The effect of unilateral vagotomy on gastric secretion in the pylorus ligated rat.
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In this rare condition, that could be congenital or acquired, there is an abnormal communication between the stomach and the duodenum. First reported in 1861 was not consider as a real entity till 1969. There are not classical symptoms for the disease, and most of the times it is an incidental finding during other studies, up to 25% of the cases remain undiagnosed. Other than the standard surgical treatment, the use of I.P.Ps. became the common practice with good results. In the acquired cases, this is a complication of gastric ulcers, we recommend its understanding and acknowledgement for a better control and follow up.
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It was shown with the aid of thymidine-H3 that the mitotic cycle of mucous-forming cells (superficial epithelial mucosal cells of the neck) of the stomach pyloric glands of mice lasted 13.5 hrs (G1+1/2M = 7.6 hrs, S = 5.3 hrs; G2+1/2M = 0.6 hrs). With the administration of a physiological dose of hydrocortisone (0.1 mg) the duration of the mitotic cycle of mucous-forming cells of the stomach pyloric glands increased by 6.7 hrs (G1+1/2M = 11.6 hrs, S = 7.8 hrs; G2+1/2M = 0.8 hrs). A high dose of the hormone had a similar effect and increased the presynthetic period to 12.9 hours and the postsynthetic one--to 2.3 hours.
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