[Physiopathology of bronchial asthma, with reference to the significance of gas exchange disturbances and blood gas changes in the etiology of dyspnea].
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After oral application of Zipeprol (Mirsol) the unchanged drug and nine degradation products were detected in human urine; six of them could be identified. All identified metabolites were detected in the alkaline urine fraction; after acid hydrolysis N-(2-hydroxyethyl)-piperazine was found as an artifact. With respect to the presented results, biotransformation of Zipeprol in man mainly follows three degradation routes: 1. alpha-cleavage leading to metabolite M4; 2. cleavage of the exocyclic N-C-bond of the piperazine ring leading to metabolites M3, M5, M6; 3. benzylic cleavage leading to benzylalcohol (M1); oxidation leading to 2-hydroxy-2-phenylacetic acid (mandelic acid, M2).
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