[Disruption of energy metabolism in nerve tissue by local anesthetics and its role in the mechanism of local anesthesia].
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The use of ultrasound as a diagnostic tool for the visualisation of the epidural space has effects on the quality and the performance of epidural anesthesia. This work presents an overview of the recent experiences with ultrasound for epidural anesthesia and on the possibilities for ultrasound imaging techniques. The results of visualisation of the epidural space and its limiting structures obtained by various working groups are presented. We review all presently available data on the prediction of the puncture depth. The various working groups found correlations between predicted and effective puncture depth between 0.79 and 0.98 and the precision of the measurement was 57-7.7 mm. Regarding the prediction of the puncture angle there was a poor correlation ranging between 0.07 and 0.31. The precision between the measured and the punctured angles was found to be 10-13.4 degrees. In all available prospective randomised studies on the puncture effects in the lumbar epidural space, the influence of ultrasound showed a significant reduction ( p<0.03) of the puncture attempts,and we found a significant ( p<0.05) reduction in the number of puncture levels. The ultrasound-guided puncture allowed an ideal needle trajectory and a more precise application of the catheter. A significant improvement of analgesia quality ( p<0.035) and patient satisfaction ( p<0.006) could be achieved. The metaanalysis of the different studies regarding puncture quality by ultrasound-guided peridural anaesthesia showed a clear advantage for the use of imaging techniques.
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In animals and humans the rate of resorption and the duration of the anesthesia have been investigated, using mepivacaine in different concentrations and volumes without addition of a vasoconstrictor. A linear relationship between duration of anesthesia and the logarithm to the concentration of mepivacaine was found.
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Nine small birds of 3 species (Melopsittacus undulatus, Serinus canarius, and Poephila guttata) were trained in an operant procedure to fly to sound sources for food reward. The angle between the 2 sound sources was varied on a session-by-session basis, and threshold (i.e., minimum resolvable angle) was taken as the angle that corresponded to a performance level of 75% correct. In all, thresholds were calculated for pure tones of 5 different frequencies, noise bands of 3 different spectral compositions, and species-specific contact or distance calls recorded from each of the 3 species. Thresholds for both simple and complex stimuli were larger than 25 degrees. There were statistically significant species differences for each stimulus set, but these differences were not correlated with species differences in head size. Birds with 1 ear plugged performed as well as binaural birds in this task. Birds deafened in 1 ear, however, performed at chance.
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We have studied postoperative analgesia in 32 patients undergoing outpatient repair of inguinal hernia. All patients received a standardized general anaesthetic of thiopentone followed by halothane or isoflurane in 70% nitrous oxide and oxygen delivered by face mask or laryngeal mask with spontaneous ventilation. No patient received premedication, opioids or neuromuscular blockers. Before wound closure the surgeon infiltrated 20 ml of a study solution into the wound. The solution contained ketorolac 30 mg in saline, 0.25% bupivacaine and ketorolac 30 mg, 0.25% bupivacaine or saline (control group). The control group received ketorolac 60 mg i.m. at the same time. Pain scores were measured 2, 6 and 24 h after operation. Pain scores for all three active groups were significantly less (P < 0.05) than the control group at all times. There were no significant differences in pain scores at any time between the three study groups. Wound infiltration with ketorolac 30 mg in saline, 0.25% bupivacaine or ketorolac 30 mg with 0.25% bupivacaine provided equivalent analgesia. Wound infiltration with ketorolac 30 mg in saline provided analgesia superior to that of ketorolac 60 mg i.m.