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Web site blues.

So far, Rachel Soltanoff's instincts had been right. As CEO in this fictional case study, she had successfully navigated TradeRite Software's transition from a news service for stockbrokers to a $70 million provider of shrink-wrapped software geared toward both brokers and the growing day-trader market. Now a well-financed start-up, Stock-net.com, was testing a very competitive product that traders could download directly over the Web. And TradeRite's Web site was nothing more than a collection of elaborate marketing brochures. Rachel knew she needed to start selling over the Web. But the e-commerce consultants she had hired to set up her Web store were behind schedule, and their 21-year-old CEO had just resigned. Her product manager, Lisa Bandini, was working overtime to transform TradeRite's entire product line into Web-aware applications to match Stocknet's, and Rachel had $2.5 million to launch them. But the consultants said it would take $5 million just to rent e-commerce capabilities. Ace sales VP Brian Rockart thought the company had already wasted too much time and money--money from his budget--on its Web site. Marketing VP Rob Collins thought TradeRite should focus on its core stockbroker customers. Chief Technical Officer Joe Martinez doesn't want to go ahead without a pilot project. Should Rachel try to convince Brian, Rob, and the rest of the senior management team that e-commerce is the way to go? Four commentators offer advice.

Commerce↗

Becoming a company person.

Physicians face a management challenge in adjusting to being part of a larger organization. By nature, physicians are not "company people." For physician executives, whose instincts can still lean toward being ferociously independent and individualistic--therein lies the struggle. Here are a few suggestions to help physician executives make the adjustments that are required of a "company person": (1) Be in the right place; (2) abandon critical/negative thinking; (3) focus on the issues; (4) maintain solidarity; and (5) make your boss look good.

Adaptation, Psychological↗

[Reconciliation and/or mediation settlements in cases of sexual abuse of minors in Cameroon].

The twofold purpose of this study was to show that cases of sexual abuse involving minors can sometimes be resolved within the victim's entourage and to gain insight into the long-term clinical consequences of such acts. The study group was composed of 17 consultees recruited between 1993 and 1994. Inclusion criteria were level of education and understanding sufficient to obtain informed consent, Cameroon nationality, at least 15 years of age, and history of sexual abuse. Persons with a history of hospitalization or psychiatric treatment were excluded. After a one-hour history-taking interview, each subject filled out a questionnaire specially designed for the study. Analysis of data showed that 94 p. 100 of the victims were female. Most subjects were adolescents or younger when the sexual abuse occurred. All had been raped. Subjects presented a range of psychiatric problems, somatic manifestations and disturbances in instinctive functions. No court action had been started in 16 cases (94 p. 100) and charges had been filed in only one case (6 p. 100). Reconciliation was achieved in 2 cases (12.5 p. 100) and negotiated settlements involving payment of financial compensation to the parents of the victim were reached to avoid court action in 14 cases (87.5 p. 100). The results of this study demonstrate that reconciliation and/or negotiated settlements based on economic incentives and social pressures are sometimes preferable to court action. The clinical manifestations observed in the subjects could be considered as the long-term consequences of sexual abuse.

Adolescent↗

Intellectual performance of chronic schizophrenic patients.

Intellectual characteristics of 116 male chronic schizophrenic patients were investigated by using the Quick's test of intelligence. Indirectly, by this test the thinking of examinees was analysed. The examinees were divided into age-groups and differentially diagnostic groups. According to age, they were divided into three groups: from 25 to 40, from 41 to 50, and from 51 to 60 years. There were four differentially diagnostic groups: paranoid, catatonic, and hebephrenic patients and patients with schizophrenia simplex. The study has shown that the intelligence of chronic schizophrenic patients, divided into age groups, was significantly different. The average IQ of patients from 25 to 40 years was 82.9, from 41 to 50 years 67.4, and from 51 to 60 years 52.0. The intelligence of examinees divided into differentially-diagnostic groups was also significantly different. The average IQ of paranoid patients was 74.3, of catatonic patients 64.8, of hebephrenic patients 59.2, and of those with schizophrenia simplex 57.4. Most cases with IQ = 0 related to the group with schizophrenia simplex. The willing-instinctive personality sphere and perceptual disturbances in chronic schizophrenic patients appear to exert a significant influence on their intellectual characteristics.

Adult↗

GATA-1 blocks IL-6-induced macrophage differentiation and apoptosis through the sustained expression of cyclin D1 and bcl-2 in a murine myeloid cell line M1.

Cytokines exert pleiotropic effects on target cells in a manner dependent on the cell type or stage of differentiation. To determine how instinctive cell properties affect biological effects of cytokine, we introduced an erythroid/megakaryocyte lineage-specific transcription factor, GATA-1, into a murine myeloid cell line M1, which is known to undergo macrophage differentiation in response to interleukin 6 (IL-6). Overexpression of GATA-1 changed the phenotype of M1 cells from myeloid to megakaryocytic lineage. Furthermore, GATA-1 blocked both IL-6-induced macrophage differentiation and apoptosis of M1 cells. Although STAT3 is essential for IL-6-induced macrophage differentiation of M1 cells, GATA-1 had little or no effect on tyrosine phosphorylation, DNA binding, and transcriptional activities of STAT3 in Western blot analysis, electropholic mobility shift assay (EMSA), and luciferase assays. During IL-6-induced macrophage differentiation of M1 cells, IL-6 down-regulated cyclin D1 expression and induced p19(INK4D) expression, leading to reduction in cdk4 activities. In contrast, sustained expression of cyclin D1 and a significantly lesser amount of p19(INK4D) induction were observed in IL-6-treated M1 cells overexpressing GATA-1. Furthermore, although bcl-2 expression was severely reduced by IL-6 in M1 cells, it was sustained in GATA-1-introduced M1 cells during the culture with IL-6. Both IL-6-induced macrophage differentiation and apoptosis were significantly abrogated by coexpression of cyclin D1 and bcl-2, whereas overexpressions of cyclin D1 or bcl-2 inhibited only differentiation or apoptosis, respectively. These results suggested that GATA-1 may not only reprogram the lineage phenotype of M1 cells but also disrupt the biologic effects of IL-6 through the sustained expression of cyclin D1 and bcl-2. (Blood. 2000;95:1264-1273)

Animals↗

[Orbitofrontal syndrome in psychiatry].

Orbitofrontal syndrome is a variant of frontal lobe syndrome in which behavioural disturbances are prevailing. It results from bilateral lesions of the orbitofrontal cortex and the medial face of frontal lobe. Patients present disorganized hyperactivity. They are distractable, impulsive, euphoric and unable to abide by social rules. They often have instinctive disinhibition (hypersexuality, hyperphagia and urinary behaviour disorders). In spite of severe behavioural disturbances cognitive functions are often intact so that orbitofrontal syndrome may be confounded with two psychiatric disorders: mania (or hypomania) and antisocial personality disorder. In this article we present a case report of orbitofrontal syndrome which was initially misdiagnosed as mania. Clinical features and possible modes of presentation of this syndrome are discussed. It is suggested that serotonin reuptake inhibitors may be of some use in this disorder.

Dementia↗

[The genetics of behavior].

A review of the papers published in the Journal of Higher Nervous Activity dedicated to behavioral and neurophysiological studies carried out using the genetic approach is presented. The review is based on classification, which subdivides the diversity of behavioral phenomena into three large categories: instinctive, acquired behavior, and elementary reasoning phenomena. The main contribution to these publications was made by researches at the Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch (Novosibirsk), Institute of Physiology, Russian Academy of Sciences (St.-Petersburg), and Department of Physiology of Higher Nervous Activity, Biological Faculty, Lomonosov State University (Moscow). The traditional lines of investigations are: behavioral and neurochemical consequences of domestication, numerous physiological correlations in rat strains selected for high and low excitability levels, and genetic studies of animal reasoning.

Animals↗

Aesthetics in implantology.

A young man presented himself with a missing maxillary central incisor and a depressed defect due to a trauma. The trauma caused the loss of No. 8 and its surrounding supportive structure. The defective results were seen by the labial bone loss in the area and a depression. The depression became a food-and-plaque trap and an unaesthetic eyesore. Before the tooth loss, iatrogenic factors from a root canal or retrograde amalgam caused a permanent gingival tattoo. The bonded temporary pontic was larger mesio-distally than the adjacent teeth, and this was very noticeable. It was dull in its finish and poor aesthetically. The patient requested an implant to avoid excess drilling of natural teeth. A combined effort was used to achieve the pleasing final result. To correct the area and improve the physiology and aesthetics, several techniques had to be understood. These techniques also need to be mastered, recalled, and used almost instinctively, and done in a proper team-like sequence. In this case we performed an aesthetic ridge augmentation and tissue surgical manipulation to acquire the form, shape, and correct color background. Deciding upon which implant and material involved choosing the size, type, and shape for the area involved. The techniques used included implant insertion, surgical second stage abutment, mucosal periosteal flap design, various suturing and gingival grafting techniques, ridge buildup augmentation, and GTR. Other choices included which resorbable membrane to use, what bone graft materials, and what oral hygiene to recommend to maintain final health. The restorative technique included full crown coverage, laminate veneers, provisional pontic design and bonding, control of porcelain materials, computer imaging, occlusion, cementing, smile designs, and implant prosthodontics.

Adult↗

Psychological principles of burn wound pain in children. I: theoretical framework.

Burn injuries and the care of burn injuries are punishing experiences for hospitalized children. Pain, novelty, and altered reinforcement schedules elicit instinctive escape and avoidance behaviors that complicate wound care. An understanding of the psychological principles that underlie these complex, complicating behaviors paves the way for effective cognitive and behavioral interventions. In this first article of a two-part series, we use the principles of classical conditioning, operant conditioning, and control coping to describe the developmentally normal emergence of avoidance behaviors that are incompatible with burn wound care. Then, using brief case examples, we outline how classical conditioning transforms neutral stimuli into anxiety-producing, fearful stimuli, how operant behaviors are intentionally or unintentionally reinforced, and how the umbrella of reduced control in the novel hospital environment makes coping difficult for children. We conclude by discussing obstacles to effective application of cognitive and behavioral strategies for the enhancement of control and of compliance with wound care.

Adaptation, Psychological↗

[Spirometry parameters of women in various positions of delivery].

UNLABELLED: Position in labour depends mostly on women's preferences, and is chosen instinctively in order to reduce labour pain. Between two different positions: vertical and horizontal, the first of them seems to guarantee more convenient gas exchange in maternal lungs. DESIGN: To prove that the vertical position in labour increase spirometry parameters in comparison with horizontal one. METHODS: Women were divided into two groups according to position in labour and spirometry examination were performed in second period of labour. Group I were composed of 17 women in vertical position whereas group II--19 women in horizontal one. RESULTS: Whole of analysed spirometral parameters had higher values in group I (8.2%-17.1%), but the increase wasn't statistically significant (p < 0.05).

Adult↗

[Man and his fellow-creatures under ethical aspects]

Preliminary remarks Preceding the detailed literary review, here a few events, topics and publications for the busy reader including * The decision of the Bundesverfassungsgericht (Federal Constitutional Court) to declare unconstitutional and invalid chicken owner ordinances permitting caging * The decision of the German parliament to declare animal protection a national goal * Publication of a number of books which are likely to influence discussions for years to come since they bring to a close developments having emerged over an extended period of time. Without claiming to be exhaustive the following should be mentioned: Marc Bekoff and Carron A. Meany, ed.: "Encyclopedia of animal rights and animal welfare", an extensive work being reviewed by Peter Thornton in chapter 3.6 of this report. For the first time, animal protection of the Anglo-American tradition is being summarised, in theory as well as in practice, and, on high standards: "The list of contributors reads like a Who"s Who of experts in their chosen fields and includes philosophers such as Peter Singer, Tom Regan, Tom Beauchamp and Bernard Rollin and welfare scientists such as Don Broom, David Fraser, Temple Grandin. Others involved in examining the role of animals in society and our relationship with them, such as Andrew Linzey, Richard Ryder, James Serpell and David Morton (to name just a few), have also provided entries" (Peter Thornton). The comprehensive monograph by Johannes Caspar: "Tierschutz im Recht der modernen Industriegesellschaft. Eine rechtliche Neukonstruktion auf philosophischer und historischer Grundlage" (Animal Protection in the Law of modern industrial Society. A new legal Construct on a philosophical and historical Base) represents an extensive critical incorporation of animal protection in Germany under legal and ethical aspects including a detailed rendering of the actual treatment of animals. The term "critical incorporation" was used on purpose since never before was cruelty to animals presented in such completeness and thoroughness, together with the distance and objectivity originating in the legal stance. The book is of invaluable significance in particular for the commentators of the German animal protection law as amended in 1998: For the first time, they are now in a position to draw from an abundance of facts and evaluations relevant to animal protection. It appears as a fortunate circumstance in this context, that not only the traditional Lorz-commentary is being continued (Albert Lorz and Ernst Metzger: "Tierschutzgesetz" [Animal Protection Law], commentary, 5th edition) but also a completely new commentary is being developed by the team of Hans Georg Kluge, ed., Antoine F. Goetschel, Jörg Hartung, Eisenhart von Loeper, Jost Dietrich Ort and Kerstin Reckwell: "Kommentar zum Tierschutzgesetz" (Commentary to the Animal Protection Law). "Moral Status" is not only the title of an important investigation by Mary Anne Warren (in the introductory chapter she describes and evaluates the basics of the Status-discussion to date) but also a topic singularly dominating the scientific discourse. Out of rejection or reservation regarding the biocentrical position of Albert Schweitzer or Paul W. Taylor, time after time new restricting concepts have been introduced. In the same way, the criterion of the ability to suffer as developed by Bentham was considered by some as too far reaching. In considering animals ethically the line can be drawn so tightly that, aside from apes and maybe some large marine mammals, the whole of the animal kingdom can be degraded to at best, the ecological worthy resources of man; and all this without being suspected of an adversary position to animal protection. At times, the impression arises that science is seeking and finding ever new hurdles in order to keep the number of morally considered fellow-creatures as small as possible. Following common opinion, even animals with moral status are only entitled to protection from pain or suffering but not from being killed, as long as it is performed without causing fear or pain. In the prevailing opinion, only animals demonstrating a conscious will to live have the right to be protected and not the host of "lower" animals who are granted only a kind of life-impulse. But why is a life-impulse so much less powerful, so much less worthy? Does not even an oyster summon up all of it"s force to defend itself, instinctively? However, it is true that we cannot protect all of life or all animals to the same degree. But there is no sufficient reason to exclude this multitude of fellow-creatures from any consideration at all just because they are only demonstrating a life-impulse. Maybe, it would be meaningful to adopt a gradually increasing moral status, granted any living creature by virtue of it"s being alive. This would mean a protection from thoughtless and random harm and annihilation. This "biophilia", regarding all life as valuable (even if it"s protection varies in range), could reconcile two formally differing ethical positions: * pathocentrism, which presumes the ability to feel in all of life, and * biocentrism, intending to do justice to each life-form according to it"s abundance and intensity.

Journal Article↗

Ergological viewpoint in real-life study.

I think that real-life studies on human work must be done, if possible, not objectively, but subjectively from an ergological viewpoint. Essentially, I consider ergology as the biology of human living and work, along German biologist Haeckel's idea. He considered ergology a field of anthropology. The instinctive (genetic) element and the learned (environmental) element constitute human behavior. It is conceivable that the adaptation by human learnability has today brought about high-tech society, and genetic human attributes (human nature) have been adapted to the living environment of hunters and gatherers, which has been long-lasting in human history. Hunters-gatherers form a band consisting of about 50 (30-100) persons and move in a more or less vaguely defined territory (1,000-3,000 km2). The unsuitableness of human nature for modern scientific civilization has caused various problems. Always keeping human nature in mind when considering human living and work is the philosophical background of human ergology. Two real-life working conditions in agriculture, the packing of leeks and promoting a system for securing employees in strawberry production, are presented.

Agriculture↗

Getting the attention you need.

Employees have an enormous amount of business information at their fingertips--more specifically, at their desktops. The floodgates are open; profitable possibilities abound. But having to handle all that information has pushed downsized staffs to the brink of an acute attention deficit disorder. To achieve corporate goals, business leaders need their employees' full attention--and that attention is in short supply. Authors Thomas Davenport and John Beck have studied how companies manage the attention of their employees and their site visitors. In this article, they analyze the components of attention management through three lenses--economic, psychobiological, and technological--and offer guidelines for keeping employees focused on crucial corporate tasks. Their lessons are drawn from the best practices employed by today's stickiest Web sites and by traditional attention industries such as advertising, film, and television. The authors say executives must manage attention knowing that it's a zero-sum game (there's only so much to go around). Managers should also consider capitalizing on the basic survival and competitive instincts we all have that help determine how much attention we pay to certain things. For instance, the threat of corporate demise--and the consequent loss of jobs and livelihoods--undoubtedly focuses workers' attention on the need to change. Likewise, internal competition among business units may give employees added incentive to pay attention to a profit or sales goal. Leaders today need to pay more attention to attention because it's widely misunderstood and widely mismanaged, the authors conclude.

Attention↗

Personality factors in selection and flight proficiency.

Personality development is a dynamic process involving life forces, instinct drives, growth processes, life stresses, reactions to significant persons, both in and out of the family, and reactions to the environment in general, along with the mastery of methods and techniques for coping in solving problems and in providing for the satisfaction of one's needs. The love and fear of flying and the motivation and conflicts in flying involve many personality factors which deserve careful evaluation in selection of pilot and other flight personnel. These personality factors, variations, and traits also require close surveillance of pilot personnel by flight surgeons, aviation medical and operational personnel in predicting and preventing potential breakdown or difficulties and, more importantly, in the interest of maintaining optimum personnel effectiveness, proficiency, and safety in aviation.

Aerospace Medicine↗

[Mechanisms regulating appetite and energy expenditure].

The nutrition instinct is regulated by central nervous system, hypothalamus, rhinencephalon, lobus limbicus, corpus amygdaloideum and cortex cerebri. These centers constantly get impulses informing about nutrition situation of tissues. There are: psychical, nervous, humoral and metabolic impulses, which are organized in central nervous system. Central nervous system sends the centrifugal impulses to regulate the mechanisms. There is dependence present between neurogenic, momentary and longwave regulation and thermogenesis.

Animals↗

Problems for clinical judgement: 3. Thinking clearly in an emergency.

The resuscitation of a patient in extremis is frequently characterized by chaos and disorganization, and is one of the most stressful situations in medicine. We reviewed selected studies from the fields of anesthesia, emergency medicine and critical care that address the process of responding to a critically ill patient. Individual clinicians can improve their performance by increased exposure to emergencies during training and by the incorporation of teamwork, communication and crisis resource management principles into existing critical care courses. Team performance may be enhanced by assessing personality factors when selecting personnel for high-stress areas, explicit assignment of roles, ensuring a common "culture" in the team and routine debriefings. Over-reliance on technology and instinct at the expense of systematic responses should be avoided. Better training and teamwork may allow for clearer thinking in emergencies, so that knowledge can be translated into effective action and better patient outcomes.

Clinical Competence↗

Swarm intelligence. A whole new way to think about business.

What do ants and bees have to do with business? A great deal, it turns out. Individually, social insects are only minimally intelligent, and their work together is largely self-organized and unsupervised. Yet collectively they're capable of finding highly efficient solutions to difficult problems and can adapt automatically to changing environments. Over the past 20 years, the authors and other researchers have developed rigorous mathematical models to describe this phenomenon, which has been dubbed "swarm intelligence," and they are now applying them to business. Their research has already helped several companies develop more efficient ways to schedule factory equipment, divide tasks among workers, organize people, and even plot strategy. Emulating the way ants find the shortest path to a new food supply, for example, has led researchers at Hewlett-Packard to develop software programs that can find the most efficient way to route phone traffic over a telecommunications network. South-west Airlines has used a similar model to efficiently route cargo. To allocate labor, honeybees appear to follow one simple but powerful rule--they seem to specialize in a particular activity unless they perceive an important need to perform another function. Using that model, researchers at Northwestern University have devised a system for painting trucks that can automatically adapt to changing conditions. In the future, the authors speculate, a company might structure its entire business using the principles of swarm intelligence. The result, they believe, would be the ultimate self-organizing enterprise--one that could adapt quickly and instinctively to fast-changing markets.

Commerce↗

[Stereotype and plasticity of utterances in gibbons (Hylobates concolor leucogenys)].

The "great call" of adult male and female Hylobates concolor leucogenys was studied in different conditions of social stimulation, using quantitative (i. e. sonographic) analysis. Vocal sequences are generally made up of mixed sounds, appearing in a fixed order and constituting a species-specific character. Qualitative diversification appears in the repetition of sequences. Different social situations alter parameters of the calling pattern: especially the length and intensity of homologous modulated sounds, and the qualitative complexity of sequences. The capacity of controlling length and intensity of modulated sounds has been shown in earlier papers for H. c. gabriellae, and by several authors, in Cebus and Rhesus monkeys. The "great call" of H. c. leucogenys shows the two fundamental characteristics of instinctive (i. e. genetically determined) activity-patterns.

Animals↗