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PubMed1982

Complement-induced solubilization of C-reactive protein-pneumococcal C-polysaccharide precipitates: evidence for covalent binding of complement proteins to C-reactive protein and to pneumococcal C-polysaccharide.

Insoluble precipitates between C-reactive protein and pneumococcal C-polysaccharide were solubilized by fresh but not heat-inactivated human serum. Solubilization was dependent on the C-reactive protein to C-polysaccharide ratio and the serum concentration and proceeded optimally at 37 degrees C. On 12 to 30% sucrose density gradients solubilized complexes sedimented as a broad peak between the 7S region and the bottom of the tube. In C2-deficient human serum, solubilization was delayed by 30 min and then proceeded at a slow rate. Immunoprecipitation experiments indicated that C3, C4, C5, and to a lesser extent C1q were deposited on solubilized complexes. After dissociating solubilized complexes with EDTA, a considerable percentage of C-polysaccharide coprecipitated with C3, C4, and C5, whereas C-reactive protein coprecipitated with only C3. SDS-PAGE analysis of solubilized precipitates indicated the formation of covalent complexes between fragments of C3 and both C-polysaccharide and C-reactive protein.

C-Reactive Protein↗
PubMed1993

[Detection and analysis of the red cell immune function, fibronectin, complement 3 and complement 4 in patients with burn injury].

The immune function and many other physiological functions are severely interfered with in patients following burn injury. This paper reports the results of determinations of the red cell immune function, the serum concentration of fibronectin (Fn), C3 and C4 in patients with burn injury, whose third-degree burns covered 11.48 +/- 5.80%. The rosette rate of red cell C3b receptors in the patients and normal individuals were 14.28 +/- 4.58% and 17.33 +/- 4.07% (P < 0.001), and that of red cell immune complex (IC) 4.68 +/- 1.77% and 4.94 +/- 1.26 (P > 0.05), the serum Fn level 234.28 +/- 98.05 mg/L and 312.50 +/- 70.99 mg/L (P < 0.01), C3 2014.24 +/- 438.40 mg/L and 1960.00 +/- 613.30 mg/L (P > 0.05) degrees C4 601.11 +/- 84.71 mg/L and 598.24 +/- 111.09 mg/L (P > 0.05), respectively. In the patients, the rosette rate of red cell IC and the serum concentration of C3 and C4 did not change remarkably, but the rosette rate of red cell C3b receptors and the serum fibronectin level were reduced markedly in comparison with normal controls. The decrease of the last two was related to the failure of anti-infectious capacity of patients with burn injury.

Adolescent↗