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At least 667 records · Page 37Linked to original sources
PubMed2003

Genetic association studies of cleft lip and/or palate with hypodontia outside the cleft region.

OBJECTIVE: The purpose of this study was to determine whether the candidate genes previously studied in subjects with cleft lip, cleft palate, or both are associated with hypodontia outside the region of the cleft. SUBJECTS: One hundred twenty subjects from the Iowa Craniofacial Anomalies Research Center were selected based on the availability of both dental records and genotype information. METHOD: The type of orofacial clefting and type and location of dental anomalies (missing teeth, supernumerary teeth, or peg laterals) were assessed by dental chart review and radiographic examination. Genotype analysis of candidate genes was performed using polymerase chain reaction/single-strand conformation polymorphism analysis. RESULTS: The prevalence of hypodontia in this sample was 47.5%, with 30.0% of subjects having missing teeth outside the cleft. There was a positive association between subjects with cleft lip or cleft lip and palate who had hypodontia outside the cleft region (compared with noncleft controls) and both muscle segment homeo box homolog 1 (MSX1) (p =.029) and transforming growth factor beta 3 (TGFB3) (p =.024). It was not possible in this analysis to determine whether this association was specifically associated with orofacial clefting combined with hypodontia or whether it was due primarily to the clefting phenotype. CONCLUSIONS: In this sample, there was a significantly greater incidence of hypodontia outside the cleft region in subjects with cleft lip and palate, compared with cleft lip only or cleft palate only. Cleft lip and/or palate with hypodontia outside the cleft region was positively associated with both TGFB3 and MSX1, compared with noncleft controls.

Anodontia↗
PubMed2006

An atypical lingual lesion resulting from the unhealthy habit of sucking the lower lip: clinical case study.

Unhealthy oral habits may be involved in the etiology of a malocclusion, since they may affect development of the orofacial region. There is little information on the habit of sucking the lower lip, to which practitioners attribute less clinical consequences. However, lower lip sucking is a harmful habit which appears frequently in children, especially during situations requiring increased attention and mental concentration. In patients presenting lower lip sucking, strong contractions of the lower lip's orbicular's muscle and the mentalis muscle, associated with hypertonicity of the upper lip caused by sucking, has to be balanced by lingual thrusting during the act of deglutition. A case is presented in which failure to identify the habit of lower lip sucking led to an atypical lesion on the tongue, caused by the tongue's impaction against the orthodontic appliance prescribed to correct a malocclusion. The recognition and elimination of an unhealthy habit is of great importance in diagnosis and the establishment of a treatment plan, so that undesirable complications can be avoided.

Child↗
PubMed1999

Periodontal disease in patients with cleft palate and patients with unilateral and bilateral clefts of lip, palate, and alveolus.

BACKGROUND: Long-term health of the stomatognathic system, as well as esthetics, is the therapeutic goal in patients with facial clefts. The aim of this study was to analyze the periodontal situation of patients with cleft palate (CP) and cleft lip, palate, and alveolus (CLPA) to elicit the differing degrees and localization of periodontal disease. METHODS: In 30 patients with unilateral cleft lip, palate, and alveolus (UCLPA), 30 patients with cleft palate (CP), and 20 patients with bilateral cleft lip, palate, and alveolus (BCLPA), the gingival situation was identified and classified according to the sulcus bleeding index (SBI). Periodontal attachment loss and pathological loosening of teeth were noted for identification of periodontal lesions. The state of oral hygiene was recorded by the approximal plaque index (API). RESULTS: In general, poor oral hygiene was found in all patients. The SBI showed a high incidence of gingivitis in patients with cleft lip, palate, and alveolus. Patients with cleft palate had a minor extent of sulcus bleeding. Periodontal disease was found to a similar extent to that in the general population in patients with cleft palate, whereas patients with cleft lip, palate, and alveolus had a predisposition to deep periodontal destruction of teeth adjacent to the cleft. The registration of pathological loosening of teeth, a result of attachment loss, corresponded to the degree of periodontal disease shown by the attachment loss. CONCLUSIONS: A critical periodontal situation was found in patients with unilateral and bilateral cleft lip, palate, and alveolus, ultimately leading to tooth loss in the front tooth region. In contrast, patients with cleft palate exhibited periodontal situations similar to that found in the general population with additional damage, which may be attributed to orthodontic treatment.

Adolescent↗
PubMed1997

Flow cytometric DNA content analysis of ultraviolet light-induced squamous cell carcinomas: a comparative study of squamous cell carcinomas of the lip and those arising from other sites of sun-damaged skin.

The development of squamous cell carcinoma (SCC) of the lip is considered to be mainly related to excessive sun exposure. However, its higher metastatic rate is distinct from that of SCCs arising from other sites of sun-damaged skin. Flow cytometric DNA content analysis, using paraffin-embedded specimens, was performed on 15 SCCs of the lip and 32 SCCs arising from other sites of sun-damaged skin. A significantly lower incidence of DNA-aneuploidy was observed in SCCs of the lip (2/15) than in those of sun-damaged skin (15/32) (p < 0.05). The mean age of patients with SCC of the lip (66.7 +/- 11.6 years; mean +/- SD) was significantly lower than that of the other patients (78.1 +/- 11.1 years) (p < 0.01). There was no significant difference between the mean diameter size of tumors on the lip (19.5 +/- 5.7 mm) and that of tumors on other sites of sun-damaged skin (30.7 +/- 20.5 mm). These results suggest that additional carcinogenic factors besides ultraviolet light may be involved in the development of SCC of the lip.

Adult↗
PubMed1999

Etiologic clues to lip cancer from epidemiologic studies on farmers.

OBJECTIVES: This study examined the risk factors for lip cancer among farmers. METHODS: A series of meta-analyses of peer-reviewed studies of lip cancer and farming were performed using 21 studies published between 1981 and 1997. Prior to the meta-analyses, all the studies were reviewed and evaluated for heterogeneity and publication bias. Combined relative risks (RR) were calculated using the random effect model. RESULTS: The combined RR for lip cancer was 2.0 [95% confidence interval (95% CI) 1.74-2.30] for all the studies and 1.28 (95% CI 0.79-2.08) for studies involving female farmers. Additional meta-analyses were undertaken on a subset of studies reporting on skin cancer among farmers. The combined RR for nonmelanotic skin cancer was 1.0 (95% CI 0.89-1.14), and for malignant melanoma it was 0.88 (95% CI 0.74-1.05). CONCLUSIONS: The findings suggest that male farmers have a significantly elevated risk for lip cancer. Lip cancer and skin cancer do not share a common etiologic factor. Besides sunlight exposure, other factors such as viral infection or reduced immunity may play a role in the etiology of lip cancer.

Agricultural Workers' Diseases↗
PubMed1993

Premaxillary protrusion: a sonographic clue to bilateral cleft lip and palate.

Sonograms from 49 fetuses with cleft lip, with or without cleft palate, were reviewed. Among 37 fetuses with adequate pathologic or clinical correlation, 10 (27%) demonstrated premaxillary protrusion, seen as a paranasal echogenic mass. Nine of ten fetuses with a paranasal echogenic mass proved to have bilateral cleft lip and cleft palate. Conversely, only two of 27 fetuses who did not show a paranasal echogenic mass proved to have bilateral cleft lip and cleft palate, and neither of these fetuses showed premaxillary protrusion at birth. Sonographic evaluation of the cleft alone erroneously misclassified eight fetuses with bilateral cleft lip and cleft palate as having unilateral clefts. Premaxillary protrusion is an important clue to the presence of cleft lip and cleft palate and may be more conspicuous than the cleft itself. Furthermore, the presence of a paranasal echogenic mass favors the presence of bilateral cleft lip and cleft palate, even when sonographic evaluation of the cleft itself suggests a unilateral cleft. This information should be useful in the detection and management of fetuses with suspected facial clefts.

Cleft Lip↗
PubMedDate not supplied

Lip biting in a patient with Chiari type II malformation: case report.

Self mutilation of lips and tongue is considered a common type of Self-Injurious Behavior (SIB). Treatment of SIB in the form of Lip-Biting in developmentally disabled individuals has been the focus of several related reports using different oral appliances preventing or inhibiting the SIB. In this paper we report a case of SIB in the form of Lip-Biting on an infant with Chiari Type II Malformation which was treated with a Lip-bumper. The Lip-bumper demonstrated to be a viable option in treating transient and acute episodes of SIB involving the lower lip and buccal mucosa.

Arnold-Chiari Malformation↗
PubMed1998

[The pathological action of surrounding connective tissues of alar cartilage in the cleft lip nose].

OBJECTIVE: This study was to explore the pathological action of the adjacent connective tissues of alar cartilage in unilateral cleft lip nose. METHODS: Anatomic-histological and pathoanatomical study was carried on 40 normal cadavers and 30 patients with secondary deformities of unilateral cleft lip during their operations. RESULTS: Six kinds of connective tissues with different histological features were found between the alar cartilage and adjacent skin, cartilage or bone. There was no histological difference in each connective tissue between the normal and the cleft lip nose. In the cleft lip nose, due to histological differences among the six connective tissues, there existed various changes of pathological dislocations between the alar cartilage and adjacent skin, cartilage or bone. CONCLUSION: The authors suggest that the surrounding connective tissues of the alar cartilage play an important role and be the intrinsic basis to produce the characteristic deformities of the cleft lip nose. The result is helpful in understanding the anatomical and histological features of the connective tissues around the alar cartilage and the deformities of the unilateral cleft lip nose so as to select a reasonable operation method.

Abnormalities, Multiple↗
PubMed2002

[Simultaneous repair of complete cleft lip and palatein infancy-preliminary observation (271 cases report)].

OBJECTIVE: To Verify the safety and reliability of one-stage repair of complete cleft Lip and palate in infancy and to obtain the primary result. METHODS: The simultaneous repair of complete cleft Lip and palate in infants 3 to 12 months of age were performed in 271 cases. The deformities include 185 cases of typical complete unilateral clefts and 75 cases of complete bilateral clefts, and other 11 atypical cleft infants. The preoperative orthopedic treatment for wide alveolar cleft was undertaken in 24 infants and the lip appearance and speech outcome were evaluated in 116 children by 1 to 4 years' postoperative follow-up. RESULTS: All infants, except for dyspnea in 2 babies, palatal fistula formation in 6 cases and temporary wound hemorrhage in 5 infants, were recovered without complications. After orthopedic treatment, the width of the alveolar cleft was reduced 6.1 mm in average. The evaluation showed that 93.1% of children had got good or excellent lip appearance. And the acceptable or excellent speech was found in 94.8% children. CONCLUSIONS: Simultaneous repair of complete cleft lip and palate in infancy is safety and reliable. The preoperative orthopedic procedure is able to reduce the wide alveolar cleft and to achieve alignment of alveolar segments. The acceptable and or excellent lip appearance and speech function could be obtained in this one-stage operative procedure in infants.

Cleft Lip↗
PubMed2003

The upper lip lift using the 'bull's horn' approach.

Our lift lip technique consists of an excision of the white part of the upper lip directly beneath the nose in the shape of a 'bull's-horn', with advancement of the inferior border of the incision to the area directly beneath the nose. Pre-operative markings on the skin ensure the lip lift is approximately symmetric. Advancement of the inferior edge of skin directly beneath the nasal base lifts the lip, producing more visible vermilion and about 3 mm of tooth show at rest. The position of the final incision is such that it is located within the shadow of the nose. Meticulous technique produces an almost invisible scar. The amount and width of skin excised is individualized depending on the desired aesthetic goals. The procedure is straightforward and is usually performed under local anesthetic. Abdominal fat is frequently injected into both the upper and lower lips to increase the volume and improve the rejuvenation. Lip lifts using this technique provide an immediate, dramatic, and permanent result.

Anesthesia, Local↗
PubMed2004

[Reconstructive operations in the treatment of carcinoma of the lower lip].

The authors sum up the results of combined and reconstructive surgical treatment of 213 cases with squamous-cell carcinoma of the lower lip, carried out in Tver Oncological Center during the recent decade. Oncological and functional esthetic results of different methods of primary cheiloplasty are analyzed. The findings confirm that clinoid resection of the lip is not permissible as a method of treatment and that indications for resection of the lower lip without primary cheiloplasty should be limited. The authors suggest their own method for surgical repair of the lower lip, which was used in the treatment of 23 patients with carcinomas. Evaluation of the adequacy and efficiency of the method and analysis of the incidence and type of postoperative complications, function of the lower lip after its repair, and esthetic results showed high esthetic and functional efficiency of the new method, due to lesser trauma of the soft tissues, lesser blood loss, and shorter time required for elevation of triangular mucous flaps, adequate blood supply to triangular mucous grafts and lower risk of their aseptic necrosis, anatomic topographic division of vertical fragments of skin and mucous wounds of the lip, and lower risk of secondary wound infection.

Adult↗
PubMed2005

[Presurgical orthodontic treatment of complete unilateral cleft lip and palate in 100 infants].

OBJECTIVE: To investigate the application and curative effect of naso-alveolar molding plate in the presurgical orthodontic treatment of complete unilateral cleft lip and palate in infants. METHODS: From January 2003 to March 2004, 100 infants with complete unilateral cleft lip and palate received presurgical orthopedics by using naso-alveolar molding plate. According to the age, 100 infants (aging 10 days to 3 months, including 60 males and 40 females) were divided into the test group (10 days to 1 month) and the control group (1-3 months). The widths of lip cleft and dentoalveolar cleft and the rate of satisfaction for nose wing were compared between 2 groups before treatment and after the treatment. RESULTS: The widths of cleft lip and dentoalveolar cleft before orthodontic (5.0 +/- 1.6 mm, 6.9 +/- 2.6 mm) and after orthodontics (4.1 +/- 2.7 mm, 6.4 +/- 2.9 mm)in the test group were less than those in the control group (7.5 3.1 mm, 12.5 +/- 4.0 mm and 8.3 +/- 3.0 mm, 10.8 +/- 2.6 mm), being statistically different (P < 0.05). The satisfactory rate of nose wing in the test group (86.3%) was significantly higher than that in the control group (62.4%, P < 0.05). CONCLUSION: The advantages of presurgical orthodontic treatment of complete unilateral cleft lip and palate in infants are as follows: repositioning the premaxillary segment, reducing the width of palate cleft, correcting the nasal deformities and facilitating surgical repair of cleft lip and palate.

Cleft Lip↗
PubMed2004

Lip curve changes in males with premolar extraction or nonextraction treatment.

AIM: This retrospective study was designed to compare the responses of the upper and lower lip curves in young growing males, to orthodontic treatment involving either four premolar extractions or the holding of the E-spaces without premolar extractions. METHOD: Pre- and post-treatment lateral cephalograms of 67 premolar extraction and 30 nonextraction patients were assessed. The results were subjected to analysis of variance to search for statistically significant differences amongst the pretreatment variables and changes in depths of lip curves. Pearson's correlation coefficients were also calculated and stepwise regression analysis undertaken. RESULTS: A wide range of lip curve behaviour was seen in individual patients within all groups. No significant differences were found in the change in depth of lip curve amongst the various extraction and nonextraction groups. The inherent morphology of the soft tissues appeared to be the greatest determinant of lip curve behaviour with treatment. CONCLUSIONS: It would appear that neither premolar extraction nor nonextraction treatment, if based on appropriate diagnostic criteria and followed with competent clinical management, will necessarily lead to direct effects on lip curvature.

Adolescent↗
PubMed2006

Arteriovenous fistula of the lower lip: case report of combined intravascular and surgical cure.

PURPOSE: We describe a patient presenting with a vascular mass of the lower lip with a history of traumatic lip-biting. The lesion was treated with preoperative intravascular embolic therapy and surgical excision. SUMMARY: Arteriovenous fistula (AVF) of the head and neck are vascular lesions with a single connection between the involved artery and vein. Trauma to the area, often in the distant past, is often seen as the inciting event. We describe a patient with a lower-lip AVF with repeated episodes of lip biting that caused expansion of the mass. The patient underwent preoperative embolic therapy and surgical excision with excellent functional and cosmetic outcome. CONCLUSION: Arteriovenous fistula of the lower lip can be successfully managed with preservation of lip function and cosmesis through combined intravascular and surgical therapy.

Adult↗
PubMed2006

[One-stage repair of unilateral cleft lip and nasal deformity].

OBJECTIVE: To investigate the method for simultaneous correction of nasal deformity and unilateral cleft lip so as to decrease the secondary operation for the deformity. METHODS: The Millard procedure (or Millard plus triangle flap insertion) was used to repair the unilateral cleft lip. Through the incisions, the greater alar and nasalis were repositioned to the normal anatomical positions. The deviated septum and columella were corrected by cutting the abnormal attachment of the orbicular muscle of mouth to the anterior nasal spine. The mattress sutures through the tip of the columella and ala nasi helped to recover the shape of the nostril. RESULTS: 108 patients were treated with this method. They aged from one month to 19 years, included 30 with second degree cleft lip and 78 with third degree cleft lip. The follow-up for as long as 3 years showed satisfactory results. CONCLUSIONS: This technique can eliminate the severe cleft nasal deformity and elevate the displaced alar cartilage at the time of lip repair without interference with nasal growth. It is recommended for the treatment of unilateral cleft lip with severe nasal deformity.

Abnormalities, Multiple↗
PubMed2006

[Developmental disturbances of medial part of face of patients with bilateral cleft lip and palate with special consideration of a nose].

UNLABELLED: Cleft is a developmental malformation, which is defined as a partial or complete lack of anatomic tissues continuity in typical areas of disorders in embryological face development. The reasons for cleft formation are not completely recognised but many hypotheses indicate both environmental and genetic factors as possible sources. The list of the cleft types is the following: cleft lip, cleft lip and alveolus, isolated cleft palate, cleft lip, alveolus and palate, and combined clefts. The malformation may occur unilateral or bilateral. According to World Health Organization cleft lip and palate is classified in the first ten of the most common developmental disorders, however the bilateral form of pathology is the least popular one. MATERIAL AND METHODS: The aim of the study is the anthropometric measurement of a nose of children and adolescents with bilateral cleft lip, alveolus and palate in comparison with data gathered as a result of healthy people measurements. The research was conducted on 26 patients with the malformation: 12 girls and 14 boys at the age range between 7 and 18. The measurements were taken with the use of small bow and slide compasses. For the purpose of the statistical analysis we used formula for standardisation. Both, the arithmetic average and the standard deviation were estimated on the basis of research done on 30 healthy people of same sex and at proper age. Intersexual comparison of these values with the use of t-Student test was done. In order to distinguish homologues features in respect to the comparative group, one-way ANOVA and test post hoc (Duncan) were used. RESULTS: Malformation was mainly reflected in increased width the base of the nose (sbal-sbal), width of nose (al-al) and its small prominence (sn-prn). Increase in head height values together with underdevelopment in sagittal plane was also observable. The increase of upper face height (n-sto) was recognized as stronger in case of females than males with the same malformation. The middle part of face was characterized by increase of height measurements together with sagittal plane underdevelopment. CONCLUSIONS: It was stated that the patients with bilateral cleft lip, alveolus and palate tended to have flat and wide nose.

Abnormalities, Multiple↗
PubMed1991

[Comparison of different types of cleft lip and palate in regards to dental anomalies and sexual incidence].

The present study addresses two questions. Does the incidence of dental anomalies differ among the four following types of cleft lip and palate: the isolated cleft palate, the unilateral cleft lip and palate, (right or left), and the bilateral cleft lip and palate. Furthermore is the sexual incidence comparable among the four above mentioned types? Radiographic records and complete family history of clefting of 156 patients with a complete cleft lip and palate were obtained from the Cleft Lip and Palate Teams of Ste-Justine Hospital. Patients in which the cleft was part of a syndrome were excluded from the study. According to the analysis of the data, the incidence of dental anomalies was relatively high, specifically as high as 92% for the bilateral cleft lip and palate. The sexual incidence differed among the four types.

Anodontia↗
PubMedDate not supplied

Associated congenital abnormalities in Nigeria children with cleft lip and palate.

This is a prospective study of 106 patients with cleft lip and or palate seen over a 5 year period between January 1981 and December, 1985 at the Lagos University Teaching Hospital. Thirty of these patients (28.3 percent) have other associated congenital anomalies which lies within the range of 3 percent to 63.3 percent reported by other authors. The associated anomaly rate was 19 percent in cleft lip only, 35 percent in cleft lip and palate and 28 percent in cleft palate only. All the associated anomalies in the cleft lip cases were single and simple. On the other hand, the multiple and more complex associated anomalies occurred in patients with cleft plate alone and cleft lip and palate combined. Three syndromes were recognised in patients with cleft palate and two in patients with cleft lip and palate.

Abnormalities, Multiple↗