Comparison of decamethonium bromide (C10) and D-tubocurarine as preventives of traumatic complications in electroshock therapy.
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The results of complex treatment of 37 patients operated on for the various acute abdominal surgical diseases were presented. Among them 22 patients for locally treated 0.02% antiseptical solution Decametoxin were used. Positively impact clinical course of the diseases reducing their purulent and septic morbidity rate in particular were evidenced separately in the patients operated on for acute necrotic pancreatitis.
The treatment of m. cutaneus pectoris-n. pectoralis preparations with 0.5 microM of alkylating derivate of hexadecamethonium, hexadecamethylene-bis-methylchloroethylamine, led to irreversible decrease of the amplitude of EPPs. The decrease was shown to be of a postsynaptic nature. After pretreatment of the neuromuscular preparations with alkylating derivate the effects of cholinesterase inhibitors were strongly diminished.
The influence of glucocorticoids and ACTH on the excitability of the hypothalamus and limbic structures of the brain in rabbits was studied in chronic tests with electrochemotrodes preliminarily implanted into the brain. Results bearing proof to a dissimilar effect produced by ACTH and glucocorticoids on the excitability of the anterior and posterior hypothalamus, hippocampus and amygdala are presented. It is suggested that the mechanism of the retroinhibitory action of corticosteroids and ACTH provides for the participation of hypothalamic and limbic structures of the brain.