multigenome alignment of 17 animal species. It can be a valuable resource for studies of gene structure evolution. ASAP II provides a new web interface enabling more detailed exploration of the data, and integrating comparative genomics information with alternative splicing data. We provide a set of tools for advanced data-mining of ASAP II with Pygr (the Python Graph Database Framework for Bioinformatics) including powerful features such as graph query, multigenome alignment query, etc. ASAP II is available at http://www.bioinformatics.ucla.edu/ASAP2.

Alternative Splicing↗

PubMed2004

Do multi-branched colonial organisms exceed normal growth after partial mortality?

One of the advantages of modular colonial growth is the capability to recover after partial mortality. Tolerance to partial mortality is a known property of some resistant species of plants that respond to mortality with vigorous regrowth or overcompensation. It is not clear whether modular marine invertebrates such as octocorals overcompensate. This study provides evidence that following injury to colonies (by breaking apical dominance), new growth exceeds normal rates of branching, as observed in some plants, in a degree correlated to the original multi-branched network setting (e.g. the number of original branches connected to main stem), in colonies of the Caribbean gorgonian octocoral Pseudopterogorgia bipinnata. This can be explained by the network of communicating vessels and canals inside octocoral colonies, which provide the structure for effective allocation of resources to regenerating parts.

Animals↗

PubMed2005

Strengthening the HIV/AIDS service delivery system in Liberia: an international research capacity-building strategy.

Liberia's prolonged post-conflict transition has negatively impacted its health infrastructure, including the functioning of its health care delivery system. Considering the current national health crises, a study was conducted to identify research gaps and the need to propose changes for improving the health care delivery system in the country. The study results clearly demonstrated a lack of HIV/AIDS research infrastructure including organizational structure, linkages, leadership, champions, expertise, resources, and policies and procedures. Alignment of research needs and practice, and research use to support HIV/AIDS service delivery programmes in the country was also limited. An international research capacity-building partnership is proposed as an effective planned change strategy to strengthen HIV/AIDS-related research infrastructure and to inform management and practice within the Liberian HIV/AIDS service delivery system. A proposed capacity-building planning model can also strengthen research infrastructure and the production and use of research to positively impact the HIV/AIDS epidemic in Liberia and other developing countries.

Community Health Planning↗

PubMed1996

Power and opportunity in public health nursing work environments.

Kanter's structural theory of power in organizations provided the conceptual framework for this comparative study on perceptions of power of two levels of nurses working in three public health agencies during a time of program transition. Forty-six public health nurses and 10 nurse managers were surveyed to examine their perceptions of the amount of power existing in their own and their counterparts' jobs. Propositions from Kanter's theory were supported by the data. Both groups rated their work environments to be somewhat low in power, although managers perceived themselves to be significantly more empowered in their work environments than did staff nurses. In addition, staff nurses perceived themselves to have significantly less access to empowerment structures (opportunity, information, support, and resources) than their managers perceived them to have. Staff nurse empowerment was found to be significantly related to perceptions of their immediate managers' power in the organization.

Adult↗

PubMed2004

Who wants to enter a long-term care facility in a rapidly aging non-Western society? Attitudes of older Koreans toward long-term care facilities.

To estimate future demand for institutional long-term care (LTC) by Koreans, the intention to use LTC facilities was estimated, and the underlying influencing factors were explored. Data from the Korean National Survey of LTC Need in the Elderly compiled in 2001 were used, and 1,850 people aged 65 and older who were classified as the targets for LTC in the survey and for whom complete data were available were sampled. The following influencing variables were selected based on Anderson's service-use model: demographics, social structural factors, family and community resources, and felt and assessed needs. The result shows that, of all the participants, 18.8% intended to use LTC facilities. A stronger intention was related to younger age, Christian religion, fewer children, lower family income, higher chronic comorbidity, and more education. The rapid industrialization of Korea has lead to a transition from the traditional family-centered mode of caregiving to a nontraditional one, but the intention to use LTC facilities is still lower than in Western developed countries. Regarding family resources, the effect of extended families comprising three or more generations is not as significant as expected, but children continue to be regarded as the main resources for LTC. The recent introduction of nontraditional religions to Korea has had a positive effect on intention to use LTC facilities, suggesting that cultural factors influence their use.

Aged↗

PubMed2006

Symbiotic bacteria as a determinant of plant community structure and plant productivity in dune grassland.

Symbiotic interactions are thought to play a key role in ecosystems. Empirical evidence for the impact of symbiotic bacteria on plant communities is, however, extremely scarce because of experimental constraints. Here, in three complementary experiments, we show that nitrogen-fixing rhizobia bacteria act as a determinant of plant community structure and diversity. Grassland microcosms inoculated with a mixture of rhizobia had a higher above-ground plant productivity (+35%), contained more nitrogen (+85%) and had significant higher community evenness (+34%) than control microcosms without rhizobia. Moreover, three of the four studied legume species required rhizobia to successfully coexist with other plant species. In contrast, the growth and survival of three grass and five forb species were not affected by the presence or absence of rhizobia. Finally, our results also showed that the legume species largely relied on symbiotically fixed nitrogen, both in the field and in the microcosms. This indicates that results in the microcosms are indicative for processes occurring in the field. It is concluded that symbiotic interactions between plants and prokaryotes can contribute to plant productivity, plant community structure and acquisition of limiting resources in legume-rich grassland communities.

Asteraceae↗

PubMed2025

Untargeted metabolomics reveals anion and organ-specific metabolic responses of salinity tolerance in willow.

Willows can alleviate soil salinisation while generating sustainable feedstock for biorefinery, yet the metabolomic adaptations underlying their tolerance remain poorly understood. Salix miyabeana was treated with two environmentally abundant salts, NaCl and Na2SO4, in a 12-week pot trial. Willows tolerated salts across all treatments (up to 9.1 dS m-1 soil ECe), maintaining biomass while selectively partitioning ions, confining Na+ to roots and accumulating Cl- andin the canopy and adapting to osmotic stress via reduced stomatal conductance. Untargeted metabolomics captured >5000 putative compounds, including 278 core willow metabolome compounds constitutively produced across organs. Across all treatments, salinity drove widespread metabolic reprogramming, altering 28% of the overall metabolome, with organ-tailored strategies. Comparing salt forms at equimolar sodium, shared differentially abundant metabolites were limited to 3% of the metabolome, representing the generalised salinity response, predominantly in roots. Anion-specific metabolomic responses were extensive. NaCl reduced carbohydrates and tricarboxylic acid cycle intermediates, suggesting potential carbon and energy resource pressure, and accumulated root structuring compounds, antioxidant flavonoids, and fatty acids. Na2SO4 salinity triggered accumulation of sulphur-containing larger peptides, suggesting excess sulphate incorporation leverages ion toxicity to produce specialised salt-tolerance-associated metabolites. This high-depth picture of the willow metabolome underscores the importance of capturing plant adaptations to salt stress at organ scale and considering ion-specific contributions to soil salinity.

Salix↗

PubMed2000

A Drosophila complementary DNA resource.

Collections of nonredundant, full-length complementary DNA (cDNA) clones for each of the model organisms and humans will be important resources for studies of gene structure and function. We describe a general strategy for producing such collections and its implementation, which so far has generated a set of cDNAs corresponding to over 40% of the genes in the fruit fly Drosophila melanogaster.

3' Untranslated Regions↗

PubMed2005

The structural biology of type II fatty acid biosynthesis.

The type II fatty acid synthetic pathway is the principal route for the production of membrane phospholipid acyl chains in bacteria and plants. The reaction sequence is carried out by a series of individual soluble proteins that are each encoded by a discrete gene, and the pathway intermediates are shuttled between the enzymes as thioesters of an acyl carrier protein. The Escherichia coli system is the paradigm for the study of this system, and high-resolution X-ray and/or NMR structures of representative members of every enzyme in the type II pathway are now available. The structural biology of these proteins reveals the specific three-dimensional features of the enzymes that explain substrate recognition, chain length specificity, and the catalytic mechanisms that define their roles in producing the multitude of products generated by the type II system. These structures are also a valuable resource to guide antibacterial drug discovery.

3-Oxoacyl-(Acyl-Carrier-Protein) Synthase↗