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PubMed2005

Reliability and validity of the occupational physical activity questionnaire.

INTRODUCTION: Few questionnaires have been designed for wide-scale, population-based surveillance of occupational physical activity (PA) behaviors. PURPOSE: This study was conducted to determine the test-retest reliability and validity of the Occupational Physical Activity Questionnaire (OPAQ) designed to assess the usual weekly duration of occupational sitting or standing, walking, and heavy labor activities. METHODS: Analyses were based on a convenience sample of 41 adults (13 men, 28 women) (mean+/- SD, 38.8+/- 9.9 yr) who worked in a broad range of occupations. Intraclass correlation coefficients (ICC) were used to evaluate the 2-wk test-retest reliability of the OPAQ. Spearman correlations were used to assess criterion (occupational PA record, Actigraph) and construct (cardiorespiratory fitness, percent body fat) related validity. Convergent validity with the current Behavioral Risk Factor Surveillance System (BRFSS) occupational PA question was evaluated with the kappa coefficient. RESULTS: The 2-wk test-retest reliability coefficients for the OPAQ hours per week ranged from an ICC of 0.55 to 0.91. Fair-to-substantial criterion validity was observed for like activities on the OPAQ and a detailed 7-d occupational PA record for sitting or standing (r=0.37), walking (r=0.74), and heavy labor activity (r=0.31). OPAQ walking was related to PA record moderate-intensity PA (r=0.41), Actigraph occupational light-intensity counts (r=0.41), and Actigraph total counts (r=0.44). Associations observed between the OPAQ and submaximal exercise heart rate or percent body fat were low (r=-0.17 to 0.32). Convergent validity displaying the ability of the OPAQ to correctly identify participants who performed mostly sitting or standing, mostly walking, or mostly heavy labor at work was substantial [kappa=0.71 (95% CI=0.49, 0.94)]. CONCLUSIONS: The test-retest reliability and validity of the OPAQ are similar to other established occupational PA questionnaires. This preliminary study supports the use of the OPAQ in research and surveillance settings.

Adult↗
PubMed2006

The physical activity recall assessment for people with spinal cord injury: validity.

PURPOSE: This study examined the construct validity of the physical activity recall assessment for people with spinal cord injury (PARA-SCI). METHODS: First, to assess convergent validity, relationships between PARA-SCI scores and measures of aerobic fitness and muscular strength were examined among 73 men and women with SCI. Second, extreme groups analyses were conducted. PARA-SCI scores from 158 people with SCI were compared between groups differing on demographic, disability, and behavioral characteristics. RESULTS: Scores from the leisure time physical activity (LTPA) and cumulative activity PARA-SCI categories correlated positively with parameters of aerobic fitness and muscular strength. Scores from the lifestyle activity PARA-SCI category were not consistently associated with fitness parameters. LTPA category scores could differentiate between groups differing by age, sex, gym or sports team membership, and frequency of participation in LTPA. Lifestyle and cumulative activity scores were unable to distinguish between most groups. CONCLUSION: The convergent validity study provided evidence of validity for the PARA-SCI LTPA and cumulative activity categories. The extreme groups analyses provided further evidence of the validity of the LTPA category by demonstrating differences in extreme groups. Together, these findings contribute to the accumulating evidence of the construct validity of the PARA-SCI LTPA category and its utility for assessing LTPA among individuals with SCI. These results also highlight measurement constraints of the lifestyle activity and cumulative activity categories.

Adult↗
PubMed2000

Reliability and validity of self-reported CD4 lymphocyte count and viral load test results in people living with HIV/AIDS.

Self-reporting is a common, convenient, and inexpensive method for collecting health status information in HIV/AIDS research, but the reliability and validity of these data remain suspect. HIV-positive persons (n=174) completed self-report measures of demographics, health status, and health literacy, and provided permission to collect CD4 cell counts and viral load results from provider charts. Clinically meaningful categories of CD4 cell counts were reliably and validly assessed using self-report measures. Self-reported viral load, however, demonstrated only marginally acceptable reliability and validity, with the greatest validity occurring for recall of undetectable viral load. Self-reported health status was most reliable and valid for persons with higher levels of education and literacy. CD4 cell counts can therefore be reliably and validly assessed through self-reporting, particularly when collected in clinically meaningful units from persons with higher education. Self-reported viral load should be interpreted with caution and is most reliable when dichotomized into detectable/undetectable categories.

Adult↗
PubMed2000

Using the eating disorder examination in the assessment of bulimia and anorexia: issues of reliability and validity.

OBJECTIVE: The Eating Disorder Examination will be assessed according to its reliability and validity in the assessment of anorexia nervosa and bulimia nervosa. METHOD: A thorough review of the literature was conducted to judge the reliability and validity of the Eating Disorder Examination and its subscales. RESULTS: The review shows that the EDE and its subscales have good interrater reliability and internal consistency reliability. Similarly, high levels of discriminant validity, construct validity, and treatment validity in the assessment of eating disorders were also found. A summary of each study concerning the various types of reliability and validity will be provided. CONCLUSIONS: The EDE is considered to be the "gold standard" by which to identify eating disorders, so this tool used in conjunction with other behavioral measures will be imperative for clinical social work practice.

Anorexia↗
PubMed2005

Validation of an abdominal muscle strength test with dynamometry.

Adequate abdominal strength prevents work- and sports-related injuries and stabilizes the spine for athletic activities. The double-leg-lowering maneuver (DLLM) is a popular test to assess abdominal strength because of its simplicity; however, its validity and reliability have not been studied thoroughly. To determine the validity and reliability of the DLLM, 4 examiners evaluated 28 subjects. The validity of the DLLM was evaluated with the Nicholas Hand-Held Dynamometer (NHHD) as the gold standard. The DLLM scores were compared to themselves for reliability and to NHHD scores for validity. Reliability for the DLLM was very high (r = 0.932). Validity of the DLLM was low (r = -0.338 to -0.446). The DLLM is reliable, but it has low validity to assess abdominal strength. The DLLM may be a useful tool to assess pelvic tilt motor control for spine stability, but it is not suitable for assessing muscle strength.

Abdominal Muscles↗
PubMed2003

Validity of the risk adjustment approach to compare outcomes.

This paper focuses on the issue of the extent to which the present mainstream risk adjustment (RA) methodology for measuring outcomes is a valid and useful tool for quality-improvement activities. The method's predictive and attributional validity are discussed, considering the confounding and effect modification produced by medical care over risk variables' effect. For this purpose, the sufficient-cause model and the counterfactual approach to effect and interaction are tentatively applied to the relationships between risk (prognostic) variables, medical technology, and quality of care. The main conclusions are that quality of care modifies the antagonistic interaction between medical technologies and risk variables, related to different types of responders, as well as the confounding of the effect of risk variables produced by related medical technologies. Thus, confounding of risk factors in the RA method, which limits the latter's predictive validity, is related to the efficacy and complexity of associated medical technologies and to the quality mix of services. Attributional validity depends on the validity of the probabilities estimated for each subgroup of risk (predictive validity) and the percentage of higher-risk patients at each service.

Humans↗
PubMed2002

Review of the validation of models used in Federal Insecticide, Fungicide, and Rodenticide Act environmental exposure assessments.

The first activity of the Federal Insecticide. Fungicide, and Rodenticide Act (FIFRA) Environmental Model Validation Task Force, established to increase confidence in the use of environmental models used in regulatory assessments, was to review the literature information on validation of the pesticide root zone model (PRZM) and the groundwater loading effects of agricultural management systems (GLEAMS). This literature information indicates that these models generally predict the same or greater leaching than observed in actual field measurements, suggesting that these models are suitable for use in regulatory assessments. However, additional validation research conducted using the newest versions of the models would help improve confidence in runoff and leaching predictions because significant revisions have been made in models over the years, few of the literature studies focused on runoff losses, the number of studies having quantitative validation results is minimal, and modelers were aware of the field results in most of the literature studies. Areas for special consideration in conducting model validation research include improving the process for selecting input parameters, developing recommendations for performing calibration simulations, devising appropriate procedures for keeping results of field studies from modelers performing simulations to validate model predictions while providing access for calibration simulations, and developing quantitative statistical procedures for comparing model predictions with experimental results.

Agriculture↗
PubMed2006

Validation of the Shriners Hospital for Children Upper Extremity Evaluation (SHUEE) for children with hemiplegic cerebral palsy.

BACKGROUND: The Shriners Hospital for Children Upper Extremity Evaluation (SHUEE) is a video-based tool for the assessment of upper extremity function in children with hemiplegic cerebral palsy. This tool includes spontaneous functional analysis and dynamic positional analysis and assesses the ability to perform grasp and release. The purpose of the present study was to assess the reliability, concurrent validity, and construct validity of this instrument. METHODS: The Shriners Hospital for Children Upper Extremity Evaluation studies for eleven subjects with hemiplegic cerebral palsy were selected for the evaluation of intraobserver and interobserver reliability. Concurrent validity was determined through analysis of the Shriners Hospital for Children Upper Extremity Evaluation, Pediatric Evaluation of Disability Inventory, and Jebson-Taylor Test of Hand Function scores for twenty children. Construct validity was determined through analysis of Shriners Hospital for Children Upper Extremity Evaluation scores for eighteen children before and after flexor carpi ulnaris to extensor carpi radialis brevis tendon transfer. RESULTS: The absolute mean differences between the two scoring sessions for three raters were 1.2 and 1.0 for the spontaneous functional analysis and the dynamic positional analysis, respectively. Although the mean differences were significantly different from 0 (p < 0.001 and p = 0.003), the differences were small and not clinically important with regard to the total possible score. There was excellent intraobserver reliability between the two sessions with regard to both spontaneous functional analysis (r = 0.99) and dynamic positional analysis (r = 0.98). Assessment of interobserver reliability revealed absolute mean differences between four raters of 3.8 and 3.7 for the spontaneous functional analysis and the dynamic positional analysis, respectively. These differences were significantly different from 0 (p < 0.001); however, the magnitudes of these differences were not important with regard to total score or clinical interpretation. There was excellent interobserver reliability for both the spontaneous functional analysis (r = 0.90) and the dynamic positional analysis (r = 0.89). There was 100% agreement within and between examiners for the grasp-and-release section. The Shriners Hospital for Children Upper Extremity Evaluation showed fair correlation with the self-care scaled score from the Pediatric Evaluation of Disability Inventory (r = 0.47) and good inverse correlation with the non-dominant total time section of the Jebson-Taylor test (r = -0.76). The Shriners Hospital for Children Upper Extremity Evaluation wrist score improved for all eighteen subjects after the flexor tendon transfer, and the mean improvement was significant (p < 0.001). CONCLUSIONS: The present study establishes the clinical reliability, concurrent validity, and construct validity of the Shriners Hospital for Children Upper Extremity Evaluation for the assessment of upper extremity function in children with hemiplegic cerebral palsy.

Adolescent↗
PubMed2004

Psychometric Validation of the National Eye Institute Visual Function Questionnaire - 25 (NEI VFQ-25) French version: in a population of patients treated for ocular hypertension and glaucoma.

OBJECTIVE: Physicians need reliable, valid and sensitive questionnaires to assess QOL related to glaucoma or ocular hypertension. This article presents the psychometric properties of the French version of the National Eye Institute Visual Function Questionnaire - 25 (NEI VFQ-25). METHODS: A mail survey was sent to 20000 households. The survey identified 581 residents with glaucoma or ocular hypertension. Of these a random sample (n = 204) took part in a telephone survey during which the NEI VFQ-25 was completed by eligible patients (those taking at least one topical treatment for glaucoma or ocular hypertension on the day of the interview). Multi-trait analysis was performed to assess the construct validity of the questionnaire. Internal consistency reliability was assessed using Cronbach's alpha and the average inter-item correlation. Known groups validity was assessed by comparing patients grouped by duration of glaucoma, adjusted for age and gender. RESULTS: One hundred and seventy-three patients participated in the survey. Analysis of convergent validity showed that all of the items in each scale correlated above 0.40 with their own scale except for the 'driving' scale. The success rate of the discriminant validity ranged from 57.1% to 100% except for the 'driving' scale, which was 7.1%. Cronbach's alpha coefficients were all above 0.70 except the 'driving' score. Participants with glaucoma for less than 20 years consistently had better 'global', 'near vision', 'distant vision', 'driving', 'social function' and 'peripheral vision' scores than those with disease of 20+ years duration, indicating better QOL in patients with a shorter disease duration. CONCLUSION: The NEI VFQ-25 is a validated instrument to measure vision-targeted QOL in French populations with glaucoma.

Activities of Daily Living↗
PubMed2006

Is the childhood asthma questionnaire a good measure of health-related quality of life of asthmatic children in Asia?: validation among paediatric patients with asthma in Singapore.

BACKGROUND: Health-related quality of life (HR-QOL) is an important outcome in the treatment of chronic childhood diseases such as asthma. However, this measure is rarely used in young children in Asia because of the difficulty of obtaining valid, reliable instruments that are developmentally and culturally suitable. OBJECTIVES: To select, culturally adapt and validate a disease-specific HR-QOL questionnaire (Childhood Asthma Questionnaire [CAQ]-B) for asthmatic children aged 7-11 years in Singapore, and to understand the relationship between patient-reported HR-QOL domains and physician- or caregiver-rated severity. METHODS: A literature review was conducted to shortlist questionnaires based on pre-specified criteria. A pre-test was conducted to assess suitability and relevance of the questionnaires in Singapore. The selected questionnaire (CAQ-B) was then adapted to more closely reflect the local culture, climate, school system and terminology. Cross-sectional validation was conducted. All asthmatic patients aged 7-11 years attending the respiratory clinic in a paediatric hospital, and without co-morbidities that could significantly affect their HR-QOL, were invited to participate. Patients and their parents or caregivers were asked to complete the relevant sections of the questionnaire before their medical consultation. The child's severity of asthma was rated by the attending physician according to guidelines from the Singapore Ministry of Health. Correlations between the child-reported CAQ-B outcomes and clinical ratings of severity by both parents and physicians were investigated. Internal reliability was tested with Cronbach's alpha, and the overall questionnaire structure was explored using principal axis analysis with oblimin rotation and extraction for factors with Eigen values >1.0. RESULTS: The adapted CAQ-B was validated in 96 patients (40 girls and 56 boys) with a mean age of 8.7 +/- 1.1 years (range 7-11). Most children had no difficulty understanding and completing the questionnaire. The median time taken to complete a questionnaire was 10 minutes. Internal consistency of the various scales ranged from 0.29 to 0.76 (Cronbach's alpha) when items were analysed according to the UK or Australian scale structure. This increased to 0.57-0.76 after item reduction. Physician-rated severity only correlated significantly with the Active Quality of Living (AQOL) domain (r = -0.29, p = 0.02). However, parent/caregiver-rated severity correlated with three of four patient-reported domains: AQOL (r = -0.359, p = 0.001), Passive Quality Of Living (PQOL) [r = -0.271, p < 0.01] and severity (r = 0.367, p < 0.001). The AQOL domain was significantly correlated with the PQOL domain (r = 0.513, p = 0.005). CONCLUSIONS: The children and parents/caregivers in this study found CAQ-B to be a simple and acceptable questionnaire with some evidence of content validity. While two of the domains did not meet internal consistency standards expected of HR-QOL instruments for adults (Cronbach's alpha = 0.70), they were acceptable for children of this age. The patterns of correlation also suggest that parent/caregivers' perception of the severity of a young child's asthma may be a better indicator of a child's HR-QOL than clinical diagnosis of severity. However, further investigation is recommended to improve and validate the internal structure of the scale.

Adolescent↗
PubMed2005

Criterion-related validity of a clinical measure of dorsal first ray mobility.

STUDY DESIGN: Test-retest methodological design using a sample of convenience. OBJECTIVE: To determine the criterion-related validity and the reliability of measuring first ray mobility with a ruler. BACKGROUND: Studies have questioned the accuracy of assessing first ray mobility by manual examination. Use of a ruler and adherence to strict guidelines in positioning of the patient may improve the measure. This study investigates the validity, and the intrarater and interrater reliability of measuring dorsal first ray mobility with a ruler while following recent recommendations to standardize the position of measurement. A valid and reliable mechanical device designed to measure first ray mobility was used as the validation criterion of measurement. METHODS: Three clinicians performed ruler measurement of dorsal mobility on 14 subjects. A separate examiner measured dorsal mobility with the mechanical device. Intraclass correlation coefficients (ICCs) and standard error of measurements (SEMs) were computed to quantify the intrarater reliability of both testing procedures and the interrater reliability of the ruler measurement. ICCs of agreement were also computed to determine the concurrent validity of the ruler measurement for each clinician. RESULTS: Mechanical device intrarater reliability ICC was 0.98 (SEM = 0.15 mm). Ruler intrarater ICCs were equal or less than -0.06 (SEMs = 1.1 mm); ruler interrater ICC was 0.05 (SEM = 1.2 mm). The ICCs of agreement between the mechanical device and ruler method ranged from -0.44 to 0.06. CONCLUSION: The ruler method of testing demonstrates poor reliability and validity as a clinical measure.

Adult↗
PubMed2004

[Cross-validation of the short version of the Japanese version of the Zarit Caregiver Burden Interview (J-ZBI_8)].

This study was aimed at confirming the cross-validity and construct validity of the short version of the Japanese version of the Zarit Caregiver Burden Interview (J-ZBI_8) developed by Arai and colleagues. A total of 169 family members caring for disabled elderly were assessed by a self-administered questionnaire which included the Japanese version of the Zarit Caregiver Burden Interview (J-ZBI). Cronbach's alpha of the J-ZBI_8 was 0.88, indicating a high reliability of this instrument. A confirmatory factor analysis revealed that the two factor model of J-ZBI_8 fitted the data. Pearson's correlation coefficient between J-ZBI_8 and J-ZBI was 0.92; and the correlation coefficient between J-ZBI_8 and item 22 (a single global burden) was 0.66. These data indicated that J-ZBI_8 had a high concurrent validity. The J-ZBI_8 was found to be significantly correlated with Barthel Index, duration of caring, hours of caregiving/day, physical fatigue and mental fatigue among caregivers, but not with the duration of caring (months). Caregivers of disabled elderly who did not have any behavioral disturbances had a significantly lower J-ZBI_8 score than those who were caring for elderly with such behaviors. Also, caregivers who declared that they did not abuse disabled elderly had a significantly lower J-ZBI_8 score than those who replied they abused them, when compared by t-test. These results indicated that J-ZBI_8 had a high construct validity. It is concluded that the J-ZBI_8 had a high cross-validity and construct validity. This instrument can thus facilitate the assessment of family caregiver burden in clinical settings.

Aged↗
PubMed2026

Discovery and validation of GNA12circle as a first-trimester plasma eccDNA marker for early-onset preeclampsia.

BACKGROUND: Early-onset preeclampsia (EOPE) is a major cause of maternal and perinatal morbidity and is characterized by placental dysfunction, systemic endothelial injury, and hypertensive vascular stress. Because hypertensive disorders of pregnancy may also signal later maternal cardiovascular and cerebrovascular vulnerability, effective biomarkers for first-trimester risk assessment remain clinically important. Extrachromosomal circular DNA (eccDNA), a stable form of circulating cell-free DNA, has emerged as a potential source of disease-associated biomarkers. This study aimed to characterize first-trimester plasma eccDNA alterations associated with subsequent EOPE and to identify and validate a candidate circulating eccDNA marker for early risk assessment. METHODS: A two-stage nested case-control study was conducted within a prospective birth cohort. In the discovery stage, plasma samples collected at 11-13&#x202f;weeks of gestation from 5 women who subsequently developed EOPE and 5 matched normotensive controls were profiled by Circle-Seq to characterize genome-wide eccDNA alterations. Candidate eccDNAs were prioritized through differential abundance analysis and were further confirmed by outward PCR and Sanger sequencing. In the validation stage, the candidate selected marker was quantified by junction-specific qPCR in an independent cohort of 109 EOPE cases and 109 controls. Its potential predictive value was further evaluated alone and in combination with routine first-trimester clinical variables. RESULTS: In the exploratory discovery analysis, 410 nominally differentially abundant candidate eccDNAs were identified as a hypothesis-generating pool. Among these, GNA12circle (chr7:2876332-2,876,692) was prioritized and experimentally validated at the circular junction. In the independent validation cohort, plasma GNA12circle levels were significantly higher in women who later developed EOPE than in controls. When combined with routine first-trimester variables, GNA12circle improved predictive performance. The RF model showed the best overall cross-validated performance among the evaluated classifiers, with a mean held-out test-fold AUC of 0.843. CONCLUSION: First-trimester plasma eccDNA profiling revealed distinct alterations associated with subsequent EOPE, from which GNA12circle was identified and validated as a candidate circulating marker. These findings support further investigation of circulating eccDNA for early EOPE risk assessment in larger multicenter populations.

Humans↗
PubMed2026

Trustworthy Agentic AI in Bioinformatics: From Workflow Automation to Traceable and Validated Biological Inference.

Agentic artificial intelligence is extending bioinformatics beyond conversational assistance by enabling systems to select tools, execute code, revise analytical plans, and interpret biological data. These capabilities may accelerate research, but they also redistribute decisions that determine whether biological conclusions are valid. We conducted a targeted, structured PubMed search in July 2026 and identified 11 peer-reviewed agentic bioinformatics systems for descriptive review based on predefined eligibility criteria for analytical decision-making, tool or code execution, iterative evaluation, or coordinated agent activity. The evidence base covered single-cell transcriptomics, microbial genomics, cancer genomics, and omics applications, together with methodological literature on reproducibility and biological validation. We examined how current systems report delegated authority, provenance, validation, evidence, abstention, and human oversight. Existing platforms implement safeguards such as sandboxed execution, restricted commands, interaction logs, evidence identifiers, automated checks, critic agents, quality scores, and expert assessment. However, published reports rarely provide a connected account linking the original biological question to samples, reference resources, analytical decisions, computational actions, statistical results, supporting evidence, validation outcomes, and final claims. We distinguish inherited bioinformatics errors, errors amplified through autonomous action, and emergent failures arising from memory, retrieval, tool interaction, or agent coordination. We further propose a multidimensional decision-rights profile, consequence-sensitive validation gates, and a claim-to-evidence provenance architecture organized through the Traceable History of Research Evidence, Agent Actions, and Decisions in Bioinformatics (THREAD-Bio) framework. Illustrative cases show that technically successful execution may still support misleading inference. Trustworthy agentic bioinformatics therefore requires claims to remain reconstructible, challengeable, validated, and proportionate to the evidence.

accountable autonomy↗
PubMedDate not supplied

Test-retest reliability and convergent validity of the Fatigue Impact Scale for persons with multiple sclerosis.

OBJECTIVE: The test-retest reliability and the convergent validity of the Fatigue Impact Scale (FIS) were evaluated using secondary data from 54 persons with multiple sclerosis (MS). METHODS: This reliability and validity study used FIS data from before and after two control periods to evaluate test-retest reliability. Convergent validity of the FIS with the Fatigue Severity Scale and with subscales of the SF-36 Health Survey was evaluated using data collected before the first control period. RESULTS: No significant differences between before and after FIS measurements and intraclass correlation coefficients ranging from .68 to .85 indicate that the FIS has good test-retest reliability except for the physical subscale. The expected moderate correlations between the FIS and several subscales of the SF-36 support its convergent validity. In contrast, the unexpected low correlation between the FIS and Fatigue Severity Scale does not support convergent validity. CONCLUSION: The FIS has adequate reliability and validity and is recommended to evaluate the effectiveness of fatigue management interventions such as energy conservation education for persons with MS.

Adult↗
PubMed2003

Validity of a single-item measure of stress symptoms.

OBJECTIVES: The objective of the study was to investigate the content, criterion, and construct validity of a single-item measure of stress symptoms. Such a concise measure would be useful in monitoring stress at work. The criteria for validity were convergence with conceptionally close measures, the plausibility of associations with health and work characteristics, and the power to discriminate between groups. METHODS: Four sets of independent cross-sectional data were used. The first data set, from Finland Post, comprised symptoms of ill health and mental resources (N=1014). The second, from four Nordic countries, included well-known validated scales on exhaustion, mental health, sleep, vitality, and optimism, and therefore the convergence between the measures could be studied (N=1015). The third, from a metal factory, included three indicators of health and four work characteristics (N=773). The fourth, representing the Finnish working population, described group differences in stress symptoms (N=2156) and allowed comparison with a study on emotional exhaustion in the working population. Distributions, correlations, and factor analysis were used for the study. RESULTS: The stress-symptoms item converged with items on psychological symptoms and sleep disturbances and with validated measures of well-being. It had theoretically grounded associations with indicators of health and psychosocial work characteristics, and it discriminated between gender and age groups and industrial branches in accordance with the validated emotional exhaustion scale. CONCLUSIONS: The stress-symptoms item showed satisfactory content, criterion, and construct validity for group-level analysis. It is suggested that the longer scales used to measure psychological stress can be replaced with it in survey research.

Adult↗
PubMed2000

Validation of a food-frequency questionnaire using multiple-day records and biochemical markers: application of the triads method.

BACKGROUND: A food-frequency questionnaire (FFQ) used to assess usual food intake in Southern France has been validated by the classical means of multiple-day food records. To minimise over-estimation of the correlation between the dietary assessments by the FFQ and the reference method, which occurs if the random errors of questionnaire and reference measurement are positively correlated, a triangular comparison, the method of triads, was used. METHODS: We applied the triads model by comparing the FFQ with two multiple-day food records and three biomarkers. Only 87 subjects were included and completed the protocol. One biomarker (beta-carotene) was used for the 87 subjects and two biomarkers (urinary nitrogen and potassium) were measured in only 40 subjects. RESULTS: For beta-carotene intake assessment, the triad model, including the weighed multiple records (PETRA), was the best with estimates of validity coefficient of 0.39 [confidence interval (CI) 0.18-0.60] for the FFQ, 0.52 (CI 0.24-0.86), for PETRA and 0.85 (CI 0.43-1) for plasma levels of the nutrient. For protein and potassium intake assessment, the triad model including the estimated multiple records was the best only for the estimates of FFQ validity coefficient (0.61; CI 0.28-0.96 and 0.31; CI 0.09-0.66 respectively). CONCLUSION: Accuracy of the dietary assessment methods permitted a satisfactory estimation of the validity coefficient for beta-carotene intake by the FFQ, despite a small sample. However, the validity coefficients for protein and potassium showed wide CI values, indicating that a sample size < 50 subjects appears unsatisfactory for validation.

Adult↗
PubMed2001

[Relevance and validity of a new French composite index to measure poverty on a geographical level].

BACKGROUND: A number of disease conditions are influenced by deprivation. Geographical measurement of deprivation can provide an independent contribution to individual measures by accounting for the social context. Such a geographical approach, based on deprivation indices, is classical in Great Britain but scarcely used in France. The objective of this work was to build and validate an index readily usable in French municipalities and cantons. METHODS: Socioeconomic data (unemployment, occupations, housing specifications, income, etc.) were derived from the 1990 census of municipalities and cantons in the Doubs departement. A new index was built by principal components analysis on the municipality data. The validity of the new index was checked and tested for correlations with British deprivation indices. RESULTS: Principal components analysis on municipality data identified four components (explaining 76% of the variance). Only the first component (CP1 explaining 42% of the variance) was retained. Content validity (wide choice of potential deprivation items, correlation between items and CP1: 0.52 to 0.96) and construct validity (CP1 socially relevant; Cronbach's alpha=0.91; correlation between CP1 and three out of four British indices ranging from 0.73 to 0.88) were sufficient. Analysis on canton data supported that on municipality data. CONCLUSION: The validation of the new index being satisfactory, the user will have to make a choice. The new index, CP1, is closer to the local background and was derived from data from a French departement. It is therefore better adapted to more descriptive approaches such as health care planning. To examine the relationship between deprivation and health with a more etiological approach, the British indices (anteriority, international comparisons) would be more appropriate, but CP1, once validated in various health problem situations, should be most useful for French studies.

Analysis of Variance↗