[Importance of shivering in thermogenesis in a dog with spinal cord destruction].
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The contribution of core cooling rate to the thermogenic response in humans, for a similar combination of core and peripheral thermal inputs, was studied. Seven male subjects were immersed in 15 degrees C water on two occasions. Trial A was conducted without any intervention. During Trial B extremity blood flow was occluded for 10 min to allow limb blood to cool toward the temperature of the surrounding tissues. Upon release of cuff pressure the cooled, trapped blood returned to the core region instigating a decrease in esophageal temperature (Tes), with a concomitant increase in heat production (H). The slope of the Tes-H relationship during the dynamic post-occlusion phase was defined as central thermosensitivity (beta B). The slope of the Tes-H relationship during Trial A (beta A), evaluated over a similar range of core temperatures but over a longer time period, was compared with beta B to determine the influence of core cooling rate on the thermogenic response. The rate of core cooling (Tes) increased from -0.05 +/- 0.01 degrees C.min-1 in Trial A to -0.23 +/- 0.02 degrees C.min-1 with cuff occlusion-release in Trial B, resulting in a significant increase in beta B when compared to beta A (-2.99 +/- 0.36 vs. -1.90 +/- 0.24 W.kg-1.degrees C-1). Results of this study indicate that during cold water immersion: 1) dynamic core temperature significantly contributes to the magnitude of metabolic heat production; and 2) individual differences exist in central thermosensitivity.
As indicated by a theophylline administration previously to a norepinephrine infusion, the nonshivering thermogenesis does not seem to be mediated by the cyclic AMP system in constant cold acclimated rats, in opposite to rats acclimated to discontinuous cold. However, in that last thermal condition, the cyclic AMP mediation was not observed in the brown adipose tissue and in the liver.
Administration of calcium chloride at a dose of 14 mg/kg of body weight in 16.6% of patients cupped off the postoperative tremor of muscles, in 73.4%--contributed to shortening of its duration from (52 +/- 8) down to (35 +/- 10) min, in 10%--stimulated it. The changes in body temperature, central and peripheral hemodynamics, acid-base state were studied.
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