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PubMedDate not supplied

Influence of castration and of the kind of sympathomimetic drug used upon the reactivity of rat seminal vesicles.

An interdependence of the hormonal state of rodents and the genital muscle response to drugs was observed either on females or on males. Castration or castration followed by oestradiol treatment increased the responses of rat seminal vesicles to parasympathomimetic drugs. As, however, the influence of such procedures upon the responses to sympathomimetic drugs is controversial, the parameters pD2 (apparent affinity constant), alpha (intrinsic activity) and rho (relative responsiveness) of adrenaline, noradrenaline, methoxamine and phenylephrine on the seminal vesicles isolated from normal and castrated rats were determined. These parameters were shown to be different, depending not only of the hormonal state of the donor animals, but also of the drugs tested on each preparation. These facts must be considered in studies about sensitivity of rat seminal vesicles to sympathomimetic drugs.

Animals↗
PubMed1987

A continuous sampling model of the seminal vesicle fluid in rat.

A continuous sampling model of the fluid excreted from the unilateral seminal vesicle was devised in the rat. Each 12 hr change in the volume was measured in 14 sexually mature male rats by use of tubing. If we assume the excretion of a small volume (less than 4 microliters) as the resting level, 3 of 14 rats showed only the resting level. The excretion of a large volume was sometimes observed in the 11 other rats both in daytime and nighttime. This model would be promising for investigations of the seminal vesicles from new aspects.

Animals↗
PubMed1987

The differential regulation of the intranuclear progestin in mouse kidney and prostate-seminal vesicles.

This study was designed to confirm the identity of the enzyme involved in the appearance of a nuclear metabolite of 6a-methyl progesterone (6MP) in mouse kidney but not in prostate-seminal vesicle. 6MP and progesterone competed for metabolism by the kidney enzyme. Using progesterone as substrate, the results of recrystallization of the product with 20a-hydroxy progesterone supported the identification of the enzyme as 20a-hydroxysteroid dehydrogenase (20aHSD). The enzyme had a substrate specificity similar to that reported for 20aHSD in other tissues. Renal enzyme activity was higher in female than in male CD-1 mice while activity was generally lower and without a sex difference in a random bred colony. Renal enzyme activity varied slightly with the estrous cycle, being highest at proestrus and lowest on day 2 of diestrus. Little enzyme activity was detected in prostate-seminal vesicles. It appears that 20aHSD is an important factor in regulating the differential presence of the 20a-metabolite of 6MP in kidney and prostate-seminal vesicle nuclei.

20-Hydroxysteroid Dehydrogenases↗
PubMed1980

Cyproterone acetate and seminal vesicles in the regulation of male fertility.

The effect of continuous release of microquantities of cyproterone acetate from subcutaneously implanted silastic capsules on the fertility of surgically manipulated seminal vesicles of rat has been studied. The experimental animals showed infertility for 3 weeks, as a consequence of removal of seminal plasma, following which normal fertility returns as efficiently as that operated control. However, a significant decrease in weight of the testes and epididymides, were recorded. It appears that seminal vesicles can synthesize seminal plasma even at very low levels of androgen in the presence of cyproterone acetate.

Animals↗
PubMed1991

Effects of seminal vesicle and coagulating gland ablation on fertility in rats.

In rats the secretions of the seminal vesicles and coagulating glands clot after ejaculation in the female tract to form a copulatory plug. The plug plays a critical role in transcervical sperm transport. Factors that influence the secretions of accessory sex glands have the potential to alter fertility without adverse effects on the gametes themselves. In the present study, the effect of surgical removal of the rat seminal vesicles and coagulating glands (SVx) on mating and fertility was investigated. SVx males were completely infertile by natural mating. Observed mating of SVx males with LHRH synchronized females confirmed that mating performance was normal and that they were capable of ejaculating sperm but could not produce copulatory plugs. In the absence of the copulatory plug, no sperm was transported into the uterus. Epididymal sperm obtained from the same males were capable of fertilization after intrauterine insemination and gave comparable numbers of embryos and unfertilized oocytes as sham operated controls. These findings underscore the importance of examining the role of both males and females during insemination and that observed matings, uterine sperm counts, and intrauterine insemination are useful adjuncts to routine fertility assessment when effects on the accessory sex glands are suspected.

Animals↗
PubMed1989

Structure and steroidogenic enzymes of the seminal vesicles of the urohaze-goby (Glossogobius olivaceus).

The in vitro steroid metabolism in the seminal vesicles of the brackish water goby (urohaze-goby, Glossogobius olivaceus) was studied using males in the breeding season. The moderate activity of delta 5-3 beta-hydroxysteroid dehydrogenase was histochemically detected only in the epithelial cells of the organ, though these cells have the characteristics of secretory cells ultrastructurally. Cell-free homogenates (800 g supernatant fluid) of the whole tissue were aerobically incubated with 14C-labeled pregnenolone, progesterone, 17 alpha-hydroxyprogesterone, androstenedione, dehydroepiandrosterone, or testosterone in the presence of NAD+ or NADPH. Pregnenolone and dehydroepiandrosterone were converted to progesterone and androstenedione, respectively. Progesterone was transformed to 5 alpha-pregnane-3,20-dione (main product) and 17 alpha-hydroxyprogesterone. 17 alpha-Hydroxyprogesterone was metabolized into androstenedione (main product) and 17 alpha-hydroxy-5 alpha-pregnane-3,20-dione. From androstenedione, 5 alpha-androstane-3,17-dione (main product) and epiandrosterone were obtained. Testosterone was transformed to 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 beta, 17 beta-diol, 5 alpha-androstane-3,17-dione, and androstenedione. These results indicate that the steroid metabolic patterns in the seminal vesicles of G. olivaceus are closely resembled to those in the testes.

Androgens↗
PubMed1982

Expression in male and genomic organization of the gene(s) coding for a major protein secreted by the rat seminal vesicle epithelium.

Double strand cDNA copies of lls poly(A)+mRNA purified from adult rat seminal vesicles (RSV), have been cloned in E.coli C600 using the Pst I site of pBR322. Filter hybridization, nucleotide sequence analysis and positive hybridization translation were used to demonstrate that one of the recombinant plasmids obtained (pRSV25) contained a 260 bp long insert coding for a significant part of the precursor to the protein IV present in the RSV secretion. By using labelled pRSV25 DNA we have found that high levels of RSV IV mRNA were present only in the rat seminal vesicle epithelium. The amounts of RSV IV mRNA present in other tissues of the same organism were below the levels detectable by the methods used. In addition, other data reported here indicate that the RSV IV gene(s) is present in both sexes, probably with a different organization.

Animals↗
PubMed2001

Morphology of the seminal vesicle of Calomys callosus submitted to experimental chronic alcoholism.

The objective of the present study was to assess the possible toxic effects of chronic alcohol ingestion on the ultrastructure of the lining epithelium of the seminal vesicle of the rodent Calomys callosus, in order to contribute to the understanding of the consequences of alcohol abuse for the morphology of the male reproductive apparatus. Twenty six adult animals aged three months were divided into two experimental groups. The control group received a solid diet (Purina chow) and tap water, and the alcoholic group received the same solid diet and ethanol P.A. diluted 20% in water (v/v). After 210 days of treatment, all animals were anaesthetised, weighed and sacrificed. At the end of treatment, mean body and seminal vesicle weight did not differ between control and alcoholic animals. The epithelial cells of the alcoholic group showed many alterations such as the presence of lipid droplets of different sizes, nuclei with increased peripheral chromatin and greater electrondensity, megamitochondria, and intense dilatation of the cisterns of the granular endoplasmic reticulum. It was concluded that 20% ethanol provokes marked ultrastructural lesions in the seminal vesicle.

Alcoholism↗
PubMed1995

Endothelin-1 contracts and increases motor responses to ATP in rat seminal vesicle.

Endothelin-1 (ET-1; 0.3-100 nM) induced graded tonic contractions in rat isolated seminal vesicle, with an EC50 of 7.2 nM and an Emax of 0.24 +/- 0.03 g/100 mg wet tissue. In contrast, norepinephrine (NE) and acetylcholine (ACh) caused short-lasting phasic contractions, yielding EC50s of 8.0 and 30.3 microM and Emaxs of 1.99 +/- 0.21 and 2.16 +/- 0.31, respectively. ET-3 and sarafotoxin S6c were 10- to 30-fold less potent than ET-1. Contractions to ET-1 (1-100 nM) were markedly inhibited by the selective ETA receptor antagonist BQ-123 (300 nM). ET-1 also potentiated, in graded fashion, contractions induced by ATP (1 mM; 30 nM of ET-1 caused a 10-fold potentiation) but not by NE (3 microM) or ACh (10 microM). Indomethacin (5.6 microM) reduced ET-1-induced contractions and abolished the potentiation of responses to ATP. Big ET-1 also contracted the preparation, being 10- to 15-fold less potent than ET-1. Therefore ET-1 causes modest tonic contractions of the rat seminal vesicle via stimulation of ETA receptors and selectively potentiates motor responses to ATP. Eicosanoids of the cycloxygenase pathway are involved in both effects.

Adenosine Triphosphate↗
PubMed1999

[Cystic dysplasia in the seminal vesicle. Case report and literature review].

Contribution of one case report of cystic dysplasia of the seminal vesicle with ipsilateral renal agenesis in a 32 year-old male presenting with primary infertility. The seminograms showed moderate astenoteratospermia while in the abdominal-pelvic ultrasound there were changes in the right seminal vesicle and right renal agenesis, which was confirmed with further complementary tests: UIV, transrectal ultrasound, urethrocystoscopy, arteriography and renal scan.

Adult↗
PubMed1998

[Seminal vesicle cysts associated with ipsilateral renal agenesis. Diagnosis, and long-term clinical course].

Congenital seminal vesicle cysts associated with ipsilateral renal agenesis or dysplasia are rare malformations. Even though they are more often diagnosed today due to the introduction of advanced, sectional imaging techniques as CT and MRI, no reliable data about the prevalence of this malformation are available. This study reports seven consecutive cases, with long-term follow-up in five cases (26-119 months, mean 52 months). All patients underwent sonography, excretory urography, CT and MRI. Only two of seven patients presented nonspecific symptoms of the lower urinary tract; five were asymptomatic. In all cases sonography revealed the cystic character of the retrovesical enlargement. The anatomy of the lower pelvis was most accurately shown on MRI, which depicted the ectopic insertion of the ureter into the seminal vesicle in five cases. Cysts demonstrated high signal intensities in T1- and T2-weighted spin-echo images. In five cases the CT density was over 40 HU. Whereas one patient (15 years) presented significant enlargement of the cysts 10 years after primary diagnosis with compression of the urinary bladder, four patients showed no changes of their malformation in the follow-up examinations. The present data therefore support the concept of treating only symptomatic patients.

Adolescent↗
PubMed1997

Renal agenesis, ureteral ectopia into seminal vesicle, vas deferens agenesis and hemivertebra: an incomplete form of caudal regression syndrome?

The association of seminal vesicle cyst and upper urinary tract malformation is well known in the literature [1]. More rarely, urogenital malformations are associated with vertebral [2] or anorectal anomalies [3]. A 35-year-old infertile man with unilateral renal and deferential agenesis, seminal vesicle cyst and hemivertebra is reported. This complex malformative syndrome has been reported previously by Sheih et al. [4] and, to our knowledge, this is the third case described in the literature.

Abnormalities, Multiple↗
PubMed1983

Amyloid of the seminal vesicles. A distinctive and common localized form of senile amyloidosis.

Amyloid deposits were found subepithelially in the seminal vesicles of 34 of 209 consecutively studied men. The incidence increased with age and was found in 21% of men over 75 years. This senile seminal vesicle amyloidosis (SSVA) is a localized disorder, and the amyloid substance has unique histochemical and immunochemical properties not shared with any other amyloid described until now.

Aged↗
PubMed1999

Duplicated seminal vesicle.

We report a case of complete, unilateral seminal vesicle duplication without concomitant reproductive duct or renal anomalies encountered during radical retropubic prostatectomy. We also discuss the possible embryologic origin of this anomaly and the clinical implications.

Humans↗
PubMed1987

The major clotting protein from guinea pig seminal vesicle contains eight repeats of a 24-amino acid domain.

The complete amino acid sequence of the major clotting protein from the guinea pig seminal vesicle (SVP-1) has been determined by nucleotide sequencing of cDNA clones corresponding to the 3' terminus of an mRNA that codes for a protein precursor to SVP-1. The first 40 amino acids of the derived protein sequence are identical to those determined by N-terminal sequencing of SVP-1 isolated from the lumen of the seminal vesicle. This finding confirms that SVP-1 is cleaved from the C terminus of a larger precursor protein. The portion of the nucleotide sequence that codes for SVP-1 contains eight highly homologous but imperfect repeats of a 72-nucleotide domain. This repeated structure is also evident at the amino acid level. The consensus 24-amino acid repeat unit contains two lysine and three glutamine residues. Since the clotting of SVP-1 is known to involve the formation of gamma-glutamyl-epsilon-lysine crosslinks, it is likely that the 24-amino acid repeating unit is the unit of function of SVP-1.

Amino Acid Sequence↗
PubMed2000

Transrectal ultrasound anatomy of the prostate and seminal vesicles in healthy men.

OBJECTIVE: This study involved transrectal ultrasound (TRUS) examination of the prostate and seminal vesicles in healthy males, for use as a reference. MATERIAL AND METHODS: A total of 125 men (aged 20-69 years) with no history or symptoms of urogenital disease underwent TRUS. Prostate size (both total and central gland), focal lesions such as calcifications, hyper- and hypoechoic areas, cysts, and size and lobulation of the seminal vesicles were noted and related to age. RESULTS: The prostate measured 19.2 +/- 4 cm3 and calcifications were found in 23.1% of men aged 20-29 years compared with 35.5 +/- 12.5 cm3 and 83% for men aged 60-69 years. Overall, hyperechoic areas were found in 59.2% of those examined, cysts in 16.8% and hypoechoic areas in about 11%, predominantly in the peripheral zone. Totally normal sonograms were seen in 29% of the men under the age of 40 and in 5% of the men aged 40 or older. CONCLUSIONS: TRUS examinations of healthy males are seldom without sonographic changes. This study provides the frequencies with which these changes occur in healthy males of various ages, all without urogenital symptoms, and may be used for future comparisons with different pathological conditions.

Adult↗
PubMed1983

Congenital cyst of the seminal vesicle.

A case of congenital cyst of the seminal vesicle in association with an ectopic ureter is presented. The clinical, diagnostic and therapeutic aspects are discussed with special emphasis on the role played by ultrasound and computerized tomography in the evaluation of pelvic pain and painful ejaculation.

Adult↗
PubMedDate not supplied

[Cysts of the seminal vesicles. Diagnosis and treatment].

Congenital cysts in the seminal vesicle represent a rare by illustrative example of embryological malformation. They are often associated with ipsilateral urinary tract anomalies. We have analyzed the diagnostic and therapeutic schemes followed in the study of this uncommon pathology.

Abnormalities, Multiple↗