Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Conjunctiva”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 649 records · Page 36Linked to original sources
PubMed1979

[Histological studies of goblet cell counts in human conjunctiva (author's transl)].

In 121 healthy subjects of all age groups the goblet cells were counted by means of conjunctival biopsies; none of these individuals showed any inflammatory or degenerative changes in their eye lids, conjunctivae or corneas. Three groups were distinguished: a small group with relatively few, a large group with an average number and a third small groups with a relatively large number of goblet cells. The number of goblet cells was usually between 26 and 40 to the square mm, but fluctuated to a great extent in all three groups. On determining age distribution, the average goblet cell counts were found to be astonishingly similar: they did not vary significantly in the different age groups. At most, one could say the goblet cell count is slightly lower from age 61 onward.

Adolescent↗
PubMed1978

Tumor and tumor-like lesions of perilimbal conjunctiva in laboratory dogs.

Review of records of 1,680 research colony Beagles revealed proliferative and neoplastic lesions in the nasal or temporal limbal conjunctiva of 8 male and 6 famale dogs. The mean age at observation was 5.2 years. The lesions ranged from acanthosis and squamous cell carcinoma of the conjunctival epithelium to vascular ectasia, hemangioma, and invasive hemangiosarcoma of the underlying lamina propria. The lesions developed under circumstances that suggested solar radiation was involved in the pathogenesis.

Animals↗
PubMed1981

Langerhans cells in the normal conjunctiva and peripheral cornea of selected species.

The distribution of Langerhans cells (LCs) in human corneal and conjunctival epithelial sheets was investigated by histochemical, immunofluorescence, and immuno-electron microscopic methods. The LCs stained positive with ATPase and with antibodies to HLA-DR antigen and were negative to DOPA-oxidase. Human conjunctiva showed 250 to 300 LCs/mm2 compared to 15 to 20/mm2 in the peripheral third of the corneal epithelium, approximately similar of LCs were present in Lewis rat, fewer cells in guinea pigs and mice, and no detectable cells in the chick.

Animals↗
PubMed1984

Ultrastructural changes in the cornea and conjunctiva of a heterozygous woman with Fabry's disease.

Heterozygous females with Fabry's disease show a typical whorled pattern in the corneal epithelium. The patient presented in this paper also had symptoms of polymyositis, necrotizing vasculitis and angiokeratomas. The diagnosis was made from the corneal changes. Electron microscopy revealed intracytoplasmic electron-dense deposits made up of lamellar stacks of uniform periodicity similar to myelin. These were present not only in the corneal epithelium but also in the epithelium, goblet cells, endothelium and mural cells of blood vessels in the conjunctiva. The material in the goblet cells may account for the known presence of ceramide trihexoside in the tears.

Adult↗
PubMed1984

[Allergic granulomatous nodule of the conjunctiva].

Six cases of conjunctival allergic granulomatous nodules are reported. This benign lesion was described by Ashton and Cook in 1979. It is commonest in children and young people. Clinically it consists of one or more raised yellow nodules beneath the epithelium of the bulbar conjunctiva. Histologically these nodules consist of an amorphous eosinophilic material surrounded by epithelioid and giant cells arranged in a palisade; often some eosinophils are found in the inflammatory reaction. In the absence of surgical intervention these lesions can disappear spontaneously or after corticotherapy in a few weeks or months. According to Ashton and Cook these granulomas show the histologic feature of the Splendore Hoeppli phenomenon, that is, a giant cell and eosinophilic granulomatous reaction to an antigen-antibody precipitate in relation to parasite or fungi. In two cases Ashton and Cook found fragments of nematode larvae but usually no foreign bodies or parasites are identified in the lesions.

Antigen-Antibody Complex↗
PubMed1980

Penetration of the unwounded immature mouse cornea and conjunctiva by Pseudomonas: SEM-TEM analysis.

Scanning and transmission electron microscopy were used to study the early ocular response to infection by Pseudomonas aeruginosa inoculated under the fused eyelids of immature mice. In the absence of experimental corneal wounding, the organisms produced lysis of the epithelium of the peripheral cornea and conjunctiva and penetrated and lysed the respective stromas as early as 15 min after inoculation. Bacteria were infrequently detected on the ocular surface at 3 hr after infection. At this time, corneal epithelial cells in the vicinity of the inoculation were markedly shrunken.

Animals↗
PubMed1978

Intraepithelial epithelioma (Bowen's disease) of conjunctiva and chronic lymphocytic leukemia.

Occurrence of intraepithelial epithelioma (Bowen's disease) of the conjunctiva in a 54-year-old white man with chronic lymphocytic leukemia and bilateral labiopalatine clefting is discussed. The lesion developed slowly during 3 years following mechanical trauma to the eye. The interrelationship between trauma, Bowen's disease, and chronic lymphocytic leukemia remains obscure. It is postulated that an altered immunologic status might be responsible for neoplastic changes in the posttraumatic healing process. Intractable lesions in a patient with abnormal immunologic system or with an already proven malignancy should be studied by excisional biopsy.

Bowen's Disease↗
PubMed1983

Case of sarcoidosis with uncommon tumorous mass formation in bulbar conjunctiva.

A case of sarcoidosis with ocular involvement, including uncommon tumorous mass formation on the bulbar conjunctiva, was reported. The patient was a 62-year-old woman who had been suffering from chronic bronchiolitis for several years. The conjuctival masses, yellowish brown in color with localized injection and follicles, were found in both eyes. In addition to the conjunctival masses, the common manifestations of sarcoidosis were observed in the eyes, showing nodules on the iris and trabeculum, discrete fluffy "snowball" opacities in the vitreous, and perivascular nodules on the retinal vessels. Microscopically, the biopsy specimen obtained from he conjunctival masses was composed of epithelioid tubercles with Langhans type and foreign body type giant cells. Ziehl-Neelsen stain revealed no tuberculous bacilli. Transbronchial lung biopsy also revealed epithelioid tubercles. Both ocular and pulmonary lesions were observed to respond well to treatment with corticosteroid hormone. We emphasized that patients with interstitial pneumonitis or pulmonary fibrosis should be examined ophthalmologically, and recommended conjunctival biopsy in patients with suspected sarcoidosis.

Biopsy↗
PubMed1982

[Characteristics of the microcirculatory status in the bulbar conjunctiva in a refractory form of heart failure].

The conjunctival biomicroscopy has been used to study the microcirculation in the bulbar conjunctiva of 88 patients with cardiac insufficiency, 67 of them had its refractory form. The changes found in the microcirculation bed in the refractory and nonrefractory forms of cardiac insufficiency differed as to the extent and a significantly greater expression in the refractory form of cardiac insufficiency.

Adult↗
PubMed1981

Corneal re-epithelialization from the conjunctiva.

After debridement of the entire corneal epithelium, epithelial cells of conjunctival origin cover the exposed corneal surface. Four to five weeks later, these cells undergo a morphologic transformation to normal-appearing corneal epithelium. To study this transformation the entire corneal epithelium was removed from rabbits with the use of n-heptanol, after which the histologic appearance of and the number of goblet cells in the regenerated epithelium were noted. Five stages of transformation were seen. Immediately after healing, the epithelium consisted of one to two squamous cell layers with no goblet cells apparent at the light microscope level (stage 1). In the following weeks goblet cells appeared at the limbal edge of the cornea (stage 2), reached a uniform distribution across the cornea (stage 3), and subsequently receded toward the limbus (stage 4), leaving an epithelium with normal corneal morphologic appearance (stage 5). To see if there was an ongoing centripetal cell migration from the conjunctiva across the cornea after initial healing, the central corneal epithelium was isolated from the periphery by a ring of glue. Such isolation resulted in a thinning of the central epithelium and a thickening of the peripheral epithelium. These studies suggest that (1) the transformation into corneal epithelium lags behind defect closure by 4 to 5 weeks, (2) goblet cells do not initially migrate as recognizable cells, and (3) there is a continuous centripetal cell motion even after the initial defect closure is accomplished.

Animals↗
PubMed1981

Effect of genetic diabetes on beta-N-acetylglucosaminidase activity in plasma, conjunctiva, muscle and kidney cortex of mice.

The activity of beta-N-acetylglucosaminidase, a lysosomal enzyme concerned with the degradation of glycoproteins and mucopolysaccharides, in plasma, conjunctiva, thigh muscle and kidney cortex of normal Swiss Albino and genetically diabetic KK mice of 20, 40, 70, 180 and 360 days of age was determined. The enzyme activity was significantly lower in the tissues of the KK mice of 180 and/or 360 days of age when compared with age-matched Swiss Albino mice. This lower enzyme activity was considered to be a reflection of the changes in the glycoprotein and basement membrane metabolism of these tissues.

Acetylglucosaminidase↗
PubMed1981

[Comparative characteristics of the self-stimulation response in rabbits following administration of angiotensin II into the cerebral ventricles and application to the conjunctiva].

Experiments on rabbits have shown that intraventricular administration of angiotensin II induces the dose-dependent suppression of the self-stimulation reaction after varying intervals. The same suppression of the self-stimulation in rabbits but after a greater interval is produced by the application of angiotensin aqueous solution to the eye conjunctiva. In both cases the amount of drinking reactions in the animals significantly rises after the oligopeptide administration as compared with controls. Examination of the time course of arterial pressure, respiration and ECG has shown that only intravenous injection of angiotensin II in doses of 500 ng provokes a temporary increase in arterial pressure, marked bradycardia and changes in respiration, whereas other routes of administration produce no changes in the characteristics studied.

Administration, Topical↗
PubMed1980

Antianaphylactic effects of dipivalyl epinephrine and related compounds in rat conjunctiva.

Topically applied dipivalyl epinephrine (DPE) and related compounds have been found to inhibit passive anaphylactic reaction in rat conjunctiva. The order of activity is as follows: isoproterenol greater than DPE greater than epinephrine greater than norepinephrine. The antianaphylactic effect of DPE was antagonized by propranolol but was not affected by phentolamine. The effects of epinephrine, norepinephrine, and isoproterenol were also antagonized by propranolol but potentiated by pentolamine. From these findings, it was suggested that DPE not only exerts its antianaphylactic action through activation of beta-adrenergic receptor but also itself has a little different action from epinephrine.

Anaphylaxis↗
PubMed1978

[Results of research on the microflora of the conjunctiva with either chemotherapeutically pretreated eyes or eyes not influenced by drugs concerning the question of the preoperative prophylaxis against infections (author's transl)].

In this study the results of 396 smears of conjunctiva are analysed concerning the microflora of chemotherapeutically pretreated eyes in comparison with eyes not treated. The results of microbiological culture indicate only a small statistically unsignificant difference in regard to the quantitity of sterile smears as well as the distribution of bacteria of both research groups. The discussion is on the question of unaimed preoperative prophylaxis of infection as conditio sine qua non before intraocular procedures on eyes free of phlogistic irritation.

Bacterial Infections↗
PubMedDate not supplied

[Effects of low-intensity laser irradiation on several parameters of microcirculation in the bulbar conjunctiva of patients with scleroderma].

Computer-aided analytical system of TV images (CASTI) of the anterior segment of the eye revealed an appreciable increase of the level of aggregation gradient in arterioles and venules of the bulbar conjunctiva of 37 children suffering from various forms of scleroderma, as against 18 healthy children. Exposure to low-energy laser of a close infrared band (approximately 890 nm) had a favorable impact on blood aggregation in patients with scleroderma. CASTI of the anterior segment of the eye proved to be an objective and highly informative method for the diagnosis and monitoring of the efficacy of various treatment modalities.

Adolescent↗