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Cronkhite-Canada syndrome: report of a case with bacteriologic, immunologic, and electron microscopic studies.

A case of Cronkhite-Canada syndrome is presented. The patient developed protein-losing enteropathy, generalized gastrointestional polyposis, skin pigmentation, onychodystrophy, and alopecia. This patient also exhibited certain unusual features such as: fluctuating dermal manifestations, sclerodermalike skin changes, elevated levels of carcinoembryonic antigen, retinal detachment, cataracts, and cerebellar atrophy. Bacteriologic studies of small intestinal fluid, chromosomal analysis, immunologic investigations, and morphologic studies failed to provide any etiologic clues.

Adult↗

[Causes of a nitrogen balance disorder in patients with cancer of the large intestine].

Assays were made of blood serum proteins, final nitrogen products of urine and faeces in 115 patients with colonic cancer and in 19 patients with polyposis. The nitrogen balance was studied in 59 rectal cancer patients prior to and after the operation. In a group of patients with the malignant tumor the endogenic protein hyperexcretion was found as well as a reduced serum proteins level and an associated dependence of hypoproteinemia on the degree of their loss with faeces. A negative nitrogen balance was noted in patients with cancer. Surgical intervention, purulent infection may aggravate this condition. The radical treatment of colonic cancer results in a gradual normalization of nitrogen-protein metabolism.

Blood Proteins↗

Cronkhite-Canada syndrome associated with sigmoid cancer case report and review of 54 cases with the syndrome.

The case of a 78-year-old man with the characteristic clinical and pathologico-anatomic pictures of the Cronkhite-Canada syndrome associated with sigmoid cancer is reported. He died ten months after the onset of his disease. Autopsy findings of the patient are described in detail. The other fifty three cases of the syndrome are reviewed, and clinical and pathologico-anatomic features of the Cronkhite-Canada syndrome are discussed.

Adenocarcinoma↗

[MALT lymphoma of large intestine as multiple large polypoid lesions].

We report a case of mucosa associated lymphoid tissue (MALT) lymphoma in the large intestine in a 38-year-old Japanese female. She developed a dull pain in the right lower abdomen and was found to have ileocecal intussusception. The terminal ileum, cecum and ascending colon were resected. Macroscopically, multiple polypoid lesions were found. Although some authors reported that MALT lymphoma of the colon tend to be solitary, the present case showed seven lesions. Two of the polypoid lesions in the present case were marked large. No such large polypoid MALT lymphoma has been described to our knowledge. A histological and immunohistochemical study revealed those seven lesions to be low grade B cell lymphomas of MALT type.

Adult↗