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At least 649 records · Page 36Linked to original sources
PubMed2006

Antiherpetic flavones from the heartwood of Artocarpus gomezianus.

The heartwood of Artocarpus gomezianus was investigated for anti-herpetic principles. During the course of the separation, a new compound, artogomezianone (1), was isolated, along with the known compounds cycloartocarpin (2), isocyclomorusin (3), artocarpin (4), norcycloartocarpin (5), norartocarpetin (6), and oxyresveratrol (7). Evaluation of these isolates for inhibitory effects against herpes simplex virus (HSV) types 1 and 2 was carried out using the inactivation method. Compounds 2, 3, 6 and 7 showed moderate activities against both types of HSV, while 1, 4 and 5 were basically inactive.

Animals↗
PubMed1998

A new prenylated flavone from Artocarpus champeden inhibits the K(+)-dependent amino acid transport in Bombyx mori midgut.

The effect of some flavonoids on the K(+)-dependent and K(+)-independent leucine uptake into brush border membrane vesicles from Bombyx mori larval midgut was investigated. Among the compounds tested, cyclochampedol, recently purified from Artocarpus champeden, was able to inhibit in micromolar range the leucine transport. The inhibition occurred both in the absence and in the presence of potassium and was not affected by leucine concentration. The apparent Ki was 0.25 mM. Cyclochampedol represents the first non-competitive inhibitor of an amino acid transport system in Lepidoptera. The relevance of this result is discussed.

Amino Acids↗