Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Differential Threshold”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 649 records · Page 36Linked to original sources
PubMed1997

[Studies on the taste perceptive threshold for 4 basic taste qualities at various sites of lingual surface].

Using filter-paper-disk method for 20 approximately 23 year-old 60 healthy females, taste perceptive thresholds for 4 basic taste qualities (sweetness, saltiness, sourness and bitterness) were measured detailedly at various sites of the lingual surface (lingual apex, lingual center, lingual margin, lingual radix). Sucrose, sodium chloride, sodium tartarate and quinine hydrochloride as taste-producing substances were used for the sweetness, saltiness, sourness and bitterness, respectively. The results revealed the apical site to be most sensitive to all of the sweetness, saltiness and sourness (and especially to the saltiness) and to be followed by marginal and radical sites in sensitiveness. The radical site was revealed to be most sensitive only to the bitterness, and the central site was remarkably hyposensitive to all of these taste qualities. These experimental results differ, in many respects, from those results of study which have been published by Kiesow in 1894 and are already established today (lingual sensitivity to taste qualities is found separately by site: sweetness, sourness and bitterness and highly perceptible at apical, marginal and radical sites, respectively, and saltiness is not very differently perceptible by site), indicating that further detailed reexamination will be needed to know how taste perceptive thresholds for 4 basic taste qualities are distributed in the lingual surface.

Adult↗
PubMed2005

Thermal perception thresholds recorded using method of limits change over brief time intervals.

Quantitative Sensory Testing (QST) of thermal perception thresholds assesses small afferent nerve function. QST has also been widely used to investigate the effects of interventions on the perception of activity within these nerve fibres, often over brief time periods. The natural variation in perception thresholds over brief time periods has not been determined, however, complicating accurate identification of induced changes. The present study therefore investigated changes in thermal perception threshold values within a 1-h period. Twenty-four healthy women volunteers aged 18-28 years (mean 20.6, SD 2.8) undertook cold sensation (CS), warm sensation (WS), cold pain (CP), and hot pain (HP) perception threshold measurements on the thenar eminence of the dominant hand during six 8-min experimental cycles. The order of stimulus presentation was randomized within pre-selected criteria. An adaptation temperature of 32 degrees C, a rate of temperature change of 0.5 degrees C/s, a 3 cm x 3 cm thermode, and a method of limits algorithm were used. Separate two-way ANOVAs with repeated measures showed statistically significant changes over time for WS, CS, and HP (p < 0.05), but not for CP (p = 0.232). The results indicate that WS, CS, and HP perception thresholds change significantly with repeated testing over a 1-h period. These results should be carefully considered when assessing the importance of observed changes in thermal perception thresholds. In research trials exclusion of a control group would be a fundamental flaw.

Adolescent↗
PubMed2005

Neural response telemetry results with the nucleus 24 contour in a perimodiolar position.

OBJECTIVE: The purpose of the study was to analyze changes in neural response telemetry using the Cochlear Nucleus 24 Contour before and after stylet removal in a human model. STUDY DESIGN: Prospective study. SETTING: Tertiary referral center. PATIENTS: Twelve patients (23-72 years old) undergoing cochlear implantation, using the Nucleus 24 Contour implant, secondary to congenital and age-related hearing loss. INTERVENTION: Cochlear implantation with Cochlear Nucleus 24 Contour implant. MAIN OUTCOME MEASURE: Neural response telemetry thresholds were recorded initially with the stylet in and then with the stylet out during the implant procedure. RESULTS: Stimulus levels to obtain neural response telemetry threshold after stylet removal were statistically lower after the stylet was removed. CONCLUSION: The Nucleus 24 Contour achieves a perimodiolar position once the stylet is removed, and this leads to reduction in the current required to elicit a threshold neural response telemetry response.

Action Potentials↗
PubMed1989

A model of spatiotemporal tactile sensitivity linking psychophysics to tissue mechanics.

Sensitivities were measured for tangible spatiotemporal sinusoids applied to the index fingertip. The sinusoids had temporal frequencies of 8 and 128 Hz, in order to selectively activate the non-Pacinian I (NP I) and Pacinian (P) cutaneous mechanoreceptor systems, respectively, and had spatial frequencies from 0.00-1.03 cycles/mm. The sensitivity of the NP I system increased as the spatial frequency increased, whereas the sensitivity of the P system generally decreased as the spatial frequency increased. A mechanical model of the fingertip was used to calculate the normal and shear strains in the tissue, and a psychophysical linking hypothesis was introduced to predict tactile sensitivities based on the calculated strains. Specifically, the fingertip was modeled as a slab of a linear, isotropic, homogeneous, viscoelastic material. The boundary conditions were imposed by the spatiotemporal sinusoid at the top of the slab and the rigidly attached bone at the bottom of the slab. It was then assumed that the detection threshold was equal to the stimulus amplitude, which produced a constant, criterion strain at the location of the receptor. For both the P and NP I responses, the agreement between the predicted and measured sensitivities was best for calculations based on the normal strain, and for spatial frequencies below 0.5 cycles/mm. At higher spatial frequencies, the measured sensitivities were higher than predicted. The model also predicted the location of the P and NP I receptors in the tissue, the thickness of the tissue, and the value of the threshold strain for both receptor types. The predicted values agreed reasonably well with independent anatomical and physiological measurements.

Differential Threshold↗
PubMed1992

Characteristics of membrane currents evoked by photoreleased inositol trisphosphate in Xenopus oocytes.

Photorelease of inositol 1,4,5-trisphosphate (InsP3) from a caged precursor was used to study characteristics of Ca(2+)-activated Cl- currents activated in Xenopus oocytes by the InsP3-Ca2+ signaling pathway. Photolysis flashes shorter than a threshold duration evoked no response, but the current amplitude then grew about linearly as the flash duration was further lengthened. Currents directly evoked by photorelease of Ca2+ from a caged precursor grew linearly with increasing flash duration and showed a small threshold before they were activated. However, the major part of the threshold of InsP3-evoked responses appears to arise because a certain concentration of InsP3 (estimated to be approximately 60 nM) is required to evoke Ca2+ liberation. Subthreshold conditioning flashes potentiated responses to subsequent flashes, and the potentiation increased linearly with increasing conditioning flash duration before abruptly declining. The potentiation decayed exponentially with a time constant of approximately 17 s with increasing interflash interval. Currents evoked by photoreleased InsP3 began after a latency that shortened from 10 s or longer to 100 ms as the photolysis intensity was increased. This dose dependence of the latency could be quantitatively explained by the time required for the InsP3 concentration to rise above threshold. Intracellular injection of heparin (a competitive antagonist at the InsP3 receptor) increased the threshold for InsP3 action, as did increased temperature. We conclude that several characteristics of InsP3-evoked responses, including their dose dependence, latency, and facilitation with paired stimuli, arise because a distinct threshold level of InsP3 is required to evoke release of Ca2+ from intracellular stores.

Animals↗
PubMedDate not supplied

Effect of testosterone on threshold of pain.

Pain threshold for thermal stimulus was studied in male albino rats before and after three days of treatment with testosterone. It was also determined 15 days after castration and three days after testosterone treatment of castrated rats. There was a significant reduction in pain threshold after testosterone treatment and a marked increase in pain threshold after castration. This increase disappeared after administration of testosterone to the castrated rats.

Animals↗
PubMed2005

Chronology of the push pull effect on nonhuman primates-shift of the arterial pressure threshold.

Fighter pilots are frequently exposed to high Gz acceleration which may induce in-flight loss of consciousness (G-LOC). One factor reducing tolerance to accelerations is a previous exposure to negative accelerations. This phenomenon, which happens during the first few seconds after the onset of the positive plateau, is called the push pull effect. Our goal was to validate a non human primate model in order to study push pull physiological mechanisms and possible changes in arterial pressure, which may occur after the first ten seconds of the positive acceleration plateau. Eight rhesus monkeys were centrifuged in profile runs, including positive Gz accelerations (+1.4, +2 and +3 Gz) with or without previous negative Gz acceleration (-2 and -3 Gz vs. +1.4 Gz). Heart rate, blood pressure and esophageal pressure were recorded during the entire centrifugation run. Results showed that the push pull effect was observed in the non human primate model. Moreover, the reduced tolerance to acceleration lingered longer than that during the first ten seconds after exposure to +Gz acceleration. It was found that, after the fourteenth second, mean blood arterial pressure stabilizes at a lower value, when the positive acceleration is preceded by a negative acceleration (15.8 kPa for -1 Gz and 15.5 for -2 Gz vs. 16.9 for 1.4 Gz). The chronology of the push pull effect seems to involve two periods. One has a short time span. The other one has a longer time span and could be induced by shift of pressure threshold, coming from exposure to previous negative acceleration.

Acceleration↗
PubMed1995

Luminance discrimination, color contrast, and multiple mechanisms.

The purpose of this study was to investigate the effect of color contrast on luminance discrimination. Observers were required to indicate the more intense of two stimuli presented briefly in a surround. In some conditions the two stimuli were the same chromaticity as the surround, while in other conditions the stimuli differed in chromaticity from the surround. The luminance of the fixed test stimulus was varied in different conditions over a range from below the surround level to above the surround level. Difference thresholds were proportional to the luminance difference between test and surround over much of the range. However, difference thresholds were higher at low luminance contrasts when the chromatic contrast between the stimuli and the surround was high. Results also indicate that the effects of chromatic contrast may be mediated by local contrast mechanisms, but that the relationship between threshold and luminance contrast is not mediated entirely by these local contrast mechanisms.

Color Perception↗
PubMed1998

Chemoreflex thresholds to CO2 in decerebrate cats.

We used a modified rebreathing technique to measure chemoreflex thresholds to CO2 in decerebrate, paralyzed and ventilated cats. Cats were hyperventilated to neural apnea (PaCO2 < 15 mmHg) with one ventilator and then switched to a rebreathing circuit consisting of a balloon inside a bottle connected to a second ventilator. The volume of the circuit was approximately 110 ml. The balloon contained 5% CO2:95% O2 for hyperoxic rebreathing or approximately 5% CO2 with 11 or 6.5% O2 for moderately and severely hypoxic rebreathing. A plateau in CO2 concentration at the onset of rebreathing indicated equilibration of CO2 between the circuit, alveolar gas and venous and arterial blood. After rapid equilibration of CO2 between the cat and the circuit, CO2 increased linearly with time during rebreathing. Under hyperoxic conditions, phrenic activity began to increase at an end-tidal P(CO2) (PET(CO2)) of 35.1 +/- 6.1 (SD) mmHg (n = 8); during hypoxia, phrenic activity began to increase at a significantly lower PET(CO2) of 27.8 +/- 4.8 mmHg (P < 0.01, n = 6). We interpret these values as the central and peripheral chemoreflex thresholds to CO2, respectively. Persistent phrenic activity prevented determination of a threshold during severe hypoxic rebreathing. Our modified method of hyperoxic and hypoxic rebreathing allows detection of the effects of hypoxia on the central and peripheral chemoreflex thresholds and, within a cat, measurements of chemoreflex sensitivities.

Animals↗
PubMed1990

Effect of pacing current strength on indexes of myocardial activation in humans: influence of chronic infarction and polarity of pacing.

The effects of current strength (threshold to 20 mA) and pacing polarity (bipolar versus unipolar) on indexes of ventricular activation during endocardial pacing (cycle length 400 to 500 ms) from 10 normal and 17 abnormal left ventricular sites were assessed in 19 patients. Abnormal sites were infarcted and demonstrated an electrogram duration greater than 70 ms and amplitude less than 3 mV during sinus rhythm. Bipolar pacing was performed from poles 1 (cathode) and 3 (1 cm interelectrode distance) of a quadripolar catheter. Unipolar cathodal pacing was performed from the tip electrode (pole 1). Local activation was indexed by the interval from the pacing stimulus to 1) the onset of the QRS complex, 2) the largest rapid deflection of the local electrogram, and 3) the end (total duration) of the local electrogram recorded from poles 2 and 4 of the quadripolar catheter used for left ventricular pacing. Distant activation was indexed by the interval from pacing stimulus to electrograms recorded at the right ventricular apex and outflow tract. Bipolar and unipolar pacing of normal sites produced a modest homogeneous reduction of all activation times by 3 to 11 ms (median) with increments in current strength from threshold (0.8 mA) to 20 mA. Bipolar pacing of abnormal sites showed marked (up to 110 ms) and heterogeneous changes in local (median 22 to 30 ms) as well as distant (median 14 to 23 ms) activation times with increases in current strength from threshold (2.7 mA) to 20 mA.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1998

Normally aging older adults demonstrate the bilateral deficit during ramp and hold contractions.

The bilateral deficit results from the maximum voluntary force of a bilaterally performed task being smaller than the sum of the maximum voluntary force of the unilaterally performed tasks. It is underlain by the limitation of the neural drive during maximum bilateral contractions and has been hypothesized to reflect the inability to fully activate high threshold motor units. Because high threshold motor units atrophy in older adults, a smaller bilateral deficit in older adults compared to young adults would further support the hypothesis. Indeed, K. Häkkinen et al. in 1995 and 1996 reported no bilateral deficit in older adults performing rapid maximum contractions. The present study extends this investigation to slowly developed maximum contractions. The results demonstrated a bilateral deficit (p < .05). This result, combined with the age related decrease in the number of high threshold motor units, tends to refute the contention that selective restriction of high threshold motor units causes the bilateral deficit during maximum voluntary isometric ramp and hold contractions.

Aged↗
PubMed2001

Intraganglionic laminar endings are mechano-transduction sites of vagal tension receptors in the guinea-pig stomach.

1. Distension-sensitive vagal afferent fibres from the cardiac region of the guinea-pig stomach were recorded extracellularly, then filled with biotinamide, using an anterograde tracing technique. 2. Most of the stretch-sensitive units of the guinea-pig stomach (41 out of 47; number of animals N = 26) had low thresholds (less than 1 mm) to circumferential stretch and showed slow adaptation. Twenty of these units fired spontaneously under resting conditions (mean: 1.9 +/- 0.3 Hz, n = 20, N = 14). 3. Adaptation of firing during slow or maintained stretch correlated closely with accommodation of intramural tension, but tension-independent adaptation was also present. 4. Nicardipine (3 microM) with hyoscine (3 microM) reduced stretch-evoked firing of gastric vagal afferents, by inhibiting smooth muscle contraction. Gadolinium (1 mM) blocked distension-evoked firing. 5. Focal stimulation of the stomach muscle wall with a von Frey hair (0.4 mN) identified one to six punctate receptive fields in each low threshold vagal distension-sensitive afferent. These were marked on the serosal surface of the stomach wall. 6. Anterograde filling of recorded nerve trunks revealed intraganglionic laminar endings (IGLEs) within 142 +/- 34 microm (n = 38; N = 10) of marked receptive fields. The mean distance from randomly generated sites to the nearest IGLE was significantly greater (1500 +/- 48 microm, n = 380, N = 10, P < 0.0001). Viscerofugal nerve cell bodies, intramuscular arrays and varicose axons were not associated with receptive fields. The results indicate that IGLEs are the mechanotransduction sites of low threshold, slowly adapting vagal tension receptors in the guinea-pig upper stomach.

Animals↗
PubMed2001

Effect of hypoxia on the hypopnoeic and apnoeic threshold for CO(2) in sleeping humans.

1. Rhythmic breathing during sleep requires that P(CO2) be maintained above a sensitive hypocapnic apnoeic threshold. Hypoxia causes periodic breathing during sleep that can be prevented or eliminated with supplemental CO(2). The purpose of this study was to determine the effect of hypoxia in changing the difference between the eupnoeic P(CO2) and the P(CO2) required to produce hypopnoea or apnoea (hypopnoea/apnoeic threshold) in sleeping humans. 2. The effect of hypoxia on eupnoeic end-tidal partial pressure of CO(2) (P(ET,CO2)) and hypopnoea/apnoeic threshold P(ET,CO2) was examined in seven healthy, sleeping human subjects. A bilevel pressure support ventilator in a spontaneous mode was used to reduce P(ET,CO2) in small decrements by increasing the inspiratory pressure level by 2 cmH2O every 2 min until hypopnoea (failure to trigger the ventilator) or apnoea (no breathing effort) occurred. Multiple trials were performed during both normoxia and hypoxia (arterial O(2) saturation, S(a,O2) = 80 %) in a random order. The hypopnoea/apnoeic threshold was determined by averaging P(ET,CO2) of the last three breaths prior to each hypopnoea or apnoea. 3. Hypopnoeas and apnoeas were induced in all subjects during both normoxia and hypoxia. Hypoxia reduced the eupnoeic P(ET,CO2) compared to normoxia (42.4 +/- 1.3 vs. 45.0 +/- 1.1 mmHg, P < 0.001). However, no change was observed in either the hypopnoeic threshold P(ET,CO2) (42.1 +/- 1.4 vs. 43.0 +/- 1.2 mmHg, P > 0.05) or the apnoeic threshold P(ET,CO2) (41.3 +/- 1.2 vs. 41.6 +/- 1.0 mmHg, P > 0.05). Thus, the difference in P(ET,CO2) between the eupnoeic and threshold levels was much smaller during hypoxia than during normoxia (-0.2 +/- 0.2 vs. -2.0 +/- 0.3 mmHg, P < 0.01 for the hypopnoea threshold and -1.1 +/- 0.2 vs. -3.4 +/- 0.3 mmHg, P < 0.01 for the apnoeic threshold). We concluded that hypoxia causes a narrowing of the difference between the baseline P(ET,CO2) and the hypopnoea/apnoeic threshold P(ET,CO2), which could increase the likelihood of ventilatory instability.

Adult↗