Bilateral iliac osteotomy. The first stage in repair of exstrophy of the bladder.
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Twenty-eight children with bladder exstrophy, prior to surgery for continence, underwent a urodynamic evaluation, cystogram, ultrasound and dimercaptosuccinic acid scan, to define parameters of lower urinary tract function that are a risk for upper tract damage and/or impair development of bladder capacity. The bladders in 7 of 28 demonstrated no storage function [leak pressure)LP) = 0]; but storage parameters could be measured in the other 21. Their LP was 10-35 cm H2O; 17 of 21 revealed involuntary contractions and 7 of 21 had an end-fill pressure greater than 10 cm H2O. Bladder capacity was better in those with a higher LP and those with no involuntary contractions. The 4 patients with bilateral hydronephrosis (3 of whom also had bilateral multiple scars) were among the 6 with LP greater than 30 cm H2O. Of the 7 with an end-fill pressure greater than 10 cm H2O, 5 had upper tract damage. Involuntary contractions may impair development of capacity. A LP of greater than 30 cm H2O is a risk factor for upper tract damage and an end-fill pressure greater than 10 cm H2O may also be a factor.
We report on 64 patients subjected to radical cystectomy; 56 had carcinoma and 8 had non-tumorous indications (contracted bladder, exstrophy of the bladder). Indications, early and late results are discussed. In case of malignancy the rate of recurrences in early stages was about the same as in advanced stages. So it is not possible to say anything definitely about the individual prognosis of recurrence in patients undergoing radical cystectomy. It is easier to justify palliative cystectomy because of the relatively low risk of operation.
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An unusual case is presented of adenocarcinoma developing at a ureterosigmoidostomy site 49 years after repair of a congenital exstrophic bladder. This is the longest latent period for tumor development in such a site reported to date.
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