Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Consequences”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 649 records · Page 36Linked to original sources
PubMed2002

Prevalence and consequences of sleep disorders in a shift worker population.

INTRODUCTION: Irregular work schedules often results in a disruption of the normal circadian rhythm that can causes sleepiness when wakefulness is required and insomnia during the main sleep episode. METHOD: Two physicians using the Sleep-EVAL system interviewed 817 staff members of a psychiatric hospital. The interviews were done during the working hours. In addition to a series of questions to evaluate sleep and mental disorders, the evaluation included a standard questionnaire assessing work conditions, work schedule and their consequences. Three work schedules were assessed: (1) fixed daytime schedule (n=442), (2) rotating daytime shifts (n=323) and (3) shift or nighttime work (n=52). RESULTS: Subjects working on rotating daytime shifts were younger than the two other groups and had a higher proportion of women. Participants working on rotating daytime shifts reported more frequently than the fixed daytime schedule workers to have difficulty initiating sleep (20.1% vs. 12.0%). The sleep duration of shift or nighttime workers was shorter than that of the two other groups. Furthermore, subjects working rotating daytime schedule reported to have shorter sleep duration of about 20 min when they are assigned to the morning shift. Work-related accidents were two times more frequent among the rotating daytime workers (19.5%) compared with the fixed daytime schedule workers (8.8%) and the group of nighttime or shift workers (9.6%). Sick leaves in the previous 12 months were also more frequently reported in the rotating daytime schedule group (62.8%) as compared with the daytime group (38.5%, P<.001); 51.9% of nighttime or shift workers took sick leave. CONCLUSIONS: Working on a rotating daytime shifts causes significant sleep disturbances. As consequences, these workers are more likely to feel sleepy at work and are more likely to have work-related accidents and sick leaves.

Adult↗
PubMed1994

The sexual and reproductive consequences of congenital genitourinary anomalies.

The major congenital anomalies of the genitourinary tract may result in disturbances of sexual and reproductive function. In general the children grow up with the same aspirations as their more normal peers, which are to marry, have intercourse and produce children. Some achieve this despite the deformities and in others specific reconstructive surgery may be needed. In exstrophy the vagina lies parallel to the floor when the girl is standing and the introitus is seen on the lower abdominal wall rather than in the perineum. Episiotomy is required in 34% and formal vaginoplasty in 23% of the cases. The exstrophy penis has a tight dorsal chordee that must be corrected to allow intercourse. The neurological and social consequences of myelomeningocele do not prevent patients from having an interest in sex. Those who are able to walk are likely to have normal sexual function compared to about 50% of those who are wheelchair bound. The recurrence risk for neural tube defects in their offspring is 1:50 for sons and 1:13 for daughters regardless of the sex of the affected parent. The physiological consequences of posterior urethral valves result in weak ejaculation in 50% and highly viscous and alkaline semen in 50% of the cases. Of male patients with ambiguous genitalia or micropenis 75% have normal intercourse.

Epispadias↗
PubMed1998

How do we predict the consequences of our actions? A functional imaging study.

Humans are readily able to distinguish expected and unexpected sensory events. Whether a single mechanism underlies this ability is unknown. The most common type of expected sensory events are those generated as a consequence of self-generated actions. Using H2 15O PET, we studied brain responses to such predictable sensory events (tones) and to similar unpredictable events and especially how the processing of predictable sensory events is modified by the context of a causative self-generated action. Increases in activity when the tones were unpredictable were seen in the inferior and superior temporal lobe bilaterally, the right parahippocampal gyrus and right parietal cortex. Self-generated actions produced activity in a number of motor and premotor areas, including dorsolateral prefrontal cortex. We observed an interaction between the predictability of stimuli and self-generated actions in several areas, including the medial posterior cingulate cortex, left insula, dorsomedial thalamus, superior colliculus and right inferior temporal cortex. This modulation of activity associated with stimulus predictability in the context of self-generated actions implies that these areas may be involved in self-monitoring processes. Detection of expected stimuli and the detection of the sensory consequences of self-generated actions appear to be functionally distinct processes, and are carried out in different cortical areas. These observations support theoretical approaches to cognition that postulate the existence of a self-monitoring system.

Acoustic Stimulation↗
PubMed1998

Health consequences of pregnancy and childbirth as perceived by women and clinicians.

OBJECTIVE: To develop patient-centered outcome measures for clinical research by characterizing the effects of pregnancy and childbirth on functioning. METHODS: Five focus groups of mothers (n = 33) and three focus groups of clinicians (midwives [n = 8], obstetricians [n = 4], and family practitioners [n = 7]) were convened. Discussions were audiotaped and transcribed. Major narrative themes were identified by using two independent readers and were confirmed by participants and additional clinicians. RESULTS: Themes were grouped into four outcome domains: physical, psychologic, sexual, and social. Themes identified included lack of knowledge about postpartum health, emotional lability, sexual satisfaction, depression, parenting skills, body image, fatigue, and incontinence. Lack of knowledge about typical postpartum health was the dominant theme for mothers and clinicians. Mothers felt unprepared for the health consequences of pregnancy and delivery. Clinicians lamented that paucity of data made counseling and treating patients difficult. Decreased functioning months after delivery was reported. Differences between mother and clinician concerns surfaced, particularly in emphasis. Mothers wanted more information about their health; providers emphasized newborn care. Mothers reported inspiration to improve their economic circumstances; clinicians emphasized improving maternal health. Mothers wanted control during labor, whereas clinicians believed control was not always possible. CONCLUSION: Women often felt poorly prepared for the postpartum period in part because functional health consequences are not well understood. This study suggests maternal functional health may be decreased for months after delivery, even among uncomplicated patients. This study identified new maternal outcome measures, which are being incorporated into an outcomes questionnaire.

Adaptation, Psychological↗
PubMed2000

Effects of sensory stimulation and post-ingestive consequences on satiation.

This study investigated the influence of sensory stimulation, with and without post-ingestive consequences, on satiation by varying the form of a preload and the timing of a mixed meal presented after the preload. Twenty-four, normal-weight, non-dieting, college-aged women were randomized to different preload groups: water preload (Water), sip-and-spit energy-dense preload (Taste), or energy-dense preload (Taste/kcal). Volume of fluid consumed prior to the meal was controlled. All participants had sessions in which a meal was provided immediately (0 min) or 30 min after the preload. Results showed equal suppression of intake for participants receiving sensory stimulation from an energy-dense preload (Taste and Taste/kcal groups) in comparison to a water preload (Water group). No effect of time from preload to food consumption was found; the suppression of intake was similar whether the meal immediately followed the preload or was 30 min after the preload. These findings suggest that sensory aspects of food can influence satiation, and in the conditions of this study, had a larger influence on satiation than post-ingestive consequences.

Adolescent↗
PubMed2003

Metabolomic analysis of the consequences of cadmium exposure in Silene cucubalus cell cultures via 1H NMR spectroscopy and chemometrics.

Several essential and non-essential metals (typically those from periods 4, 5 and 6 in groups 11-15 in the periodic table) are commonly detoxified in higher plants by complexation with phytochelatin. The genetic and gross metabolic basis of metal tolerance in plants is, however, poorly understood. Here, we have analyzed plant cell extracts using 1H NMR spectroscopy combined with multivariate statistical analysis of the data to investigate the biochemical consequences of Cd(2+) exposure in Silene cucubalus cell cultures. Principal components analysis of 1H NMR spectra showed clear discrimination between control and Cd(2+) dosed groups, demonstrating the metabolic effects of Cd(2+) and thus allowing the identification of increases in malic acid and acetate, and decreases in glutamine and branched chain amino acids as consequences of Cd(2+) exposure. This work shows the value of NMR-based metabolomic approaches to the determination of biochemical effects of pollutants in naturally selected populations.

Cadmium↗
PubMed1999

Causes and consequences of acidic pH in tumors: a magnetic resonance study.

A consequence of metabolism in any tissue is the formation of hydrogen ions, which are actively transported out of the cell. However, although most solid tumors maintain their intracellular pH (pHi) within a narrow range to provide a favorable environment for various intracellular activities, their extracellular pH (pHe) is on average about 0.2 pH units more acid. It is important to understand the relationship between tumor metabolism and pH, and how it differs from that of normal tissue and to ask the question: How does an understanding of pH and tumor metabolism affect strategies for therapeutic approaches? Although, in vitro, isolated cell experiments have shown positive correlations between pHi and pHe the relationship is complex and somewhat dependent on experimental conditions. Measurement of pHi in solid tumors by non-invasive Magnetic Resonance Spectroscopy (MRS) has been possible for some time now and recently several specific markers for measuring pHe have become available. As a result we have been able to study the relationship between pHi and pHe in vivo in several different solid tumor types. In only one tumor type (HT29 xenografts) was there a significant correlation between pHi and pHe; in 3 other tumor types (RIF-1 in mice, GH3 prolactinomas and H9618a in rats) there was no correlation. A significant correlation between pHi and NTP/Pi ratios was seen across all tumor types. Theoretical considerations of causes of tumor acidity, hypotheses to explain extracellular acidity and the possibility that low pHe might be an intrinsic feature of the tumor phenotype and not merely the consequence of metabolic activity have been discussed. In addition the consquences for concepts of treatment based on pH are considered.

Adenosine Triphosphate↗
PubMed2002

Animal models of long-term consequences of early exposure to repetitive pain.

Although animal models will never match the complexity of human systems, a number of basic mechanisms can be accessed only by using animal models. Results from studies using animal models of pain can give insight into basic mechanisms underlying long-term consequences of pain and provide sufficient data to generate hypotheses to be tested in human infants. Interaction between clinicians and basic scientists, with an understanding of the domain in which each group is working, is critical to the meshing of efforts from these domains. With collaboration between these groups, more relevant research can be conducted that can lead to the decrease in pain and its consequences in neonates.

Acute Disease↗
PubMed1999

Refractive error consequences of reversed-optic AMO SI-40NB intraocular lens.

OBJECTIVE: To evaluate the refractive consequences of inadvertently implanting a reversed-optic AMO SI-40NB posterior chamber intraocular lens (IOL). DESIGN: Retrospective case series. METHODS: One surgeon (BLH) implanted 457 SI-40NB IOLs over a 2-year period beginning on January 1, 1996, and ending on December 31, 1997. Six of these IOLs (1.3%) were noted to have been implanted with a reversed optic. The authors retrospectively reviewed the target spherical equivalent refractive errors (SEREs) and actual postoperative SEREs for all 457 eyes. MAIN OUTCOME MEASURES: The SRK-II formula was used to predict target SEREs. Actual postoperative SEREs were determined at 1 month after surgery using either a manifest or an automated refraction. Target postoperative SEREs were subtracted from actual postoperative SEREs to calculate diopter surprises, or the degree to which the actual SEREs differed from the target SEREs. RESULTS: The mean (+/-standard deviation) diopter surprise for reversed-optic SI-40NB IOLs was 0.01 (+/-0.89) diopter (D) more myopic than predicted; diopter surprises ranged from -1.39 D to +1.42 D. The mean diopter surprise for nonreversed SI-40NB IOLs was 0.18 (+/-0.81) D more hyperopic than predicted; diopter surprises ranged from -1.88 D to +2.56 D. The difference between the mean diopter surprises (0.19 D) was not statistically significant (t = 0.56, P = 0.57). CONCLUSIONS: A reversed-optic SI-40NB IOL is as likely to produce a satisfactory refractive result as a nonreversed IOL. Therefore, the refractive consequences of a reversed-optic SI-40NB IOL do not warrant the risks associated with repositioning the lens.

Aged↗
PubMed2003

Consequences of displaying abnormal social behaviour: avoidance and reduction of social reinforcement.

BACKGROUND: Abnormal social behaviour, which is a common feature of psychiatric disorders, is associated with rejection. A passive lack of participation or involvement has been studied as characteristic of depression but active forms of nonparticipation have received little experimental attention. This study examined the interpersonal consequences of four distinct types of social behaviour by using the role enactment method. Two of the roles portrayed abnormal social behaviour, active nonparticipant 'manic' and passive nonparticipant 'sad', and two portrayed normal social behaviour, active participant 'warm' and passive participant 'shy'. METHODS: Sixty-three normal subjects were randomly allocated to a brief dyadic social interaction with a confederate acting one of four roles. Subsequently, they rated their level of rejection of the confederate and took part in the mixed-motive game with him/her. RESULTS: The subjects were more likely to reject confederates in the abnormal social behaviour roles. This was shown on both their nonverbal behaviour and their verbal report. On the mixed-motive game, subjects gave fewer points and less cooperative and ingratiating messages to the confederates who had displayed abnormal social behaviour. LIMITATIONS: This result might only reveal the effects of first impressions of a confederate who behaves in a particular way, but not be generalised to long term acquaintanceship. CONCLUSIONS: These results extend previous findings that passive nonparticipant behaviour leads to rejection to active nonparticipant behaviour and show that the consequences of displaying such behaviour not only result in rejection but also in the reduction of social reinforcement. This might slow a patient's recovery process.

Adolescent↗
PubMed2000

Prevention of recurrent depressive episodes with milnacipran: consequences on quality of life.

BACKGROUND: Depression is now seen as a chronic disabling condition that spans the patient's lifetime and creates significant medical, economic and quality of life consequences. METHODS: 500 depressed patients were treated with milnacipran for 6 months. A total of 214 recovered patients were randomised to receive either milnacipran (50 mg bid) or a matching placebo for a 1-year recurrence prevention phase. Recurrence rate was the primary criteria; quality of life (QoL) consequences were evaluated through a shortened version of the French Sickness Impact Profile (SIP), the Depression Impact Profile (DIP). RESULTS: Milnacipran demonstrated its ability to reduce recurrences (Odds-Ratio=1.5; P<0.05), with a more marked effect in recovered patients with few residual symptoms (Odds-Ratio=3.0). Responders who continued treatment with milnacipran had a dramatic improvement in their quality of life, although patients with residual symptoms still experienced some deterioration in their QoL (recreation, emotional, social, alertness and home assistance scores). Even recovered patients having zero scores on the Hamilton Depression Rating Scale-21 items (HDRS) had some QoL deterioration. The DIP emotional score was found to be more predictive of recurrence than the HDRS. Overall, the QoL was improved for those in the milnacipran group in comparison to placebo on the mobility, communication, psycho-social and total scores. LIMITATIONS: The QoL evaluation was a secondary criteria; no a priori sample size estimate was performed. The choice of a generic QoL instrument might have reduced the sensitivity to clinical changes in depression. CONCLUSIONS: Prevention of recurrence in MDD with milnacipran contributes to an improvement in the QoL.

Adolescent↗
PubMed2002

Modelling the consequences of receptor-G-protein promiscuity.

Many G-protein-coupled receptors interact with more than one type of G protein, giving rise to extreme variability in the effects of receptor activation, depending on, for example, receptor density and desensitization, efficacy of agonists, and availability of specific G proteins. This leads to errors in interpretation of data. To facilitate understanding the consequences of receptor-G-protein promiscuity, we use two simplified models to simulate such consequences. Applied to the regulation of adenylyl cyclase and phosphoinositidase, the models predict seemingly paradoxical situations and explain some phenomena that, at first sight, might seem to require the induction of agonist-specific (G-protein-selective) receptor conformations.

Adenylyl Cyclases↗
PubMed1999

Simulated economic consequences of foot-and-mouth disease epidemics and their public control in France.

The efficient management of foot-and-mouth disease (FMD) epidemics in France was examined through a simulation model which combines epidemiological and economic modules. From the reactions of the importing countries in terms of the products subject to import bans and the regionalization commitments, the economic module assesses the financial consequences of FMD outbreaks borne not only by the breeding sector but also by the other economic sectors on regional and national levels. Among the control options for FMD, the strategy of stamping out infected herds and dangerous in-contact herds most often contributes to reducing the economic consequences of FMD epidemics. Implementing a campaign of emergency vaccination is socially optimal if the additional export losses associated with the delay of slaughtering the vaccinated animals are offset by the gains of reducing the duration of the FMD epidemic. The importance of reducing as much as possible the total duration of the import bans is stressed by the estimated cost of an extra week of import bans. The optimal control strategy was unaffected by the introduction of stochastic parameters.

Animals↗
PubMed2001

Alcohol, marijuana, and American youth: the unintended consequences of government regulation.

This paper analyzes the impact of increases in the minimum drinking age on the prevalence of alcohol and marijuana use among high school seniors. The empirical analysis is based on a large sample of students from 43 states over the years 1980-1989. We find that increases in the legal minimum drinking age did slightly reduce the prevalence of alcohol consumption. We also find, however, that increased legal minimum drinking ages had the unintended consequence of slightly increasing the prevalence of marijuana consumption. Estimates from a structural model suggest that this unintended consequence is attributable to standard substitution effects.

Adolescent↗
PubMed2003

Does training have consequences for the walk-run transition speed?

A number of authors when studying the walk-run transition phenomenon focused either on the mechanical or energy expenditure whilst only a few used both parameters concurrently. Moreover the literature demonstrates that the contribution of these variables changes along with the level and method of training. Consequently the purpose of this study is to find, by analyzing concurrently these two variables, if the walk-run transition speed is linked to the type of training. To this end we calculated two theoretical transition speeds: one based on the metabolic energy expenditure St(1) and the second one based on the internal work St(2). Subjects were divided into three groups (untrained, sprint and endurance-trained men) who were required to walk and run on a treadmill at increasing speeds. Firstly we show that the relationship between St(1) and St(2) differs depending on the groups. Sprinters have a significantly lower St(2) than St(1) whereas the opposite is found for untrained subjects. We also show that the transition speed is linked to the subject's type of training. To conclude it seems that acquiring running techniques through specific training has consequences for the walk-run transition phenomenon.

Acceleration↗
PubMed2001

Fear and social isolation as consequences of tuberculosis in VietNam: a gender analysis.

SETTING: The study was conducted in four districts in different regions of Vietnam. OBJECTIVE: To describe the socio-economic consequences of tuberculosis (TB) in Vietnam with special reference to gender differentials concerning social stigma and isolation. DESIGN: Sixteen focus group discussions were carried out with men and women, TB patients and non-TB participants. Data was analysed using modified grounded theory technique. RESULTS: Generally, the participants had good knowledge about TB. However, knowledge and practice were not closely related in the sense that most non-TB participants perceived that TB can be successfully cured, while patients were seriously shocked when they were told that they had TB. Male patients often worried about economic-related problems, while female patients worried about social consequences of the disease. Both in the family and the community, isolation could be subtle, but it could also be obvious and had a tendency to continue much longer than medically justified. CONCLUSION: Information on stigma and isolation due to TB and gender differences is important for understanding patient dynamics and its effects on the disease. Tuberculosis control programmes need better understanding of the gender differences in attitudes and beliefs to improve case-detection and treatment outcome.

Fear↗
PubMed2002

Financial consequences of changes in health care demands related to tobacco consumption in Mexico: information for policy makers.

This paper presents the results from a longitudinal study in which the main purpose was to determine the health-care costs and financial consequences of changes in the health care demands related to tobacco consumption in Mexico. Eleven health interventions were selected to conduct this study and four probabilistic models were developed to forecast the expected changes in the epidemiologic profile of selected diseases. The costing method was based on the identification of case management costs using the instrumentation and consensus techniques, probabilistic models were designed using the Box-Jenkins technique and allowed us to identify the expected case trends for the 2001-2003 period. The generation of information on case management costs for the selected interventions is a central instrument in the planning of health programs, above all in that which refers to resource allocation by type of demand. On the other hand, the identification of expected cases and the financial consequences allowed us to know the growing trends of the sums required to satisfy health care demands for the period under study. The three types of information are a relevant resource for decision-makers in the production and financing of health services.

Case Management↗