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PubMed1990

[Chemotherapeutic regimens for nontuberculous mycobacterial infection based on in-vitro susceptibility test results].

Treatment of nontuberculous mycobacterial infection should be carried out by the chemotherapeutic regimens most suitable for each species. We performed in-vitro susceptibility tests for various species and determined the probability in which the mycobacteria of each species are inhibited by blood concentrations attainable by the dosages usually used. From such determinations, the following regimens have been recommended: 1) M. avium-M. intracellulare complex, Rifampicin + Enviomycin + Ethambutol; 2) M. kansasii, Ofloxacin + Enviomycin + Rifampicin; 3) M. szulgai, Enviomycin - Ethambutol + Isoniazid; 4) M. fortuitum, Ofloxacin. The effectiveness of the treatment of the infection caused by M. avium complex is less than 15% even using the above regimen, while it is high in the treatment of infections caused by M. kansasii and M. szulgai. There are no effective regimens for the treatment of infection caused by M. chelonae or M. simiae. The above recommendations are useful in practice, because, at present, reliable susceptibility testing of nontuberculous mycobacteria is not yet done commonly.

Drug Resistance, Microbial↗
PubMed1989

[In vitro susceptibility testing of nontuberculous mycobacteria to streptomycin, kanamycin and enviomycin].

In vitro susceptibility testing to streptomycin, kanamycin and enviomycin was carried out in nontuberculous mycobacteria and the results were compared with those of M. tuberculosis strains. Among nontuberculous mycobacteria tested, only M. xenopi strains exhibited similar minimal inhibitory concentration (MIC) values to streptomycin with M. tuberculosis strains. On the other hand, M. xenopi, M. malmoense and M. marinum strains showed the same MIC values to kanamycin with the MIC values for M. tuberculosis strains. The MICs of enviomycin for M. kansasii, M. malmoense, M. szulgai, M. xenopi and M. marinum strains were similar to those for M. tuberculosis strains. Out of 64 strains of M. avium complex, the MIC value similar to that for M. tuberculosis strains was shown in 16% of strains to streptomycin, in 42% of strains to kanamycin, and in 50% of strains to enviomycin.

Enviomycin↗