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At least 649 records · Page 36Linked to original sources
PubMed1997

Histone and histone fold sequences and structures: a database.

A database of aligned histone protein sequences has been constructed based on the results of homology searches of the major public sequence databases. In addition, sequences of proteins identified as containing the histone fold motif and structures of all known histone and histone fold proteins have been included in the current release. Database resources include information on conflicts between similar sequence entries in different source databases, multiple sequence alignments, and links to the Entrez integrated information retrieval system at the National Center for Biotechnology Information (NCBI). The database currently contains over 1000 protein sequences. All sequences and alignments in this database are available through the World Wide Web at: http: //www.ncbi.nlm.nih.gov/Baxevani/HISTONES/ .

Amino Acid Sequence↗
PubMed2003

A methodology for multi-source Record Linkage.

As patient's medical data is disseminated in different health structures, building a data-warehousing system at a regional level, for healthcare co-operation, has some specific requirements compared to intra healthcare structure data-warehousing projects. In particular, there is no common patient electronic record's identifier among all the sources. Hence, data integration and Record Linkage is the most important issue in such projects. In this paper, we present Background on Information integration with the two main approaches of the problem: Schema Integration approach and Entity reconciliation approach. We show the limits of each of the two approaches and propose an approach based on theory of a set partitioning and instance identification.

Computer Systems↗
PubMed1988

Genetic information could be integrated extrinsically for simplest life forms.

Polynucleotides and proteins coupled in mutual synthesis are widely believed to have been needed for the origin of life, but this theory encounters grave problems. Simple catalysts reproducing by positive feedback, sometimes advocated as an alternative, lack a built-in mechanism for generating and accumulating genetic information. Modern organisms, however, integrate genetic information by extrinsic in addition to intrinsic mechanisms, and extrinsic mechanisms were available even at the beginning of chemical evolution for any self-reproducing entities that might have appeared. Novel molecules were generated by reactions among prevailing molecules, and a catalyst multiplying by positive feedback would have transmitted structural information not only to progeny molecules of its kind, but to derivatives and by-products. New molecules derived immediately or remotely from successfully reproducing catalysts would be favored to have catalytic properties. New catalysts with effective positive feedback would increase autocatalytically and be integrated with others into a metabolizing system by natural selection.

Biological Evolution↗
PubMedDate not supplied

[Design and implementation of an integrated HIS-RIS-PACS system: our experience].

PURPOSE: To develop an integrated information system to support the administrative and healthcare work processes in a highly specialised research-oriented healthcare institution composed of one hospital and a separate outpatient centre. The project, developed within the context of an ongoing process of technological innovation, aimed to improve the efficacy and efficiency of the services provided. In particular, over the past year our efforts focused on developing and implementing a RIS-PACS system to support the management of clinical data and radiological reports and images. MATERIALS AND METHODS: The RIS-PACS system was implemented in four phases to meet the technical-functional needs of the Units of the Department of Diagnostic Imaging. The plan was developed considering the work flow between the Department, the outpatient centre and the hospital wards with the aim of creating a filmless and paperless organisational model for the Radiology Units. The four implementation phases were characterised by defining and developing protocols that would integrate the systems (HIS, RIS, PACS and modalities) to guarantee correct and complete management of the work flow. RESULTS: Phases I and II have already been completed and have led to efficient, safe and complete interaction between the hospital wards, the outpatient centre and the Radiology Units. Overall performance of the hospital has improved and the outpatient centre is now completely managed in digital mode. Phases III and IV will extend these positive results by enabling the routine distribution of radiological reports and images to all hospital wards and clinics and associated facilities. As a result, the use of film and printing and developing materials will gradually be reduced, enabling all the required clinical and diagnostic information to be immediately and securely shared. DISCUSSION AND CONCLUSIONS: This project is one of the first examples in Italy of the routine implementation of a single virtual radiology department distributed across physically remote locations. In particular, the project was successfully completed thanks to the approach used in planning and defining the clinical and functional specifications, and in the implementation phase. We conclude that setting up an information system truly capable of supporting the routine clinical activity of a Diagnostic Imaging Department requires a detailed operational project and careful planning of each implementation phase.

Diagnostic Imaging↗
PubMed2001

Children's ability to make tentative interpretations of ambiguous messages.

Consistent with prior research, 5- and 6-year-old children overestimated their knowledge of the intended referent of ambiguous messages. Yet they correctly revised their interpretations of ambiguous messages in light of contradicting information that followed immediately, while maintaining their initial interpretations of unambiguous messages (Experiment 1). Children of this age were able to integrate information over two successive ambiguous messages to identify the intended referent (Experiment 2). However, unlike 7- and 8-year-olds, they were no more likely to search for further information following ambiguous messages compared with unambiguous ones (Experiment 3). We conclude that although 5- and 6-year-olds' interpretations of ambiguous messages are not tentative at the outset, they can use source monitoring skills to treat them as tentative retrospectively, at least over short time spans.

Age Factors↗
PubMed2002

Disruptive visions.

A number of concepts have been advocated for the next generation operating room based on some inadequacies of the current systems. Most have focused on removing excess tubes and wiring, others on information systems or robotics. An analysis of other industries, a projected direction of current technologies, a focus on the importance of integrated information systems, and a serious consideration of emerging basic technologies suggest a significantly different approach.

Anesthesia↗
PubMed1990

Effects of aging on source monitoring: differences in susceptibility to false fame.

Older adults were less likely than young adults to spontaneously recollect the source of familiarity for previously read nonfamous names. Older adults were more likely to call old nonfamous names famous when subsequently encountered in a fame judgment task. Poor source monitoring by the elderly could not be accounted for by inability to recognize earlier read nonfamous names when specifically asked to do so. Both source-monitoring errors and recognition memory performance were based on attributions made about the experience of familiarity. Elderly subjects most prone to making familiarity errors recalled fewer items on a verbal learning task and were less likely to chunk information into semantic categories as it was recalled. This finding suggests that a decline in the tendency to spontaneously organize and integrate information underlies the poor source monitoring observed.

Adolescent↗
PubMed2000

Pitch matches between unresolved complex tones differing by a single interpulse interval.

The experiment compared the pitches of complex tones consisting of unresolved harmonics. The fundamental frequency (F0) of the tones was 250 Hz and the harmonics were bandpass filtered between 5500 and 7500 Hz. Two 20-ms complex-tone bursts were presented, separated by a brief gap. The gap was an integer number of periods of the waveform: 0, 4, or 8 ms. The envelope phase of the second tone burst was shifted, such that the interpulse interval (IPI) across the gap was reduced or increased by 0.25 or 0.75 periods (1 or 3 ms). A "no shift" control was also included, where the IPI was held at an integer number of periods. Pitch matches were obtained by varying the F0 of a comparison tone with the same temporal parameters as the standard but without the shift. Relative to the no-shift control, the variations in IPI produced substantial pitch shifts when there was no gap between the bursts, but little effect was seen for gaps of 4 or 8 ms. However, for some conditions with the same IPI in the shifted interval, an increase in the IPI of the comparison interval from 4 to 8 ms (gap increased from 0 to 4 ms) changed the pitch match. The presence of a pitch shift suggests that the pitch mechanism is integrating information across the two tone bursts. It is argued that the results are consistent with a pitch mechanism employing a long integration time for continuous stimuli that is reset in response to temporal discontinuities. For a 250-Hz F0, an 8-ms IPI may be sufficient for resetting. Pitch models based on a spectral analysis of the simulated neural spike train, on an autocorrelation of the spike train, and on the mean rate of pitch pulses, all failed to account for the observed pitch matches.

Adult↗
PubMed1988

The epidemiological information system.

Increasing demand for health care services coupled with limited resources require that services should be planned and delivered on the basis of a priority of needs. The Eastern Health Board is developing an Epidemiological Information System in order to measure such needs. The system will bring together computerized health data from diverse sources into an integrated information system and powerful software will be used to analyse and map the data on a small area basis. Pilot work suggests that this approach can be useful in identifying areas of greater need.

Catchment Area, Health↗
PubMed2005

Recurrent feedback in the mormyrid electrosensory system: cells of the preeminential and lateral toral nuclei.

Many sensory regions integrate information ascending from peripheral receptors with descending inputs from other central structures. However, the significance of these descending inputs remains poorly understood. Descending inputs are prominent in the electrosensory system of mormyrid fish and include both recurrent connections from higher to lower stages of electrosensory processing and electric organ corollary discharge (EOCD) signals associated with the motor command that drives the electric organ discharge. The preeminential nucleus (PE) occupies a key position in a feedback loop that returns information from higher stages of electrosensory processing to the initial stage of processing in the electrosensory lobe (ELL). This feedback reflects the integration of ascending electrosensory input from ELL, descending input from the lateral toral nucleus (torus), and EOCD inputs to PE. We used intracellular recording and axonal tracing of stained cells to characterize EOCD and electrosensory responses of several cell types in PE and the torus. PE and toral cells exhibit prominent EOCD responses that are not due to EOCD inputs from ELL. PE cells giving rise to a direct feedback projection to ELL respond to electrosensory stimuli with rapid, precisely timed spikes that will affect ELL neurons early during the same EOD cycle. EOCD and electrosensory responses in toral cells are similar to those observed in PE and may be important in shaping feedback to ELL. These results provide an initial description of electrosensory feedback to ELL as well as information about how ascending, descending, and EOCD inputs are combined at higher stages of electrosensory processing.

Action Potentials↗
PubMed1998

Toward a general model for the description of multimedia clinical data.

The patient folder integrates information originating from heterogeneous sources. For this reason computerized tools for patient data management should exploit the advantages of multimediality and offer an integrated environment for data presentation, and image and biosignal visualization. Object-oriented modeling is the best approach for designing systems for multimedia patient folder management. We propose an object-oriented model, able to define the entities constituting the patient folder and their logical organization. This model has sufficient flexibility to adapt to the most varied clinical environments. It allows the physician to structure the information needed for his/her patient folder without employing a programming language.

Computer Simulation↗
PubMedDate not supplied

Parallel processing of motion and colour information.

When the two eyes are confronted with sufficiently different versions of the visual environment, one or the other eye dominates perception in alternation. A similar situation may be created in the laboratory by presenting images to the left and right eyes which differ in orientation or colour. Although perception is dominated by one eye during rivalry, there are a number of instances in which visual processes nevertheless continue to integrate information from the suppressed eye. For example the interocular transfer of the motion after-effect is undiminished when induced during binocular rivalry. Thus motion information processing may occur in parallel with the rivalry process. Here we describe a novel example in which the visual system simultaneously exhibits binocular rivalry and vision that integrates signals from both eyes. This apparent contradiction is resolved by postulating parallel visual processes devoted to the analyses of colour and motion information. Counterphased gratings are viewed dichoptically such that for one eye the grating is composed of alternating yellow and black stripes (luminance) while for the other it is composed of alternating red and green stripes (chrominance). When the gratings are fused, a moving grating is perceived. A consistent direction of motion can only be achieved if left and right monocular signals are integrated by the nervous system. Yet the apparent colour of the binocular percept alternates between red-green and yellow-black. These observations demonstrate the segregation of processing by the early motion system from that affording the perception of colour. Although, in this stimulus, colour information in itself can play no part in the cyclopean perception of motion direction, colour is carried along perceptually (filled in) by the moving pattern which is integrated from both eyes.

Color Perception↗
PubMed2004

Interplay between growth factor and nutrient signaling: lessons from Drosophila TOR.

During normal development, cellular and organismal growth is coordinately regulated. Each cell and each individual organ integrates information about nutrient availability, hormonal signals, and intrinsic growth programs. Describing the signaling pathways involved in these processes and how they are integrated is important to understand how growth is controlled during development and may also permit the development of means to curb uncontrolled growth in disease. In recent years, the biochemical analysis of cellular growth in cultured cells and the genetic dissection of growth control in model organisms has identified two conserved signaling pathways dedicated to cellular growth. The target of rapamycin (TOR) pathway regulates growth in response to nutrients, and the insulin/IGF pathways are involved in coordinating cellular growth in response to endocrine signals. This review discusses recent advances in the understanding of the interaction between these pathways, with a special focus on the contribution of the genetic analysis of these pathways in Drosophila.

Animals↗
PubMed2006

Genetic advances in inflammatory bowel disease.

The translation of basic science advances to tangible benefits in clinical practice remains a fundamental goal of biomedical research. Genetic approaches provide a unique opportunity to enhance bench-to-bedside translational efforts, with inflammatory bowel disease (IBD) being a model genetic disorder in several respects. The association of the NOD2 (CARD15) mutations to Crohn's disease (CD) represents, in complex human disorders, one of the clearest cases of a definitive disease association. The NOD2 gene is located in the IBD1 genetic linkage region on chromosome 16 and functions as an intracellular pattern recognition receptor for components of bacterial peptidoglycan. CD-associated variants within NOD2 have a decreased capacity to appropriately signal with peptidoglycan and provide an important example of gene-environment interactions. Genetic variation in other innate immune receptors, notably Toll-like receptor (TLR)4, has been defined and may also play a role in CD pathogenesis. Replicated CD association in the IBD5 region on chromosome 5q has been reported, and candidate functional polymorphisms within the organic cation transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5) have been described. Confirmatory studies demonstrating altered OCTN activity and expression in primary human cells stratified on the IBD5 risk haplotype would provide important confirmatory support for disease contribution. A comprehensive understanding of IBD will involve integrating information from animal models, functional human polymorphisms, and expression studies from human IBD tissues. Genes and pathways implicated as contributing to IBD pathogenesis through multiple lines of evidence should be more intensively examined, including the tumor necrosis factor-alpha, MDR1, and peroxisome proliferator-activated receptor (PPAR)gamma pathways. To attain full advantage of new genetic information, novel methods of classifying patients that go beyond phenotypic classifications presently utilized will be required. Genetic data will need to be integrated with novel biomarker development in IBD, including functional, expression (mRNA or protein), or biochemical indicators of physiologic/disease processes and responses to therapies.

Journal Article↗
PubMed1985

The periventricular anteroventral third ventricle (AV3V): its relationship with the subfornical organ and neural systems involved in maintaining body fluid homeostasis.

The periventricular tissue surrounding the anteroventral third ventricle (AV3V) is critically involved in the maintenance of normal body fluid balance and distribution. The present review examines the anatomical, neurochemical, and functional relationship of the AV3V with neural systems subserving body fluid homeostasis. In particular, the nature of AV3V afferents from the subfornical organ (SFO) and from brainstem noradrenergic cell groups is discussed. A model is presented proposing that specific structures within the AV3V, particularly along the ventral lamina terminalis, function to integrate information derived from blood-borne angiotensin II (via the SFO) with input arising from vascular pressure/volume receptors. The resultant of this integration is important for the generation of a normal component of thirst (i.e., drinking) associated with extracellular dehydration.

Afferent Pathways↗
PubMed2005

Effect of implant size and shape on implant success rates: a literature review.

Understanding and using biomechanical theories that effect endosseous implant design may improve the performance of implants in varying load conditions and allow the clinician to better apply this information with potentially improved success rates. The following article presents information from English peer-reviewed journals identified by a Medline search covering the years from 1974 through 2004, and attempts to integrate information available in the dental literature and address current controversies and issues in selecting diameter, length, and shapes of dental implants.

Biomechanical Phenomena↗
PubMed2026

Conditional Diffusion Model-Based Method for Annotation of Antibiotic Resistance Gene Properties.

The crisis of bacterial antibiotic resistance, which has led to a decline in the effectiveness of antibiotics originally used to combat bacterial infections, has emerged as an urgent challenge for public health. Antibiotic resistance genes (ARGs) are one of the key reasons for bacteria to develop resistance to antibiotics. Therefore, accurately identifying and annotating the critical properties of ARGs is of great importance for addressing the antibiotic resistance emergency. Although existing deep learning models demonstrate remarkable effectiveness in extracting local features from sequence data, they still face limitations in the capacity to further gain the enriched latent representations within the data. To address the critical challenge of extracting higher-quality representations from ARGs sequence data, we propose a novel ARGs properties annotation method based on the conditional diffusion model which is used to learn latent representations through domain-specific knowledge injection. Specifically, during the conditional information integration phase, we systematically incorporate ARGs' domain knowledge to guide the diffusion process in generating high-quality latent representations. To overcome information redundancy caused by direct concatenation of conditional information and intermediate features, we design a cross-attention mechanism that enables feature fusion between heterogeneous information sources, thereby enhancing further the quality of obtained representations. Experimental results on widely used data sets demonstrate the framework's effectiveness in achieving superior prediction performance compared to existing methods.

Anti-Bacterial Agents↗
PubMed1990

Memory factors in age-related differences in simple reasoning.

Adults in their 50s were compared with adults in their late teens or 20s in the accuracy of relatively simple reasoning decisions involving varying amounts of information. Because the magnitude of the age differences in decision accuracy was independent of the amount of information relevant to the decision, it was suggested that adults in their 20s and 50s do not differ in the effectiveness of integrating information across multiple premises. However, the 2 groups differed in the accuracy of trials involving only a single relevant premise, and thus it was inferred that 1 factor contributing to reasoning differences within the age range from 20 to 60 may be a failure to encode, or retain, relevant information.

Adult↗