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[Prosthesis: indications, contraindications and follow-up].

The use of stents or endoprostheses to treat tracheobronchial obstruction is firmly established. The most important indication for stent placement are inoperable stenoses of the central airways, whose main component is extrinsic compression due to malignant, less frequently to benign disease. In experienced hands the short- and long-term results are excellent. When considering stent placement the functional benefit for the patient should be highly likely. With respect to this, the parameters to be assessed before and in regular intervals after stent placement include a physical examination, a chest roentgenogram or a CT scan, pulmonary function tests, bronchoscopy, and quality of life. Of all the various stents on the market the cylindrical silicone stent designed by Dumon is the one most widely used and represents the standard against which all other models have to compete. Expandable metal stents have advantages over most silicone stents through their thin walls and their excellent adaptability to greatly varying airway diameters. The current development of covered expandable stents should make it possible to combine the good biocompatibility known of silicone stents with the excellent flexibility and favorable wall to inner diameter ratio of the metal stents. This development will make expandable stents much more versatile for the treatment of malignant and benign obstructions of the central airways. Effective sealing of fistulas in airways without a concomitant obstructive component is another most welcome indication for this type of stents. The future might well belong to hybrid stents with metallic components and a smooth synthetic covering of silicone or polyurethane. The ongoing research in stents shows that the "ideal stent" for all purposes does not exist and probably never will. Quite often the specific stent type needed can only be determined during therapeutic endoscopy. Every specialist practicing in the area of stenting should therefore have an armamentarium of a few different types available and use the one best indicated in a specific situation.

Airway Obstruction↗

Which drugs are contraindicated during breastfeeding? Practice guidelines.

QUESTION: Many breastfeeding mothers are concerned about taking medications that might affect their babies. Are there any guidelines on which drugs are safe? ANSWER: Only a few drugs pose a clinically significant risk to breastfed babies. In general, antineoplastics, drugs of abuse, some anticonvulsants, ergot alkaloids, and radiopharmaceuticals should not be taken, and levels of amiodarone, cyclosporine, and lithium should be monitored.

Anticonvulsants↗

Patient selection for dental implants. Part 2: Contraindications.

In today's dentistry, dental implants have become an excellent choice of treatment for multiple situations. The prognosis of this treatment modality, like any other in dentistry, is highly dependent on appropriate case selection. A multi-stepped data-gathering process, while lengthy, is very important. This process should include a patient interview to gather personal information, the chief complaint, medical history, and dental history. Extra-oral and intra-oral clinical examinations and a radiographic examination should be included.

Contraindications↗

Stroke is not a contraindication for urgent valve replacement in acute infective endocarditis.

BACKGROUND AND AIM OF THE STUDY: A treatment dilemma arises when endocarditis is complicated by cerebral embolism. Secondary cerebral hemorrhagic complications may arise following suppression of coagulation during extracorporeal circulation. Extensive valvular vegetation is regarded as an indicator for urgent surgery. The study aim was to determine the relative risk of thromboembolic complications, and to analyze the prognostic influence of different treatment strategies following onset of these complications, in particular, secondary cerebral hemorrhagic events after urgent surgery. METHODS: Between 1978 and 1993, endocarditis was diagnosed in 288 consecutive patients. Patients treated before 1982 (6.9%) were analyzed retrospectively. The remaining patients (93.1%) were followed prospectively (mean 4.3+/-1.7 years). RESULTS: In 50 patients (17.4%), the clinical course was complicated by one embolism, and in 58 patients (20.2%) by recurrent embolisms. In total, 71% of all embolisms were cerebral events. The operated patients were categorized with regard to the time between recurrent thromboembolic events and cardiac surgery (<72 h, 3-8 days, and >8 days). The prognosis for patients operated within 72 h was significantly more favorable (p <0.0001) than for those treated medically. Patients undergoing cardiac surgery more than eight days after stroke, and those treated conservatively, had poor prognoses. CONCLUSION: When endocarditis is complicated by stroke, it is recommended that cardiac surgery be performed within 72 h of the cerebral embolism, when the risk of secondary cerebral hemorrhage appears to be low. Cranial computed tomography is obligatory immediately before surgery in order to identify patients with early reperfusion hemorrhages due to spontaneous fragmentation of the thrombus. In these patients, cardiac surgery must be postponed because of the high risk of severe cerebral bleeding during extensive perioperative anticoagulation, and is only justified in the case of an otherwise unfavorable prognosis.

Acute Disease↗