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At least 649 records · Page 36Linked to original sources
PubMed2001

In vitro activities of ABT-773, a new ketolide, against aerobic and anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis.

The comparative in vitro activities of ABT-773 against 207 aerobic and 162 anaerobic antral sinus puncture isolates showed that erythromycin-resistant pneumococcal strains were susceptible to ABT-773 (< or =0.125 microg/ml); the MIC at which 90% of the isolates tested were inhibited for Haemophilus influenzae and other Haemophilus spp. was 4 microg/ml; and all Moraxella spp. and beta-lactamase-producing Prevotella species strains were inhibited by < or =0.125 microg/ml. Among the anaerobes tested, only fusobacteria (45%) required > or =4 microg of ABT-773/ml for inhibition. ABT-773 may offer a therapeutic alternative for sinus infections.

Adult↗
PubMed2002

Septic cavernous sinus thrombosis secondary to sinusitis: are anticoagulants indicated? A review of the literature.

This article reviews the contemporary literature for septic cavernous sinus thrombosis (CST) with a focus on anticoagulation. Modern emphasis is placed on suspecting and treating this condition early, which is aided by recognizing clinical features attributable to sepsis, orbital venous congestion, and involvement of cranial nerves within each cavernous sinus. Established treatments include high dose broad-spectrum parenteral antibiotics, and selective surgery for concurrent suppurations. The role of anticoagulation is contentious because its efficacy is undetermined and it may cause or exacerbate concurrent intracranial haemorrhage in patients with septic CST. Moreover, prospective trials of anticoagulation may never be performed due to the rarity of this condition. Nevertheless, retrospective reviews of published reports indicate that haemorrhage caused by anticoagulation is rare, and that early adjunctive anticoagulation is beneficial in these patients if commenced after excluding the haemorrhagic sequelae of CST radiologically.

Anti-Bacterial Agents↗
PubMed1990

Endoscopic sinus surgery in children with chronic sinusitis: a pilot study.

This pilot study assessed the safety and preliminary data on the efficacy of endoscopic ethmoidectomy in children with chronic sinusitis. A total of 168 patients were evaluated for chronic sinusitis, and 31 were deemed appropriate candidates for ethmoidectomy. All patients were medical management failures. Twenty-six percent of the patients had asthma, 23% had some immune deficiency, 23% had allergies, and 2 patients (1%) had cystic fibrosis. All patients were followed for at least 1 year postoperatively. The only surgical complication was minor middle meatal scarring that developed in two patients. Overall, 71% of the patients were considered normal by their parents 1 year postoperatively. Of the 24 patients who did not have an underlying systemic disease (immune deficiency or cystic fibrosis) postoperatively, 80% were considered normal by their parents, 12% were improved but continued to have some symptoms, and 8% had unsatisfactory results. Seven children with underlying systemic disease had to undergo revision ethmoidectomy for persistent symptoms.

Child↗
PubMed1992

[Enophthalmos following radical operation of the maxillary sinus and ethmoidal sinus].

Enophthalmos is usually a consequence of orbital trauma resulting in a blowout fracture of the orbital floor. We report here the case of a 35-year-old male who had a radical operation of the maxillary sinus and the ethmoidal sinus, and 2 months after the operation, developed spontaneous enophthalmos and ocular pain. The left orbit was enophthalmic by 5mm according to Hertel enophthalmometry. Surgical correction was performed under general anesthesia. The left orbit was explored through a transcutaneous incision of the left lower lid which revealed marked periosteal adhesions and absence of the bony floor of the orbit. A rib cartilage graft was used to reconstruct the floor of the orbit, and the globe was brought forward by means of retrobulbar placement. Enophthalmos and ocular pain disappeared postoperatively.

Adult↗
PubMed2002

Hepatocellular carcinoma with metastasis to the skull base, pituitary gland, sphenoid sinus, and cavernous sinus.

Two cases of hepatocellular carcinoma, with metastases to the skull base, pituitary gland, sphenoid sinus, and cavernous sinus are reported. Patients presented with diplopia, retro-orbital headache, and multiple cranial nerves palsies. Pituitary metastases may require surgery as palliative treatment, and for the confirmation of histology. One of the current cases was diagnosed with hepatocellular carcinoma prior to transphenoidal resection of the pituitary metastasis. The second patient was found to have hepatocellular carcinoma after review of histology, and the development of signs and symptoms relating to the primary tumour.

Adult↗
PubMed2002

Endoscopic sinus surgery for solitary abducens palsy in patients with isolated sphenoid sinus disease: report of four cases.

Solitary abducens palsy secondary to isolated sphenoid sinus disease (ISSD) is rare and early management is important. There is no report regarding the results of endoscopic sinus surgery (ESS) for prolonged abducens palsy due to ISSD. We present four cases of ISSD with solitary abducens palsy that received ESS from 1995 through 2000. The interval between onset of diplopia and ESS was longer than 96 hours (range, 4 days to 42 months). The sphenoid lesions were caused by Aspergillosis in two patients and inflammation in two. Three patients recovered completely from abducens palsy after 4-17 months and had no surgical complications. In conclusion, ESS is a safe and effective treatment for ISSD with abducens palsy. Recovery from abducens palsy is slow and progressive. Improvement of extraocular movement is an early sign of recovery.

Abducens Nerve Diseases↗
PubMed2004

[Maxillary sinus polyp and cyst excised by endoscopes surgery in chronic sinusitis and significance].

OBJECTIVE: To look for a simple and convenient surgical method to treat the maxillary sinus polyp and cyst. METHOD: By means of Rudolf 4.5 mm cannula paracentetic needle trough inferior nasal meatus the polyp and cyst were be cut by cutter. RESULT: For half a year, 50 cases were followed and no relapse was found by X-ray or CT. CONCLUSION: Maxillary sinus polyp and cyst can be excised by endoscope surgery through inferior canal, and it is a minimally invasive operation. The effective is positive.

Adolescent↗
PubMed2004

Giant osteoid osteoma of ethmoid sinus: role of functional endoscopic sinus surgery.

A case of giant ethmoid osteoma treated by functional endoscopic sinus surgery is described. The tumour was closely adherent to the surrounding anatomical structures--lamina papyracea, cribriform plate, spheno-ethmoidal recess--and protruded into the nasopharynx. Complete removal of the tumour, under general anaesthesia, using intranasal drill and diode L.A.S.E.R, was achieved. The principal aspects in favour of this surgical technique vs. open procedures (fronto-basal craniotomy, supraciliar and coronal approach) are discussed. Functional endoscopic sinus surgery is herewith concluded to be a convenient and safe technique with advantages over the open procedures, widely used in the past. The reduced morbidity, length of hospital stay and better cosmetic results are distinct advantages of this technique that has the potential to become the treatment of choice for selected ethmoid tumours, such as giant osteoma, described in the present report.

Endoscopy↗
PubMed2005

[Cholesterol granuloma in paranasal sinus. An unfrequent pseudotumor in maxillary sinuses].

The cholesterol granuloma is well known in the middle ear, in the mastoid antrum and the air cells of temporal bone, mostly related to a chronic infectious process. There are other localizations such as the pleura, lung, pericardium, kidneys, arterial wall, nerves, brain, testicles, lymphatic ganglion and in the paranasals sinuses. Its localization in the mediofacial area is very unfrequent, having only been described 44 cases up to the year 2002. We present a 42 year-old patient, who required surgical treatment because of a increase in the volume of area her left facial of one month's old. It resulted to be secundary to an expansion of the maxilar sinus, such as seen on the computerized tomography carried out on the patient. The diagnosis was cholesterol granuloma, performed, through the anatomo-pathology study. We review the litterature on this subject and analyse the possible etiologic cause of this lesion, its clinic, diagnostic methodology and treatment.

Adult↗
PubMed1987

The usefulness of irrigation of the maxillary sinus in children with maxillary sinusitis on the basis of the Water's X-ray.

The authors studied 80 children with sinusitis, all treated with amoxycillin and a decongestive preparation. The authors reached the conclusion that in 30 out of 80 children the third standard X-ray becomes normal without further treatment. In the remaining 50 children the usefulness of irrigation of the maxillary sinus was studied: one group was treated with antroscopy and sinuscopy while the second group did not receive this treatment (control). In both groups control X-rays were performed after three weeks. There was no significant difference between the two groups, which indicates that irrigation does not lead to a better cure. A correlation of 71% was found between X-ray findings and antroscopic findings. As a first treatment antibiotics are recommended.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Study of proteolytic enzymes and their inhibitors in maxillary sinus exudates in patients with chronic suppurative maxillary sinusitis].

Specific proteolytic and antitryptic activities were measured in the sinus exudate of 27 patients with chronic suppurative maxillary sinusitis. Most patients showed a shift in the proteinase-inhibitor system with proteolytic activity being predominant. In the course of treatment antitryptic activity in the exudate increased. It was found that biochemical data were correlated with clinical manifestations. It is concluded that patients with the above pathology should be prescribed proteolytic enzymes on an individual basis and that natural proteinase inhibitors should be included into the combined therapy.

Adolescent↗
PubMed1989

[The choice of stimulation mode in patients with cardioinhibitory or mixed carotid sinus hypersensitivity, with or without associated sinus dysfunction].

In this prospective study, we evaluated pacing therapy in 60 consecutive patients affected by syncopes or pre-syncopes and cardioinhibitory or mixed carotid sinus hypersensitivity. We preferred DDD/DVI pacing for the 26 patients who had: 1) the cardioinhibitory form and presence of symptomatic pacemaker effect, or 2) the mixed type I form and presence of symptomatic pacemaker effect, ventriculo-atrial conduction, or orthostatic hypotension, or 3) the mixed type II form, or 4) the presence of severe sinus bradycardia. We preferred VVI mode in the other 34 patients. Syncope or pre-syncope persisted in one patient of the VVI group after the pacemaker implant and in one patient of the DDD/DVI group. Therefore, we obtained the suppression of severe symptoms in 97% of cases (58/60 pts). Yet minor symptoms persisted in 35% and 38% of patients of the two groups, respectively. No patient developed clinical signs of cardiac insufficiency or intolerance to pacing therapy. Besides, in DDD/DVI patients, we performed a single-blind, randomized, cross-over study for a comparison between the DDD/DVI and VVI mode: each patient was paced for two months using each mode and for each period symptoms were analyzed. The VVI period, compared to the DDD/DVI, resulted in a significantly higher incidence of symptoms: syncope 8% vs. 0%; pre-syncope 31% vs 0%; minor symptoms 58% vs. 31%; cardiac failure 19% vs. 0%. So the DDD/DVI mode was preferred by 69% of the patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1985

[A case of adenoid cystic carcinoma in the paranasal sinuses with 8-year survival after pulmonary metastasis-- clinicopathological reference to 6 non-squamous cell carcinoma cases in the paranasal sinuses].

Most cases of paranasal sinuses cancer are histologically squamous cell carcinoma. However, adenocarcinoma is rarely found even among cases of submucosal mucous gland origin. As adenocarcinoma has tendencies to local recurrence and distant metastasis, the five-year survival rate of this type of tumor has been reported to be worse than that of squamous cell carcinoma. On the other hand, some investigators insist that the survival rate at 10 or 20 years should be discussed because of the slow-growing nature of this tumor. We report herein clinicopathological studies on six cases of adenocarcinoma of the paranasal sinuses, including one long survivor, a 63-year-old man who lived 11 years and 3 months after the first visit and 8 years after pulmonary metastasis.

Adenocarcinoma↗
PubMed1988

Special radiologic imaging of paranasal sinuses. A prerequisite for functional endoscopic sinus surgery.

Endoscopic diagnosis and surgery of inflammatory diseases of the lateral nasal wall and the paranasal sinuses require a very detailed preoperative knowledge of the individual anatomical conditions and pathological changes. Pluridirectional tomography and computed tomography are used best to visualize this region. The complicated radiologic anatomy of the lateral nasal wall together with the most important anatomical variations are demonstrated and the underlying pathophysiologic principles of chronic recurrent sinusitis are discussed.

Endoscopy↗
PubMed1986

[Current status of detection and treatment of malignant nasal and paranasal sinus tumors. 1. Pathology, diagnosis and staging of nasal and paranasal sinus tumors].

Malignant tumours of the nasal cavity and paranasal sinuses are uncommon amounting to 0.3-1% of all tumours and 3%-5% of carcinomas of the upper respiratory tract. Modern diagnostic techniques include endoscopy and computer tomography. Prognosis and therapy depend on the histological type, site of origin and extent of the tumour. The variety of possible treatment modalities demands individual therapy planning. A combined surgical and radiotherapeutic approach, possibly supplemented by small volume intracavitary brachytherapy or polychemotherapy in some defined histological tumour types, has been generally accepted, enabling a five year survival rate of 35%-45% to be achieved. The causes for failure are firstly local persistence of tumour (18%) or a local recurrence (37%). The cumulative recurrence rate after one and two years was 76% and 95% respectively. Late recurrences occur in 2.5% of cases. The complication rate with combined-modality therapy reaches 27% with minor complications occurring in 12% and major complications in 15% especially affecting the irradiated homolateral eye. The present statistical results show a number of weak points that cast doubt on their validity. We recommend a controlled, prospective, randomised, multi-centre and multi-disciplinary study to define the prognostic parameters for tumours of the paranasal sinuses and to choose the most effective, individually tailored therapy.

Adenocarcinoma↗
PubMed1984

[Juvenile sinusitis maxillary sinusitis--an indication for sinusoscopy?].

Transnasal sinuscopy was performed in 43 children with maxillary sinusitis diagnosed by x-ray film. 70 maxillary sinuses were inspected. On 30 occasions a mucosa specimen was taken for histology. A comparison was made between endoscopical, radiological and histological findings. While we found a high degree of agreement between endoscopy and x-ray film, there was no correlation between endoscopic and histologic findings.

Adolescent↗
PubMed1998

Spontaneous enophthalmos associated with asymptomatic maxillary sinus disease (silent sinus syndrome): case report.

BACKGROUND: Cases of spontaneous enophthalmos (in otherwise asymptomatic patients) that are unrelated to trauma, surgery, or systemic disease have been reported infrequently in the literature. CASE REPORT: We present a 41-year-old patient who demonstrated this recently reported constellation of findings referred to as silent sinus syndrome. CONCLUSION: Consideration should be given to the causes of spontaneous and acquired enophthalmos and the possibility of silent sinus syndrome. Other causes of enophthalmos based on the clinical features should also be considered.

Adult↗
PubMed1998

The effect of endoscopic sinus surgery on mucociliary clearance in patients with chronic sinusitis.

The saccharin test was used to measure mucociliary clearance in 50 patients with symptoms of chronic sinusitis. Samples of the nasal mucosa were also examined under transmission electron microscopy before and after functional endoscopic sinus surgery (FESS). Before surgery, the mean saccharin clearance (ST) was 37.0 +/- 15.7 min, with nasal mucosa exhibiting ciliary loss as well as other ultrastructural changes. Three months after surgery, the mean ST had improved to 20.3 +/- 7.5 min and significant regeneration of cilia was observed. It was therefore concluded that FESS had successfully corrected mucociliary dysfunction in these patients.

Adolescent↗