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PubMed2004

Molecular evolution of the phytochrome gene family in sorghum: changing rates of synonymous and replacement evolution.

The photoreceptor phytochromes, encoded by a small gene family, are responsible for controlling the expression of a number of light-responsive genes and photomorphogenic events, including agronomically important phenotypes such as flowering time and shade-avoidance behavior. The understanding and control of flowering time are particularly important goals in sorghum cultivar development for diverse environments, and naturally occurring variation in the phytochrome genes might prove useful in breeding programs. Also of interest is whether variation observed at the phytochrome loci in domesticated sorghum, or in particular races, is a result of human selection. Population genetic studies can reveal evidence of such selection in patterns of polymorphism and divergence. In this study we report a population genetic analysis of the PHY gene family in Sorghum bicolor (L.) Moench in a diverse panel including both cultivated and wild accessions. We show that the level of nucleotide variation in all gene family members is about half the average for this species, consistent with purifying selection acting on these loci. However, the rate of amino acid substitution is accelerated at PHYC compared to the other two loci. In comparisons to a closely related sorghum species, PHYC shows a pattern of intermediate frequency amino acid changes that differ from the patterns observed in comparisons across longer evolutionary distances. There is also a departure from expected patterns of polymorphism and divergence at synonymous sites in PHYC, although the data do not fit a simple model of directional or diversifying selection. Cultivated sorghum has a level of variation similar to that of wild relatives (ssp. verticilliflorum), but many polymorphisms are subspecies-specific, including several amino acid variants.

Amino Acid Sequence↗
PubMed1998

Delayed-type hypersensitivity to contact allergens in psoriasis. A clinical evaluation.

The possibility for patch testing procedures to detect contact allergy was examined in 85 hospitalized patients with forms of psoriasis. Exclusion criteria were active lesions on the back, the use of strong topical corticosteroids, methotrexate, cyclosporin and UV therapy. After screening, a group of 47 patients with different forms of psoriasis were selected for patch testing. Personal history, including topical treatment, occupation and domestic circumstances, were reasons to extend the standard series of allergens. Tars, nickel sulfate, perfume and balsam of Peru scored high. The overall positive rate was 68%. This is higher than that observed in earlier studies. The unexpected results are discussed in the light of the possible mechanism of action.

Adolescent↗
PubMed2006

Genetic diversity of nine populations of the black goat (Capra hircus) in Sichuan, PR China.

Sixteen polymorphic primers screened from 100 random primers were selected to analyze the randomly amplified polymorphic DNA (RAPD) of 540 domesticated black goats (Capra hircas) from 9 different geographical populations in Sichuan Province of China. After the test, 170 entirely repeatable RAPD markers representing goat polymorphisms were obtained from the 16 polymorphic primers, the lengths of the markers ranging from 0.1 to 2.5 kb. The genetic distance among the black goat populations ranges from 0.1051 to 0.2978. The similarity coefficient (0.9002) between Jintang and Lezhi black goats was the highest in the 9 populations, followed by the coefficient (0.8953) between Jialing and Yinshan goats, while that between Jiangan and Huili goats was found to be the lowest (0.7424). The coefficient of differentiation among population genes (Gst) was 0.2766, indicating a comparatively low degree of differentiation among the black goat populations. A UPGMA dendrogram constructed from similarity coefficients showed that the two populations from Huili and Baiyu, which are found mostly on the Western Sichuan plateau and in mountainous areas, clustered together, and the other seven populations formed another group. It can also be clearly seen that the Huili and Baiyu populations are very special, and must have been closely related in the past, even though their link with the other populations is quite weak as a result of genetic communication. The results of the experiment offer some crucial scientific data useful for the breeding of black goats.

Animals↗
PubMed1993

The political and economic determinants of health outcomes: a cross-national analysis.

This article investigates the impact of selected political and economic processes on the well-being of domestic populations within samples of 50 to 84 peripheral and noncore nations. Existing research by Cereseto and Waitzkin on the relative merits of market versus socialist systems for the provision of health and welfare needs of their populations is extended by employing a more complex model than the original study. More specifically, the authors assess the impact on measures of population health and mortality rates of regime ideology, state strength, multinational corporate penetration, and position in the world economy. In general, high levels of democracy and strong left-wing regimes are associated with positive health outcomes, and strong right-wing regimes have populations with lower life expectancies and higher levels of various measures of mortality. These findings support the conclusion that political systems make a difference in health and well-being independent of national (gross national product per capita) and international (investment dependency) economic factors.

Adolescent↗
PubMed2001

Comparison of different life-cycle impact assessment methods for aquatic ecotoxicity.

Human and ecotoxicity impact categories are problematic to quantify within life-cycle impact assessment (LCIA) because their local scope makes them difficult to aggregate with the traditional global-impact categories used in life-cycle assessment (LCA). For being able to assess local impacts such as toxicity, LCIA developers increasingly include fate modeling into LCA. This article follows this development by comparing different LCIA methods for aquatic ecotoxicology and by investigating the importance of fate within LCIA, the necessity of considering freshwater and seawater compartments separately, and the key degradation and intermedia transfer processes involved. The methods are compared by assessing an example study of domestic clothes washing in former West Germany. Four LCIA methods are selected and applied to four substances emitted during the washing process. The conclusion is that the consideration of environmental fate does matter and that aquatic ecotoxic impacts can differ significantly for the same substance in freshwater and in marine ecosystems. The way (bio)degradation, photolysis, volatilization, and transfer from agricultural soils are considered plays an important role as do the system boundaries chosen. This means that the LCIA methodology should remain flexible so that appropriate methods can be chosen for different applications. Fate models being developed in the environmental risk assessment of chemicals can contribute to the further improvement of LCIA methods.

Agriculture↗
PubMed1990

[Clinical application and therapeutic effects of elementalin].

Elementalin, similar to Vivonex NH in composition. consisted of an amino acid mixture and many other essential nutrients. The amino acid mixture was extracted from swine blood and supplemented with some crystal L-amino acids. Animal experiment suggested that it have a better therapeutic effects than a domestic elemental diet. 86 malnourished patients with digestive tract diseases were selected to carry out its clinic evaluation. The results showed that it could maintain or increase body weight, improve nitrogen balance and elevate the level of plasma proteins postoperatively. The total effective rate was 94.2%. No obvious side effect was found.

Adult↗
PubMed1996

Swedish pesticide risk reduction 1981-1995: food residues, health hazard, and reported poisonings.

The Swedish Government has initiated three pesticide risk-reduction programs since the mid-1980s. Risk-reduction achievements have been measured mainly in terms of reduction in quantities sold. In this review, risk-reduction achievements have been described also in terms of pesticide residues in foods, both imported and grown domestically, acute health hazard to the users, and reported poisonings. The time periods selected for comparisons are 1981-1985 (which is the Government's baseline period), 1990-1994 for food residues and poisonings, and 1991-1995 for acute health hazard and quantities sold. The quantity of pesticides as active ingredient (ai) sold for use in agriculture, horticulture, and forestry decreased from a total of 22,800 tons during 1981-1985 to 8450 tons in 1991-1995, a 63% reduction. Published data on pesticide residues in domestically grown fruits and vegetables show that the proportion of cases of reported residues higher than 20% of the maximum residue limit has decreased only slightly, from 6.9% to 6.2%. Residues in imported food crops of the same type increased from 31% to 37%. Overall, the achieved 63% reduction of quantities used may have resulted in only a 10% reduction in number of cases of reported residues. A forthcoming report on pesticide intake via food from the National Food Administration may shed light on any trends in actual residue levels. The degree of goal fulfillment for the pesticide residue monitoring program and for pesticide residue levels in food is difficult to judge because of imprecise goal formulations. An estimate of the potential acute health hazard to the pesticide users, based on quantities and acute toxicity of individual pesticides, indicates that the acute health hazard in terms of "acute toxicity equivalents" decreased by 71%. The number of poisonings caused by acute exposure at the workplace has decreased between 1984 and 1994, whereas the number of mostly harmless incidents at home has increased. The decline in workplace-related accidents and the favorable pattern and low frequency of pesticide poisonings in Sweden compared to many other countries, especially developing countries, is the result of several factors, such as the mandatory training of workers using pesticides professionally, severe restrictions in availability of pesticides for use in households, and withdrawal from the market of the most toxic pesticides. To improve the worrisome global situation, it would seem appropriate that the United Nations Food and Agriculture Organization pay greater attention to the need for promotion of restrictions on availability of highly toxic and other pesticides, as recommended by FAO and WHO in 1975 (WHO/FAO 1975).

Environmental Exposure↗
PubMed2003

Predicted rates of inbreeding with additive maternal effects.

Maternal effects play an important role in fitness and other aspects of individual performance in many species, particularly mammalian, yet their impact on genetic variation within species and its rate of loss during selection has been neglected. In this paper we extend the theory of expected long-term genetic contributions to include maternal effects, and tested the accuracy of predicted rates of inbreeding for populations under mass selection by comparison with simulations. The model includes selective advantages of direct and maternal additive genetic effects, and also the selective advantage of a common maternal environmental effect. The population structures investigated had a fixed number of dams per sire and fixed family size. Most prediction errors of the rate of inbreeding (deltaF) were less than 8% of the simulated means and were lower in magnitude than the prediction errors of genetic gain (deltaG). The predictions of deltaG from contributions equalled previously published predictions. A variation in maternal genetic effects resulted in a much larger deltaF than for an equally sized variation in common maternal environmental effects. For a fixed genetic gain, deltaF increased as the maternal heritability increased. The influence of family size, mating ratio and age structure on deltaF was greater with maternal effects than with only direct genetic effects included. In conclusion, maternal effects can be a very important aspect to consider when predicting deltaF in populations under selection, and the developed methodology gives good predictions.

Animals↗
PubMed2006

Changes in fuelwood use and selection following electrification in the Bushbuckridge lowveld, South Africa.

Fuelwood is the primary energy source for domestic purposes throughout the developing world, in both urban and rural environments. Due to the detrimental impacts of biomass use on human and environmental health, many governments have sought to reduce its use through provision of potentially cleaner energies, of which electricity is the dominant form. Yet there are surprisingly few studies of changes in fuelwood use following the introduction of electricity, especially in rural areas of Africa. This paper reports on a longitudinal study of fuelwood use, using identical approaches, in five rural villages in the Bushbuckridge region of South Africa, spanning the period over which electricity became widely available. Almost a decade after the introduction of electricity, over 90% of households still used fuelwood for thermal purposes, especially cooking, and the mean household consumption rates over the 11-year period had not changed, even with a policy of 6 kWh per month of free electricity. The proportion of households purchasing fuelwood had increased, probably in response to a number of factors, including (i) increased fuelwood scarcity in the local environment as reflected by increased fuelwood collection times, changes in fuelwood species preferences, and ranking of scarcity by local collectors, and (ii) increases in the price of fuelwood well below that of other fuels and the prevailing inflation rate. Overall, there was an increase in the number of species harvested over the 11-year period. The implications of these findings for rural energy provision are discussed.

Cooking↗
PubMed1985

[Plasma lipoproteins and fattening: description of a model in the domestic chicken, Gallus domesticus].

Developmental changes in the lipid transport system in two lines of broilers, selected for high or low adiposity, have been investigated during the first 7 weeks after hatching. The major lipoprotein classes in the plasma of lean and fat chickens 2, 3, 4, 5 and 7 weeks old were isolated by density gradient ultracentrifugation. The 2-week old chickens presented an heterogeneous distribution of high-density lipoproteins (HDL), often appearing as two distinct gradient bands; their very-low-density lipoproteins (VLDL) were rich in cholesterol (25-30%) and relatively poor in triglycerides (approximately 35%). As the birds grew older, the HDL subclass of lower density disappeared, tending to fuse with that of higher density; at the same time, the triglyceride content of VLDL and HDL levels increased progressively in the two lines, their concentration being significantly higher in the fat line. These developmental changes suggest that our two lines of chickens are a suitable model for studies of the onset and hormonal control of the specific fattening process during growth.

Adipose Tissue↗
PubMed2003

Melanocortin receptor variants with phenotypic effects in horse, pig, and chicken.

The melanocortin system is of considerable interest in domestic animals because their energy metabolism and pigmentation have been under strong selection. This article reviews our work on MC1R variants in horse, pig, and chicken, as well as a study on MC4R polymorphism in the pig. The chestnut coat color in horses is caused by an MC1R missense mutation (S83F). In the pig, we have described seven MC1R alleles controlling four different coat color phenotypes (wild type, dominant black, black spotting, and recessive red). The most interesting allele is the one causing black spotting because it carries two causative mutations, a frameshift and a missense mutation. The frameshift mutation is somatically unstable, and the black spots reflect somatic reversion events restoring the reading frame. Classic genetics have established eight alleles at the Extended black locus in chicken, which is assumed to correspond to the Extension locus in mammals. We have analyzed the co-segregation of alleles at MC1R and Extended black using a red jungle fowl x White Leghorn intercross and provide compelling evidence that these loci are identical. A previous study indicated that a missense mutation (D298N) in pig MC4R has an effect on fatness, growth, and feed intake. We could not confirm this association using an intercross between the wild boar and Large White domestic pigs, but it is possible that our F(2) generation was too small to detect the rather modest effect reported for this polymorphism.

Alleles↗
PubMed1992

Identification and partial purification of serum growth hormone binding protein in domestic animal species.

The chemical nature and variations in serum concentrations of growth hormone binding protein (GHBP) from humans, rabbits, and rodents have been reported. To date little is known about the GHBP of domestic animals. Therefore, we initiated these studies to determine whether a serum GHBP was present in domestic animals and to purify the binding protein (BP) from serum of selected species. Using a dextran-coated charcoal separation assay, specific growth hormone (GH) binding was demonstrated in ovine, bovine, chicken, human, goose, porcine, and equine serum (listed in sequence from lowest to highest binding). Variation in BP activity was relatively high, both within and between species. Yearling ewes had higher serum GHBP than either prepubertal (4 mo) or older (5 yr) ewes. The GHBP was partially purified from chicken, ovine, and porcine serum using GH affinity chromatography. These BP had high affinity (Ka = 2 x 10(8) to 2 x 10(9) L/mol, depending on species) and low capacity (2 x 10(-10) to 5 x 10(-11) mol/unit of protein) for human GH but showed lower binding affinity for homologous GH (Ka = 2 x 10(7) L/mol). The porcine GHBP had the highest and ovine GHBP the lowest affinity for human GH. Other heterologous somatotropic hormones, ovine placental lactogen, and ovine GH displayed higher binding affinity to chicken and pig BP than the respective homologous hormones. Further chromatographic purification of the porcine GHBP resulted in an additional 1,000-fold purification. The estimated molecular weight of porcine GHBP is 50,000 to 60,000 Da. These results demonstrate that the serum from all domestic species tested contains a specific GH-binding moiety and that under the conditions described here human GH is a more efficient ligand than the homologous hormone.

Animals↗
PubMed1993

Feline immunodeficiency virus infection of cats as a model to test the effect of certain in vitro selection pressures on the infectivity and virulence of resultant lentivirus variants.

Three groups of specific pathogen-free (SPF) domestic cats, each containing 5 animals, were infected with one of three closely related FIV variants and monitored for 36 weeks. A fourth group of 5 cats was sham-infected and served as uninfected controls. FIV variants included: (1) a fully virulent animal passaged FIV-Petaluma; (2) a Crandell feline kidney (CrFK) cell-adapted FIV-Petaluma (FIV-CrFK); and (3) a variant of FIV-CrFK (FIV-CrFKAZT) that had been selected in vitro for resistance to azidothymidine. Cats infected with fully virulent FIV-Petaluma strongly seroconverted, became persistently viremic, and exhibited lymphadenopathy, neutropenia, and inversion of the CD4+:CD8+ T cell ratio. Cats infected with FIV-CrFK seroconverted but the antibody responses were much weaker and more variable; two of the cats became transiently viremic and no hematologic abnormalities or clinical signs of illness other than a very mild lymphadenopathy were observed. None of the five cats inoculated with FIV-CrFKAZT seroconverted, became viremic, or exhibited any gross or hematologic signs of disease, even though proviral DNA was transiently detected in tissue following inoculation. This study demonstrates that the FIV infection model can be used to assess differences in the virulence of FIV variants, including variants selected for antiretroviral drug resistance.

Animals↗
PubMed1981

Comparison of techniques for detection of domestic infestations with Triatoma infestans in Brazil.

The detection of infestations of Triatominae in houses in regions endemic for Chagas's disease is a criterion frequently used in the selection of areas, or of individual houses, for treatment in insecticide campaigns as well as in the evaluation of insecticide performance. Several different methods for detecting domestic infestations with Triatominae were compared: night capture, capture of five bugs with the aid of a flushing-out agent and use of card boxes of the Gómez-Núñez type. The flushing-out and Gómez-Núñez box methods were found to be equally sensitive, although each failed to detect some infestations which the other detected. The night capture method was slightly more sensitive but was found to be impractical for insecticide trials. Improvement to the flushing-out method, notably the introduction of a systematic search technique, made it much more sensitive than the Gómez-Núñez box method for heavily infested houses and for houses three months after insecticide treatment. Although the sensitivity of the Gómez-Núñez box method increases when the boxes are left in place for a long time, this also limits the value of the information obtained regarding the evaluation of insecticides. On the basis of the results presented, the flushing-out method using a systematic search of the house was found to be the most suitable sampling technique, but it is recognized that this method still has limitations.

Animals↗
PubMed2006

Dog and cat bites to the hand: treatment and cost assessment.

PURPOSE: To assess the demographic patterns, clinical morbidity, and treatment costs associated with domestic animal bites to the hand. METHODS: A retrospective review was performed on 111 patients who suffered either a dog or cat bite to the hand. Demographic data were collected for both the patient and the animal involved. RESULTS: The patient population had suffered 71 dog bites and 40 cat bites. Two scenarios were identified that increased the likelihood of a bite: (1) attempting to separate fighting animals and (2) attempting to aid an injured animal. More than half of the victims (61 of 111) were bitten by an animal with which they were familiar. Bite injuries ranged from relatively minor wounds to major injuries that included open fractures, persistent deep infection including osteomyelitis, nerve laceration, tendon laceration, or tissue loss. Approximately two thirds of patients required hospital admission at least for intravenous antibiotics. Approximately one third of animal bite victims required at least 1 surgical procedure. Thirteen patients required long-term intravenous antibiotics and/or multiple surgeries and incurred medical expenses in excess of dollar 77,000. CONCLUSIONS: Domestic animal bites to the hand are common injuries that can produce considerable morbidity. Stray animals did not account for the majority of incidents. Bite prevention strategies should focus on careful handling of animals that are fighting or injured. Animal bite wounds often require intravenous antibiotics and hospitalization and the cost of care for deep infections can be enormous. Our patient population was selected from a small geographic area over a relatively short collection period, suggesting that domestic animal bite injuries may represent a major public health issue. TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic, Level IV.

Adolescent↗
PubMed2005

A simultaneous procedure for deriving selection indexes with multiple restrictions.

The formulas given in literature for the construction of restricted indexes were designed only for the imposition of a single restriction (zero, fixed, or proportional). This study presents both the theory and the methods of a simultaneous procedure for constructing indexes with single or multiple restriction(s). Numerical examples are given to verify the theoretical development and to demonstrate the implementation of the procedure. The simultaneous procedure presented brings the construction of various restricted indexes into a simple computational scheme. In addition to the use of the proposed procedure to handle multiple traits, it can be used to modify the growth curve of meat animals or the lactation curve of dairy animals, which generally requires simultaneous imposition of different restrictions on different stages of the curves. A misconception in the literature is that the variance of an index (b'Pb) is not equal to the covariance between an index and its net merit (b'Ga) when the index is a restricted one. This study showed generally that b'Pb and b'Ga are equal in the restricted or unrestricted case only when elements of b represent the original solutions from the index equations and are not equal when elements of b are expressed in terms of proportions.

Animals↗
PubMed1993

A suburban focus of endemic typhus in Los Angeles County: association with seropositive domestic cats and opossums.

Thirty-three cases of locally acquired murine typhus were reported in Los Angeles County residents from May 1984 through February 1988. Only eight cases were reported over the previous 20-year period. Thirty (91%) cases resided within a suburban area encompassing approximately 50 km2 in northcentral Los Angeles or had contact with an animal from this area. Serologic testing (complement fixation and indirect fluorescent antibody) of selected animals in close association with human cases revealed a high prevalence of seropositivity among domestic cats and opossums. Nine (90%) of 10 resident cats tested had demonstrable antibody titers compared with none (0%) of 20 cats from a control area (P < 0.001). Suburban typhus cases were more likely than neighborhood controls to own a cat or dog (odds ratio = 6.9, 95% confidence interval = 1.8, 25.9, P = 0.002). Sixteen (42%) of 38 opossums trapped in close proximity to the residences of cases were seropositive versus none (0%) of 36 opossums from control areas (P < 0.001) A low frequency (2.8%) of seropositivity was found in commensal rodents, and the classic vector of murine typhus, Xenopsylla cheopis, was not found. Ectoparasite indices form seropositive opossums revealed heavy infestations with the cat flea, Ctenocephalides felis (mean flea count = 104.7), a species that readily bites humans. These data provide evidence that a suburban focus of murine typhus exists in Los Angeles that differs substantially from the classic transmission cycle, and that cats, opossums and C. felis may play an important role in the occurrence of human cases.

Adolescent↗