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At least 649 records · Page 36Linked to original sources
PubMed1990

Observations on intracranial dynamics during respiratory physiotherapy in unconscious neurosurgical patients.

The effects of airway care procedures on intracranial dynamics were studied in 12 patients with intracranial lesions. The patients had controlled ventilation and were treated according to a standardized protocol with endotracheal suction and bag squeezing. Intracranial, arterial blood and airway pressures were recorded and cerebral perfusion pressure was calculated. Both methods used for airway care elicited marked changes in intracranial, arterial blood and cerebral perfusion pressures during the treatment session. However, within 1 min after termination of the procedure the different pressure levels returned to pretreatment values except for the intracranial and arterial blood pressure in endotracheal suction. Cerebral perfusion pressure, calculated at different time intervals: 1, 5 and 15 min after the treatment, showed only minor deviations from values before treatment. The mean values varied from 70 to 90 mmHg (9.3 to 12.0 kPa) and the lower limit of the 99% confidence interval of the means was never below 55 mmHg (7.3 kPa). At times complementary administration of sedatives during endotracheal suction was found to induce a drop in arterial blood pressure and cerebral perfusion pressure. In conclusion, patients with severe brain injuries treated on mechanical ventilation are exposed to equal risks when using bag squeezing for airway care as when using traditional endotracheal suction. Regardless of the method used, patients should be adequately sedated before starting the procedure in order to reduce the risk of adverse effects.

Adolescent↗
PubMed2006

A 19-year-old male with generalized seizures, unconsciousness and a deviation of gaze.

Light chain deposition disease (LCDD) is a form of monoclonal immunoglobulin deposition diseases (MIDD) which in contrast to light-chain derived (AL) amyloidosis is characterized by non-congophilic, non-fibrillary monoclonal protein deposits. Systemic organ deposits are common with the kidney being a major target organ. A clonal lymphoplasmocytic proliferation, e.g. plasmacytoma, is present in the majority of cases. Here we report on a 19-year-old male who presented with generalized seizures and an enhancing white matter lesion on MRI scans. A stereotactic brain biopsy revealed a low-grade B cell lymphoma with plasmacellular differentiation as well as lambda light chain deposits without birefringence under polarized microscopy. No systemic lymphoma manifestations or systemic light chain deposits were found, nor was a monoclonal gammopathy detectable in serum and urine. After systemic chemotherapy with three courses high-dose methotrexate the size of the lesion and the condition of the patient have remained stable for 24 months now. This is the first description of cerebral LCDD developing without systemic disease in conjunction with the diagnosis of a cerebral low-grade B cell lymphoma. We present the clinical, laboratory and radiological findings and discuss the pathogenesis of this unusual LCDD manifestation.

Adult↗
PubMed1984

Evidence of unconscious semantic processing from a forced error situation.

A study was carried out to determine whether subjects extracted information from words presented below their recognition and awareness thresholds. A series of target words was used to generate the word matrix, which was a set of 24 words related to the target in specified ways. Following subthreshold exposure of a target word, subjects chose the word they thought had been shown from the word matrix for that particular target. It was held that the alternative chosen was a function of the type of processing the target was receiving. Results showed that structural analysis of the target predominated below recognition threshold, whereas semantic analysis predominated below awareness threshold.

Adolescent↗