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PubMed1991

[Yersinia enterocolitica septicemia associated with idiopathic hemochromatosis and deferoxamine therapy. A case].

Yersinia enterocolitica septicaemia is an infrequent condition. We report a case in which septicaemia developed after an infusion of desferrioxamine in a man with idiopathic haemochromatosis. According to the literature, the association of idiopathic haemochromatosis, liver disease and desferrioxamine therapy is extremely favourable to the development of Yersinia septicaemia because iron intake is known to enhance the virulence of this organism, and desferrioxamine, acting like a chelator, enables Yersinia to incorporate iron, which it does not normally do.

Deferoxamine↗
PubMed1991

[Disseminated mucormycosis in a hemodialyzed female patient treated with deferoxamine].

A case is presented of a patient affected of chronic renal failure caused by multiple myeloma who was under a chelating treatment with Depreroxamine as a consequence of iron intoxication and suffered a disseminated mucormycosis. We performed a literature search of previous cases and discuss the probable relation between this opportunistic infection and depheroxamine treatment.

Deferoxamine↗
PubMedDate not supplied

[Poisoning of retinal pigment epithelium by deferoxamine. A case report].

A patient undergoing hemodialysis was treated intravenously with desferrioxamine (3 g) for an aluminum encephalopathy. He presented a sudden xanthopsia with visual loss. Fundus examination showed diffuse macular irregular pigmentary disturbances. We discuss current knowledge and possible pathogenesis of these observations published since 1983. Awareness of the side effects of desferrioxamine implies an ophthalmologic follow up similar as chloroquine.

Aged↗
PubMed1989

Iron excretion in thalassemia children treated with deferoxamin methansulfonat: intravenous drip compared to the subcutaneous routes.

The iron excretion in the three beta-Thal/Hb E patients were determined comparing the effect of DF given by subcutaneous push, subcutaneous drip and intravenous drip. The subcutaneous drip or intravenous drip increased urine iron excretion by 5.6-11.2 times whereas the subcutaneous push, 3.5-5.3 times only. It is recommended that for countries where the infusion machine is very expensive the DF should be given by intravenous drip or the modified, simple and inexpensive equipment for subcutaneous drip.

Adolescent↗
PubMed1989

[Treatment of post-transfusion iron overload by deferoxamine].

Iron chelation therapy must be associated with the regular blood transfusions required for thalassaemia and other chronic anemias. We report here a study concerning 4 groups of patients, aged 6 to 28, regularly transfused at Necker Enfants-Malades hospital: a) 20 with thalassaemia major; b) 6 with thalassaemia intermedia; c) 2 with sickle cell disease and d) 2 with Blackfan-Diamond syndrome. The transfusion regimen consisting of monthly or quarterly transfusions varied as a function of the groups. Desferal was used in all patients. The dosage and the route of administration (IV, IM, SC) were adapted to the amount of iron transfused and to the nature of the disease. The serum ferritin level was considered as the indicator of the iron overload. Comparisons were established between the quantities of iron transfused, ferritin levels, and parameters such as dosage, route of administration and compliance to Desferal. During the period of study 3 patients died from cardiac failure due to transfusional hemosiderosis. Endocrine complications (diabetes 2 cases, hypocalcemia 3 cases, hypothyroidism 1 case and delayed puberty 7 cases) were observed. This high incidence of complications induced by post-transfusional iron overload has recently prompted us to improve the quality of chelation therapy through the use of the services of a specialized center where patients as well as their families can be trained more adequately in home care and self-treatment.

Adolescent↗