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[Biological properties of the Escherichia of serological group 06 isolated in acute intestinal diseases of undetermined etiology].

The authors describe new serological and biochemical types of escherichia belonging to serological group 06, isolated in group and sporadic cases of sickness, from the affected children. Circulation of seven serological types was revealed--partial composition of the O-antigen proved to be serologicaly nonhomogeneous. Escherichia of a single sero-anzymatic type (06a6b: K13: H1) were isolated in a group affection.

Acute Disease↗

[Clinico-immunologic characteristics of acute intestinal diseases caused by Pseudomonas aeruginosa].

The examination of 118 intestinal disorders caused by Ps. aeruginosa in patients aged 18-60 provided evidence on its higher incidence in summer and autumn, acute onset, short latent period, systemic toxic and dyspeptic syndromes. Intestinal picture involved syndromes of gastroenteritis, gastroenterocolitis, in the severe course--of hemocolitis. Grave forms of Ps. aeruginosa infection entail drastic changes in immune status registered till the discharge from hospital: T-lymphopenia, high CIC levels, a lower immunoregulatory index.

Acute Disease↗

Familial occurrence of renal and intestinal disease associated with tissue autoantibodies.

Chronic tubulointerstitial renal disease and villous atrophy of the small intestine occurred in two first cousins. Both had protracted diarrhea with malabsorption and died despite intensive parenteral alimentation. In one patient signs of generalized proximal tubular dysfunction developed, followed by nephrotic syndrome and progressive renal insufficiency. A renal biopsy specimen disclosed severe tubulointerstitial disease and membranous glomerulopathy. In this patient, circulating immune complexes were detected and granular deposits of IgG and C3 were seen in the intestinal epithelial cells by direct immunofluorescence. Antiintestinal antibodies (IgG class) were demonstrated by indirect immunofluorescence. The other patient had interstitial nephritis but no glomerular abnormality. On direct immunofluorescence, both patients had confluent granular staining of the renal tubular basement membranes. These immunopathologic studies suggest a common immunologic mechanism in the pathogenesis of the renal and gastrointestinal disorders in these infants.

Autoantibodies↗