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At least 667 records · Page 37Linked to original sources
PubMed1999

[Epstein-Barr virus in a donor kidney as a cause of non-Hodgkin lymphoma].

A 22-year-old male who had received a kidney transplant from his father (HLA haploidentical), presented with fever and malaise. After transplantectomy was performed because of rejection, the patient developed abdominal pain due to perforation of the small intestine. Non-Hodgkin's lymphoma was found in both the transplant and the small bowel. The patient had suffered a primary Epstein-Barr virus (EBV) infection, probably transferred through the transplanted kidney. DNA analysis showed that the lymphoma was of patient origin. After withdrawal of immunosuppressive therapy, no recurrence of the lymphoma was seen. EBV is a well-known aetiologic agent of non-Hodgkin's lymphomas arising in the immunocompromised patient.

Adult↗
PubMed1999

[Primary intestinal type adenocarcinoma of the urinary bladder: a case report].

A 43-year-old man was referred to our hospital with complaints of macroscopic hematuria, micturition pain, and pollakisuria. Cystoscopy revealed a papillary broad-based tumor of 4 cm in diameter at the posterior wall and trigone of the urinary bladder. A punch biopsy specimen was diagnosed histopathologically as adenocarcinoma mimicking colorectal cancer. Computed tomographic (CT) scan demonstrated a large tumor involving both the urinary bladder and the rectum. Total cystoprostatectomy and low anterior resection following colorectal anastomosis, double barreled colostomy, and ileal conduit urinary diversion were performed. The tumor was diagnosed histopathologically as primary intestinal type adenocarcinoma of the urinary bladder infiltrating the sigmoid colon and the small intestine. The patient died 12 months after the operation due to peritonitis carcinomatosa.

Adenocarcinoma↗
PubMed1975

Intestinal tumors in mice treated with a single injection of N-nitroso-N-butylurea.

N-Nitroso-N-butylurea was injected once at dosage levels of 150 or 75 mg/kg into 3- or 6-week-old male C57BL/L mice. Intestinal tumors occurred in 100% of the mice that survived more than 15 weeks after injection with a high dose of N-nitroso-N-butylurea at 6 weeks of age, and in 35 to 70% of the mice in other treatment groups. These intestinal tumors were seen primarily at the junction of the pylorus and duodenum and in the anterior portion of the small intestine, with a few in the cecum, colon, and rectum. The tumors at the junction were not very invasive tumors and frequently appeared as polypoid growths. Tumors not at this location were adenocarcinomas that invaded all the layers of the gut wall but which did not metastasize. Colorectal tumors were adenomas and adenocarcinomas. N-Nitroso-N-butylurea also induced tumors of the stomach, hematopoietic system, lung, and liver.

Adenocarcinoma↗
PubMed1979

Determination of the caloric requirement of patients with cancer.

The weight change of 16 adult patients with cancer receiving total parenteral nutrition for an average period of 12 days was evaluated. The nitrogen to calorie ratio of the hyperalimentation fluid ranged from 1:144 to 1:235. The amount of nonprotein calories delivered was expressed as a multiple of the resting metabolic expenditure, and patients were divided according to the following different rates of calories delivered/resting metabolic expenditure into three groups: group 1, 1.11 to 1.48, mean 1.33; group 2, 1.55 to 1.76, mean 1.67, and group 3, 1.78 to 2.10, mean 1.87. The weight change in group 2 patients, +0.32 kilograms per day, was statistically different from that of group 1 patients, p less than 0.01, but not from that of group 3 patients. We conclude that the optimal hyperalimentation infusion rate to achieve weight gain in patients with cancer includes 50 nonprotein calories per kilogram per day as well as 1.5 grams of amino acids per kilogram per day with a nitrogen to calorie ratio of 1:208.

Adenocarcinoma↗
PubMedDate not supplied

Small bowel metastases of lung cancer as unique metastatic lesions: CT, MRI and small bowel enema findings. a case report.

Small bowel metastases of lung cancer as unique secondary lesions are a very rare occurrence and may be clinically missed due to the aspecificity of the symptoms. Diagnosis is usually made at acute abdominal symptomatology that requires emergency surgical treatment. We report a case of 69-year-old woman, previously treated for epidermoid lung carcinoma, complaining only of aspecific asthenia; blood cell count and chemistry showed a moderate but progressive anemia; no signs of small bowel occlusion were present. The follow-up CT scan showed two large masses at the small bowel level, without any evidence of hepatic, lung, adrenal or brain metastases. MRI and small bowel enema confirmed the presence of the masses, and the diagnosis of small bowel metastases was hypothesized. Surgical specimens of the masses confirmed the radiological suspicion.

Aged↗
PubMed1975

[The carcino-embryonic antigen of experimental tumors of the intestine].

The occurrence of a tumour-specific antigen in the intestinal tumours (induced in 51 albino rats by subcutaneous injection of 1,2-dimethylhydrazine), as well as in the blood serum was studied by double immunodiffusion in agar gel. Intestinal tumours proved to contain a water-soluble antigen absent in other tissues, including the colonic mucosa of control animals. This antigen was found in 70 per cent of the tumour-bearing rats. The antigen is perchloric acid-solubilized and is also present in the embryonic tissues in toto on the 7th and the 9th days of rat gestation. The features of this antigen were analogous with those of the carcino-embryonic antigen in human digestive tract tumours.

Animals↗
PubMed1975

[Change in cell membrane permeability, and composition and properties of hexokinase during induced carcinogenesis].

The isoenzyme hexokinase (HK) spectrum from normal rat large intestinal mucosa consisted of 3 isoenzymes. In tumours of this localization induced by 1,2-dimethylhydrazine there proved to be a lack or marked decrease in the most rapid anodic isoenzyme. Only one HK isoenzyme was found in the metastases. Km (glucose) for tumour HK was 2--3 times lower than for normal intestinal HK; the HK activity was detected in the serum from the 1st month of the carcinogenic administration, and by the 5th month it was found in 80% of the tumour-bearing animals. No serum HK activity was ever found in control rats.

Adenocarcinoma↗
PubMed2003

[Metastatic obstruction of the small bowel revealing or complicating squamous-cell lung cancer. Two cases and a review of the literature].

Gastrointestinal metastasis from lung cancer is exceptional and generally asymptomatic. Other secondary localizations are often present. Metastastic dissemination may involve any portion of the gastrointestinal tract. Clinical expression is variable: dysphagia, anemia, bowel obstruction, peritonitis. Surgical treatment may be indicated in selected patients. We describe the cases of two patients who developed obstruction of the small bowel due to metastases from squamous-cell lung cancer. Bowel obstruction was in the inaugural sign in the first patient. Mesenteric metastasis was associated in the second patient.

Carcinoma, Non-Small-Cell Lung↗