Aggregation of red cells and blood viscosity under near-zero gravity.
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A falling ball viscometer is used to measure whole blood and plasma viscosities. The principle of the device is to determine the fall time of a ball contained in a disposable syringe; the periodic run of the sphere prevents blood sedimentation during the measuring cycle but does not prevent the aggregation process which takes place with a short relaxation time. The analysis of the flow field is discussed relative to previous papers. The study of the dynamics of the falling ball provides two characteristic rates of deformation for the mixed extensional and shear flow field. The Reynolds numbers are calculated using different velocities and radii. Results on blood and plasma viscosity of patients suffering from rheumatoid arthritis are given in relation with clinical and biological indexes.
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The paper presents a study on the behaviour of blood and plasma viscosity before and after vasospastic crises induced by cold testing. The study was performed in 10 subjects with Raynaud's disease and in control group of 10 normal subjects. The data obtained do not suggest correlation between variation in viscosity and angiospastic crises.
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The objective of the study was to investigate the effect of isradipine on red blood cell filtrability in 20 men with mild-to-moderate hypertension. In this prospective, double-blind study, parallel groups of hypertensive male patients were randomized to receive either isradipine (n = 11) or placebo (n = 9). An additional group of nine normotensive age-matched volunteers served as controls. Tests were performed before and after patients were treated with either isradipine or placebo. The hypertensive patients differed from the normotensive controls in having a higher level of fibrinogen (P less than .04), a higher hematocrit (P less than .001), a higher filtration rate (P less than .05; impaired red blood cell deformability), and a higher mean corpuscular volume (MCV; P less than .005). Treatment with isradipine lowered blood pressure and improved red blood cell filterability (P less than .05) compared with placebo.