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At least 667 records · Page 37Linked to original sources
PubMed1994

[Study on mucosal carcinomas of the large intestine, polypectomized for the recent 5 years].

Intramucosal carcinomas of the large intestine, polypectomized from 1988 to 1992 were investigated. Out of 111 lesions of intramucosal carcinoma, 106 cases (95.5%) co-existed with adenoma. The incidence of co-existence with adenoma was 0%, 14.4%, 31.5%, 26.1%, 18.9% and 9.0% in the lesions within 4mm, 5-9mm, 10-14mm, 15-19mm, 20-29mm, and over 30mm in diameter, respectively. The incidence of gross findings in the co-existed cases of cancer and adenoma was 0.9%, 15.1%, 32.1%, and 51.9% for IIa, Is, Isp, and Ip types, respectively. Histological incidence of co-existed adenomas was 63.2%, 31.1% and 5.7% for tubular, tubulovillous and villous types. Occupation rate of cancer tissue was within half in the majority of co-existed lesions.

Adenoma↗
PubMed1976

[Differential diagnosis of clinical forms of polyposis of the large intestine].

The author presents an analysis of 1603 clinical observations. By means of electronic computors the possibility to determine interrelations and dependence between forms of the disease and symptoms was realized. A computor recorded 156 possible variants of combinations of the forms and clinical manifestations.

Diagnosis, Computer-Assisted↗
PubMed1994

Gastrointestinal bleeding in infancy and childhood.

In summary, the causes of GI bleeding in infancy and childhood are varied, ranging from congenital and hereditary disorders to those more commonly seen in the adult population. Many causes of GI bleeding in the pediatric population are restricted to a narrow range regarding age of onset, frequently enabling the physician to narrow the differential diagnosis before proceeding with invasive investigation; however, GI bleeding may involve any portion of the intestinal tract, from mouth to anus, as in adulthood, and many causes common to the adult population also must be considered.

Adenomatous Polyposis Coli↗
PubMed1993

[Intermediate lymphocytic lymphoma with multiple lymphomatous polyposis of the gastrointestinal tract].

We report a case of intermediate lymphocytic lymphoma (ILL) with multiple lymphomatous polyposis. A 56-year-old man presented with general fatigue and bloody stool. Physical examination showed cervical and axillary lymphadenopathy, bilateral tonsillar hypertrophy, and moderate splenomegaly. Leukocyte count was 9,570/microliters with 11% abnormal cells, infiltration of which was observed in the bone marrow too. Examinations of the gastrointestinal tract revealed diffuse small polypoid lesions throughout the stomach and the entire large bowel. The biopsied specimens from both the stomach and large bowel showed diffuse infiltration of medium-sized lymphoid cells in the submucosa and the lamina propria. Lymph node biopsies showed ILL (mantle zone lymphoma). The phenotype of lymphoma cells was CD5 (+) CD10 (-) CD19 (+) CD20 (+) CD21 (+), and sIg mu delta-lambda. The patient was initially given the multiple agent chemotherapy, which did not improve the peripheral blood findings and was switched to the regimen that comprised of etoposide and prednisolone. The patient's lymphoma is well controlled by this regimen 35 months after diagnosis.

Humans↗
PubMed1995

Mast cells in the gastrointestinal tract.

The morphology and functions of gastrointestinal mast cells (MCs) under physiological and pathological conditions were described. Special attention was paid to the MCs origin, differentiation and morphological and biochemical aspects of their degranulation. Mast cells are important component of normal architecture of the gastrointestinal tract. Many substances released from MCs during degranulation are biologically active and mediate numerous processes: blood flow regulation, epithelial and endothelial permeability, mucosal secretion, gastrointestinal tract motility, immunological events related to the antigens of various origin, angiogenesis, cancer development. Thus MC is often considered as an important agent in pathogenesis of many gastrointestinal diseases. The gastrointestinal diseases which was described in this paper are following: bacterial and parasitic infections, peptic ulcer, ulcerative colitis, Leśniowski-Crohn's disease, inflammatory polyps, intestinal graft-versus-host reaction, neoplastic tumors, mastocytosis, intestinal ischemia.

Adrenergic Fibers↗
PubMed1977

Peutz-Jeghers syndrome: case presentation.

The different aspects of the Peutz-Jeghers syndrome are discussed following a case presentation of a 36-year-old woman with Peutz-Jeghers syndrome, sex cord tumor with annular tubules of Scully, mucinous metaplasia of tubal epithelium, and adenocarcinoma of the endocervix. The latter two findings have not been described with the syndrome and an attempt is made to correlate them with Peutz-Jeghers syndrome.

Adenocarcinoma↗
PubMed1977

Carcinoembryonic antigen in colonic lavage.

Colonoscopic lavage was performed for assay of carcinoembryonic antigen (CEA) concentration in patients with small and large colonic adenomas, in patients with adenocarcinoma of the colon, and in normal controls. CEA concentration was considerably higher in colonoscopic lavage as compared to plasma. CEA concentration in normal controls and in patients with colonic adenomas less than 1 cm in size were not significantly different. CEA concentrations in patients with colonic adenomas greater than 1 cm in size and in patients with adenocarcinoma of the colon were significantly higher than those observed in patients with small adenomas and in the normal controls. In all except 2 patients, plasma CEA concentrations were normal. Assay of CEA concentrations in colonic lavage may have potential application in the further assessment of the mucosa at risk for colon adenomas and for colon cancer. It does not appear to be accurate enough for diagnosis of colon cancer in individual patients.

Adenocarcinoma↗
PubMed1977

[Double-contrast technique for diagnostics of the large intestine (author's transl)].

The results of 1300 radiographic examinations of the colon with the double-contrast method were reported. In preparation for the examination, only a laxative (cascara salax) was administered and the patient not permitted to eat. The importance of horizontal films was mentioned in particular. A malignant tumor in the colon was discovered in 137 cases. A malignant degeneration was established via histologic examination in 23 of the 152 patients with polypoid lesions. Juxtaposition of a malignant tumor and a polypoid lesion or a second carcinoma was discovered via radiological examination in 28 patients.

Adult↗
PubMed1997

The investigation of symptomatic inguinal hernia: a complication of barium enema.

The controversy surrounding the value of performing screening barium enema in patients with inguinal hernia persists. It was Myers & Zollinger who, in 1942, reviewed 200 consecutive cases of inguinal hernia and noted that 18%; of patients complained of gastrointestinal symptoms. Of these, two cases of adenocarcinoma were discovered on further evaluation. Subsequently, many authors have reported a low diagnostic yield of barium enema in patients with inguinal hernia unless specific colonic symptoms were present. We present a case in which this investigation was indicated, but led to irreducibility.

Adenoma, Villous↗
PubMed1998

Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients.

The synovial fluid or group II secretory phospholipase A2 (sPLA2) has been implicated in various inflammatory processes and has been shown to release arachidonic acid for prostaglandin biosynthesis. In human colorectal cancer, both arachidonic acid and eicosanoid levels are elevated. Recently, sPLA2 has been identified as a candidate gene that modifies the Apc gene in the Min mouse, a murine model for familial adenomatous polyposis (FAP). Loss of sPLA2 gene function results in susceptibility to the Min phenotype and the formation of multiple intestinal polyps, whereas mice expressing an active sPLA2 gene are resistant to polyp formation. Therefore, there are two potentially contrasting roles for sPLA2 in colon cancer; one is protection against polyp formation, and the other, the release of arachidonic acid for prostaglandin production and subsequent tumor promotion. To investigate these contrasting dual roles of sPLA2, we have examined the expression and sequence of the sPLA2 mRNA in normal mucosa and duodenal and colorectal polyps from FAP patients. In 11 of 14 patients, there was a significant increase in sPLA2 mRNA levels in the adenoma over the normal tissue. In some cases, there was over 100-fold increase in mRNA levels in the adenoma compared with normal tissue. Analysis of multiple adenomatous polyps from individual patients revealed that not all polyps contained elevated levels of sPLA2 mRNA. Immunoblot analysis also showed that sPLA2 protein expression was elevated in adenoma over normal tissue in five of six FAP patients analyzed. Furthermore, sequence analysis of sPLA2 mRNA present in these samples did not reveal mutations in the coding region. The implications of the up-regulation of sPLA2 in FAP is not clear, but unlike the Min mouse model, it does not seem to have a significant effect on polyp formation. In contrast, the high level of sPLA2 expression is more likely contributing to the elevated levels of arachidonic acid found in colorectal cancer and, in conjunction with the elevated expression of cyclooxygenase-2, could be another factor in tumor formation.

Adenoma↗