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At least 631 records · Page 35Linked to original sources
PubMed1984

Influence of pH on the responses of guinea-pig isolated trachea to sympathomimetic amines.

Sympathetic amines were tested on isolated trachea of guinea pig at physiological (7.4) and acid (6.6) pH. At physiological pH noradrenaline and phenylephrine relaxed the spontaneous tone of the tracheal muscle preparation; when propranolol was previously added to the organ bath solution, noradrenaline and phenylephrine didn't affect the tracheal muscle tone. Tested at acid pH (6.6), noradrenaline and phenylephrine still relaxed tracheal muscle preparations, but in the presence of propranolol these drugs increased the muscle tone. The spasmogenic effect produced by noradrenaline and phenylephrine after beta-receptor blockade by propranolol, was completely abolished by phentolamine. The present results suggest that acidosis could alter the responsiveness of both alpha- and beta-adrenoceptors in the tracheal muscle of guinea pig.

Animals↗
PubMed2002

Conformationally restrained analogues of sympathomimetic catecholamines. Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2',5'-morpholines].

The 5,6- (10a) and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-)-2',5'-morpholine](11a) and their N-isopropyl derivatives (10b and 11b) (DDSNMs), which can be viewed as the result of the combination of the structure of the 2-(3,4-dihydroxyphenyl)morpholine 5a or 5b (DPMs) with the structure of the corresponding 1-(aminomethyl)-5,6-dihydroxy- (8a or 8b) or 1-(aminomethyl)-6,7-dihydroxy-1,2,3,4-tetrahydro-1-naphthalen-ol (9a or 9b) (1-AMDTNs) were synthesised. The new compounds DDSNMs 10a,b and 11a,b were assayed for their alpha- and beta-adrenergic properties by means of binding experiments and functional tests and the results were compared with those obtained for catecholamines 1a, b and the previously described morpholine (5) and tetrahydronaphthalene (8, 9) derivatives. The affinity and activity indices thus obtained indicate in general a low ability of the new compounds 10 and 11 to interact with the alpha- and beta-adrenoceptors, which, in all cases, was lower than that of the corresponding morpholine (5) and tetrahydronaphthalene (8, 9) analogues.

Adrenergic Agonists↗
PubMed1997

Visual hallucinations in a toddler: accidental ingestion of a sympathomimetic over-the-counter nasal decongestant.

Hallucinations are uncommonly encountered in the young child. The differential diagnosis of such behavior includes a number of potentially serious syndromes such as central nervous system malignancy, encephalitis, temporal lobe epilepsy, closed head trauma with frontal lobe confusion, hypoglycemia, drug intoxications, and childhood psychiatric syndromes. Organic explanations are most often discovered and frequently involve toxicologic causes. A case is presented of a toddler with hallucinations caused by inappropriately high doses of pseudoephedrine.

Bronchodilator Agents↗