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At least 649 records · Page 36Linked to original sources
PubMed1990

A case of adenoid cystic carcinoma of the parotid gland--an immunohistological study.

We treated a case of adenoid cystic carcinoma that occurred in the right parotid gland of a 51-year-old woman. Although the tumor, including part of the parotid gland, was resected based on a clinical diagnosis of pleomorphic adenoma, it was later diagnosed as adenoid cystic carcinoma of mixed cribriform-solid type by histopathological examination after resection. Therefore, postoperative irradiation with a dose of 51 Gy was performed. Immunohistological examination of the resected specimen showed that the profiles of carbohydrate antigens were Lewis (a-, b+) in both the tumor and surrounding normal parotid tissue. NCC-SG-007 antigen was observed in the tumor tissue but not in the normal parotid gland, suggesting that this antigen was associated with the tumor.

Antigens, Tumor-Associated, Carbohydrate↗
PubMedDate not supplied

The effects of adenoid hypertrophy and subsequent adenoidectomy on pediatric nasal airway resistance.

To investigate how adenoid hypertrophy and subsequent adenoidectomy affect pediatric airway resistance, we developed a prospective controlled study. Fifty children, aged 3 to 12 years, diagnosed with adenoid hypertrophy and selected for adenoidectomy, preoperatively had their nasal airway resistance assessed by active anterior rhinomanometry. Twenty-five of these children were subsequently followed up postoperatively, undergoing nasal resistance evaluations at 1 month, 3 months, 6 months, and 12 months. Another 25 children, without chronic upper airway obstruction symptoms, were enrolled as a control group, and their airway resistance was assessed in the same fashion. We concluded that the children selected for adenoidectomy, compared to the control group and before surgery, had mean resistance values up to two- to threefold higher, in both untreated and decongested nose states. Surgery was found to dramatically reduce airway resistance, but only in children under the age of seven. However, the postoperative values still tended to remain higher than the control subjects results. If in a significant number of children the operation failed in completely resolving their complaints, no pre-operative rhinomanometric pattern could be found to specifically relate to a complete surgical success.

Adenoidectomy↗
PubMedDate not supplied

Adenoid cystic carcinoma of the paranasal sinuses.

Adenoid cystic carcinoma of the paranasal sinuses is a rare neoplasm whose propensity for perineural spread frequently results in positive surgical margins at the skull base. Radiation therapy (RT) may be used to treat unresectable tumors or as an adjuvant for positive surgical margins after attempted resection. A retrospective review of the experience at the University of Michigan Medical Center was undertaken to study the factors influencing survival and to compare the efficacy of RT alone versus as an adjuvant treatment to surgical resection. All patients selected for review (n = 17) had a histologically confirmed diagnosis of adenoid cystic carcinoma arising from the paranasal sinuses with an average follow-up of 6 years. The choice of treatment modality was based upon the resectability of the tumor by clinical and radiologic parameters. This was therefore not a randomized study and there was a clear bias against the radiation only group, which contained the more advanced and locally aggressive tumors. The 6-year survival for the combined surgery + RT group was 73% compared with 50% for the radiation only group (p = NS). The overall local recurrence rate was 76% and the rate of distant metastases was 18%. Of the 10 patients who underwent surgical resection eight (80%) had positive surgical margins at the skull base.

Adult↗
PubMed1995

Adenoid cystic carcinoma of Bartholin's gland--a review of the literature and report of a patient.

A case of adenoid cystic carcinoma of the Bartholin's gland, a rare vulval tumor, is reviewed with respect to clinical and pathological characteristics. Histological transition from normal Bartholin gland to adenoid cystic carcinoma was evident in this case. Local recurrences are common and often precede distant metastases. The recommended primary treatment is vulvectomy, obtaining clear margins and bilateral inguinofemoral node dissection.

Aged↗
PubMedDate not supplied

Immunohistochemical and ultrastructural observations on adenoid cystic carcinoma of salivary glands. With special reference to intermediate filaments and proteoglycan particles.

In adenoid cystic carcinoma (ACC) of salivary gland origin, intermediate filaments of tumour cells were investigated by immunohistochemical techniques and complex carbohydrates within the pseudocysts by ultrastructural methods. The intermediate filament proteins vimentin and cytokeratin were found in most neoplastic cells. The pseudocysts of the tumours were found to contain proteoglycan particles stainable after glutaraldehyde fixation--but not after osmium fixation alone. Ruthenium red (cationic dye) enhanced the staining whereas periodic acid-chromic acid-silver methenamine staining or phosphotungstic acid staining did not visualize the proteoglycan particles mainly containing acid proteoglycans which are normally produced by mesenchymal tissue. The cells of adenoid cystic carcinoma thus have an intermediate filament content and produce complex carbohydrates characteristic of both epithelial and mesenchymal tissue. Hence, an origin in an undifferentiated pluripotential cell seems plausible.

Carcinoma, Adenoid Cystic↗
PubMedDate not supplied

Effect of erythromycin on adenoid bacteria.

Seventy-eight patients with secretory otitis media were given erythromycin ethylsuccinate 50 mg/kg/day, divided into 2 doses, for 7-8 days before undergoing adenoidectomy and tympanostomy. Nasopharyngeal swabs for bacterial culture were obtained before medication and at surgery and the adenoid homogenate was also studied for bacteria. Pneumococci and Branhamella strains became significantly reduced, while Hemophilus influenzae showed no change. Pneumococcus and Branhamella strains partially returned one month after surgery and in part were found in patients who had not had these strains before antimicrobial therapy. Erythromycin ethylsuccinate can sterilize neither the adenoids nor the middle ear space if the causative agent is Hemophilus influenzae.

Adenoidectomy↗
PubMed1988

Etiological role of adenoids upon otitis media with effusion.

To clarify the etiological role of adenoids in OME, the effects of adenoidectomy on Eustachian tube function and nasal sinusitis were examined. Adenoids were found to exert no influence upon tubal opening pressure, nor patency of the Eustachian tube in a static condition. Active function of the tube during swallowing, however, was improved significantly by the adenoidectomy. In addition, adenoidectomy improved nasal sinusitis, and in such patients, their active tubal function was satisfactory. From these results, adenoidectomy was considered to cure OME, partly via improvement of the pathological condition of the nasopharynx represented by nasal sinusitis.

Adenoidectomy↗
PubMed1995

Flow cytometric quantification of lymphocyte subpopulations and immunoglobulin-containing cells in adenoid tissue in relation to secretory otitis media and age.

This study was designed to identify differences in the immunological reactions in adenoid tissue between children suffering from chronic secretory otitis media (SOM) and control children without ear disease. Cell populations were identified using monoclonal antibodies and flow cytofluorometry to facilitate quantitative comparisons. A modification of the FOG method was developed to quantify lymphocytes with intracellular IgG and IgA. Immunological screening was done in the first part of the study. No significant differences were found between the groups regarding cells positive for CD3, CD4, CD8, CD20 or CD25. A significantly higher number of PCA-1 positive cells (presumably plasma cells) were found in the SOM group. The second part of the study concentrated specifically on cells containing IgG or IgA. No statistically significant differences in number of positive cells were found between the groups. When we related the percentage of positive cells to age, a statistically significant decrease with age for IgA-positive cells was found in the SOM group but not in the control group. This result supports the hypothesis that SOM is associated with an immunological reaction that influences immunoglobulin production in adenoid tissue.

Adenoids↗
PubMed1984

Cerebral gliosarcoma, pulmonary adenoid-cystic carcinoma, and pulmonary metastatic gliosarcoma: report of an untreated case.

An elderly woman had a cerebral gliosarcoma with a single pulmonary metastasis, together with a separate pulmonary adenoid-cystic carcinoma. Spontaneous extraneural metastases of primary intracranial neoplasms are exceedingly unusual; so far, only 8 proven cases are recorded in the English language medical literature. The association of cerebral gliosarcoma and a pulmonary adenoid-cystic carcinoma is presumably coincidental.

Aged↗
PubMed1991

Adenoid cystic carcinoma in a juvenile male breast.

Adenoid cystic carcinoma of the breast is uncommon and comprises less than 1% of all mammary cancers. Its occurrence in the male breast is very rare. We describe the first case of adenoid cystic carcinoma in a juvenile male breast. The patient is alive and well 2 1/2 yrs following subcutaneous mastectomy. The details of the 4 previously reported cases of the same tumor in male breasts are reviewed.

Adolescent↗
PubMedDate not supplied

Maxillary adenoid cystic carcinoma with annulate lamellae.

Of 29 reviewed ultrastructural studies of adenoid cystic carcinoma, only 1 mentions the presence of annulate lamellae. The present report describes a 65-year-old woman who presented with an adenoid cystic carcinoma in her left maxillary sinus. At the light microscopic level, most of the connective tissue was loose and myxomatous and contained fine strands, cords, and islands of epithelium that in places had a cribriform pattern. The ultrastructural appearance was similar to that described by others. Two epithelial cell types predominated. The cytoplasm of one type contained mainly ribosomes, and that of the other type also had peripheral microfilaments. Also present were pseudocysts, lumina with microvilli, and replicated basal lamina. In addition, a number of both types of cells contained parallel arrays of cisternae that had regular small pores. These were annulate lamellae.

Aged↗
PubMed1984

Solitary renal metastasis 23 years after extirpation of a bronchial adenoid cystic carcinoma.

In a 47-year-old man left nephrectomy was performed in 1982 because of a solitary metastasis arising from a bronchial adenoid cystic carcinoma which had been extirpated 23 years previously, in 1959. Whole-body CT scanning one year after nephrectomy disclosed no local recurrence or further metastasis. The importance of long follow-up after surgery for adenoid cystic carcinoma is emphasized.

Bronchial Neoplasms↗
PubMedDate not supplied

Adenoid cystic carcinoma of the lacrimal gland in a six-year-old girl.

A 6-year-old white female was found to have an adenoid cystic carcinoma originating in a lacrimal gland. Eighteen months following diagnosis, the tumor recurred. Conservative surgery has been the sole mode of therapy. To date, after four operations and quadrimenstral imaging surveillance, there is no sign of disease progression. Our purpose is to record the unusual occurrence of an adenoid cystic carcinoma of the lacrimal gland in a child. An interim report, 32 months after diagnosis, is presented.

Adenoma, Pleomorphic↗
PubMed1997

[Clinicopathological study of 54 cases of adenoid cystic carcinoma in the head and neck].

A retrospective analysis was performed on 54 patients with adenoid cystic carcinoma in the head and neck, treated from January 1971 to July 1997 in the Kurume University Hospital. The patients consisted of 35 females and 19 males, with a mean age of 59 years. The site of the lesion was the oral cavity in 13, nasal cavity in 11, submandibular gland in 8, parotid gland in 5, paranasal sinus in 3, nasopharynx in 3, oropharynx in 3, external auditory canal in 3, orbita in 2, lip in 1, lacrimal gland in 1 and trachea in 1. The over all 5-year, 10-year and 15-year survival rates as determined by the Kaplan-Meier method were 72%, 53%, and 46%, respectively. There was no relationship between survival rate and the site of the original lesion. According to the histologic criteria reported by Szanto et al., when more than 30% of the neoplasma showed a solid pattern, its treatment outcome appeared poor. In this study, the same tendency was seen. Fifteen patients died of the tumor. Ten died of distant metastasis and 5 died of local recurrence invading the cranium. No patient died of neck metastasis. Adenoid cystic carcinoma was thought to be radioresistant, but recently some authors have reported this tumor as radiosensitive. This study also showed that postoperative radiotherapy was effective, producing an increase in the survival rate.

Adult↗
PubMed1990

[A comparative study on proliferative activity in different histological patterns of adenoid cystic carcinoma--from a viewpoint of nuclear DNA contents].

Adenoid cystic carcinoma generally consists of the following histologic features: tubular, cribriform, trabecular, and solid. To investigate how these histological patterns affect the prognosis of this carcinoma, we determined the proliferative activity of each of the histologic patterns by cytofluorometry. Twenty-six cases of adenoid cystic carcinoma, obtained by surgical resection, were studied. According to predominant histological pattern, they were divided into three groups: seven cases were of cribriform pattern, nine cases of trabecular pattern, and ten cases of solid pattern. The region with each dominant pattern was obtained from biopsy specimen, and the nuclear DNA contents of the tumor cells of the regions were assayed. In four of twenty-six cases, that of the tumor cells of the region with other patterns in the same specimens were also assayed. The results were the following: 1) The mean incidence of over 4.5C-polyploid cells of the region with predominant pattern of each tumor significantly increased in the following order: cribriform pattern and solid pattern. 2) The incidence of over 4.5C-polyploid cells, in comparison of a predominant pattern with other histologic patterns in the same tumor, were calculated. It was higher in solid pattern than in trabecular pattern, and was higher in trabecular pattern than cribriform pattern. 3) Only two of ten cases, had aneuploidy in the region with predominant solid pattern and the other cases had diploid stem line. Judging from the above results, it was concluded that proliferative activity of each pattern increased in the following order: cribriform pattern, trabecular pattern, solid pattern.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed2004

Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features.

CONTEXT: Basaloid squamous cell carcinoma (BSCC) of the esophagus is a rare malignant tumor that morphologically could bear some resemblance to adenoid cystic carcinoma (ACC) originating from salivary glands. OBJECTIVE: The purpose of this study is to describe the histologic, immunohistochemical, and ultrastructural findings of BSCCs of the esophagus, with an emphasis on comparing tumors with or without adenoid cystic features. DESIGN: We reviewed 239 cases of primary esophageal carcinoma and detected 12 cases (5%) of BSCC. The light and electron microscopic findings and immunocytochemical localization of various antigens, including cytokeratins (AE1, AE3), carcinoembryonic antigen, epithelial membrane antigen, S100, smooth muscle actin, and p53, were examined in these BSCC cases. RESULTS: Histologically, all BSCCs were composed of solid lobules or nests of basaloid cells with well-demarcated outlines surrounded by a fibrous stroma. Seven of 12 tumors showed areas of ACC-like features, that is, cribriform-like pseudoglandular lumina formation and hyaline material surrounding the tumor nests, whereas the remaining 5 tumors were apparently pure basaloid carcinomas. These 2 groups of tumors were histologically and immunohistochemically identical in many aspects, namely, high-grade nuclei of the tumor cells with frequent mitoses, abundant comedo-type necrosis, focal areas of concomitant squamous differentiation, consistent immunoreactivity for cytokeratins, and poor or absent staining for S100 and smooth muscle actin. Ultrastructurally, the basaloid tumor cells exhibited relatively undifferentiated cellular characteristics and undeveloped cell organelles. CONCLUSION: Basaloid squamous cell carcinomas of the esophagus frequently have an intimate association with ACC-like patterns, but their histologic, immunocytochemical, and ultrastructural features correspond more to poorly differentiated squamous cell carcinoma than to salivary gland ACC. This distinction is important because genuine ACC is much less aggressive than BSCC.

Biomarkers, Tumor↗
PubMed1998

[Adenoid cystic carcinoma of the prostate. A case report].

Adenoid cystic carcinoma is most commonly encountered in the salivary glands. It is rarely found in the prostate but distinctive variant of prostatic adenocarcinoma. This case report is thought to be the first one in the Japanese literature. A 51-year-old man was admitted with urinary difficulties and frequency since one month. Digital rectal examination revealed an enlarged stony hard prostate. The transurethral prostatectomy was performed and the histopathological diagnosis was the adenoid cystic carcinoma. PSA and PAP were normal. The findings of computerized tomography suggested the invasion to the bladder and rectum. Therefore the total pelvic excenteration was carried out. He subsequently received radiation therapy (50 Gy to the pelvis), anti-androgen therapy and three courses of chemotherapy using Cisplatin, Peplomycin, Epirubicin and so on. But the metastatic disease involving the liver and pelvic lymph nodes developed, and he died two years seven months postoperatively.

Carcinoma, Adenoid Cystic↗
PubMed1998

[The adenoid as lymphoid tissue].

The adenoid is part of the mucosa-associated lymphoid tissue and is organized in distinct compartments. The lymphoid follicles and the interfollicular zone are areas of B lymphocytes and of T lymphocytes, respectively. The adenoid may thus function both as an immunologic inductive and effector organ.

Adenoids↗