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[Diagnostic methods in parotid gland pathology].

A check over the used techniques on salivary glands pathology, that is to say: anamnesis, inspection, palpation, laboratory tests, quantitative and qualitative sialometry, gammagram, single radiology, sialography, CAT, MRI, fine needle biopsy in tumorous and non tumorous pathology. It is seen the practical value of each one of these techniques and when they must be utilized. Nowadays are of great value the CAT and MRI. Under the anatomical pathology are of great importance fine needle biopsy for tumoral studies and Daniel's biopsy for Sjögren' syndrome. Regarding surgery to get an untimely biopsy is fundamental.

Biopsy↗

[Comparative sonographic, x-ray and morphological studies of the salivary glands in Sjögren's syndrome].

AIM: To define diagnostic value of parotid gland (PG) sonography in Sjogren's syndrome (SS) as compared to sialography and morphological changes of labial salivary glands (LSG). MATERIALS AND METHODS: Examination of 50 females with primary (20 patients) and secondary (30 patients) SS consisted of clinical, ultrasonic, x-ray and morphological investigations. RESULTS: Sonographically, PG in SS is characterized by nonhomogeneity of parenchymal picture detected in 75% of patients with primary and 50% of patients with secondary SS. Moderate and severe nonhomogeneity of PG parenchyma was seen in the stage of marked manifestations of chronic parenchymatous parotitis. CONCLUSION: Relationship between PG sonographic image in SS and morphological changes in LSG need further study. PG sonography may help in combined examination of SS patients.

Adult↗

Sjögren's syndrome (SS) in patients with human T cell leukemia virus I associated myelopathy: paradoxical features of the major salivary glands compared to classical SS.

OBJECTIVE: To characterize imaging features of the major salivary glands in patients with human T cell leukemia virus I (HTLV-I) associated myelopathy (HAM) associated with Sjögren's syndrome (SS), and to compare these features with those in HAM negative patients with SS. METHODS: The study population included 31 HAM patients (12 had associated SS), 15 HTLV-I seropositive/HAM negative patients with SS, and 41 HTLV-I seronegative patients with SS. Twenty HAM negative patients with sicca syndrome only were also studied. Diagnostic imaging (sialography, magnetic resonance imaging, and sonography) of the salivary glands, labial gland biopsy, Schirmer test, Saxon test, and serological tests were performed on these patients. RESULTS: The parotid and submandibular glands in 11 (92%) of the 12 HAM patients with SS completely lacked the abnormal imaging features characteristic of the disease, while they displayed decreased salivary flow rates at levels similar to those in the HAM negative patients with SS. The labial glands from the HAM patients with SS exhibited significantly lower magnitudes of mononuclear cell aggregation compared with those in the HAM negative patients with SS. In contrast, all HAM negative patients with SS showed abnormal imaging features characteristic of the disease, and the severity in salivary dysfunction correlated well with the imaging findings. CONCLUSION: These results suggest that SS in patients with HAM may occur in part via a mechanism distinctive from classical SS in HAM negative patients.

Adult↗

Three-dimensional computed tomography imaging in dentistry.

The authors have presented several 3-D CT imaging techniques that may be useful in dentistry. MPR and dental MPR provides cross-sectional images of the jaws and the dental arches, and its utility in implant treatment planning is widely recognized. SSD allows the clinician to visualize the surface of an anatomic structure that is selected by a threshold value. Volume rendering is a powerful and flexible three-dimensional imaging technique that can create various unique images. MIP may be useful in contrast-enhanced CT examinations, such as sialography. Model production and virtual reality three-dimensional imaging may become major techniques in the near future. Although the increased radiation dose to the patients has to be considered, future imaging demands will bring more access to 3-D CT imaging by dental patients and, with adequate three-dimensional rendering techniques, more accurate diagnosis and treatment planning.

Anatomy, Cross-Sectional↗

[Chronic recurrent parotitis in childhood].

INTRODUCTION: Chronic recurrent parotitis is an uncommon disease in childhood. Its cause remains unknown. METHODS: Retrospective study of 30 patients with recurrent parotitis followed up at our hospital during the last 4 years. Guidelines for the management of this disease, as well as the main epidemiological data, diagnostic tests performed, treatments given and outcome, are presented. RESULTS: Mean age at onset of symptoms was 6 years. The most common pattern was 34 attacks per year. The most common clinical features were pyrexia and painful swelling. Pus (through Stensen's duct) was absent in most patients. Mean duration of each episode was 1 week. CONCLUSION: The epidemiological data were similar to those found by other authors. In all cases, diagnosis was made by sialography, a technique that may itself resolve symptoms. Ultrasonography is also useful and, because it is innocuous, it could be a first step investigation.

Adolescent↗

[Bilateral swelling of the parotid glands as part of a systemic disease].

In four patients, a man aged 34 years and three women aged 35, 32 and 55 years respectively bilateral swelling of the parotid glands was caused by systemic disease i.e. HIV-salivary gland disease, mucosa-associated lymphoid-tissue (MALT) lymphoma, sarcoidosis with coexisting Sjögren's syndrome, and sialosis and hypothyroidism, respectively. The HIV patient was treated with antiretroviral therapy, the first two women were treated expectantly and the third woman was given a thyroid hormone supplement which resulted in regression of the bilateral parotid enlargement. Bilateral enlargement of the parotid glands is not necessarily caused by infection, it can also be of systemic origin. Minimal invasive investigations of the salivary glands, such as sialography, measurement of salivary secretion rate (sialometry) and analysis of salivary composition (sialochemistry) can offer valuable information about the origin of the parotid gland swelling. Histopathological investigation of an incision biopsy of the parotid gland is an easy way to confirm the diagnosis. The morbidity associated with parotid biopsy is negligible.

Adult↗

[Results of surgical treatment of benign and malignant parotid tumors (author's transl)].

Of the total of 241 parotid tumors surgically treated between 1956 and 1975 at the Clinic of Otorhinolaryngology, Karl Marx University at Leipzig, 190 were of benign and 51, of malignant character. Patients of advanced age showed preferential development of parotid tumors. In more than ninety percent of the cases, the results of sialography were in agreement with surgical results. Surgical removal of the entire parotid gland was performed with the exception of those cases where the tumor showed good encapsulation and was confirmed to the pars superficialis of the parotid gland. Three cases of complete, permanent facial palsy resulted from surgical treatment of 190 cases of benign parotid tumors. The prognosis of malignant parotid tumors is extremely bad, and it is characterized by a proportion of successful surgical operations of only 26.5 percent.

Adolescent↗

[Sialographic, sialoendoscopic and irrigation fluid study in chronic obstructive parotitis].

OBJECTIVE: To study the sialographic changes and to compare the changes with sialoendoscopic and irrigation fluid findings in chronic obstructive parotitis (COP). METHODS: This study involved 27 patients with a long history of parotid swelling. All patients were examined by X-ray, sialography, and were diagnosed as COP without sialolithiasis. Sialoendoscopy was used to observe the ductal system and irrigation treatment performed. The irrigated liquid was centrifuged and the deposits of fluid were stained and observed under microscopy. The sialographic changes were classified as previous studies and compared with sialoendoscopic and irrigation fluid findings. RESULTS: The sialographic changes of COP in 27 patients included 9 cases with type I, 5 cases with type II, 9 cases with type III and 3 cases with type IV changes, 1 case was normal. Marked obstructive factors such as stricture of ductal system were revealed in 21 cases on the sialogram. Sialoendoscopic examination showed that the ductal system was filled with fiber-like substances and hyperaemia of ductal wall in all cases. While few and thin fiber-like substances were found in the COP with sialographic type I and type II changes, many thick wadding or mass fiber-like substances were revealed in COP with sialographic type III and IV changes. Microstones were found in 2 COP with sialographic type III changes which were stained and identified by microscopy. Foreign body (drug bar) was found in one COP with sialographic type I changes with sialoendoscopy. Irrigation fluid examination showed fiber-like substance was composed of desquamative duct epithelial cells, neutrophil, lymphocytes, acidophile. Some epithelial cells were found in two microliths. CONCLUSIONS: The pathological basis of fiber-like substance on sialoendoscopy is desquamative duct epithelial cells. Fiber-like substance in the lumen of ductal system is considered as one of the obstructive factors in COP. Sialoendoscopic findings is related to sialographic changes.

Adult↗

[Recurrent infectious parotiditis in the child (author's transl)].

On the basis of 18 cases of recurrent parotiditis in the child, the authors offer the current review of this condition: clinical features, radiological features, bacteriological features, course. They emphasize the importance of precise technique during sialography, which must include straight and lateral films. The progress of this condition is characterised by recurrences. These may be avoided by prolonged and appropriate antibiotic therapy. The improvement which takes place at puberty is of etiopathogenic significance. Bucco-dental septis, constantly present, is one of the causes favourising infectious parotiditis in child.

Bacterial Infections↗

[Sialographic and computed tomographic studies in pathology of the major salivary glands].

A retrospective study is reported which took place over 3 years (1986-1989) and included 99 patients (57 men and 33 women, age range 8-90 years) with lesions attributable to salivary gland diseases. Patients were examined using CAT and sialographic tests. From an analysis of the results it is clear that sialography retains its importance as a means of diagnosis in inflammatory diseases, calculosis and autoimmune disorders, whereas CAT should be used as the preferential diagnostic test for neoplastic lesions.

Adult↗

[Sialolithiasis].

The calcified structures that form within the parenchymal tissues or the canal of the salivatory glands are called salivatory stones or sialolithiasis. They contain calcium phosphate, 74.3%; calcium carbonate 11.1%; soluble salt, 6.2%; organic elements, 2.2% and water. The stones are formed by the precipitation of calcified structures around a nucleus that is made of the foreign bodies in the gland, desquamated epithelial cells, degradation products of the bacteria or the bacteria itself. 83% of the salivatory stones is found in the submandibular gland, 10% of them belongs to the parotid and the sublingual gland comes up with 7%. Aside from the major salivatory glands, the minor ones also contain stones. The stones can be classified as anterior, posterior and intraglandular according to the position. The unilateral stones, usually, when reached to the considerable size, cause to partial or total obstruction of the canals. We examined the two cases that have stones localized within the canals of submandibular gland when we were unable to use the sialography technique because of the obstruction the ultrasoundography was our other choice we had direct measurements of the stones and the gland both. After the operation a chemical analysis showed that the stones include calcium and magnesium as cations and phosphate and carbonate as anions.

Humans↗

[Image diagnosis and pleomorphic adenoma].

We examined the imaging technical findings of 11 benign pleomorphic adenomas of major salivary glands. The imaging technical included sialography, echography, computed tomography and gammagraphy. We compared the diagnostic usefulness of each of these imaging technical. The purpose of this paper is to identify the actual advantages, disadvantages and uses of these diagnostic methods.

Adenoma, Pleomorphic↗

[Variations in salivary immunoglobulins in Sjögren's syndrome (author's transl)].

A study of salivary immunoglobulins (IgA, IgG, IgM) was made in 74 subjects with or without Sjögren's syndrome. In the normal subjects, only IgA could be detected by classical immunodiffusion techniques. A correlation was sought between the presence of IgG and/or IgM in the saliva, and various clinical or objective clinical examinations, as well as with accessory salivary gland biopsy. This study indicates that in Sjögren's syndrome the detection of IgG and/or IgM is strongly correlated with sialography which is the surest examination used clinically. Thus the detection and estimation of salivary immunoglobulins is thus a simple and specific complementary examination in Sjögren's syndrome.

Humans↗

Assessment of salivary gland pathology.

At this institution, inflammatory problems and calculous disease are evaluated by plain films or sialography. CT can be used for stone evaluation but is not usually necessary. Although CT has been the mainstay of tumor evaluation, magnetic resonance imaging has several very definite advantages and is likely to supercede CT as the procedure of choice.

Diagnostic Imaging↗

[The value of comparison of echography and sialo-tomography in the preoperative evaluation of parotid tumors].

Studying information provided by sialo-tomography and parotid ultrasonography in the pre-operative investigation of parotid tumors, the authors compare results provided by the two types of investigation. Whilst ultrasonography, a non-invasive technique, provides more detail concerning the topography and appearance of the tumor than sialography, it cannot yet be used as a substitute for this radiological investigation. The two would appear to be complementary, leading the last word to histopathology.

Adolescent↗

The radiologic diagnosis of malignant tumors of the salivary glands.

Radiologic investigation of possible salivary gland malignancy may answer in part questions concerning the lesion under study. Is it an invasive tumor, as evidenced by tissue destruction? Is the tumor intrinsic or extrinsic in origin to the salivary gland? Does the tumor extend into the deep portion of the salivary gland or beyond it into surrounding soft tissues? Sialography plays the major diagnostic role in consideration of the radiologic diagnosis of malignant tumors of the salivary glands. However, certain advanced radiologic modalities such as salivary gland scanning with sodium pertechnetate or 67Gallium citrate, as well as cervical ultrasound and computed tomography, may prove useful. This paper attempts to provide some answers to these questions.

Adult↗

Correlation between postsialographical changes of salivary isoamylase levels in serum and histopathological findings in sublingual glands in patients with Sjögren's syndrome.

Salivary isoamylase values in sera were evaluated before and after sialography in 14 patients with Sjögren's syndrome (SS) and were compared with those in non-SS patients. Non-SS patients consisted of cases of systemic lupus erythematosus, rheumatoid arthritis and ulcerative colitis. In non-SS patients, salivary isoamylase 3 to 6 hours after injection of Conray-400 increased to 2.3 +/- 0.5 fold higher than that prior to the injection and returned to the previous values after 48 hours. On the basis of increases in salivary isoamylase after injection of Conray-400, SS could be divided into three groups: the high response group, the group showing the same values as in non-SS patients and the low response group. The high response group was further classified into two subgroups. Salivary isoamylase before injection in the high response group was higher in patients who showed mild mononuclear cell infiltration histopathologically in their sublingual glands and was lower in patients whose sublingual glands showed diffuse infiltration of mononuclear cells. Mononuclear cells had infiltrated severely in the sublingual glands of patients in the low response group, although they showed salivary isoamylase values before injection within the same ranges as in non-SS patients. These data suggest that both salivary isoamylase before injection and maximum salivary isoamylase increased significantly in cases of mild sialadenitis, the former value decreased with increasing infiltration of mononuclear cells into the sublingual glands, and both values were lower in cases of severe sialadenitis.

Amylases↗