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At least 631 records · Page 35Linked to original sources
PubMedDate not supplied

[Effectiveness and mechanisms of the protective action of sidnocarb in experimental weightlessness and cooling].

Twenty-one subjects took part in experiments with acute cooling (maximally allowable time for swimming in ice-cold water and two-day exposure to winter field conditions) or two-day exposure to microgravity (simulated by water immersion). They were divided into a placebo group (5, 5 and 6 man-exposures) and a sydnocarb group (6, 6 and 4 man-exposures) and examined by biochemical, radioimmune and radioligand methods. It was found that physiological responses to cold and microgravity effects as well as sydnocarb were similar. During cold exposures the thermal steady-state was achieved by taking maximum daily doses of the drug. In thermoneutral water immersion body temperature fall was controlled by therapeutic doses of the drug. Body temperature decline beginning with immersion day 2 can be related to the endogenous decline of heat production due to a new functioning level which is well known in gravitational physiology, i. e. this is the effect of microgravity per se. With respect to old and new information about the pharmacological properties of sydnocarb, mechanisms of its high thermoregulatory effects on CNS structures responsible for heat production and heat loss are discussed.

Body Temperature Regulation↗
PubMedDate not supplied

[The effect of weightlessness on vestibular function].

During and after space missions crew members showed significant vestibular changes. The cosmonaut-researcher of the orbital complex Soyuz T-7--Salyut-7 developed inhibition of compensatory and enhancement of nystagmic eye movements in response to active head movements in the frontal plane. During an acute stage of readaptation crew members of the orbital complex Soyuz T-4--Salyut-6 displayed attenuation of the oculomotor reaction to optokinetic stimulation. One of them exhibited overt asymmetry of this oculomotor reaction. This cosmonaut also developed distinct spontaneous nystagmus in the dark and floating eye movements when he tried to fix his gaze at a stationary object. These findings give evidence that space flight may induce vestibular asymmetry and disorders of mechanisms of opto-vestibular interaction.

Eye Movements↗
PubMed1991

About the great importance of venous blood circulation in the pathogenesis of spaceman state disturbances in weightlessness.

CVP increasing observed in OS "Mir" flights lets to consider it as one of the chief factors in stateman state disturbance. It is necessary to use prophylactic means to prevent pathological changes in long flights. The received data confirm physical training and clamping cuffs application efficiency as a blood volume decentring and CVP decreasing.

Blood Circulation↗