[Critical study of the normal electrocardiogram of the aged patient through ergometry and continuous electrocardiography. Holter's system].
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AIM: Verify the value of the combined use of Dipyridamole Stress Echocardiography (DSE) and Exercise Testing (ET) for predicting cardiac events after Thrombolysed Myocardial Infarction (TMI). STUDY DESIGN: Prospective, with a medium follow-up of 221 days (range 30-446). CLINICAL SETTINGS: Coronary Care Unit with Cardiology Service. PATIENTS: 32 consecutive patients, 24 men and 8 women, mean age 61 years (range 39-72) with acute myocardial infarction. INTERVENTIONS: Systemic thrombolysis with PTPA. DSE and ET in therapeutic wash out 12 +/- 3 days after admission to the Coronary Care Unit. RESULTS: 9 patients had positive ET, 18 patients had negative ET, 5 patients did not perform ET. 19 patients had positive DSE, 13 patients had negative DSE. Patients with positive DSE had in 6 cases (group 1) WMA remote from the infarction area (WMAR), in 13 cases (group 2) WMA appeared in the infarct related area. Cardiac events occurred in 15 patients: 1 cardiovascular death, 1 myocardial re-infarction, 13 cases of unstable angina. 2 patients with negative DSE had cardiac events. All patients in group 1 had events, 1 patient with a previous positive ET, 3 patients with previous negative ET. 2 patients in this group didn't perform ET. 7 patients in group 2 had cardiac events, in all cases with a previous positive ET. 1 single patient in this group with negative ET had events. CONCLUSIONS: 1) Patients without WMA at DSE are at low risk for cardiac events after thrombolysed myocardial infarction. 2) Presence of WMAR appears to be associated with a higher risk, whatever the result of ET may be. 3) Patients without WMAR can be further stratified by ET in therapeutic wash out. High risk patients seem to be those with positive DSE and positive ET. 4) Combined use of DSE and ET seem to allow optimal risk stratification after thrombolysed myocardial infarction.
Measuring lactate during moderate exercise is a useful tool in the diagnosis of mitochondrial disorders. It was the aim of this study, to develop reference limits for lactate at rest, during exercise and after the exercise. We investigated 18 healthy subjects and 6 patients with a mitochondrial disorder. In controls, serum lactate levels were comparable to already reported findings. In 4 patients lactate levels were markedly increased during the exercise. Measurement of serum lactate is a simple and useful step in the diagnosis of mitochondrial disorders.
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INTRODUCTION: The present study compared blood lactate and glucose values obtained from capillary and venous samples, and examined the utility of a modified capillary tube (55 mm in length) for a YSI 2300 Stat analyzer. METHODS: Sixteen subjects (17-26 yrs) completed a graded exercise test using a cycle ergometer. Blood samples were collected during the last minute of each three minute stage from an indwelling venous catheter and via finger puncture. All samples were analyzed for glucose and lactate using the YSI 2300 Stat analyzer (Yellow Springs Instruments, Yellow Springs, OH). RESULTS: Post hoc analysis indicated that venous blood lactate values were significantly lower than capillary values at 150 (p = 0.03) and 200 (p = 0.002) Watts. No differences were measured between the venous and capillary blood glucose values. CONCLUSIONS: Attempts should be made to quantify potential capillary and venous differences in blood lactate resulting from various experimental protocols and environments.
7 patients aged 30-56 years with the perception of subjective increased fitness 4-22 months after single lung transplantation were tested for the objective benefit. Using a standardized ergometric test protocol cardiopulmonary parameters (ventilation, blood gases, gas exchange, blood pressure, ECG) were measured 5 males and 2 females. After transplantation in all patients the objective fitness was increased by 30-60 watts and the blood gases were markedly improved. The physical fitness of the subjects under study was probably limited by the reduced lung function of the native lung, the reduced mobility of the diaphragm in elderly patients and the impaired muscular strength and endurance.
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The correlational connection between some factors of risk and ergometric indices in patients with ischemic heart disease was studied. The results of an examination covering 188 patients and 56 practically healthy persons which involved the use of a graded stepwise increasing loading on a veloergometer under a monitored control of the pulse rate, ECG and arterial pressure were analyzed. To the risk factors were referred hypercholesterinemia, hypertension, smoking, obesity and hypodynamia. With a rising number of risk factors a significant and progressive decline of the patients' physical performance capacity was ascertained. The most essential correlational connection between the risk factors and the maximally tolerable load and chronotropic and aerobic reserves was educed.
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The relationship was studied between the increase in oxygen uptake (VO2) measured breath-by-breath at the mouth, and the increase in femoral artery blood flow measured continuously with pulsed and echo Doppler methods. Five men exercised at 50 W on a knee extension ergometer in both the supine and the upright posture. The kinetics of the responses were determined by curve fitting to obtain the mean response time (MRT = 63% of the time required to achieve steady state). In the upright position, the increase in blood flow (MRT = 12.4 +/- 9.4 s, mean +/- SD) was faster than the increase in VO2 (29.6 +/- 9.3 s). Likewise in the supine position, blood flow increased more rapidly (25.1 +/- 9.7 s vs. 36.7 +/- 9.6 s). It should be noted that the increase in blood flow appeared to be faster than VO2, yet when blood flow adapted more slowly in the supine posture, it had an impact on the adaptation of VO2. This suggests that blood flow might have important effects on metabolism at the onset of submaximal exercise.
Studies performed under conditions of a 120-day HDT in the female human subjects demonstrated that out of 20 biochemical parameters of the blood characterizing the carbohydrate and lipid exchange only 14 indices changed significantly during hypokinesia. As this takes place, the maximum number of changes was revealed with the help of the graded physical load test (GPL-test) and only in case of 9 indices the alterations were found at rest. Physical loads which have been used during HDT as the preventive measures had no effect only on insignificant part of metabolic shifts such as hypokinesia-associated increase of an activity of blood lactate dehydrogenase and relative content of phosphatidylcholine as well as an increased blood content of phosphates and decreased relative portion of phospholipids which also revealed with the aid of GPL-test. All other changes which have been revealed in HDT both at rest (increased blood level of triglycerides, lactate, relative content of free fatty acids, free cholesterine and sphingomyelin with augmented decrease in glucose concentration) as well as with the help of GPT-test (an increase of absolute blood content of free fatty acids with a decrease in their relative content; an increase of the relative content of total cholesterine with decreased portion of cholesterine ethers) have been stopped.
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In 168 patients with ischaemic heart disease an ergometric loading test on a bicycle ergometer was made before coronarography. A total of 19 patients had on coronarography a finding of significant stenosis of the lumen of the trunk of the left coronary artery--group A. These patients were compared with a control group of 20 patients with confirmed coronary heart disease (narrowing of the diameter of the lumen by 50 or more percent) without affection of the trunk of the left coronary artery-group B. As to the investigated parameters of the ergometric test the two groups differed significantly in the total time of the load (group A: 6.21 minutes, group B: 7.94 minutes, p < 0.05), while in all other parameters--total amount of performed work, sum of depressions of the ST segments during a maximum load, time of onset of stenocardias, time since development of 1 mm depressions of the ST segment, maximal depression of the ST segment in lead V5 and number of leads with ST depressions above 1 mm--no significant difference was found. From the work ensues that from the ergometric loading test the finding of stenosis of the left coronary artery on coronarography cannot be predicted.
Exercise reconditioning has long been considered an essential component of the pulmonary rehabilitation regime. To investigate the long-term effects of exercise training on exercise endurance and dyspnea in patients with chronic pulmonary emphysema (CPE), we developed a supervised exercise program using bicycle ergometers. Nineteen patients (mean age: 67) with moderate to severe airflow limitation (average FEV1/FVC, 39.8%) were enrolled in a predominantly outpatient rehabilitation program. After their lactate thresholds were measured by an incremental symptom-limited maximum test, patients engaged in exercise training 15 to 30 minutes per day in an arbitrary frequency and at a work rate at or below their lactate threshold (average: 20.1 w). No significant improvements were observed in resting pulmonary function, blood gas, nutrition, or systemic muscle volume. After long-term exercise training (average period: 33 months; average frequency: 6.5 times per month, individually), the patients demonstrated significantly improved exercise endurance and relief of their dyspnea during exercise. These findings provide a physiologic rationale for long-term exercise training by patients with CPE.