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PubMedDate not supplied

Caroli's disease. Report of 5 cases and review of literature.

In 1958 Caroli was the first to define exactly in literature the congenital dilatations of the intrahepatic bile ducts, concerning a segment, a lobe, or both lobes of the Liver. Later Todani involved it in his classification of the bile duct cysts as type V. Caroli's disease (CD) is quite a rare entity (about 150 cases reported in literature). In CD, stenosis and dilatation cause initially biliary stasis, leading to intrahepatic biliary lithiasis and secondary infection. The spontaneous course of CD is dominated by biliary infection: cholangitis (cholangiohepatitis), septicemia and intrahepatic and subphrenic abscesses. That is why the disease must be recognized before serious complications develop. The authors report about 5 cases of Caroli's disease--2 women and 3 men. Diffuse spread in one patient (25-year-old man) and in four--left lobe involved predominantly. Most common signs and symptoms were: fever, cholangitis, upper quadrant abdominal pain, hepatosplenomegaly, obstructive jaundice, Charcot's triad (in two). Importance for the exact diagnosis involves the use of ultrasonography (US), computer tomography (CT) scan, endoscopic cholangiopancreatography (ERCP), intraoperative cholangiography and cholangioscopy, allowing early diagnosis and therefore a better therapeutic and surgical approach.

Adult↗
PubMed2005

[The splenic hydatid disease: our experience].

The Authors report on a series of 5 patients with splenic hydatidosis submitted to surgery during the period 1974-2003. In 2 cases the cyst was solitary while 2 patients had a concomitant liver hydatidosis and 1 a synchronous lung cyst; one patient had been previously submitted to surgery twice for an hepatic cyst. In 1 patient the disease was asymptomatic, while 2 cases were revealed by pain and 3 by an abdominal mass. In all patients the diagnosis was preoperatively made by serological test in 1 and by CT scan in 5 and it was proved by surgery and pathology. All the patients underwent splenectomy with complete removal of the cyst. Median postoperative hospital stay was of 17.5 days (range 7-31 days). Postoperative course was regular without mortality and morbidity in 4 patients, while 1 patient developed a subphrenic abscess (overall morbidity = 20%) that required surgical drainage. No recurrences occurred after a mean follow-up of 187 months (range 169-217 months). The Authors believe that the diagnosis of splenic hydatid disease is more accurate today because of the new image techniques and that splenectomy is the surgical procedure to be preferred because it is simple and safe.

Adult↗
PubMedDate not supplied

Two-stage hepatectomy for multiple bilobular liver metastases from colorectal cancer.

BACKGROUND/AIMS: To determine an appropriate surgical treatment for patients with multiple liver metastases, we evaluated the efficacy of two-stage hepatectomy in patients with multiple bilobular liver metastases from colorectal carcinoma. METHODOLOGY: Some patients with multiple liver metastases are not candidates for a complete resection by a single hepatectomy, even when downstaged by chemotherapy, after portal embolization. In two-stage hepatectomy, the highest possible number of tumors is resected in a first, noncurative intervention, and the remaining tumors are resected after a period of liver regeneration. Two-stage hepatectomy was performed in 11 patients. RESULTS: Two-stage hepatectomy was feasible in all of the 11 patients. In 3 of them, the first stage was a major resection (more extensive than a lobectomy). This first hepatectomy was uneventful in all patients. The second hepatectomy was also uneventful in nine patients, but in one of the other two, a perihepatic fluid infection occurred, and in the other, postoperative liver failure developed due to a right subphrenic abscess. However, all patients were discharged. The percentage of the expected resection volume at one time, calculated from CT volumetry, was 75.5+/-1.2% and the prognostic score as surgical risk was 56.6+/-4.5. In two-stage hepatectomy cases, the percentage of the resected volume and the prognostic score in the first hepatectomy were 25.4+/-6.4% and 6.7+/-7.3, and in the second, 45.7+/-4.5% and 28.5+/-5.8. During the follow-up procedures, a residual hepatic recurrence was observed in 6 patients, and pulmonary recurrence in 9. The 1- and 3-year survival rates after the first hepatectomy were 90% and 45%, with median survivals of 18 months from the first hepatectomy. CONCLUSIONS: Two-stage hepatectomy is a surgical modality intended for patients with initial unresectable metastases. However, following such surgery, protective treatment against residual liver recurrence and lung metastasis will be a most important issue.

Aged↗
PubMed1992

Postsplenectomy leukocystosis: physiologic or an indicator of infection?

The records of 42 patients who underwent splenectomy following blunt abdominal trauma were reviewed to determine whether white blood cell (WBC) count is a useful indicator of acute infection in the postoperative period. Patients, ranging in age from 14 to 54 years, were divided into two groups: 1) infected (n = 18) and 2) noninfected (n = 24). Group average daily WBC counts (thousands/mm3) and differential counts (polymorphonuclear leukocyte/bands) were evaluated for the first 14 postoperative days. The infected group had a mean WBC of 21.2 and a mean differential count of 73/8. The average daily WBC count began to rise on Day 4 (WBC = 10.8) and peaked on Day 7 at 27.8. There were 30 episodes of infection: 14 pneumonias and 16 others, including sinusitis, empyema, subphrenic abscess, urinary tract infection, and bacteremias. The noninfected group had a mean WBC count of 14.2 and a mean differential of 73/5. For this group, the average WBC peaked by the postoperative Day 2 (WBC = 15.9), then the trend was downward. Thus, for patients with traumatic splenic injuries, WBC count may predict infection in the postsplenectomy period. In the noninfected group, the authors observed no average daily WBC count above 16; whereas, in the infected group, no average daily WBC count less than 16 was observed. The differential counts were not significantly different between the two groups.

Abdominal Injuries↗
PubMedDate not supplied

Verres needle decompression of distended gallbladder to facilitate laparoscopic cholecystectomy in acute cholecystitis: a prospective study.

BACKGROUND/AIMS: Grasping a thick and distended gallbladder is one of the most common technical difficulties of laparoscopic cholecystectomy in acute cholecystitis. This prospective study was conducted to investigate the use of the Verres needle decompression method to facilitate laparoscopic cholecystectomy in acute cholecystitis. METHODOLOGY: Between April 1998 and April 2002, patients with acute cholecystitis scheduled to receive laparoscopic cholecystectomy emergently were included. A Verres needle was applied through the subcostal area to decompress the acute inflamed distended gallbladder after establishing pneumoperitoneum. RESULTS: In total 54 patients, 30 male and 24 female with mean age 53.50 years (range 21-80), consented to the operation. Laparoscopic cholecystectomy was performed successfully in 44 patients. The conversion of laparoscopic cholecystectomy to open surgery was needed in 10 patients (conversion rate: 18.5%). The failure to identify the triangle of Calot is the only risk factor associated with conversion. The more severe acute cholecystitis is, the higher the conversion rate is (11.5% in uncomplicated cholecystitis, 31.6% in complicated cholecystitis). No bile duct injury was noted. Postoperative morbidity happened in three cases: two port-site discharge and one subphrenic abscess. No mortality occurred. CONCLUSIONS: Verres needle decompression of the acute inflamed gallbladder did facilitate laparoscopic cholecystectomy in acute cholecystitis with low conversion rate.

Acute Disease↗
PubMed2006

[Adult-to-adult living donor liver transplantation].

OBJECTIVE: To investigate the approach which could improve the survival rate of adult-to adult living donor liver transplantations, that right lobe liver grafts were performed by a modified technique. METHODS: During from March to June 2005, 13 patients underwent the living donor liver transplantation with right lobe grafts via the improved surgical techniques including the reconstruction of right hepatic vein; the tributaries of the middle hepatic vein were reconstructed by interpositioning a vein grafts; the anastomosis of the hepatic arteries and bile ducts. All cases underwent the direct anastomosis of right hepatic vein and IVC, of whom 5 cases were added with the reconstructions of right inferior hepatic vein, and other 5 cases added with reconstructing the tributaries of the middle hepatic vein by interpositing a vein graft to provide sufficient venous outflow. RESULTS: No donor suffered from severe complication or death. Four complications occurred in recipients who got the hepatic artery thrombosis (1 case), bile leakage (1 case), right subphrenic abscess (1 case) or pulmonary infection (1 case) respectively. The recipient with pulmonary infection died of MOF. The graft organ and recipient weight ratio (GRWR) were between 0.72% and 1.24%, that the ratios of 9 cases was < 1.0% and 2 cases < 0.8%, with no "small-for-size syndrome" occurred. CONCLUSIONS: The improved surgical techniques, especially the reconstruction of hepatic vein to provide sufficient venous outflow, can make the adult-to-adult living donor liver transplantation with right lobe liver grafts become a relatively safe operation and prevent the "small-for-size syndrome".

Adult↗
PubMed1991

New possibilities for major liver surgery in patients with Klatskin tumors or primary hepatocellular carcinoma--an old problem revisited.

An impaired liver function secondary to liver disease is considered a contra-indication for extensive liver resection because of the risk of liver failure. Selective embolization of the portal branch corresponding to the part of the liver that is considered for resection, carried out three to four weeks before surgery, reportedly induced atrophy of the embolized part of the liver with hypertrophy of the nonembolized part. This policy showed satisfactory early results in 46 patients who had extended liver resection. One patient with severe cholangitis died in the first 30 days. Seven patients had minor complications, which responded well to conservative management (subphrenic abscesses 3, wound infections 3, pulmonary infection 1). Selective portal embolization was well tolerated and was associated with temporary mild side effects. Liver functions before and after embolization returned to pre-embolization values. The present results support the policy of selective portal embolization in patients with impaired liver function in whom extensive liver resection is necessary. Embolization is a promising ancillary preoperative alternative.

Adenoma, Bile Duct↗
PubMed2006

Modified techniques for adult-to-adult living donor liver transplantation.

BACKGROUND: Because of critical organ shortage, transplant professionals have utilized living donor liver transplantation (LDLT) in recent years. We summarized our experience in adult-to- adult LDLT with grafts of right liver lobe by a modified technique. METHODS: From January 2002 to August 2005, 24 adult patients underwent living donor liver transplantation with grafts of the right liver lobe at West China Hospital, Sichuan University, China. Twenty-two patients underwent modified procedures designed to improve the reconstruction of the right hepatic vein and the tributaries of the middle hepatic vein by interposing a great saphenous vein (GSV) graft and the anastomosis of the hepatic arteries and bile ducts. RESULTS: No severe complications and death occurred in all donors. In the first 2 patients, (patients 1 and 2), operative procedure was not modified. One patient suffered from "small-for-size syndrome" and the other died of sepsis with progressive deterioration of graft function. In the rest 22 patients (patients 3 to 24), however, the procedure of venous reconstruction was modified, and better results were obtained. Complications occurred in 7 recipients including acute rejection (2 patients), hepatic artery thrombosis (1), bile leakage (1), intestinal bleeding (1), left subphrenic abscess (1), and pulmonary infection (1). One patient with pulmonary infection died of multiple organ failure (MOF). The 22 patients underwent direct anastomosis of the right hepatic vein to the inferior vena cava (IVC), 9 direct anastomosis plus the reconstruction of the right inferior hepatic vein, and 10 direct anastomosis plus the reconstruction of the tributaries of the middle hepatic vein by interposing a GSV graft to provide sufficient venous outflow. Trifurcation of the portal vein was met in 3 patients. Venoplasty or separate anastomosis was performed. The ratio of graft to recipient body weight ranged from 0.72% to 1.17%. Among these patients, 19 had the ratio <1.0% and 4 <0.8%, and the ratio of graft weight to recipient standard liver volume was between 31.86% and 62.48%. Among these patients, 10 had the ratio <50% and 2 <40%. No "small-for-size syndrome" occurred in the 22 recipients who were subjected to modified procedures. CONCLUSIONS: With the modified surgical techniques for the reconstruction of the hepatic vein to obtain an adequate outflow and provide a sufficient functioning liver mass, living donor liver graft in adults using the right lobe can be safe to prevent the "small-for-size syndrome".

Adult↗
PubMed1991

Colonic interposition for reconstruction after resection of cancer in the esophagus and gastroesophageal junction.

In 26 patients with carcinoma of the esophagus or gastroesophageal junction, intestinal interposition was performed in post-resection reconstruction, using left colon in 21 cases, right colon in one and a long jejunal segment in four cases. The tumor involved the gastric cardia in 16 patients with colonic interposition and five underwent palliative resection. Infectious pulmonary and abdominal complications were common. Three patients required reoperation, for empyema, ischemic colonic segment and subphrenic abscess, respectively. Ischemia of the interposed segment occurred in two patients, necessitating removal of the segment in one. There was no anastomotic dehiscence and no tumor in the margins of the resected tissue. The 30-day postoperative mortality was 1/22 and the mean postoperative hospital stay 24 days, with 11 patients discharged directly to their homes. The functional results 6 months postoperatively were favorable in most survivors, and only three complained of dysphagia.

Adenocarcinoma↗
PubMed2006

[Modifications of surgical technique in adult-to-adult living donor liver transplantation].

OBJECTIVE: To report the authors' experience with adult-to-adult living donor liver transplantation using right lobe liver grafts performed by a modified technique. METHODS: From March to June 2005, 13 patients underwent living donor liver transplantation using right lobe grafts. Among these, one patient received two left lobes from his two elder sisters, one received a right lobe from his mother and a left lobe from a cadaveric donor. All patient underwent a modification designed to improve the reconstruction of right hepatic vein, the reconstruction the tributaries of the middle hepatic vein by interpositioning a vein grafts, and the anastomosis of the hepatic arteries and bile ducts. RESULTS: There were no severe complications and deaths found in donors. Four complications occurred in recipients including hepatic artery thrombosis (n = 1), bile leakage (n = 1), left subphrenic abscess (n = 1) and pulmonary infection (n = 1). The patient with pulmonary infection died of multiple organ failure (MOF). All patients underwent direct anastomosis of right hepatic vein and inferior vena cava (IVC), 5 cases plus the reconstructions of right inferior hepatic vein, and the other 5 cases plus the reconstruction of the tributaries of the middle hepatic vein by interpositioning a vein graft to provide sufficient venous outflow. The graft and recipient weight ratio (GRWR) were between 0.72% and 1.24%, among these, 9 cases < 1.0% and 2 cases < 0.8%, and there was no "small-for-size syndrome" occurred. CONCLUSIONS: With modifications of surgical technique, especially the reconstruction of hepatic vein to provide sufficient venous outflow, living donor liver transplantation in adults using right lobe liver grafts can become a relatively safe procedure and prevent the "small-for-size syndrome".

Adult↗
PubMedDate not supplied

[External biliary fistulas selectively managed by endoscopic retrograde cholangiography with sphincterotomy and/or stent placement].

External bile duct fistulas are inherent postoperative complications that usually appear after biliary tract surgery, traumatic bile duct injuries and liver surgery for hepatic hydatid disease or liver transplant. The management is highly individualized, while the success and long-term results of endoscopic and surgical techniques are conflicting. The study included 32 cases with external bile duct fistulas managed by endoscopic retrograde cholangiography (ERC) with sphincterotomy and/or stent placement, including "rendez-vous" procedures in 2 cases. The causes of the external fistula were represented by cholecystectomy with/without retained common bile duct stones or strictures (22 cases), cholecystectomy and drainage of a subphrenic abscess caused by severe acute pancreatitis (1 case) and surgical interventions for hepatic hydatid disease (9 cases). Due to the prospective protocol of the study we were able to apply an individualized endoscopic treatment: sphincterotomy with proper relief of the bile duct obstruction (stone extraction) or sphincterotomy with large-size (10 Fr) stent placement for large-sized bile duct defects. The results consisted in closure of the fistula in 3.5 +/- 1.7 days for the subgroup of patients with sphincterotomy alone. Among the patients with stent insertion, fistulas healed slower in 14 +/- 3.5 days. There were no complications after endoscopic treatment; however the stent could not be passed in one patient that required subsequent surgery. In conclusion, endoscopic intervention is the treatment of choice for small external biliary fistulas complicating biliary tract surgery or liver surgery for hepatic hydatid disease. When the fistula is large, the placement of a 10 Fr endoprosthesis becomes necessary, while failure of endoscopic treatment leads to surgery with hepatico-jejunal anastomosis.

Biliary Fistula↗
PubMedDate not supplied

[Ecographic evaluation of the vitality/fertility in the hepatic hydatidosis as indication for pericistectomy].

Hepatic hydatidosis is still now a frequently observed pathology and the total pericistectomy, for surgical difficulties, often request a subtotal pericistectomy with complications such as biliary fistula, haemorrhage and subphrenic abscesses. The Authors reconsidered their hepatic hydatidosis cases to evaluate the indication to the surgery that in their opinion, should have to consider first of all the functional state of the cysts. Infact, only the vital and the fertil ones, less frequent even if rarely found, should have indications to the surgery, because more likely complicated. The dead and steril ones, instead being asymptomatic, should go under periodic control, since destined to degeneration and calcification. Are also compared the pre-surgery data with the parasitologic exam, to evaluate ETG reliability to determine the functional state of the cyst. Twenty one cysts out of 76 were operated correctly because vital/fertile and in 19 of these the ultrasound indications were correct (90.5%). 55 didn't have indications to the surgery since dead/steril and for 51 (92.7%) the ultrasound indication was correct. So we can say that morphological ultrasound data permitted a correct surgery indication for 70 cyst's on their functional state (93.4% of total). In this way the post-operative complication were reduced of 5%. The Authors found morphologic and/or functional ultrasound error for 6 cysts (7.9%), and in only 3 cases (3.9%) the error were both morphological and functional Infact we believe that a ultrasound morphologic classification should have a functional corrispective for the surgical indication So only the unilocular and multivescicular cysts, vital and fertil one, should have indication to the surgery. On the contrary the solid ones should have an ultrasound follow up and treated by chemotherapy if necessary.

Adolescent↗
PubMed1991

[Is ischemia of the liver, lasting longer than an hour, a severity factor in hepatectomies? Apropos of 19 cases].

Nineteen hepatic resections with continuous liver ischemia exceeding one hour (60 to 85 min, m = 68 +/- 8 min) are reported. Surgery was undertaken for 15 malignant tumors, mainly metastatic, and 4 benign tumors. In 16 out of 19 cases, a major hepatic resection was necessary to remove massive and central lesions. Vascular clamping was a Pringle maneuver (9 cases), associated with inferior vena cava clamping-complete hepatic vascular exclusion (10 cases). 2050 +/- 2000 ml of packed red cells were infused peroperatively. No operative nor hospital mortality was recorded. Major complications developed in 6 patients: 3 intraperitoneal haemorrhages leading to complementary hemostasis of the raw surface of the liver in the first 24 hours, 1 erosive gastritis, 2 subphrenic abscesses treated by percutaneous drainage. Severe liver failure developed after left trisegmentectomy on a steatotic liver and led to emergency transplantation on the 17th day with success. Except this case, biochemical liver tests demonstrated slight and transitory alteration. Magnetic resonance imaging confirmed the rapidity of the regenerative process and liver biopsies at 6 and 12 months did not show any late changes. There is no relation between the duration of liver ischemia in the limits of this study and post operative morbidity rate, which is more influenced by the magnitude of the resection and the quality of the liver remnant.

Adult↗
PubMedDate not supplied

Emergency laparoscopy in patients submitted previously to abdominal surgery: a study of 20 cases.

The authors performed 20 laparoscopies in patients previously submitted to abdominal surgery, in whom after clinical evaluation by the medical staff, the existence of intra-abdominal affection was still questioned. In this study group 14 patients exhibited more than 19 days old former abdominal incisions while in six patients they were recent ones. The incisions were median and para-median, McBurney incisions and Pfannenstiel incisions; one patient had been previously submitted to laparoscopy. The laparoscopic findings were hemoperitoneum, encapsulating peritonitis, ascites, subphrenic abscess, acute adnexitis, acute traumatic pancreatitis, genital tuberculosis, acute cholecystitis and one case of peritonitis due to a hollow viscus perforation by a fish bone. In one patient presenting encapsulating peritonitis the laparoscopic examination was complicated by a hollow viscus perforation.

Abdomen, Acute↗
PubMed1991

[Peritoneal echinococcosis. Diagnostic and therapeutic problems. Apropos of 34 cases].

By the light of retrospective study of a series of 34 cases of peritoneal echinococcosis the authors are reminding epidemiological, etiopathologenical, diagnostic difficulties and treatment of this endemic affection in their country. In their study they noted a frequency of 4.5%. With a female predominance (73.5%), the main age was 47 years 80% of the patients were noted to have a rural origin. The treatment was conservative for the primitive kyste as for the peritoneal locations. The post operative course was uneventful in 76% of cases and complicated in 24% (subphrenic abscess in 5 cases and cholerragy in 2 cases). They deplored 3 deaths the follow up was assured clinically; echographically and biologically; they have reoperated 9 relapses.

Adult↗
PubMed1991

[Hiatal hernia. Symptoms, diagnosis and therapy].

Forty-eight patients with a mean age of 53 years were treated for hiatal hernia at the University of Würzburg Department of Surgery between 1983 and 1989. The cohort was subdivided according to type of herniation, age and sex, and symptoms. Conservative treatment sufficed in 22%, but the majority (78%) underwent surgery. Nissen's fundoplication predominated (48%); other methods used were gastropexy (17%), antrectomy with Roux's Y-gastrojejunostomy (6%) and Angelchik's prosthesis (6%). Intra- and postoperative complications included 5 splenectomies following iatrogenic trauma to the spleen, 2 cases of subphrenic abscess, and 2 with pleural effusions. The extensive discussion stresses the various operative treatment procedures and their respective advantages and drawbacks.

Adolescent↗
PubMed1991

Efficacy and distribution of single-dose preoperative antibiotic prophylaxis in high-risk gastroduodenal surgery.

Although a single preoperative dose of antibiotic is now the accepted means of preventing postoperative surgical infection, the method has not been investigated adequately. In patients at high risk of infection who underwent gastroduodenal operations, the authors compared single-dose prophylaxis by intravenous cefotaxime (26 patients) with short-course perioperative prophylaxis (27 patients). No wound infection occurred, but in one patient in each group a subphrenic abscess developed after leakage at the anastomosis. The half-life of cefotaxime (1.23 +/- 0.12 hours) and its apparent volume of distribution (16.7 +/- 2.6 L/1.73 m2 resulted in perioperative levels of the antibiotic in blood (34.76 +/- 4.21 micrograms/mL), gastric mucosa (32.04 +/- 5.22 micrograms/mL) and subcutaneous fat (24.98 +/- 5.89 micrograms/mL) more than twice the usual minimal inhibitory concentration of the drug for organisms grown from the stomach contents and wound fat. These clinical and pharmacologic findings validate the efficacy of a single preoperative intravenous dose of the antibiotic in preventing postoperative infection in high-risk patients who undergo gastroduodenal surgery.

Adult↗
PubMed1991

[Auxiliary drainage of the intraperitoneal course of transhepatic tubes in benign common bile duct stenosis].

The authors used Penrose drains around intraperitoneal portion of Silastic tubes to prevent subphrenic collections in transhepatic intubation. In 31 cases of benign stenosis of the biliary tree, this peritoneal drainage was employed in 18 and no collections were observed. In the other group, 3 patients developed subphrenic abscess. Even with a result not statistically significant (P less than 0.05), the authors consider the procedure useful in transhepatic intubation.

Adult↗