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Results for “Fallopian Tube Neoplasms”

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At least 667 records · Page 37Linked to original sources
PubMed1999

Sigmoid colon carcinoma metastatic to the myometrium.

Metastases to the uterus from extragenital cancers are significantly rarer than metastases to the ovaries. Of the approximately 200 cases of metastases to the uterus from extragenital cancers that have been reported in the literature, more than half are cases of metastases from breast carcinoma and only 16 are cases of metastases from colorectal carcinoma. A case of isolated metastases restricted to the myometrium of the right uterine comu from sigmoid colon carcinoma, without involvement of the ovaries, is described. The patient who six months previously had surgery for sigmoid colon carcinoma presented with right lower abdominal pain and a palpable mass in the region of the right uterine cornu. The diagnosis of isolated metastases restricted to the myometrium of the right uterine cornu was confirmed by total abdominal hysterectomy and bilateral salpingo-oophorectomy. This case illustrates that a growing uterine mass in a patient with a history of primary extragenital cancer, regardless of whether abnormal uterine bleeding is present or absent, should alert the physician to consider the possibility of uterine metastases.

Abdominal Pain↗
PubMed1997

Uterine carcinoma in mice treated neonatally with tamoxifen.

The induction of preneoplastic and neoplastic lesions by the widely used antiestrogen Tamoxifen was studied in female mice. Outbred CD-1 mice were treated with Tamoxifen (1, 2, 5, 10, 25 or 50 microg/pup/day) for the first 5 days after birth. At 14-17 months, reproductive tract tissues were examined for pathological changes. In the ovary, corpora lutea were lacking while cysts were quite common in Tamoxifen-exposed mice at all doses; cystadenomas were seen in two mice. Structural malformations and epithelial hyperplasia of the oviduct were seen in 100% of the treated mice. Malformations of the uterus, cervix, and vagina were also seen. Excessive vaginal keratinization was not a common feature although vaginal adenosis was observed more often after Tamoxifen treatment than previously reported after similar treatment with diethylstilbestrol (DES). The most striking histological features, however, were seen in the uterus. One hundred percent of the Tamoxifen-treated mice at all doses exhibited uterine hypoplasia with focal areas of basal cell hyperplasia in the lining endometrium. Progressive cellular atypias were seen in the lining endometrium ranging from atypical hyperplasia to uterine adenocarcinoma; the highest incidence of uterine adenocarcinoma was 7/14 (50%) observed in the Tamoxifen 10 microg/pup/day dose group. No similar tumors were observed in corresponding control mice. The induction of atypical uterine hyperplasia and adenocarcinoma combined with other abnormalities observed in genital tract structure following neonatal treatment with Tamoxifen suggests the developing reproductive tract is exquisitely sensitive to perturbation by compounds with hormonal activity. These studies provide the basis for future investigation into the mechanisms of Tamoxifen's carcinogenic effects in experimental animals, and to the risk benefit analysis for the prophylactic use of Tamoxifen in healthy women who are at risk of developing breast cancer.

Adenocarcinoma↗
PubMed2004

Intrauterine versus transvaginal sonography for benign and malignant disorders of the female reproductive tract.

OBJECTIVE: To determine the usefulness of high-frequency intrauterine (IUS) vs. transvaginal (TVS) sonography in the evaluation of benign and malignant uterine and tubal abnormalities. METHODS: For IUS sonography, a high-frequency (10-30 MHz) microtip probe with a maximum beam penetration depth of 126 mm was inserted intracervically; radial scanning (360 degrees) was performed without cervical dilatation and without local or general anesthesia. For TVS, a 7.5-MHz probe was used. The study population comprised 48 patients. Thirty-three patients had gynecological diseases (cervical and endometrial cancer (n = 12), uterine leiomyomas (n = 10), sterility disorders (n = 11)); the remaining 15 patients served as a control group and had no gynecological diseases. RESULTS: IUS was accomplished in 45/48 (94%) patients. In contrast to TVS, preoperative staging by IUS-with assessment of depth of tumor invasion-concurred with the histopathological findings in all patients with cervical and endometrial cancer. The sonographic resolution of submucosal and intramural leiomyomas was superior with IUS vs. TVS. For patients with sterility disorders, intraluminal sonography of the Fallopian tubes was achieved in 64% of cases; endometrial nodules of the Fallopian tubes were depicted by intraluminal sonography (but not TVS). CONCLUSIONS: IUS is superior to TVS in the evaluation of uterine and tubal abnormalities.

Endometrial Neoplasms↗
PubMed1997

Aggressive endometrial cancer in a young patient.

An unusually aggressive case of endometrial cancer in a 30 year old woman is presented. The patient experienced abnormal uterine bleeding, at times requiring blood transfusions, for almost half a year before the diagnosis was revealed. For obvious reasons there is a reluctancy to perform invasive examinations in young women. The diagnostic options are discussed.

Adenocarcinoma↗
PubMed2001

Surgery for endometrial cancer: what type and by whom?

Endometrial cancer has far too long been regarded as a simple disease to treat. As such it has generally remained in the hands of the generalist obstetrician/gynaecologist. In order to optimize the choice of surgery, careful pre-operative evaluation is essential with respect to pathology of a biopsy, radiological assessment of extent of disease and evaluation of fitness for anaesthesia. The standard procedure is a total abdominal hysterectomy and bilateral salpingo-oophorectomy. However, consideration should be given to pelvic lymphadenectomy in high-risk cases. Surgery for high-risk endometrial cancer should be performed by gynaecological oncologists.

Biopsy↗
PubMedDate not supplied

[Neoplastic encephalopathy in the light of 2 observed cases].

The authors report two cases of neoplastic encephalopathy. In one patient with oviduct carcinoma it had the form of cerebellopathy. In the other case of renal carcinoma it appeared as encephalopathy with a nearly exclusive involvement of cerebral hemispheres. The reaction of microglia, lymphocytes and diffuse demyelination found in these cases are regarded by the authors as a result of autoimmunization in the course of malignant neoplasm. Attention is called to the importance of axial computer tomography in the intravital diagnosis of this encephalopathy.

Adenocarcinoma↗
PubMed1976

Primary carcinoma of the fallopian tube in a Nigerian.

The first documented report of a rare neoplasm, primary carcinoma of the fallopian tube in a postmenopausal Nigerian is presented. The patient complained of postmenopausal bleeding which persisted after curettage and satisfactory treatment of a pre-existing senile vaginitis and cervicitis. The diagnosis of tubal carcinoma was made only at the time of exploratory laparotomy at which a total hysterectomy and bilateral salpingo-oophorectomy was performed and confirmed at histopathological examination of the specimen. Problems relating to its unusual symptomatology, its association with pelvic inflammatory disease and pelvic tuberculosis, diagnostic difficulties, choice of treatment and factors that may influence survival are discussed.

Adenocarcinoma↗
PubMed2005

Proteasome antibodies in paraneoplastic cerebellar degeneration.

Antibodies to proteasome have been detected in several autoimmune diseases, including multiple sclerosis. We have investigated the presence of such antibodies in patients with paraneoplastic neurological syndromes, by Western blotting and immunohistochemistry. Antibodies to 20S proteasome were detected in the majority of patients with paraneoplastic cerebellar degeneration (PCD), but in only one of nine sera from patients with paraneoplastic encephalomyelitis/sensory neuronopathy (PEM/SN), and were not found in cancer patients in general. The results suggest that the immune responses in PCD differ from those of PEM/SN, whereas the functional significance of proteasome antibodies in PCD is yet to be determined.

Antibodies, Neoplasm↗
PubMed1986

Clinical usefulness of three monoclonal antibody-defined tumor markers: CA 19-9, CA 50, and CA 125.

This article reviews the clinical usefulness of three monoclonal antibody-defined tumor markers: CA 19-9 or GICA, CA 50, and CA 125. These markers have been regarded as worthwhile tools for diagnosis and monitoring the management of patients with cancers in selected sites. The CA 19-9 test in combination with the CEA test is a useful adjunct for staging in some advanced cases and for monitoring therapy in the majority of patients with carcinoma of the stomach. Sensitivity of these assays performed concurrently is comparable to CEA alone in colorectal carcinoma. The CA 19-9 test alone is useful for staging and monitoring management of patients with carcinoma of the pancreas. In colorectal carcinoma the CA 19-9 test is redundant because of significantly lower sensitivity than that of the CEA assay; the latter remains the test of choice. The CA 50 test per se is redundant since the CA 19-9 antigen is the target for both the C50 MAb and the NS 19-9 MAb. The CA 125 test contributes to staging and is a useful adjunct for monitoring management of patients with non-mucinous carcinomas of the ovary. If positive after initial surgery and chemotherapy, this test provides evidence of the presence of residual or metastatic tumor and thus may obviate the need for second-look surgery. These conclusions are based on a review of recent relevant publications as well as on our own results obtained from preoperative evaluation and postoperative follow-up of about 600 patients with cancers in relevant sites.

Antibodies, Monoclonal↗
PubMedDate not supplied

Prospective self-controlled study on prevention of hysteroscopic dissemination in endometrial carcinoma.

Patients diagnosed to have endometrial carcinoma without prior hysteroscopic examination were recruited from March 2000 to August 2003. Normal saline was used to distend the uterine cavity during the hysteroscopic examination to look for endocervical spread before the definitive surgical treatment. We performed laparotomy, clamped both fallopian tubes, and collected peritoneal washing before the hysteroscopic examination was performed. Peritoneal washing was collected once more after the hysteroscopic examination. Hysteroscopic assessment was performed in 103 patients. Of them, 10 patients were excluded from the study due to previous history of tubal sterilization or blockage. The final analysis was confined to 93 patients. Positive peritoneal cytology was found in 10 (10.8%) patients and this finding was significantly related to the tumor grading (P = 0.023), adnexal involvement (P = 0.003), cervical invasion (P = 0.01), and the presence of peritoneal seedlings (P = 0.001). In five of the 10 patients with positive peritoneal cytology before the hysteroscopic examination, malignant cells could also be recovered in the peritoneal washing collected after the hysteroscopic examination. For patients with negative peritoneal cytology before hysteroscopy, none exhibited positive peritoneal cytology after the procedure. Our data suggested that complete occlusion of both fallopian tubes can effectively prevent the dissemination of endometrial malignant cells into the peritoneal cavity during hysteroscopy.

Adult↗
PubMed1991

Enhancement of tumor-associated glycoprotein-72 antigen expression in hormone-related ovarian serous borderline tumors.

The immunoreactivity of monoclonal antibody (MoAb) B72.3 with ovarian serous tumors of borderline malignancy from 44 women who were pregnant, were on hormone medication containing a progestin, or were known to be in the secretory phase of the menstrual cycle, was compared with that of similar tumors of 32 patients who were not known to be in any of these three categories. All 76 borderline tumors expressed the tumor-associated glycoprotein (TAG-72) recognized by MoAb B72.3. Striking staining differences (P less than 0.0001) were observed between the hormone-related and the nonhormone-related tumors. Differences were also noticed between the staining of tumors from pregnant patients and that of previous, persistent, or recurrent tumors of the ipsilateral or contralateral ovaries when the same patients were not pregnant. Tumor MoAb B72.3 reactivity increased with progressive gestational age and fell to lower levels at term and during the postpartum period. Although it has been suggested by cell culture studies, enhanced TAG-72 expression in human tumors under hormonal stimulation has not been described before.

Antibodies, Monoclonal↗
PubMed1996

Abdominal dissemination of malignant cells with hysteroscopy.

BACKGROUND: The increase in uterine pressure during hysteroscopy may lead to dissemination of malignant cells into the abdominal cavity. CASE: In a patient with adenocarcinoma of the endometrium, hysteroscopy was performed after peritoneal cytology had been obtained by washing with saline. In contrast to this first washing, a second peritoneal lavage immediately after hysteroscopy led to positive cytology. CONCLUSION: Viability and peritoneal implantation of these disseminated cells are questionable. However, routine hysteroscopy in cases of suspected endometrial carcinoma should not be recommended.

Abdomen↗