Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Modernization”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 667 records · Page 37Linked to original sources

Rethinking theatre in modern operating rooms.

Metaphor is a means through which a widely accepted meaning of a word is used in a different context to add understanding that would otherwise be difficult to conceive. Through etymological and metaphorical associations, we contend that aspects of "theatre" are still relevant in the modern operating rooms and that the use of dramaturgical metaphors can add another layer of understanding about the social reality in this setting. We begin by exploring the historical roots and derivation of the word theatre as it applied to anatomical dissection and surgery. Briefly, we touch on the work of Erving Goffman and examine how his work has been used by others to explore aspects of operating room nursing. Then, drawing on data from a postmodern ethnographic study that has been used to examine communication in operating room nursing, four dramaturgical metaphors are used to illustrate the argument. They are drama, the script and learning the lines, the show must go on, and changing between back stage and front stage. To conclude, the small amount of previously published literature on this topic is compared and contrasted, and the relevance of using dramaturgical metaphors to understand modern operating rooms is discussed. Being able to distinguish between the inherent drama in operating room work and the dramatic realisation of individuals who work within, can help operating room nurses to think differently about, and perhaps re-evaluate their social situation and how they function within it.

Anthropology, Cultural↗

Prenatal growth and development of the modern human labyrinth.

The modern human bony labyrinth is morphologically distinct from that of all other primates, showing derived features linked with vestibular function and the overall shape of the cranial base. However, little is known of how this unique morphology emerges prenatally. This study examines in detail the developing fetal human labyrinth, both to document this basic aspect of cranial biology, and more specifically, to gain insight into the ontogenetic basis of its phylogenetically derived morphology. Forty-one post-mortem human fetuses, ranging from 9 to 29 weeks gestation, were investigated with high-resolution magnetic resonance imaging. Quantitative analyses of the labyrinthine morphology revealed a number of interesting age-related trends. In addition, our findings show that: (1) the prenatal labyrinth attains an adult equivalent size between 17 and 19 weeks gestation; (2) within the period investigated, shape changes to all or most of the labyrinth cease after the 17-19-week size maturation point or after the otic capsule ossifies; (3) fetal cochlea development correlates with the surrounding petrosal morphology, but not with the midline basicranium; (4) gestational age-related rotations of the ampullae and cochlea relative to the lateral canal, and posterior canal torsion are similar to documented phylogenetic trends whereas other trends remain distinct. Findings are discussed in terms of the ontogenetic processes and mechanisms that most likely led, in part, to the emergence of the phylogenetically derived adult modern human labyrinth.

Cochlea↗

The care of patients with dementia: a modern Jewish ethical perspective.

Patients with dementia and their families can face many difficult and agonizing ethical dilemmas over the course of the illness. An awareness of the Jewish ethical response to some of these issues can help clinicians in treating patients of the Jewish faith and also serve as an example of how one ethical system addresses these questions. The Jewish response is grounded in a profound respect and value for human life in all its forms and man's responsibility to preserve it, but Judaism rejects unproven therapies and recognizes the limitations of modern medicine. Jewish law also codifies normative obligations that children have toward their elderly parents. With these principles in the forefront, this article analyzes a Jewish ethical response to various problems in the care of the demented patient such as truth telling, transfer to a nursing home, artificial nutrition, and end-of-life care, taking into account modern concepts of the doctor-patient relationship and ancient Jewish tradition.

Aged↗

Runaway in a modern "soft top" pacemaker.

Although runaway pacemaker was a relatively common occurrence, modern pacemaker design has made it extremely rare. We report a case occurring with a modern "soft-top" pacemaker that resulted from a loss of hermeticity. Although the different treatment options are discussed, the definitive maneuvre is explantation of the faulty pacemakers

Aged↗

Test of an alternative method for determining sex from the os coxae: applications for modern Americans.

A recently proposed method for determining sex from the os coxae reports a 98% success rate using European collections. The purposes of the present study are to (1) evaluate the success rate of this proposed method using modern American os coxae from different population subgroups; (2) compare the success rate of the new method with that obtained using traditional techniques; and (3) determine replicability of the new method and interobserver error. Eight hundred and seventy-six adult left os coxae were independently evaluated by both authors. Summary statistics for sex classifications were calculated for the total sample and for a random sample of 400 individuals. The impact of sex and ancestry on the success of each method was calculated on the random sample using Pearson's chi2 values. Results demonstrate that for modern American os coxae, neither sex nor race have a significant impact on the success rate for either the new or traditional methods (p < 0.01). Additionally, the success rate of the new method is comparable with that obtained using traditional techniques. Finally, interobserver error using the new method for overall sex determination is low.

Adult↗

Migration and the diffusion of modern contraceptive knowledge and use in rural Guatemala.

This article uses the concept of social networks as it is employed in the research literature on family planning and migration to explore the impact of out-migration on modern contraceptive knowledge and use in rural Guatemala. Data for this study come from the 1995 Guatemalan Survey of Family Health. Results from multilevel regression models indicate that urban migration experience, having migrant kin in urban or international destinations, and living in a community where urban migration is common are all associated with greater contraceptive knowledge. Social ties to urban or international migrants are also associated with a greater likelihood of modern contraceptive use among married women, but this association works primarily through increased contraceptive knowledge. The findings of significant diffusion effects provide support for recent theories of fertility decline that emphasize the role of social interactions.

Adolescent↗

The Puerperium in the Modern Dairy Cow: A Review.

The puerperium represents a critical physiological period during which the bovine reproductive tract transitions from pregnancy to renewed fertility. In the modern high-producing dairy cow, this transition is challenged by profound metabolic, endocrine, immunological, and structural demands that collectively influence uterine health, ovarian function, and subsequent reproductive performance. This review examines current understanding of the physiology of the puerperium in dairy cattle, with particular emphasis on uterine involution, immune clearance of postpartum contamination, endocrine regulation, and resumption of ovarian cyclicity. Further, it contrasts high-yielding Holsteins with fertility selected dairy populations. Normal uterine involution involves coordinated myometrial contraction, tissue remodelling, endometrial regeneration, and tightly regulated inflammatory responses. Failure of these processes predisposes cows to postpartum uterine disorders, including retained fetal membranes, metritis, endometritis (purulent vaginal discharge with cytological confirmation), and pyometra, which remain major contributors to subfertility and economic loss. Central to the pathophysiology of puerperal disease is negative energy balance, which disrupts immune competence, alters hepatic steroid metabolism, impairs ovarian signalling, and compromises oocyte and embryo quality. Emerging evidence highlights the complex interplay between metabolism, immunity, and the uterine microbiome, shifting current perspectives away from pathogen-centric models toward host resilience. Advances in biomarkers, genomic selection, and precision monitoring offer new opportunities for targeted reproductive management. Ultimately, optimisation of transition period management remains the cornerstone of supporting physiological puerperal recovery and sustaining reproductive efficiency in modern dairy systems.

Animals↗

Cutoff frequencies and cross fingerings in baroque, classical, and modern flutes.

Baroque, classical, and modern flutes have successively more and larger tone holes. This paper reports measurements of the standing waves in the bores of instruments representing these three classes. It presents the frequency dependence of propagation of standing waves in lattices of open tone holes and compares these measurements with the cutoff frequency: the frequency at which, in an idealized system, the standing waves propagate without loss in such a lattice. It also reports the dependence of the sound field in the bore of the instrument as a function of both frequency and position along the bore for both simple and "cross fingerings" (configurations in which one or more tone holes are closed below an open hole). These measurements show how "cross fingerings" produce a longer standing wave, a technique used to produce the nondiatonic notes on instruments with a small number of tone holes closed only by the unaided fingers. They also show why the changes from baroque to classical to modern gave the instruments a louder, brighter sound and a greater range.

Humans↗

A timing model for word-initial CV syllables in Modern Greek.

Measurements of the temporal characteristics of word-initial stressed syllables in CV CV-type words in Modern Greek showed that the timing of the initial consonant in terms of its closure duration and voice onset time (VOT) is dependent on place and manner of articulation. This is contrary to recent accounts of word-initial voiceless consonants in English which propose that closure and VOT together comprise a voiceless interval independent of place and manner of articulation. The results also contribute to the development of a timing model for Modern Greek which generates closure, VOT, and vowel durations for word-initial, stressed CV syllables. The model is made up of a series of rules operating in an ordered fashion on a given word duration to derive first a stressed syllable duration and then all intrasyllabic acoustic intervals.

Greece↗

African origin of modern humans in East Asia: a tale of 12,000 Y chromosomes.

To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.

Africa↗

Emergence of modern human behavior: Middle Stone Age engravings from South Africa.

In the Eurasian Upper Paleolithic after about 35,000 years ago, abstract or depictional images provide evidence for cognitive abilities considered integral to modern human behavior. Here we report on two abstract representations engraved on pieces of red ochre recovered from the Middle Stone Age layers at Blombos Cave in South Africa. A mean date of 77,000 years was obtained for the layers containing the engraved ochres by thermoluminescence dating of burnt lithics, and the stratigraphic integrity was confirmed by an optically stimulated luminescence age of 70,000 years on an overlying dune. These engravings support the emergence of modern human behavior in Africa at least 35,000 years before the start of the Upper Paleolithic.

Aluminum Silicates↗

Old World fossil record of modern-type hummingbirds.

I report on tiny skeletons of stem-group hummingbirds from the early Oligocene of Germany that are of essentially modern appearance and exhibit morphological specializations toward nectarivory and hovering flight. These are the oldest fossils of modern-type hummingbirds, which had not previously been reported from the Old World. The findings demonstrate that early hummingbird evolution was not restricted to the New World. They further suggest that bird-flower coevolution dates back to the early Oligocene and open another view on the origin of ornithophily in Old World plants.

Americas↗

Going east: new genetic and archaeological perspectives on the modern human colonization of Eurasia.

The pattern of dispersal of biologically and behaviorally modern human populations from their African origins to the rest of the occupied world between approximately 60,000 and 40,000 years ago is at present a topic of lively debate, centering principally on the issue of single versus multiple dispersals. Here I argue that the archaeological and genetic evidence points to a single successful dispersal event, which took genetically and culturally modern populations fairly rapidly across southern and southeastern Asia into Australasia, and with only a secondary and later dispersal into Europe.

Africa↗

Early Upper Paleolithic in Eastern Europe and implications for the dispersal of modern humans.

Radiocarbon and optically stimulated luminescence dating and magnetic stratigraphy indicate Upper Paleolithic occupation-probably representing modern humans-at archaeological sites on the Don River in Russia 45,000 to 42,000 years ago. The oldest levels at Kostenki underlie a volcanic ash horizon identified as the Campanian Ignimbrite Y5 tephra that is dated elsewhere to about 40,000 years ago. The occupation layers contain bone and ivory artifacts, including possible figurative art, and fossil shells imported more than 500 kilometers. Thus, modern humans appeared on the central plain of Eastern Europe as early as anywhere else in northern Eurasia.

Archaeology↗

Permanence in book papers; investigation of deterioration in modern papers suggests a practical basis for remedy.

Deterioration of paper in the book stock-especially among books of recent decades-has become a serious problem for libraries, but exact measures of the extent or rate of this deterioration have not been available. By the same token, no good indications have been available of the expected useful life of paper in books currently coming off the press. Furthermore, although attention has been given to means of counteracting one of the recognized causes of deterioration-pollutants absorbed from the atmosphere-similar attention has not been given to the problems of identifying and counteracting the other recognized source of deterioration-agents left in or introduced into the paper at the time of manufacture. Our investigation was undertaken in an attempt to fill some of these gaps in our knowledge. It has been found that modern books-even those written with a serious or scholarly purpose ("nonfiction") and published ("to last!") in hard bindings-are deteriorating rapidly, and many of those issued 25 to 50 years ago are now almost unusable. The paper of an average American publication of the first decade of this century retains only 4 percent of the folding endurance of a typical new book paper of today; even the paper in the average publication of the 1940's has already declined in folding endurance to 36 percent of today's new book paper. Meanwhile this typical new book paper itself shows low initial strength (for example, folding endurance on the order of only 20 percent of that of book papers already 200 to 500 years old) as well as indications that it is subject to rapid deterioration. Acidity appears to be the principal cause of deterioration, both in the older papers and the new. A stabilizing process for neutralizing this acidity was developed and was brought during the investigation to an initial stage of economic feasibility. This process appears to inactivate the most injurious properties found in new book papers and precipitates compounds into the fibers which should, in addition, counteract the effect of pollutants absorbed from the air. A principal technique used for predicting the durability of paper is the accelerated aging procedure developed by the National Bureau of Standards; by extending the use of this technique, interesting decay curves have been obtained which facilitate comparison of modern papers with papers which have already demonstrated their stability for several centuries. These curves offer other values as well for the study of permanence in paper and suggest that a principle exists relating extended accelerated aging to even longer periods of natural aging than those with which it has hitherto been equated. During the past 300 years the papermaker has done an excellent job in meeting the demand for more and cheaper paper. A by-product of this accomplishment has been the production of many weak and unstable papers. This does not give rise to any problem where strength or stability are not critical, but where permanence is important, as in libraries of record, the problem becomes serious. While the present study describes a procedure for stabilizing initially unstable paper, much more remains to be done if relatively stable papers are to be made for books of lasting value. There is evidence that this is possible-that such papers can be made from certain types of chemical wood fibers at but little additional cost. But more research is needed, and the cooperation of the scientist, papermaker, printer, publisher, and librarian will be required to assure permanent books for the future.

Books↗

Genetic and fossil evidence for the origin of modern humans.

The origin of living Homo sapiens has once again been the subject of much debate. Genetic data on present human population relationships and data from the Pleistocene fossil hominid record are used to compare two contrasting models for the origin of modern humans. Both genetics and paleontology support a recent African origin for modern humans rather than a long period of multiregional evolution accompanied by gene flow.

Africa↗

Rapid detection of the Mycobacterium tuberculosis Beijing genotype and its ancient and modern sublineages by IS6110-based inverse PCR.

The Mycobacterium tuberculosis Beijing genotype strains appear to be hypervirulent and associated with multidrug-resistant tuberculosis. Therefore, the development of a both rapid and simple method to detect the M. tuberculosis Beijing genotype is of clinical interest per se. Previously, we described a simple and fast approach to detect the Beijing genotype based on IS6110 inverse-PCR typing. Here, we evaluated this method against a large, diverse, and recent collection of strains. The study sample included 866 M. tuberculosis strains representing but not limited to the regions in Russia, Europe, and East Asia where the Beijing genotype is endemic. Based on a spoligotyping method, 408 strains were identified as Beijing genotypes; they were additionally subdivided into ancient and modern sublineages based on the analysis of the NTF locus. All strains were further subjected to the IS6110-based inverse PCR. All of the Beijing genotype strains were found to have identical two-band (ancient sublineage) or three-band (modern sublineage) profiles that were easily recognizable and distinct from the profiles of the non-Beijing strains. Therefore, we suggest using IS6110-based inverse-PCR typing for the correct identification of the Beijing genotype and its major sublineages. The method is fast and inexpensive and does not require additional experiments but instead is implemented in the routine typing method of M. tuberculosis.

Bacterial Typing Techniques↗

Modern tennis rackets, balls, and surfaces.

Modern rackets have facilitated a change in playing style from one of technique to one characterised by power and spin. The combination of the increased stiffness of modern rackets and the tendency for tennis balls to have become harder has led to an increased shock transmission from the racket to the player, which is probably a major contributor to tennis elbow. The paucity of tennis specific research on shoes and surfaces makes it difficult to link their characteristics with lower limb injury, although, as their interaction directly affects the magnitude of the forces to which the player is exposed, such a link seems reasonable.

Equipment Design↗