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At least 667 records · Page 37Linked to original sources
PubMed1994

Serum levels of insulin-like growth factor in subjects with osteoarthritis of the knee. Data from the Baltimore Longitudinal Study of Aging.

OBJECTIVE: To examine the relationship between serum levels of insulin-like growth factor 1 (IGF-1) and osteoarthritis (OA) of the knee. METHODS: Serum IGF-1 levels were compared in 162 male and 101 female subjects age > or = 20 stratified by presence of radiographic changes of OA of the knee. RESULTS: Mean serum IGF-1 levels were significantly lower in subjects with knee OA; however, after adjustment for age-related changes in IGF-1 levels, these differences were no longer significant. CONCLUSION: These data fail to support the hypothesis that serum IGF-1 levels are reduced in subjects with OA of the knee independent of the known age-related changes in these levels.

Adult↗
PubMed1979

LRC Coronary Prevention Trial: Baltimore.

Intense, initial efforts to enroll 250 individuals in the Coronary Prevention Trial at Johns Hopkins University through referrals from private physicians and from commercial laboratories were largely unsuccessful. Not until a mass-screening effort was initiated in the community were we able to contact sufficient nunbers of potential study candidates. The time needed to acquire the trial candidates was 2.5 times as long as our original estimate, and 35,000 individuals were tested in the process.

Cholesterol↗
PubMed1987

Allogeneic, syngeneic, and autologous bone marrow transplantation in the acute leukemias--Baltimore experience.

In presentation of our data in context of other clinical series, we have identified a few bone marrow transplant preparative regimens that appear to have a superior advantage over others as far as their antileukemic effects are concerned. So far, the delayed and late effects of the treatment appear to be quite acceptable considering the ultimate fatal outcome in the acute leukemias, in particular those in their second remission. GvHD and viral infections account for about two-thirds of the mortalities in series where leukemic relapse is very low. It is hoped that solutions or at least partial solutions will not only improve the overall therapeutic results, but will allow us to extend the procedure to older patients. It is suggested that the need for unrelated HLA "matched" donors may be supplanted by the use of autologous bone marrow transplants, particularly in the older patients.

Acute Disease↗