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At least 667 records · Page 37Linked to original sources
PubMed1983

HLA-DR-MT matching improves graft survival rate in cadaver kidney transplantation. A prospective multicenter analysis of the South German Cooperative Study Group for Kidney Transplantation.

The influence of prospective HLA-DR matching on the graft survival rate was investigated in a multicenter analysis of 85 transplants. Simultaneously in a retrospective analysis of graft outcome the importance of matching for MT-antigens MT1, MT2 and MT3 as a newly defined B-cell alloantigen system was evaluated. HLA-DR antigens and MT-specificities were determined on B-cells enriched by nylon-wool filtration using locally well characterised HLA-DR antisera and the antiserum set of the 8th International Histocompatibility Workshop ("disease set") which allowed the definition of the HLA-DR specificities HLA-DR 1-9 and of the MT-antigens MT1-3. HLA-DR matching showed a significantly improved graft outcome only in HLA-DR identical donor-recipient combinations. In 11 of 60 patients with one HLA-DR compatibility additional matching for two MT-antigens, however, improved the two year graft survival rate from 60% to 91%. Altogether 17 patients were matched for two MT-specificities with their kidney donor and showed a superior prognosis of 94% at two years compared to 53% or 17% of recipients with one or zero MT compatibility. Graft outcome in this patient group was also superior to that of HLA-DR identical or HLA-AB identical grafts. These data suggested that the MT-system rather than the HLA-DR antigens may be of critical importance in cadaver kidney transplantation. In addition a favorable influence of pretransplant blood transfusions on less HLA-DR matched grafts was confirmed.

B-Lymphocytes↗
PubMed1994

Morphological variants of the suprapatellar septum. An anatomical study in neonatal cadavers.

In order to study the incidence and variations of the suprapatellar septum, 100 knee joints of 50 neonatal cadavers were examined anatomically. In 26% of the neonatal knee joints, a complete septum was found. Perforated septa with different shapes and residual septa were seen in 64% knees. A complete involution of the former septum was found in 10 of our cases. A suprapatellar septum combined with a mediopatellar plica was found in 18 knees.

Cadaver↗
PubMed1982

Dopamine treatment of human cadaver kidney graft recipients: a prospectively randomized trial.

In a prospectively randomized trial, 50 human cadaver kidney graft recipients were tested for the effect of dopamine infusion on kidney function after transplantation. The kidneys were taken from beating-heart donors under optimal conditions. The dopamine infusion did not affect the dialysis frequency in the 1st week after transplantation, in the dopamine group only slightly better creatinine clearances could be detected. However, the diuresis increased significantly when dopamine was given and this resulted in the fact that in the dopamine group 47.4% of the patients were dialyzed although the diuresis amounted to more than 11/day as compared to 15.7% of such patients in the nondopamine group. These findings correspond to experimental data, which showed that the dopamine infusion of the recipient mainly ameliorated renal function in those cases where kidneys were taken after hypotensive injury of the donor.

Cadaver↗
PubMed1995

Cadaver kidney transplantation: ethics and consent.

Organ transplantation began to develop soon after the Second World War. The constant progress made in organ transplantation has resulted in an increase in the number of operations carried out. The laws governing transplantation are often drawn up to deal with the de facto situation in a particular country. The study focuses on Guideline 1 adopted by 44th World Health Assembly (resolution WHA 44-25) concerning consent in cadaver kidney transplantation. The discussion of the question of consent is based on a comparative study of the laws regarding kidney transplantation in the countries of what is known as Greater Europe. The points of discussion presented are not offered with a view to advocating a system where soliciting the consent of the family would be considered as ethically necessary. Given the current legal constraints, the presumed consent procedure, with consultation of the family would appear to be more appropriate.

Cadaver↗
PubMed1979

Improved visualization of radiographic cadaver sections using xerotomography.

A new technique using xerotomography for axial images obtained from slices of abdominal cadavers is described. Radiographs were also made in sagittal planes for a complete study of visceral relationships. Xerotomography allows a wider range of visualization in the same plane of anatomical structures, from retroperitoneal fascial planes and vessels to abdominal viscera.

Cadaver↗
PubMed1995

Endovascular femoropopliteal bypass: early human cadaver and animal studies.

We report herein a feasibility study of a minimally invasive endovascular femoropopliteal bypass procedure. The steps include the following: (1) a small groin incision to expose the femoral artery, (2) guidewire passage and mechanical dilatation of the diseased superficial femoral artery, (3) semiclosed endarterectomy of the superficial femoral artery using an expandable metal endarterectomy catheter that engages atheroma, (4) placement of a 6 mm thin-walled PTFE graft, (5) balloon dilatation of the graft to press the graft flat against the arterial wall, and (6) a standard end-to-end anastomosis of the proximal graft to the femoral artery. This technique was tested in 13 limbs from eight fresh (stored 1 to 5 days at 4 degrees C) human cadavers (seven females and one male). Five limbs had stenotic superficial femoral artery lesions, 1 to 15 cm (mean 7.6 cm). Four limbs had occlusive lesions, 9 to 38 cm long (mean 26.8 cm). Four limbs had no disease. We successfully completed the procedure in 10 of 13 limbs. Completion arteriography showed a widely patent graft and a popliteal artery with a smooth distal graft/arterial interface in 9 of 10 limbs; one had a distal graft fold due to a size mismatch. Histologic studies of the superficial femoral artery revealed intima, atheromatous plaque, and media. We failed to complete our procedure in three limbs: two because of inadequate instruments and one because of perforation of the artery. We also performed the same procedure unilaterally in six dogs, except that no endarterectomy was performed.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1984

[Postmortem DNA and RNA synthesis. Preliminary studies in human cadavers].

Postmortem DNA and RNA synthesis was detected in tissue specimens harvested from two cadavers at different intervals between 2.5 and 32 h postmortem. Each tissue specimen was incubated for 1 h in a 3H-thymidine or 3H-cytidine solution. DNA- as well as RNA-synthesizing cells were found in skin tissue and bone marrow throughout the interval investigated. Cytidine incorporation decreased progressively during the course of the postmortem interval. DNA and RNA synthesis was also observed in cells of the testis, which were predominantly spermatogonia cells in the case of DNA. Low-grade RNA synthesis was detected in bowel epithelial cells up to 2.5 h postmortem; DNA synthesis was not present during the interval investigated. No supravital phenomena were observable in the splenic tissues examined.

Adult↗
PubMed1997

A new hydroxyl radical scavenger "EPC" on cadaver heart transplantation in a canine model.

This study was performed to determine if an "arrested" heart, resuscitated with cardiopulmonary bypass (CPB) after the cessation of beating, can be successfully transplanted, and whether a hydroxyl radical scavenger EPC can reduce ischemic and reperfusion injury during resuscitation of the arrested heart and following orthotopic heart transplantation. A total of 16 pairs of canines were divided into a control group of eight pairs and an EPC-treated group of eight pairs. Cardiac arrest of the donor heart was induced by the discontinuation of respiratory support after the induction of brain death. The cadaver heart was then resuscitated and core-cooled to myocardial temperature of 15 degrees C using CPB. The donor heart was harvested using cold cardioplegia and orthotopically transplanted. All of the transplanted hearts in the EPC group were weaned from CPB without any inotropic support after 60 min of bypass support, whereas all the animals in the control group required 5 micrograms/kg/min dopamine (P = 0.001). Moreover, cardiac function (Emax) 1 h after orthotopic heart transplantation was better preserved in the EPC group than in the control group, at 110 +/- 36% vs. 70 +/- 21% of the post brain death values (P = 0.02) These findings demonstrate that EPC reduces posttransplant reperfusion injury, and thus it may prove to be a valuable adjunct in this challenging model.

Animals↗
PubMed1999

The effects of recombinant tissue-type plasminogen activator (rt-PA) on canine cadaver lung transplantation.

The intrapulmonary thrombi that form after the cessation of circulation are thought to be one of the major causes of graft function failure. We evaluated the effect of recombinant tissue-type plasminogen activator (rt-PA) in a canine cadaver lung transplant model. Donor dogs were killed by the intravenous administration of pancuronium bromide without heparinization, and left for 2 h at room temperature. The donor lungs were then flushed with low potassium dextran glucose (LPDG) solution, being subjected to a total ischemic time of 3 h. Following left lung transplantation, the contralateral pulmonary artery of the recipient dogs was ligated. In group 1 (n = 6), chloride solution was administered from the main pulmonary artery for 90 min, commencing 15 min prior to reperfusion. In group 2 (n = 6), 2.5 microg/kg per min of rt-PA, and in group 3 (n = 6), 5.0 microg/kg per min of rt-PA, were continuously infused in the same manner as in group 1. Lung function, including arterial blood gases and pulmonary hemodynamics, was measured for 3 h. The side effects of rt-PA were evaluated by measuring the prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, alpha2-plasmin inhibitor (alpha2-PI), plasminogen, and fibrin/fibrinogen degradation product (FDP). All of the animals in the three groups survived throughout the observation period. The group 3 animals had significantly better gas exchange than the group 1 animals, and the pulmonary hemodynamics were significantly better in the group 2 and 3 animals than in the group 1 animals. The FDP levels in the group 2 and 3 animals were significantly higher than those in the group 1 animals, while the PT and APTT were significantly prolonged in the group 3 animals. These findings led us to conclude that rt-PA improves early lung function, particularly pulmonary hemodynamics.

Analysis of Variance↗
PubMed1985

Volumetric analysis of right ventricular cadaver models viewed in axially angled projections.

Axial cinematography of 15 cadaver cast models of the right ventricle was performed, using 16 different real and simulated single and biplane axial oblique projections. Heart volumes were then calculated by Dodge's area-length method and Ferlinz' method. In our volumetric studies of models, the smallest positive deviation from real volumes was 3.7% with the simulated long-axis projection (SLP2), evaluated from the frontal plane and calculated by the area-length method. Volumetric determinations of most usefulness, as ranked by mean differences and mean quadratic deviations, were achieved with the simulated long-axis projection, (SLP1--ranked third and SLP2--ranked first), evaluated from the frontal plane and calculated by Dodge's method; with biplane orientation and calculation by Ferlinz' method (SLP1 + SLP1C1-- ranked seventh, deviation from real volumes was 23%, SLP2 + SLP2C2--ranked fourth). We found that single-plane hepatoclavicular projection (HCP--ranked second and fifth), calculated by Dodge's or Ferlinz' method, as well as single-plane sitting-up projection (SUP--ranked sixth), calculated by the area-length method, were also acceptable for right ventricular volume measurements.

Angiocardiography↗
PubMed1999

Esophageal and tracheal distortion by the Esophageal-Tracheal Combitube: a cadaver study.

PURPOSE: To understand the anatomical relationships of the Esophageal-Tracheal Combitube (ETC) with the larynx, pharynx, esophagus and trachea. METHODS: An extensive dissection of the neck and thorax of a 70-yr-old caucasian male cadaver was done to expose the larynx, pharynx, trachea and esophagus. The ETC was inserted following the manufacturer's recommendations. Effects of the ETC on the surrounding structures were observed with the ETC first inserted in the esophagus and then, in the trachea. RESULTS: When inserted in the esophagus, the ETC produced marked bulging of the anterior wall of the esophagus and anterior displacement (4.5 cm) of the trachea. Inflation of the distal cuff of the ETC produced distension of the esophagus. When inserted in the trachea, the ETC also caused anterior protrusion. CONCLUSION: Protrusion of the anterior wall of the esophagus and distension resulting from inflation of the distal cuff could lead to esophageal injuries. These observations may explain the previously reported complications associated with the use of the ETC.

Aged↗
PubMed2004

In cadavers, directly measured mucosal pressures are similar for the Unique and the Soft Seal laryngeal mask airway devices.

PURPOSE: We compare the Soft Seal and Unique single-use, plastic laryngeal mask airway devices with respect to intracuff pressure, directly measured mucosal pressure and in vitro elastance. METHODS: Ten fresh male cadavers were studied. Microchip pressure sensors were attached to the following locations: A) the anterior middle part of the cuff side; B) the posterior tip of the cuff; C) the anterior base of the cuff; D) the posterior middle part of the cuff side; E) the backplate; and F) the posterior tube. The size 5 Unique and size 5 Soft Seal were inserted in random order using laryngoscope-guidance. Intracuff pressure and mucosal pressure were documented at 0 to 40 mL cuff volume in 10 mL increments. In vitro elastance was determined between 20 to 40 mL cuff volume. RESULTS: For both devices, mucosal pressure increased with cuff volume at most locations. Intracuff pressures and in vitro elastance (5.2 +/- 0.7 cm H(2)O/mL vs 3.8 +/- 0.4 cm H(2)O/mL, P < 0.0001) were higher for the Unique than the Soft Seal (P < 0.0001), but there were no differences in mucosal pressures at any location or cuff volume. CONCLUSION: Intracuff pressures and in vitro elastance are higher for the Unique than the Soft Seal, but mucosal pressures are similar suggesting that the airway morbidity will be similar.

Aged↗
PubMed2003

[Emergency cricothyrotomy--puncture or anatomical preparation? Peculiarities of two methods for emergency airway access demonstrated in a cadaver model].

OBJECTIVES: The aim of the study was a demonstration of peculiarities of two invasive airway management methods performed by anesthesiology residents as a subgroup of emergency physicians. METHODS: During an airway management training seminar,2 groups including 18 anaesthesiology residents and 2 students performed a simulated emergency surgical cricothyrotomy on unfixed cadavers. The more experienced physicians in group 2 started with a puncture technique preceding a blind surgical approach. The time needed to perform each procedure and resulting complications were analyzed. RESULTS: The time taken ranged from 75 to 280 s (median 180 s) in group 1 and from 53 to 255 s (median 73 s) in group 2. The surgical approach caused "bleeding" in 40% (group 1) and 30% (group 2) and damage to the cartilages occurred in 20% and 30%, respectively. Punctures were performed within 10-36 s (median 25 s) and 70% were successful without complications. CONCLUSIONS: Puncture of the cricothyroid membrane can serve as initial emergency approach or as intermediate airway access until a surgical method is available.

Anesthesiology↗
PubMed2002

[Thiel method fixed cadaver ears. A new procedure for graduate and continuing education in middle ear surgery].

BACKGROUND AND OBJECTIVE: An efficient training program in ear surgery needs suitable models to learn the specific preparation techniques. However, conventionally fixed or fresh frozen ears of human corpses do not meet all demands. Therefore we investigated the feasibility of ears fixed according to Thiel for surgical training in the temporal bone lab. METHODS: Various surgical techniques on external and middle ears were evaluated on ears from cadavers fixed according to Thiel. Structure and consistency of the tissues were compared to vital conditions by means of a standardized questionnaire. RESULTS: Structure and consistency of the tissues of the auditory canal, the tympanic cavity and the mastoid were comparable to vital conditions. Merely the cartilage of the auricle was considerable softened. This enabled a surgical preparation under conditions close to the intravital situation. CONCLUSIONS: Under the aspects of quality assurance and efficiency of continuous medical education in middle ear surgery, the Thiel fixation technique provides an excellent prerequisite.

Cadaver↗
PubMed2005

[What is the influence of the approach to intraoperative measurement of the knee joint on total knee arthroplasty? A navigation-controlled study on a cadaver knee].

Correct postoperative leg alignment and stability of the total knee prosthesis over the full range of movement is one critical factor for successful TKA. The anatomic approach is still the subject of controversy. The aim of our study was to elucidate the influence of the surgical approach on the ligament balancing and the anterioposterior limb axis.On five cadaver knees we studied the influence of the subvastus, midvastus, medial parapatellar, rectus snip, and tuberosity osteotomy approaches on the anterioposterior leg axis in extension and the rotation of the femoral component in flexion. Measurements were performed and documented by CT-free Ci-Navigation-System. Ligament tension was measured with a tensor device. We found that the subvastus approach leads to less widening of the medial compartment than all other approaches in extension. In 90 degrees flexion we found a similar influence. The consecutive release from subvastus to midvastus to medial parapatellar approach leads to a further opening of 0.5-1 degrees valgus in extension as well as in flexion. An everted patella amplifies this influence. The surgeon has to be aware of the impact on the ligament situation in regard to the anatomic approach when ligament balancing and soft tissue releases are carried out. Patella eversion should be avoided when managing soft tissues.

Arthroplasty, Replacement, Knee↗
PubMed2007

[Primary stability of the capsule-labrum complex after reconstruction with the Mitek Bioknotless anchor system in human cadaver models].

BACKGROUND: This study examines the postoperative stability of the Mitek Bioknotless anchor system with biomechanical draw-out pulling in human cadaver shoulders. METHOD: With simulation of anterior shoulder dislocation a test group (n=10, Ø 45 years) was tested against a native group (n=8, Ø 47 years). All shoulders were dissected up to the passive stabilizers. In the test group an artificial Bankart lesion was created and repaired with three Mitek Bioknotless anchors. The humeri of both groups were fixed in 60 degrees glenohumeral abduction and 90 degrees external rotation and then dislocated in a ventral direction. For evaluation purposes the ultimate draw-out strength, mode of failure, translation of humeral head, capsular slope, and bone density in the test group were measured. RESULTS: In the test group the ultimate strength was a median of 937 N (min. 554 N, max. 1,294 N) with 28 bony anchor dislocations, 1 suture rupture, and 1 capsular rupture, and in the native group with 6 Bankart and 2 HAGL lesions it was 1,214 N (708 N, 1,471 N). The bone density showed a positive correlation to the draw-out strength regarding cortical density and total density. CONCLUSION: Regarding the high draw-out strength the Mitek Bioknotless anchor system provides enough stability for early functional treatment.

Cadaver↗
PubMed2000

[Lesions of peripheral structures of cadaver fingers caused by Kirschner wires].

Fractures of the hand skeleton are common injuries. These are or are associated with phalangeal fractures. Kirschner wires can be used for osteosynthesis, but can cause lesions of peripheral finger structures. The aim of our study was to record the incidence of lesions in peripheral structures of the fingers caused by retrograde crossed inserted Kirschner wires of 1.0, 1.25, 1.4 and 1.6 mm diameter into the middle and proximal phalanges of the long fingers and the proximal phalanx of the thumb of 120 fresh cadaver hands. We found an increase of insertion attempt frequency and an increasing number of lesions with increasing Kirschner wire diameter. Because of these findings Kirschner wires of 1.0 or 1.25 mm diameter should be preferred to prevent the peripheral functional finger structures.

Bone Wires↗
PubMed2002

[Kinematic investigations of the talocrural joint in human cadaver specimens. Basic studies for the development of a hinged fixator].

To determine the specifications of a hinged fixator for the upper ankle joint, biomechanical investigations were performed on 20 human cadaver specimens and the talocrural axis was recorded by X-ray cinematography in all levels of the space. The results showed a medium variation of the axis in zero position (mean: 5.8 degrees ) from 3 degrees to 10 degrees in the anterior-posterior view. The span of the axis migration around zero position amounted to a minimum of 3 degrees and a maximum value of 10 degrees (mean: 7.2 degrees ). It could be ascertained that the axis kinetics does not move linearly in all cases. The talus rotation (the axle deviation from the sagittal plane) amounted to a minimum value of 2 degrees and a maximum value of 12 degrees (mean: 5.3 degrees ). In the transverse level, the axis kinetics was tracked by separate X-ray markings of the lateral and medial cortical of the talus in the zero point of the talocrural axis. The results were typical migration curves of the X-ray markings, demonstrating a ventral convex curve at the medial and lateral cortex. This migration of the cortex crossing point of the axis was geometrically entered in a coordinate system. The variance of the axis cortex crossing point at the medial cortical was X(M)=4.2 mm (min: 2 mm, max: 7 mm) and Y(M)=4.7 mm (2-7 mm), at the lateral cortical X(L)=3.7 mm (1-9 mm) and Y(L) =4.1 mm (1-8 mm). Regarding the clinical relevance for the development of a hinged fixator for the upper ankle joint, the results indicate that an external axis guidance of these axoids is not possible, but that an adjusted axis is necessary taking into consideration the values measured using ligamentotaxis.

Analysis of Variance↗