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PubMed1982

[Indirect breast lymphography (author's transl)].

Intradermal areolar contrast injection of a new water-soluble contrast medium, Iotasul, results in regular demonstration of the latero-cranial breast lymphatics and of the subareolar lymphatic plexus. It has been possible, for the first time, to show lymph nodes with this water-soluble contrast medium, although the results are not entirely satisfactory. There have been no side effects.

Breast Neoplasms↗
PubMed2002

A novel formulation for superparamagnetic iron oxide (SPIO) particles enhancing MR lymphography: comparison of physicochemical properties and the in vivo behaviour.

The major aim of this study was to prove or disprove the theories concerning the correlation between physicochemical properties of superparamagnetic iron oxide (SPIO) particles and their accumulation in the lymph nodes. New SPIO particles were produced using starch as stabilising polymer shell. The synthesis was done in a two-step procedure using conventional wet-chemical precipitation technique and subsequent coating of the iron oxide cores. The particles were physicochemically characterised and their lymphotrophy studied in rats using well described lymphotropic dextran-coated SPIO particles as reference. Despite the short blood half-lives of approximately 13 min and the relatively large sizes (approximately 60-90 nm), the starch SPIO particles proved at least as efficient in lymph node accumulation as the small 25 nm dextran SPIO particles having a half-life of 90 min. The currently accepted theories concerning the connection between particle properties and their uptake into lymph nodes are not generally valid, or have at least to be limited for dextran-coated SPIO particles. Lymph node targeting could be achieved despite the present theories consider small size (<30 nm) and long circulation times in the blood as prerequisites. Histological examination showed, that SPIO particles could only be found in lymph node areas where macrophages could be marked which enclosed the particles. Localisation in marginal areas of the lymph nodes indicates endothelial transcytosis as the major accumulation pathway.

Animals↗
PubMedDate not supplied

Hepatography and liver lymphography by retrograde biliary ethiodol infusion: an experimental study in the dog.

Ethiodol in dosages of 0.5-3 ml/kg was retrogradely infused with hydrostatic pressure of 50--100 cm water into the biliary system of nine cholecystectomized dogs equipped with a Thomas cannula in the second portion of the duodenum, allowing cannulation of the common bile duct with a Foley catheter under direct vision. A total of 18 examinations were performed. A dense hepatogram and complete visualization of the hepatic lymph nodes were obtained when the infused Ethiodol dosage exceeded the capacity of the biliary system by 10 ml or more. The hepatogram lasted for three to four months and the lymph nodes were opacified for a year and longer. Contrary to angiographic contrast agents, Ethiodol retrogradely infused into the biliary system primarily refluxes from the biliary system to the lymph and not to the blood. Judged by serial chest radiographs and lung scans, pulmonary Ethiodol emboli did not occur. A significant temporary increase in serum bilirubin and liver enzymes followed the procedure but these returned to normal within a week to a month. Periodic needle biopsies of the liver showed Ethiodol droplets initially in the interstitium and lymphatics, and subsequently in hepatocytes, Kupffer's cells and the epithelium of small bile ductules. No hepatic damage was found histologically on long-time follow-up examinations.

Animals↗
PubMedDate not supplied

Transabdominal lymphography after intraperitoneal injection of Rous virus in newborn rats.

Newborn rats were inoculated in the peritoneal cavity with Rous sarcoma virus (Schmidt-Ruppin strain). They were studied lymphographically and histologically after various intervals of time. As a result of lesions of the lymph vessels and nodes, the lymphatic drainage of the peritoneal cavity was increasingly impaired. Pleural effusion developed as a result of leakage through the walls of the lymphatics. The passage through the lymph nodes was blocked and large lymph cysts arose in the mediastinum and retroperitoneally.

Animals↗
PubMed2002

Interstitial magnetic resonance lymphography using a polymeric t1 contrast agent: initial experience with Gadomer-17.

RATIONALE AND OBJECTIVES: The detection of lymph node metastases is an important step in tumor staging and is significant for therapy planning. Lymph node-specific contrast agents can raise the sensitivity and specificity of modern diagnostic methods. This study investigated the suitability of the dendritic contrast agent Gadomer-17 in magnetic resonance (MR) lymph node imaging and compared three different dosages in such an application. METHODS: Doses of 1.0, 2.5, and 10.0 micromol Gd/kg body weight were interstitially injected into the hind legs of dogs; the signal intensities of two successive lymph node groups (inguinal and iliacal) were then recorded up to 120 minutes after injection. RESULTS: Gadomer-17 induced a strong increase in signal intensity of the examined lymph node groups. At 15 minutes postinjection, the enhancement increased by 120% to 680%, depending on the dose. The maximum enhancement was 450% to 960% at 60 to 90 minutes postinjection. Doses of 2.5 and 10.0 micromol Gd/kg showed comparable results; even the lowest dose (1.0 micromol Gd/kg) enhanced the contrast of the inguinal lymph nodes in 4 of 5 animals and the iliacal lymph nodes in three of five animals. Therefore, the minimum effective dose of Gadomer-17 in this study was approximately 2.5 micromol Gd/kg. CONCLUSION: This study revealed the excellent suitability of the dendritic contrast agent Gadomer-17 for MR imaging of the lymphatic system (lymph nodes and lymph vessels).

Animals↗