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PubMed2000

Positive and negative outcomes of anger in early adolescents.

The purposes of this study were to examine symptom patterns and diminished general well-being as negative outcomes and vigor and change as positive outcomes of trait and state anger via two structural equation models. In a school auditorium, a convenience sample of 141 boys and girls, ages 12-14 years, responded to the Trait Anger Scale and the State Anger Scale and to instruments measuring general well-being, symptom patterns, vigor, and change. In the negative outcome model, results indicated that diminished general well-being and increased symptom patterns were outcomes of trait anger and state anger in early adolescents. In the positive outcome model, contrary to expectation, less vigor and less inclination to change were outcomes of trait anger in early adolescents, while state anger had no appreciable influence on the same variables. The findings suggest that anger, particularly trait anger, had a negative influence on the outcome variables studied.

Adolescent↗
PubMedDate not supplied

Biological and behavioural determinants of the frequency of mild, biochemical hypoglycaemia in patients with Type 1 diabetes on multiple insulin injection therapy.

BACKGROUND: Severe hypoglycaemic episodes are an important source of morbidity in people with Type 1 diabetes. The occurrence of severe hypoglycaemia is strongly related to the frequency of low blood glucose readings. The aim of this exploratory study was to identify determinants of the frequency of mild, biochemical hypoglycaemia in patients with Type 1 diabetes treated with multiple insulin injection therapy. METHODS: We studied 31 patients with Type 1 diabetes in reasonable glycaemic control (HbA(1c)</=8.3%) during multiple injection therapy. The study had a prospective, observational design. We used standardised home blood glucose monitoring (HBGM) diaries to assess the frequency of hypoglycaemia (HBGM readings<3.5 mmol/L) over a period of 6 weeks. Potential determinants studied included biological factors, self-management factors (including weekly total physical activity and vigorous physical activity), psychological factors (including psychological distress) and mediating factors [average and standard deviation (SD) of the HBGM readings and self-reported hypoglycaemia awareness]. RESULTS: Determinants of mild hypoglycaemia frequency identified in univariate regression analyses were: SD and mean of HBGM (beta 0.6, p=0.001 and beta -0.6, p=0.001), diabetes duration (beta 0.5, p=0. 008) and self-reported hypoglycaemia unawareness (beta -0.5, p=0. 003). A trend was observed for performance of vigorous physical activities (beta 0.3, p=0.06) and external eating behaviour (beta -0. 3, p=0.1). These relations were confirmed in multivariate analyses. CONCLUSIONS: Patients with Type 1 diabetes who have a high blood glucose variability and low average blood glucose concentration, diabetes of long duration, low body mass index, self-reported impaired awareness of hypoglycaemia and those participating in vigorous physical activities, specifically require interventions aimed at preventing hypoglycaemia.

Adult↗
PubMed1996

Relationship of running to musculoskeletal pain with age. A six-year longitudinal study.

OBJECTIVE: To determine, by longitudinal study, whether long-distance running, maintained for many years, is associated with increased musculoskeletal pain with age. METHODS: A 6-year prospective longitudinal study of 410 runners' club members and 289 community controls, age 53-75 years at study initiation, was conducted. Subjects were also categorized as ever-runners (n = 488) and never-runners (n = 211). The primary dependent variable was pain score as indicated on a horizontal double-anchored analog scale; data for this variable were available beginning in 1987. Statistical adjustment for age, education level, smoking, alcohol consumption, history of arthritis, and presence of other major medical conditions was done by analysis of covariance. Further analyses of previously reported associations of regular vigorous physical activity with decreased disability and mortality after 9 years were performed. RESULTS: The degree of musculoskeletal pain was slightly lower in the exercise group compared with controls, and the difference was statistically significant for women but not for men. Average adjusted pain scores for men were 18.3 (SEM 0.8) in runners' club members, 20.2 (1.2) in controls, 18.6 (0.8) in ever-runners, and 20.3 (1.6) in never-runners. For women, these scores were 17.5 (1.8) in runners' club members versus 22.8 (1.4) in controls (P < 0.05), and 17.2 in ever runners versus 23.7 (1.5) in never-runners (P < 0.002). Disability had continued to develop in runners' club members at a rate only one-third that in the controls after 9 years of observation. Mortality over 9 years consisted of 51 deaths, of which 41 were in the control group and only 10 were among runners' club members. CONCLUSION: Vigorous running activity over many years is not associated with an increase in musculoskeletal pain with age, and there may be a moderate decrease in pain, particularly in women. Vigorous physical activity is associated with greatly decreased levels of disability and with decreased mortality rates.

Age Factors↗
PubMed2001

Proportional treatment effects for count response panel data: effects of binary exercise on health care demand.

We define conditional and marginal treatment effects appropriate for count data, and then conduct an empirical analysis for the effects of exercise on health care demand using panel data from the Health Retirement Study. The response variables are office visits to doctors and hospitalization days, and the treatments of interest are light and vigorous exercises. We found that short-run light exercise increases health care demand by 3-5%, whereas long-run light exercise decreases it by 3-6%. We also found that short-run vigorous exercise decreases health care demand by 1-2%, whereas long-run vigorous exercise decreases it by 1-3%. However, many of these numbers are not statistically significantly different from zero. These findings suggest that it will be difficult to reduce health care cost much by encouraging people to do more exercise--at least in the short-run.

Adult↗
PubMed1999

Conserved hepatitis C virus sequences are highly immunogenic for CD4(+) T cells: implications for vaccine development.

The HLA class II-restricted T-cell response to hepatitis C virus (HCV) antigens is believed to influence the final outcome of hepatitis C, because it is vigorous in patients who recover from acute hepatitis C, but it is weak in those who develop a chronic infection. For this reason, exogenous stimulation of T-cell responses in chronic HCV infection may represent a strategy to cure patients with chronic hepatitis C by approximating the vigor of their T-cell reactivity to that of patients who succeed in recovering from hepatitis. It may also be a preventive approach to avoid spread of the virus by facilitating the development of a vigorous protective response at the very early stages of infection. T-cell-based vaccines composed of immunodominant, promiscuous, and conserved T-cell epitopes may represent a powerful tool to achieve optimal stimulation of the T-cell reactivity. To identify HLA class II-restricted T-cell epitopes useful for this purpose, 22 subjects with acute HCV infection were studied and followed for an average time of 29 months. Eight of them recovered from hepatitis, and 14 developed a chronic infection. Overlapping 20-mer peptides covering the entire core and NS4 antigens and a panel of peptides representing highly conserved regions of core, NS3, NS4, and NS5 were used. By direct peripheral blood T-cell stimulation and by fine-specificity analysis of HCV-specific T-cell lines and clones, highly immunogenic T-cell epitopes were identified within core, NS3, and NS4. All these epitopes are immunodominant and highly conserved among the known HCV isolates. Moreover, they are promiscuous, because they can be presented to T cells by different HLA class II molecules. Immunodominance, sequence conservation, and promiscuity make these epitopes ideal components of preventive or therapeutic T-cell-based vaccines against HCV.

Acute Disease↗
PubMed2002

Recreational physical activity and ovarian cancer in a population-based case-control study.

Results from epidemiologic studies of physical activity and ovarian cancer have been inconsistent, with 2 prospective studies reporting a modest positive association. We evaluated this relationship in a population-based case-control study conducted in Massachusetts and Wisconsin. Incident cases diagnosed between 1991 and 1994 were identified through statewide tumor registries. Community controls were selected randomly from lists of licensed drivers and Medicare recipients. Participation in moderate and vigorous recreational physical activity at age 12, age 20 and 5 years prior to diagnosis was assessed by telephone interview. Data were available for 327 cases and 3,129 controls. Results were adjusted for age, parity and other ovarian cancer risk factors. Total and vigorous physical activity were not associated with a substantial decrease in ovarian cancer risk at any age. The relative risk (RR) for women reporting > or = 7 vs. 0 hr/week of recent vigorous activity was 0.85 [95% confidence interval (CI) = 0.39-1.86; p for trend = 0.31]. When metabolic equivalent task (MET) hours of activity were estimated, only women in the highest category had any reduction in risk (RR for > 42 MET-hours/week at the reference age = 0.70; 95% CI = 0.36-1.35; p for trend = 0.41). Overall, our results provide only limited support for an inverse association between recreational physical activity and risk of ovarian cancer.

Adult↗
PubMed2003

Locomotor inhibition induced by procaine injections into the nucleus accumbens core, but not the medial ventral striatum: implication for cocaine-induced locomotion.

We examined whether injections of the local anesthesia procaine into the nucleus accumbens core disrupts locomotion more readily than those into the medial ventral striatum. Spontaneous locomotion decreased during the first 10 min immediately following injections of procaine into the core. When procaine was co-administered with d-amphetamine into the core, the injections also decreased amphetamine-induced locomotion during the initial 10 min. On the other hand, no detectable effect on spontaneous or amphetamine-induced locomotion was found when procaine was injected into the medial ventral striatum, including the medial shell and medial olfactory tubercle. We replicated our recent finding that cocaine injections into the core induced delayed, modest locomotion, while cocaine injections into the medial ventral striatum induced immediate, vigorous locomotion. Injections of amphetamine into the core induced as equally vigorous locomotion as that of the medial ventral striatum. These results show that the neurons of the core involved in locomotion are more vulnerable to local anesthesia than the neurons of the medial ventral striatum. In other words, cocaine at the doses inducing vigorous locomotion in the medial ventral striatum induces local anesthesia when applied to the core.

Anesthetics, Local↗
PubMed1997

Stability Factors of Foam Film in Contrast to Fluctuation Induced by Humidity Reduction

We have examined the relationship between dynamic surface properties of aqueous SDS solutions and foam film stability by observing the dynamic surface tension (gammat ), elongation of the lamellae (L lamellae ), and the thickness of the lamellae measured by FT-IR. Three foam film models were used by controlling such factors as the Marangoni effect by changing the SDS concentration, the disjoining pressure with the addition of electrolytes, and the surface viscosity with the addition of glycerin. In order to obtain information about the most effective factor in foam film stability, the lifetime of these films was measured under the circumstances of low relative humidity, at which vigorous fluctuation occured in the foam film. Foam film stability was found to be remarkably enhanced by the Marangoni effect and surface shear viscosity in a thin aqueous film at a relative humidity between 60 and 75%. Under these conditions, mild fluctuation would occur in the films. On the other hand, foam film stability was found to be maintained by the disjoining pressure in a thin aqueous film at the humidity below 60%. Under these conditions, vigorous fluctuation would occur in the foam film. It is concluded that foam film stability of an ionic surfactant solution mainly depends on the disjoining pressure which generates a repulsion force between the two surfaces in contrast to the vigorous fluctuation induced by humidity reduction.

Journal Article↗
PubMed1994

Observed levels of elementary and middle school children's physical activity during physical education classes.

BACKGROUND: The benefits of childhood physical activity include fitness, weight control, and exercise habits that may carry over into adulthood. School physical education is the primary program responsible for training the nation's youth to be physically active and national objectives call for students to be engaged in moderate-to-vigorous physical activity at least 50% of class time. The purpose of this study was to determine through systematic observation in a regional sample of elementary and middle schools the amount of moderate-to-vigorous physical activity students obtain during physical education classes. METHODS: Twenty elementary schools and 7 middle schools were randomly sampled from the 355 elementary schools and 117 middle schools in the 20 school districts in Harris County, Texas. In addition, 9 elementary and 6 middle schools that were identified as having excellent physical education programs were sampled purposively to provide a comparison. Seven systematic observations of student's physical activity were conducted during physical education in each school. RESULTS: The average moderate-to-vigorous physical activity in the randomly selected elementary schools was 8.6%, significantly less (P < 0.05) than for the randomly selected middle schools (16.1%) or for the comparison elementary schools (20.6%) and middle schools (24.0%). CONCLUSIONS: The average amount of physical activity observed in this regional sample of schools was less than the estimated national average of 27% and far less than the national recommendation calling for a minimum of 50%.

Adolescent↗
PubMed2000

Leisure-time, occupational, and household physical activity among professional, skilled, and less-skilled workers and homemakers.

BACKGROUND: Adults in lower status occupations are at higher risk of premature cardiovascular disease, for which physical inactivity is a major risk factor. While lower rates of leisure-time physical activity have been found to be associated consistently with lower income and education levels, the association between occupational and home-based physical activity with membership of different occupational categories is not well understood. METHODS: An urban-representative population data set derived from a self-completion questionnaire was used to examine both self-reported leisure-time physical activity and a combined measure of occupational/home-based physical activity of adult less-skilled, skilled, and professional workers and homemakers (3795 males; 4140 females). chi(2) analyses, ANOVA, and logistic regressions were used to examine the associations between occupational group membership and physical activity. RESULTS: After adjustment for age, body mass index, education, country of birth, marital status, and smoking, less-skilled workers were less likely to report any form of leisure-time physical activity. However, occupational category was not a strong predictor of participation in combined vigorous occupational/home physical activity. Homemakers and those in lower status occupations were less likely to report participation in vigorous leisure-time physical activity sufficient for cardiorespiratory fitness. With the inclusion of time spent in combined vigorous occupational/home physical activity, there was no longer an association of activity with occupational status for males. However, for females the association remained. CONCLUSIONS: The assessment of occupational and household physical activity in addition to leisure-time activity may be important for understanding associations between occupational categories, physical activity, and increased levels of health risk and for the development of physical activity promotion strategies.

Adult↗
PubMed2002

Socioeconomic status differences in recreational physical activity levels and real and perceived access to a supportive physical environment.

BACKGROUND: Spatial access to recreational facilities and perceptions of the neighborhood environment and physical activity levels were examined by the socioeconomic status of area of residence (SES). METHODS: A cross-sectional survey of adults (18-59 years) (n = 1,803) stratified by SES using a geographic-based index was conducted. RESULTS: Respondents in low SES areas had superior spatial access to many recreational facilities, but were less likely to use them compared with those living in high SES areas. They were more likely to perceive that they had access to sidewalks and shops, but also perceived that their neighborhood was busier with traffic, less attractive, and less supportive of walking. After adjustment, respondents living in low SES areas were 36% less likely to undertake vigorous activity. While they were more likely to walk for transport, this was not statistically significant (OR, 1.27; 95% CI, 0.98-1.64), nor were other SES differences in walking for recreation and walking as recommended. Modifiable environmental factors were associated with walking and vigorous activity, especially perceived access to sidewalks and neighborhood attractiveness. Spatial access to attractive, public open space was associated with walking. CONCLUSIONS: Creating supportive environments--particularly sidewalks in attractive neighborhoods--has the potential to increase walking and vigorous activity.

Adolescent↗
PubMedDate not supplied

Clinical predictors of treatment reduction in hypertensive patients.

OBJECTIVE: To demonstrate that some hypertensive patients under good blood pressure (BP) control can reduce medications, and to identify predictors of successful reduction. DESIGN: Observational study with 11-month follow-up. SETTING: Outpatient hypertension clinic at the Seattle Veterans Administration Hospital. PATIENTS: 59 males (51% of those eligible) with diastolic BP less than 95 mm Hg for greater than or equal to 6 months; 57 patients (97%) completed the study. INTERVENTION: Gradual reduction of medications unless diastolic BP rose above 95 mm Hg. MEASUREMENTS AND MAIN RESULTS: Intensity of treatment with BP medications was assessed using a scale of their comparative "vigors." 35 patients (59%) reduced medications successfully. By the end of the study, systolic BP had risen by 8.2 +/- 12.3 mm Hg (mean +/- SD) in successful patients, while diastolic BP did not change significantly. Two predictors of treatment reduction were statistically significant in both univariate and multivariate analyses: successful patients had been treated more intensively (2.7 +/- 1.7 vs. 1.3 +/- 0.5 "vigor units," p = 0.0001), and they had been enrolled in the clinic longer (5.5 +/- 3.0 vs. 3.1 +/- 2.3 years, p = 0.003). Lower systolic BP, higher urinary sodium excretion, lower compliance, and younger age were significant predictors of treatment reduction on univariate analysis only. Age less than or equal to 65 years had the highest sensitivity (86%) for treatment reduction, while treatment with two or more "vigor units" had the highest specificity (79%) and likelihood ratio (3.3). CONCLUSIONS: Treatment reduction is feasible in many well-controlled hypertensives, though systolic BP rises. Patients with high intensity and long duration of treatment are most likely to reduce medications successfully.

Antihypertensive Agents↗
PubMed1991

Physical activity and risk of coronary heart disease in a survey of adults in Kilkenny, Ireland.

A questionnaire survey was carried out to estimate activity levels in a sample of 784 men and women aged 35 to 64 years in County Kilkenny, Ireland. Men were more likely to have sedentary, heavy or very heavy work activity while the majority of women had moderate activity during an average day. Only a small minority of respondents walked or cycled to work. 44% of those surveyed had leisure pursuits which were sedentary. At leisure, a higher proportion of men were involved in active sports or other vigorous activities for at least three hours per week. Men also spent longer each day walking, cycling or jogging. 16.5% of those surveyed engaged in vigorous activities for at least 20 minutes on one to three occasions weekly while 5.1% did so on four or more occasions. Younger people were more likely to take such exercise while older people were more likely to take less vigorous exercise. Path analysis using multiple regression techniques found that an increase in activity levels in this population could lead to substantial reductions in blood pressure, some of which would be mediated through changes in body weight.

Adult↗
PubMed2006

[Assessment of the number of cardio- and cerebrovascular events due to rofecoxib (Vioxx) in Germany between 2001 and 2004].

BACKGROUND AND PURPOSE: After the recall of rofecoxib (Vioxx), there was repeated national and international discussion on the potential number of patients harmed by causally related cardio- and cerebrovascular events. In individual cases, it cannot be determined whether a myocardial infarction or stroke that occurred during rofecoxib therapy was actually directly caused by this drug. On the basis of the results of the Vioxx Gastrointestinal Outcomes Research (VIGOR) trial and German prescription data provided by the Scientific Institute of the Local Health Care Fund, the authors therefore conservatively estimated the number of patients harmed by rofecoxib in Germany between 2001 and 2004. METHODS: Under simplifying assumptions that, as in the VIGOR study, the risk of rofecoxib or naproxen therapy can be described by a Cox model with exponentially distributed event times, it is possible to calculate the daily risk of cardio- and cerebrovascular events in patients treated with these drugs. The estimated number of patients experiencing cardio- and cerebrovascular events under rofecoxib or naproxen therapy can be calculated by multiplying the daily risks by the defined daily doses prescribed in Germany. The difference between these numbers produces the estimated number of patients harmed by rofecoxib. RESULTS: On the basis of the data pool, a total of 7,092 additional diseased or deceased patients due to rofecoxib therapy were estimated (95% confidence interval: 2,004-15,416). The simplifying assumptions made together with the underreporting of events in the VIGOR trial are more likely to lead to an underestimation than an overestimation of affected patients. When assessing the benefit-harm ratio of rofecoxib, it needs to be considered that its protective gastrointestinal effects were not assessed compared with the optimum long-term therapy. It can be assumed that a comparison of rofecoxib with a combination of nonsteroidal anti-inflammatory drugs (NSAIDs) and gastric mucosal barrier protectors (e. g., misoprostol) would not have shown an advantage in favor of rofecoxib therapy. CONCLUSION: The example of rofecoxib and the relatively high number of patients harmed by it in Germany indicate that, before widely prescribing a new drug, a more thorough assessment of the benefit-harm ratio of the drug is required as well as a stronger consideration of therapeutic alternatives and a timely conduct of meaningful clinical studies. The results of these studies should be promptly communicated in full to physicians and patients.

Adult↗
PubMed2004

Relationship between quantitative ultrasound, anthropometry and sports participation in college aged adults.

The college years are an opportune timepoint of intervention in the primary prevention of osteoporosis. Physical activity is an important modifiable risk factor, yet national surveys reveal that young people are insufficiently active. To determine patterns of physical activity associated with improved skeletal status at this life stage, we assessed the relationship between self-reported physical activity patterns, grip strength, anthropometric measures, and calcaneal quantitative ultrasound (QUS) measures in a study of college students (n=235), the Tufts Longitudinal Health Study (TLHS). Univariate analyses revealed several highly significant relationships between QUS parameters and anthropometry, but only among women, with the highest correlation for skeletal muscle mass. Grip strength was significantly related to broadband attenuation (BUA) and stiffness index (SI) in both men and women. Multiple regression analysis revealed that among the modifiable body composition compartments, muscle mass but not fat mass was significantly associated with higher BUA in men (P<0.05) and women (P<0.001), and higher SI in women (P<0.001). Among our sample of college students, current weight training (P=0.004), and moderate (P=0.003) and vigorous (P<0.001) sports participation were each significantly associated with higher SI. Multiple regression analysis revealed that sports participation (moderate and/or vigorous) was associated with higher SI by 10.22+/-3.93 units (P=0.011) among men and 7.28+/-2.36 units (P=0.002) among women. These data suggest that improved skeletal status in young adulthood may require more specific moderate to vigorous physical activity, such as that achieved with sport, than is currently recommended for overall health.

Adipose Tissue↗
PubMed2006

Estimating energy expenditure using accelerometers.

The purpose of this study was to examine the validity of published regression equations designed to predict energy expenditure (EE) from accelerometers (Actigraph, Actical, and AMP-331) compared to indirect calorimetry, over a wide range of activities. Forty-eight participants (age: 35 +/- 11.4 years) performed various activities that ranged from sedentary behaviors (lying, sitting) to vigorous exercise. The activities were split into three routines of six activities, and each participant performed at least one routine. The participants wore three devices (Actigraph, Actical, and AMP-331) and simultaneously, EE was measured with a portable metabolic system. For the Actigraph, 15 previously published equations were used to estimate EE from the accelerometer counts. For the Actical, two published equations were used to estimate EE from the accelerometer counts. For the AMP-331 we used the manufacturer's equation to estimate EE. The Actigraph and Actical regressions tended to overestimate walking and sedentary activities and underestimate most other activities. The AMP-331 gave a close estimate of EE during walking, but overestimated sedentary/light activities and underestimated all other activities. The only equation not significantly different from actual time spent in both light and moderate physical activity was the Actigraph Freedson kcal equation. All equations significantly underestimated time spent in vigorous physical activity (P < 0.05). In conclusion, no single regression equation works well across a wide range of activities for the prediction of EE or time spent in light, moderate, and vigorous physical activity.

Acceleration↗
PubMed2006

Biologically based complementary and alternative medicine use among breast cancer survivors: relationship to dietary fat consumption and exercise.

Previous literature has shown that more than half of all female cancer survivors use some form of complementary and alternative medicine (CAM). Although the prevalence of CAM use in this population is becoming apparent, few researchers have examined the relationship between CAM use and lifestyle factors that could influence patients' well-being. The present study examined whether breast cancer survivors who use biologically based CAM are more likely than CAM nonusers to follow a low-fat diet and maintain moderate or vigorous exercise. Sixty-five female breast cancer survivors who were within 3 months of completing primary treatment were recruited. CAM use was measured by self-reported use of one or more of a list of 15 supplements. Dietary fat was measured by a 23-item self-report measure estimating fat consumption in the past month. Dietary fat stage of change and moderate and vigorous exercise stage of change were assessed using measures based on the Transtheoretical Model of Behavior Change. Results showed that biologically based CAM users maintained a lower percentage of calories from fat in their diet (t=2.12, p<0.05), and there was a trend for CAM users to be more likely than CAM nonusers to be in the action or maintenance stage for dietary fat consumption (p<0.09). However, this study did not find that CAM users were more likely to be in the action or maintenance stage of change for moderate or vigorous exercise. These findings suggest that biologically based CAM use among breast cancer survivors is associated with some, but not all, healthy lifestyle behaviors.

Adult↗
PubMed2006

Physical activity and quality of life in head and neck cancer survivors.

PURPOSE: To examine the prevalence of exercise in head and neck cancer survivors and determine preliminary associations with quality of life (QoL), fatigue, and depression. MATERIALS AND METHODS: Fifty-nine of 65 (91%) eligible head and neck cancer survivors recruited from an academic oncology clinic completed a self-administered survey including the modified Godin Leisure-Time Exercise Questionnaire and Functional Assessment of Cancer Therapy-Head & Neck (FACT-H&N), which includes physical, social, emotional and functional well-being (FWB) as well as additional concerns, and the FACT-General (FACT-G). Medical variables were obtained by medical record review. RESULTS: The majority of participants were men (83%) and were Caucasian (92%), with mean age of 58+/-12.8. Cancer sites were primarily the oral cavity (24%), oropharynx (37%), or larynx (25%), with 20% being stage I, 7% stage II, 19% stage III, and 54% stage IV disease. Chemotherapy and/or radiation were ongoing in 14% of the participants. Half of the participants (51%) were diagnosed <6 months ago. Only three (5%) participants reported any vigorous exercise minutes (M=7.3+/-35.4), and only seven (12%) participants reported any moderate exercise minutes (M=19.5+/-70.6). Light exercise was reported by 26 (44%) (M=83.4+/-147.1). Only five (8.5%) participants were meeting current public health exercise guidelines. Partial correlations adjusting for age, medical comorbidity, and alcohol use showed that the total exercise minutes (i.e., light + moderate + vigorous) was positively associated with FWB (r=0.30, p=0.027), FACT-G (r=0.25, p=0.071), and FACT-H&N (r=0.26, p=0.064), was negatively associated with fatigue (r=-0.27, p=0.051), and had no association with depression (r=0.10, p=0.500). CONCLUSIONS: Few head and neck cancer survivors are participating in any moderate or vigorous exercise, and over half are completely sedentary. Meaningful and potentially beneficial associations between total exercise minutes, QoL, and fatigue were demonstrated. An exercise intervention may have utility in this understudied cancer survivor group. Further research is warranted.

Adult↗