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At least 667 records · Page 37Linked to original sources
PubMed1999

[Periodic colonoscopic examinations of persons with a positive family history for colorectal cancer. Work Group 'Hereditary non-polyposis- colon-rectum cancers'].

Individuals with one first-degree relative with colorectal cancer diagnosed before age 45 years and those with two first-degree relatives with colorectal cancer run a significantly increased risk (relative risk: 4-6) of developing colorectal cancer. Based on calculation of the mortality due to colorectal cancer for the age group 50-70 years (which is higher than the mortality due to breast cancer) surveillance may be justified, e.g. by colonoscopy at 5-year intervals from the age of 45-50. The total number of people in the Netherlands in this high risk group is estimated at 10,000. The authors conclude that prospective studies are needed to assess the cost-effectiveness of such a programme.

Aged↗
PubMed2000

Should we colonoscope women with gynecologic cancer?

Retrospective analysis of the Surveillance Epidemiology and End Results (SEER) program database for the period 1974 through 1995 identified 101,734 white and African-American women, age > or = 25 yr, with prior cervical, endometrial, or ovarian cancer. Subsequent follow-up demonstrated no increased risk of colorectal cancer in women with cervical cancer. For endometrial cancer patients, increased risk of colorectal cancer was confined to women whose diagnosis of endometrial cancer was before age 50, but the increased risk was substantial in this group (RR 3.39; 95% CI 2.73-4.17). For ovarian cancer patients, increased risk for colorectal cancer was substantial for those diagnosed with ovarian cancer before age 50 (RR 3.67; 95% CI 2.74-4.80), and there was some increased risk for women diagnosed at ages 50-64 yr (RR 1.52; 95% CI 1.25-1.83).

Adult↗
PubMed1999

[Treatment of colonoscopic perforations].

Perforations of the large intestine during colonoscopy are relatively rare but serious complications of this routine examination. In recent years the approach to their treatment has changed in favour of more conservative procedures, in particular in perforations which occurred during polypectomy. In the authors' department during the last five years 12 patients were treated with perforations which occurred during colonoscopy. Ten patients were operated on (4x suture of the perforation, 2x primary anastomosis, 5x derivation of the gut), two patients were successfully treated by conservative methods without surgery. Fifty per cent of the operated patients had complications. Nobody died. The mean period of hospitalization was 27.9 days in the operated patients and 4.5 days in those who did not undergo surgery. From the results ensues that a differentiated approach must be used in perforations and in indicated cases (perforations after polypectomy, satisfactory condition of the patient, minimal assumed contamination of the abdominal cavity) a conservative method can be used. Correct surgical tactics reduce the morbidity and mortality.

Adolescent↗
PubMed1976

Diagnosis and management of occult gastrointestinal bleeding: visualization of the small bowel lumen by fiberoptic colonoscope.

In 95 per cent of patients, the source of gastrointestinal bleeding can be determined by the usual roentgenographic and endoscopic methods. In the remaining five per cent of patients, the source of bleeding is obscure and special diagnostic procedures will be necessary. Among the special procedures that have been reported are the fluorescein string test, stepwise aspiration of intestinal contents, detection of radioactive red blood cells by stepwise aspiration, Geiger counter or scanning, and selective visceral angiography. An additional procedure, reported here, combines exploratory celiotomy with total endoscopic examination of the bowel.

Aged↗
PubMed1976

Hemangiomas of the cecum. Colonoscopic diagnosis and therapy.

Five cases of hemangiomas of the cecum and gastrointestinal bleeding are presented. All were demonstrated by colonscopy after more conventional diagnostic methods failed. The hemangiomas were bright red, flat lesions clearly seen through the colonscope. They were successfully treated by electrocoagulation. All patients in this series had some type of associated cardiac or vascular disease. These patients may represent a syndrome of gastrointestinal blood loss of obscure cause, hemangiomas of the cecum, and cardiovascular disease.

Aged↗
PubMed2001

Colonoscopic treatment of colon cancers.

Recent advances in endoscopic technology have enabled conservative treatment for patients with carcinoma in situ. The treatment of submucosally invasive carcinomas, or malignant polyps, is still controversial, however. The use of widely advocated histologic criteria, such as poorly differentiated histology (Grade III cancer), level 4 invasion or involved margin status, or lymphatic venous invasion as risk factors for adverse outcome, should be examined by multivariate analysis. Unfavorable histology at the invasive margin, PCNA, MUC-1 expression, and chromosomal abnormalities may be new candidates for prognostic indicators in patients with submucosally invasive carcinoma.

Carcinoma in Situ↗
PubMedDate not supplied

Preliminary results of examination of the large bowel with the colonoscope.

In 20 patients the colon was inspected with a CF-LB "Olympus" coloscope. The most frequent indication for colonoscopy were doubtful radiological changes in the colon requiring differential diagnosis. Thirteen patients were examined trying to inspect the whole colon and in 9 cases the cecum was reached after 10 to 60 min. In 3 cases colonoscopy demonstrated presence of colonic carcinoma (two tumors located in the cecum), and in 4 other cases this possibility was ruled out and it was possible, thus, to avoid exploratory laparotomy.

Adult↗
PubMed2000

[Isolation and phenotypic analysis of lamina propria mononuclear cells from colonoscopic biopsy specimens].

This study was directed to the method of isolation of lamina propria mononuclear cells (LPMC) from mucosal biopsy specimens and the phenotypic analysis of the cells. Ten biopsy specimens, taken individually from 8 patients with ulcerative colitis (UC), 5 normal controls and 22 patients with colorectal cancer, were collected to compare the factors that influence isolation and cell yield and to analyze the lymphocyte subsets by means of two-color flow cytometry. LPMC yield averaged 10(6) with a viability of more than 95% in UC, twice the yields in other two groups. The percentages of total T, B cells in three groups were similar (P > 0.05). When the UC group was compared with the other two groups, a significantly higher proportion of CD3(+)-CD4(+)-T cell (49.98% vs 37.54% and 37.25%, P < 0.01) was noted, whereas a lower proportion of CD3(+)-CD8(+)-T cell (23.64% vs 31.52% and 31.07%, P < 0.01) was observed. These data showed that the yield and viability of LPMC isolated from biopsy specimens were good enough for a phenotypic or functional analysis, which might be helpful to mucosal immune research on gut disorders, such as UC.

Biopsy↗