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At least 649 records · Page 36Linked to original sources
PubMed1980

Analysis of pathogenesis and topography of replacement root resorption (ankylosis) after replantation of mature permanent incisors in monkeys.

The pathogenesis and topography of replacement root resorption (ankylosis) after replantation of incisors was examined in green Vervet monkeys (Cercopithecus aethiops). Incisors were replanted after 0,18 or 120 min. storage and examined histometrically for replacement resorption after 2, 4 and 8 weeks. There was a significant preference for certain locations upon the root surface. Thus, ankylosis was found significantly more often on the rounded labial and lingual surfaces than on the flat or concave proximal surfaces, and on the apical portion of the root in contrast to the coronal portion. At two-weeks' observation periods, two types of initial ankylosis were seen after 120 min. dry storage. In the cervical areas and on the labial and lingual surfaces, the most common finding was a complete mineralization of the entire periodontal ligament, while on the remaining parts of the root surface, the initial ankylosis area consisted of a layer of bone deposited upon the root surface and socket wall with an intervening soft connective tissue zone. These two zones were in some areas united by bony bridges formed along the Sharpey's fiber bundles. It is suggested that the first type of initial ankylosis represents areas where both the cemental and alveolar parts of the periodontal ligament are avital; whereas the second type represents areas where only the cemental part of the periodontal ligament is avital (i.e., from dry storage). It is concluded that ankylosis after replantation is presumably a response in the periodontium to areas of the periodontal ligament and/or the root surface damaged by the extraction procedure or storage conditions prior to replantation.

Animals↗
PubMed2004

Use of self-expanding, hydrophilic osmotic expanders (hydrogel) in the reconstruction of congenital clinical anophthalmos.

PURPOSE OF REVIEW: Rehabilitation of the congenitally anophthalmic orbit is frustrating to both the parents and physician. Traditional methods involve using progressively enlarging static acrylic conformers to expand the conjunctival socket, followed by placement of conventional static spherical orbital implants, dermis-fat grafts, or inflatable balloon expanders for orbital enlargement. Limitations of these methods typically result in less-than-optimal cosmetic outcomes, with retardation of bony orbital and overlying soft tissue growth adversely affecting midfacial growth and symmetry. Recent advances in tissue expansion technology may offer additional, novel alternatives to conventional therapies. RECENT FINDINGS: Hydrogel tissue expanders were recently adapted for use in congenital anophthalmia. The expanders are placed in their dry, contracted states, and expand gradually to their full size via osmosis of surrounding tissue fluid, with up to a 10-fold increase in volume. Offering the benefit of predictable and controllable self-expansion, hydrogel expanders may offer yet another alternative or adjunctive therapy to the early rehabilitation of the contracted socket. Separate appliances are used for conjunctival and orbital reconstruction. Initial results appear promising. Tempering the enthusiasm for their use, however-particularly in terms of implanted orbital expanders-is the recent spate of long-term complications reported from previous uses of hydrogels as scleral buckling material. SUMMARY: Self-expanding hydrogel tissue expanders appear to offer an intriguing reconstructive alternative to the frustrating condition of congenital anophthalmia. Long-term safety of the material as an orbital implant has not yet been demonstrated, but early results are promising.

Anophthalmos↗
PubMedDate not supplied

[Unilateral occurrence of blowfly maggots in the face of a decomposing body].

The corpse of a 41-year-old medical doctor was found in his bed. The body was partially dried out; parts of the hip region were skeletonized due to maggot activity. In the facial region of the corpse, blowfly maggots (Lucilia (Phaenicia) sericata [Meigen]) were found exclusively in one eye socket. This is an unusual occurrence since on that side, a bedlight (40 W light bulb) had been burning during the seven week post mortem interval. All other lights in the apartment were switched off, and no direct sunlight could enter the space where the body was found (only a TV set had been running all the time, ca. 2 m away from the head at the foot end of the bed). Obviously, the maggots who usually flee light had used up the one eye that was further away from the bedlight as a feeding source. Since the continuing mummification of the corpse led to a substantial restriction of feeding material, the maggots finally switched to the eye that the light was shining on.

Adult↗
PubMed1998

Alveolar bone formation at dental implant dehiscence defects following guided bone regeneration and xenogeneic freeze-dried demineralized bone matrix.

The present study evaluated rate and extent of alveolar bone formation in dental implant dehiscence defects following guided bone regeneration (GBR) and implantation of xenogeneic freeze-dried demineralized bone matrix (xDBM). A total of 16 titanium plasma-sprayed (TPS) and 16 hydroxyapatite-coated (HA) titanium cylinder implants were inserted in 4 mongrel dogs following extraction of the mandibular premolar teeth. Four implant sites per jaw quadrant (2 TPS and 2 HA implant sites) were prepared into extraction sockets in each dog. Buccal alveolar bone was removed to create 3 x 5 mm dehiscence defects. Two jaw quadrants in separate animals received GBR, GBR + xDBM, xDBM (control), or gingival flap surgery alone (GFS; control). Thus, four conditions were available for each implant type (TPS or HA): GBR, GBR + xDBM; xDBM and GFS. The animals received fluorescent bone labels to allow observations of rate and extent of bone formation. Animals were sacrificed at 12 weeks postsurgery and block sections were harvested for histologic analysis. There were no apparent histologic differences between TPS and HA implant defects. GBR and GBR + xDBM resulted in almost complete bone closure of the dental implant dehiscence defect. Rate of bone formation appeared higher following GBR alone. Extent of bone formation appeared somewhat greater following GBR + xDBM; however, delayed. xDBM alone did not adequately resolve the bony defect. In conclusion, GBR results in rapid, clinically relevant bone closure of dental implant dehiscence defects. Adjunctive implantation of xDBM does not appear to significantly improve the healing response in the model used.

Alveolar Process↗
PubMed2002

Adverse tissue reactions to wear particles from Co-alloy articulations, increased by alumina-blasting particle contamination from cementless Ti-based total hip implants. A report of seven revisions with early failure.

We revised seven alumina-blasted cementless hip prostheses (Ti-alloy stems, cp Ti threaded sockets) with low- or high-carbon Co-alloy bearings at a mean of 20.1 months after implantation because of pain and loosening. Histological examination of the retrieved periprosthetic tissues from two cases in which the implant was stable and three in which the socket was loose showed macrophages with basophilic granules containing metal and alumina wear particles and lymph-cell infiltrates. In one of the two cases of stem loosening the thickened neocapsule also contained definite lymphatic follicles and gross lymphocyte/plasma-cell infiltrates. Spectrometric determination of the concentration of elements in periprosthetic tissues from six cases was compared with that of joint capsules from five control patients undergoing primary hip surgery. In the revisions the mean concentration of implant-relevant elements was 693.85 microg/g dry tissue. In addition to Cr (15.2%), Co (4.3%), and Ti (10.3%), Al was predominant (68.1%) and all concentrations were significantly higher (p < 0.001) than those in the control tissues. The annual rates of linear wear were calculated for six implants. The mean value was 11.1 microm (heads 6.25 microm, inserts 4.82 microm). SEM/EDXA showed numerous fine scratches and deep furrows containing alumina particles in loosened sockets, and stems showed contamination with adhering or impacted alumina particles of between 2 and 50 microm in size.

Aged↗
PubMed2000

Ridge preservation utilizing an acellular dermal allograft and demineralized freeze-dried bone allograft: Part I. A report of 2 cases.

Alveolar ridge deformities are usually the result of trauma, periodontal disease, surgical insult, or developmental defects. Preventing ridge collapse with the extraction of maxillary anterior teeth is vital to an esthetic restorative result. Several techniques are available to prevent ridge collapse. In these case presentations, ridge preservation was achieved utilizing an acellular dermal matrix as a barrier membrane with a demineralized freeze-dried bone allograft. This report demonstrated an acceptable esthetic result with no loss of ridge height or width. Soft tissue dimensions were also preserved. The two graft materials were well accepted by the body and healing was rapid and without significant discomfort. The technique illustrated provides the surgeon with another option to prevent ridge collapse and ultimately improve esthetics.

Adult↗
PubMed2000

Ridge preservation utilizing an acellular dermal allograft and demineralized freeze-dried bone allograft: Part II. Immediate endosseous implant placement.

When maxillary anterior teeth are extracted, subsequent ridge collapse can significantly compromise esthetics. Preservation of an adequate volume of bone is vital to successful implant placement. Ridge preservation achieved utilizing an acellular dermal matrix as a barrier membrane with a demineralized freeze-dried bone allograft has been previously reported. In this case presentation, guided bone regeneration was achieved around an immediate endosseous implant when this same technique was used. As in the previous case reports, this technique demonstrated an acceptable esthetic result with virtually no loss of ridge height or width. Soft tissue dimensions were also preserved. Both the hard and soft tissue grafts were well accepted by the body and healing was rapid and without significant discomfort. This surgical technique provides the clinician with an option to provide immediate implant therapy when primary closure cannot be achieved.

Adult↗
PubMed1997

[Establishment of immediate implant animal model in mongrel dog's fresh extraction socket].

The purpose of the study was to establish the animal models which had clinical characteristics in bone defect sizes around immediate implants. The mesial region of dogs' fresh extraction sockets were made with 3 mm x 3 mm x 5 mm size bone defects around implants with a round bur, then observed their osseous changes at 2 weeks, 4 weeks, 8 weeks, 12 weeks with and without demineralized freeze-dried bone allograft (DFDBA) filled. The results showed that the bone defects in DFDBA grafted group were substituted by new bone, but the defects in ungrafted group were only substituted to 3/5. Such animal models had the advantages of simple preparations and similar clinical characteristics, so they were beneficial to investigation of the immediate implantation.

Animals↗
PubMedDate not supplied

A retrospective study of 1925 consecutively placed immediate implants from 1988 to 2004.

PURPOSE: The purpose of the present study was to evaluate implant survival rates with immediate implant placement (IIP) into fresh extraction sockets and to determine risk factors for implant failure. MATERIALS AND METHODS: A retrospective chart review was conducted of all patients in whom IIP was performed between January 1988 and December 31, 2004. Treatment required atraumatic tooth extraction, IIP, and mineralized freeze-dried bone allograft with an absorbable barrier to cover exposed implant threads. Implant failure was documented along with time of failure, age, gender, medical history, medications taken, postsurgical antibiotic usage, site of implant placement, and reason for implant failure. Statistical analysis was performed using chi-square and logistic regression analysis methods. RESULTS: A total of 1925 IIPs (1398 machined-surface and 527 rough-surface implants) occurred in 891 patients. Seventy-one implants failed to achieve integration; a total of 77 implants were lost in 68 patients. The overall implant survival rate was 96.0% with a failure rate of 3.7% prerestoration and 0.3% postrestoration. Machined-surface implants were twice as likely to fail as rough-surface implants (4.6% versus 2.3%). Men were 1.65 times more likely to experience implant failure. Implants placed in sites where teeth were removed for periodontal reasons were 2.3 times more likely to fail than implants placed in other sites. Patients unable to utilize postsurgical amoxicillin were 3.34 times as likely to experience implant failure as patients who received amoxicillin. CONCLUSIONS: With a 1- to 16-year survival rate of 96%, lIP following tooth extraction may be considered to be a predictable procedure. Factors such as the ability to use postsurgical amoxicillin and reason for tooth extraction should be considered when treatment planning for IIP.

Adolescent↗
PubMed1999

Immediate placement of implants in extraction sites of maxillary impacted canines.

BACKGROUND: Treatment of asymptomatic impacted maxillary canines in adults is inevitable when primary canine becomes lost through extraction or exfoliation or when the impacted tooth becomes symptomatic. Treatment alternatives include an orthodontic procedure to bring the unerupted tooth to the dental arch or prosthetic replacement of the missing tooth. The authors describe an alternative treatment that involves immediate placement of implants into extraction sockets of the teeth. CASE DESCRIPTION: A patient with bilateral palatally impacted upper canines chose to have the unerupted teeth removed and replaced with implants and crowns. Two hydroxyapatite cylindrical implants were inserted through the alveolar ridge into the extraction sites. The unfilled areas in the extraction sites, around the dental implants, were packed and covered with demineralized freeze-dried bone allograft in conjunction with a collagen membrane barrier. Six months after implantation, computed tomography revealed complete osseous fill of the extraction defects and no bone loss around the implants. The implants were uncovered, and porcelain-fused-to-metal restorations were fabricated and placed. CLINICAL IMPLICATIONS: This treatment modality avoids the need for conventional preparation of teeth as part of prosthetic reconstruction or prolonged orthodontic treatment aimed at bringing the impacted canine to the dental arch. Combining the implantation with bone augmentation preserved the alveolar bone and shortened the treatment period.

Bone Transplantation↗
PubMed1997

Guided bone regeneration around titanium implants: report of the treatment of 1,503 sites with clinical reentries.

Guided bone regeneration procedures were carried out around 1,503 implants, including 237 that were noted in a previous publication, using Gore-Tex membranes over demineralized freeze-dried bone allograft, freeze-dried bone allograft, an equal combination of these, or demineralized freeze-dried bone allograft combined with equal parts of resorbable tricalcium phosphate. Comparison of findings at the time of clinical reentry and preoperative photographs and measurements yielded an overall success rate of 97.0% in the treatment of dehisced or fenestrated implants or fixtures placed in immediate extraction sockets. Success was defined as the presence of regenerated hard tissue covering all previously exposed implant surfaces (complete success) or as the presence of two threads or 2 mm or less of residual dehiscence (partial success).

Bone Density↗
PubMed1991

A study on citric acid as a proposed replacement resorption inhibitor.

The material consisted of 36 one-rooted immature teeth in 6 mongrel dogs. 12 teeth were immediately replanted after extraction, while 24 teeth were extracted and stored dry for 120 min before re- or autotransplantation. Root planing and topical citric acid treatment of the root of dry-stored teeth did not prevent the development of progressive root resorption and ankylosis, not even when special care was taken to prevent damage to the superficial, demineralized layer of the root during and after the transplantation procedures in an experimental model, which included autotransplantation of teeth to sockets, which were much larger than their original sockets.

Alveolar Process↗
PubMed2006

[Individual 3-D image prototyping models for orbital reconstruction].

OBJECTIVE: To fabricate a rapid prototyping (RP) 3-D image models for individual reconstruction of orbital bony loss. METHODS: The skull was placed on a helical CT scanner table and the Frankfort plane was perpendicular to the table. The CT data was obtained by a Aquilion (TOSHIBA, Japan) with 1 mm thickness section in spiral mode. By adjusting of CT threshold value and pixels in order to stack the segmental defects, we obtained an approximate 3-dimension visual model of the scanned skull using MedGraphics software. An orbital RP model based on the dataset of the 3-dimension visual model was fabricated by RP machine. Both 3-dimension visual model and RP model were measured against the skull with several anatomic landmarks to examine the accuracy of the models, and the errors were analysed. RESULTS: Integrity precision rapid RP models of the orbital region were reconstructed. The anterior orbital rim, middle orbital section and posterior orbital section were all fabricated. Optic foramen, superior orbital fissure, infraorbital foramen, inferior orbital fissure, lacrimal sac socket and naso-lacrimal duct were shown clearly. But some fine hole and slot, such as the anterior ethmoidal foramen, posterior ethmoidal foramen and zygomaticofrontal suture were not obviously seen. The mean difference between the 3-dimension visual model and the skull was 0.10 +/- 1.02mm. For the RP and dry skull, the mean difference was 0.22 +/- 1.04mm. There were no statistical differences between them. CONCLUSIONS: Integrity precision orbital RP models were fabricated which fulfilled the requirements of the individual reconstruction with bony orbital pathologic changes. The keys to fabricate the precision orbital RP models included a closer cooperation between the surgeon and engineer, thin CT slice in 1mm thick and an appropriated threshold value. Better results for the orbital deformities should be achieved for the contour of orbital region or eye function.

Humans↗
PubMed1982

Scanning electron-microscopic study of lens fibers of the pig.

Whole pigs lenses were fixed, critical-point dried and fractured, and the internal surfaces examined with a scanning electron microscope. At various locations from the equator to the center of the lens four types of fibers can be distinguished. The superficial fibers have small interdigitations. Cortical lens fibers, which are hexagonal in shape exhibit well developed "ball-and-socket" junctions. Other cortical fibers appear slightly undulated and show fine granulations. The core lens fibers are characterized by microplicae on the cell surfaces and by a more rounded or rectangular form. Results are discussed in relation to previous electron-microscopic studies of other species.

Animals↗
PubMed1995

Experimental topical tetracycline-induced neuritis in the rat.

PURPOSE: Recent studies have reported that tetracycline may induce chronic inflammatory responses in the adjacent soft tissues. The purpose of the present study was to determine if dry, powdered tetracycline evoked an inflammatory response in nerve tissue. MATERIALS AND METHODS: Twenty male Sprague-Dawley rats were anesthetized and bilateral mental nerves were exposed. Half of the 40 nerves were intentionally injured by removing the epineurium, and the remaining nerves were uninjured. In a prospective, randomized, double-blind manner, equal volumes of color-matched, precoded tetracycline powder or Gelfoam (Upjohn, Kalamazoo, MI) powder control was placed in intimate contact with the nerves and sealed in polyethylene tubes. Forty-five days later the animals were killed and 5-micron sections of the nerves were prepared for histologic examination. The presence of epineurium, fascicular number, and fascicular area were measured. An inflammatory response in nerve tissue and the intrafascicular and epifascicular inflammatory index was measured by counting darkly stained nuclei with a Jandel Video Analysis System (Jandel Scientific, Corte Madera, CA). RESULTS: Experimental injury (ie, epineurectomy) of nerves resulted in a statistically significant increase in fascicular number (P = .034), but not in fascicular area. For the intrafascicular inflammatory index, there was a significant main effect for drug (P = .002) and injury (P = .002). Experimental injury in both Gelfoam control and tetracycline grouped nerves resulted in an increase in intrafascicular inflammation. There was no significant increase in intrafascicular inflammation in either Gelfoam control or tetracycline grouped nerves when the epineurium was intact. The combination of both tetracycline and epineurectomy resulted in the largest increase in intrafascicular inflammation found among the groups studied. For epifascicular inflammatory index, there was a significant main effect for drug (P = .003) and injury (P = .001) that mirrored the intrafascicular inflammatory pattern. CONCLUSION: The results of the present study suggest that dry, powdered tetracycline accentuates the inflammatory response in intrafascicular and epifascicular nerve tissue following epineurectomy. The maintenance of epineurium inhibited the inflammatory response in intrafascicular and epifascicular nerve tissues. Gel-foam was an inert material when placed against exposed nerve tissue. These findings suggest that tetracycline should not be placed in extraction sockets when injury of the inferior alveolar and/or lingual nerves are present.

Administration, Topical↗
PubMed2006

Morphometric and microscopic evaluation of the effect of solution of acetazolamide as an intracanal therapeutic agent in late reimplanted rat teeth.

The use of substances that inhibit root resorption may be an alternative for cases of unsuccessful reimplants. Hence, the purpose of this study was to test a solution of acetazolamide, a resorption inhibitor, as an intracanal therapeutic agent for late reimplanted teeth. Thirty rat maxillary right central incisors were avulsed and kept dry for 30 min. The teeth were instrumented, and the root surfaces treated with 1% hypochlorite solution followed by application of 2% sodium fluoride. Thereafter, the teeth were divided into two groups according to the intracanal dressing: Group I, solution of acetazolamide and Group II, calcium hydroxide paste. Teeth were then reimplanted in their respective sockets. The animals were killed at 15, 30, and 60 days after reimplantation and the samples processed for morphometric and microscopic analysis. The results showed that calcium hydroxide paste limited root resorption, even though not avoiding it. In contrast, no root resorption was observed after 60 days in the acetazolamide group, confirming the efficacy of the substance in inhibiting root resorption.

Acetazolamide↗
PubMed1981

The structure of bimodal chemo-, thermo-, and hygroreceptive sensilla on the antenna of Locusta migratoria.

Coeloconic sensilla on the antenna of Locusta migratoria were investigated electrophysiologically, labeled and then examined under the scanning or transmission electron microscope. They can be categorized into two main morphological types: 1) sensilla with wall pores and two concentric cuticular walls (wp-dw sensilla), and 2) sensilla lacking wall pores (np-sensilla). Hygroreceptors were observed only in np-sensilla. Olfactory receptors were observed in wp-dw sensilla, but not in np-sensilla. Cold-sensitive units were fund in both types. Wp-dw sensilla with a cold-sensitive unit also manifest a fatty acid olfactory receptor. This cold-sensitive unit appears to be less sensitive to drops in temperature than the cold receptor combined with hygroreceptors in np-sensilla. Recordings from both types revealed up to three or sometimes four units that could be distinguished on the basis of impulse amplitude. The number of np-sensilla on each antennal segment ranges from 0 to 6. These sensilla are pegs 4--5 micrometer long with a terminal swelling. The dendritic outer segments of two sensory cells fit tightly into these pegs. The dendrite of the third sensory cell ends at its base. All three are up to 1 micrometer thick, unbranched, and densely filled with microtubules. The cuticular wall and socket of the peg are characterized by (1) an electron-dense inner layer surrounding the dendrites and continuous with electron dense clusters at the base of the peg, and (2) clefts in the cuticle at the insertion of the peg. The present observations favor the hypothesis that insect sensilla combining the triad of moist air, dry air and cold receptors generally lack pores. Specifically, though still alternative roles in stimulus transduction can be suggested for substructures demonstrated in the present and previous electron microscopic investigations.

Animals↗
PubMed2005

Assessment of three-dimensional X-ray images: reconstruction from conventional tomograms, compact computerized tomography images, and multislice helical computerized tomography images.

Three-dimensional X-ray images (3D images) were used for imaging diagnosis in the oral and maxillofacial region. These images could be fundamentally reconstructed from various tomograms, though clinical 3D images were mainly reconstructed from computerized tomography (CT) images. In this investigation, 3D images were reconstructed from conventional tomograms with a panoramic unit, compact CT images, and multislice helical CT images, and the usefulness of each system was subjectively assessed for dental implant treatment. Three hemilateral dried human mandibles were used and were examined by linear tomography with a panoramic unit, compact CT, and multislice helical CT, and 3D images were reconstructed by using the rendering software for each system. The 3D images were visually evaluated on a 5-point scale covering the alveolar ridge, buccal and lingual bone surface, mental foramen, and tooth sockets. As a result, 3D images reconstructed from conventional tomograms with the panoramic unit were assessed as fair to unsure, compact CT 3D images were assessed as unsure to good, and multislice helical CT 3D images were assessed as good to excellent. It was concluded that compact CT 3D images and multislice helical CT 3D images were useful in dental implant treatment.

Dental Implantation, Endosseous↗