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PubMed2006

[Present situation of national surveillance of antimicrobial resistance in bacteria isolated from farm animals in Japan and correspondence to the issue].

The Japanese Veterinary Antimicrobial Resistance Monitoring System (JVARM) was formed in 1999 in response to international concerns about the impact of antimicrobial resistance on public health. The aim of the present investigation was to provide insight into the occurrence of antimicrobial resistance among bacterial strains isolated from cattle, swine and poultry on farms across Japan. In this paper, we summarize a nationwide investigation (1999-2003) on antimicrobial susceptibility of the targeted bacterial species for the JVARM, namely Salmonella, Campylobacter, Enterococcus and Escherichia coli, isolated from the feces of healthy domestic animals. Minimum inhibitory concentrations (MICs) of 10-18 antimicrobial agents including the major generic groups were determined using an agar dilution method according to the international NCCLS guideline in principle. The outline of present results is as follows: (1) A total of 307 Salmonella, 3,225 Escherichia coli, 2,822 Enterococcus and 1,122 Campylobacter were isolated from healthy domestic animals and examined for antimicrobial susceptibility. (2) The isolates of all targeted bacterial species represent high rates of antimicrobial resistance to both oxytetracycline (OTC) and dihydrostreptomycin (DSM). (3) Among the isolates of Campylobacter and E. coli, the frequency of isolation of resistance to fluoroquinolones ranged from 14 to 24% and 2 to 3%, respectively. (4) Resistance to fluoroquinolones was not observed among the isolates of Salmonella or Enterococcus. Continious investigation at the nation level of antimicrobial resistance among the isolates from healthy domestic animals remains a high priority for the JVARM program. Furthermore, appropriate and prudent use of antimicrobials for diseased animals should be considered essential.

Animals↗
PubMed2007

Cardiac resynchronization treatment of heart failure.

Cardiac resynchronization therapy (CRT) is well established as a treatment for patients with moderate to severe heart failure on optimal medical therapy. Early studies demonstrated improved functional capacity and evidence of reverse remodeling; more recently, CRT has been associated with a survival benefit in advanced heart failure both with and without a defibrillator. We review the eight landmark trials in CRT. To date, criteria have focused on electrical delay, but echocardiographic parameters emphasize the importance of mechanical delay or ventricular dyssynchrony. With the exponential rise in implants, new issues have emerged, such as optimal device programming, identifying appropriate candidates, and accounting for cases without clinical benefit from CRT.

Cardiac Pacing, Artificial↗
PubMed1996

Enhanced reproductive responses to melatonin in juvenile Siberian hamsters.

Reproductive responses to melatonin (Mel) exposure were assessed in male Siberian hamsters gestated in long (16 h light/day; 16L) or short (8 h light/day; 8L) day lengths (DLs). Hamsters were maintained in constant light beginning at 14 days of age (day 14) and were infused for 3 successive days beginning on day 18, 25, or 32 with long (12 h/day) or short (6 h/day) durations of Mel or saline. Two weeks later, testis and body weights were determined. Responsiveness to Mel was enhanced in hamsters beginning shortly after weaning and was influenced by photoperiodic history. Gonadal growth in 16L hamsters was inhibited by 12-h Mel infusions initiated on day 18 or day 25, but infusions initiated on day 32 were ineffective. Hamsters gestated in 8L were not responsive to Mel treatments initiated on day 18, but discriminated 12-h from 6-h infusions at day 25 and manifested reduced gonadal growth after 12-h Mel infusions on day 32. Hamsters born in 8L to dams judged as photoinsensitive to short DLs did not respond to 12-h infusions on day 32 as inhibitory signals. We propose that maternal Mel secretion provides juvenile males with a photoperiodic history, which allows them to compare gestational with early postweaning Mel signals and thereby program seasonally appropriate developmental trajectories.

Aging↗
PubMed1977

Computer-based system for analysis of respiratory responses to exercise.

A computer-based system for the determination of tidal volume, respiratory frequency, minute ventilation, oxygen transfer, carbon dioxide transfer, respiratory exchange ratio, end-tidal oxygen, end-tidal carbon dioxide, and heart rate is presented. These variables are first determined on a breath-by-breath basis from data (expired carbon dioxide and oxygen fractions, airflow, and ECG) prerecorded on an FM magnetic type system. The breath-by-breath data are then averaged for each experimental run in 5-s increments. The 5-s increment data from a group of subjects can then be averaged and the SEM determined at prescribed periods of time. For the study of individual respiratory transient we found the 5-s increment data to be more useful than the breath-by-breath data because it has a lesser degree of fluctuation. The system is especially adapted to careful observation of the responses within the first few seconds of a change in work load. Appropriate computer programs are discussed. The results of several experiments are compared with data from other sources and found to be in good agreement.

Carbon Dioxide↗
PubMed2003

Comparison between different types of surveillance samples for the detection of GBS colonization in both parturient mothers and their infants.

OBJECTIVE: To find the optimum screening method in detecting group B streptococcal (GBS) colonization in both mother and infant, and to identify the risk factors that influence GBS colonization in the infants. PATIENTS AND METHODS: 1,120 singleton pregnant women were evaluated for GBS colonization by combined lower vaginal-anorectal swabs (LVRS) and urine tests, while their infants were evaluated for colonization with skin, ear and gastric aspirate samples. RESULTS: LVRS swabs were positive in 14.2% of mothers while urine was positive in 7.6%. Among the infants skin, ear and gastric aspirate samples were positive in 7.0, 6.9 and 3.5%, respectively. Prolonged rupture of the membrane was the only significant factor associated with colonization in these infants (p < 0.001). CONCLUSIONS: Lower vaginal-anorectal swab is an effective method in detecting colonization in mothers especially when combined with urine culture. Skin or ear swabs are equally effective in detecting colonization in neonates. GBS colonization rate in our parturient and neonatal population is comparable to that was reported from other countries. A well-developed screening program and appropriate management strategies for both GBS colonized mothers and infants are recommended.

Anal Canal↗
PubMed1996

The predatory strike of free ranging praying mantises, Sphodromantis lineola (Burmeister). I: Strikes in the mid-sagittal plane.

The predatory behavior of free ranging praying mantises, Sphodromantis lineola (Burmeister), in response to prey at various positions in the midsagittal plane, was examined using high speed (200 frames per second) videography. Predatory strikes fell neatly into two categories based on the elevation of the prey from the surface on which the mantises stood: high strikes and low strikes. When the prey was 35 degrees or more above the surface (measured from the mesothoracic tarsus), mantises assumed a posture that elevated and pointed the body upwards (high strikes). When prey was near or below the surface on which the mantises stood, they assumed a posture that lowered the body and shifted its center of gravity forward (low strikes). Each of these two initial postures was followed by distinctly different constellations of movements, which included a rapid grasping movement of the raptorial forelegs and, if the prey was sufficiently distant, a displacement of the body upwards (high strikes) or forwards (low strikes). Our analyses suggest that prothoracic angle and, to a lesser degree, head angle and the degree to which the mesothoracic legs are extended provide the critical proprioceptive cues used in programming the appropriate attach sequence. Based on our results, we hypothesize that mantises process visual and proprioceptive information indicating prey location in 'pterothorax-centered space'.

Animals↗
PubMed2003

The role of binocular information in the 'on-line' control of prehension.

Binocular visual information may be involved in the selection of appropriate motor programs before a reach is executed or it may be involved during the movement-execution phase in order to monitor and guide the hand to the target object. Here we introduced binocular information after 0%, 25%, 50% or 75% of the movement-execution phase and determined its effects on the kinematic indices of prehensile movements made to objects of different sizes placed at different distances. Kinematic indices linked to the transport component, such as peak velocity and time-to-peak velocity, were unaffected by the presence of binocular cues whereas later occurring indices, such as peak grip aperture and time in the slow phase, were significantly affected. Although the magnitude of the peak grip was affected by the presence of binocular cues, the time at which it occurred did not change. This pattern of results suggest that the visuo-motor control of prehensile movements utilises both feedforward and feedback strategies and that binocular cues are particularly important for the fine manual adjustments typical of the latter.

Adult↗
PubMed2005

Does supported living in residential homes improve the quality of life and mental stability of older adults with chronic mental disorder?

OBJECTIVE: Supported living in residential homes for the elderly is an innovative, age-appropriate residential program for older adults with chronic mental disorders. The program involves 1) accommodation in ordinary "elder care" homes; and 2) provision of on-site mental health care by professionals from the local psychiatric hospital. The authors asked whether the program succeeds in improving the patients' quality of life without compromising their mental stability. METHODS: Patients in 18 supported living programs (N=96) were compared with similar patients in eight psychiatric hospitals (N=78), in a cross-sectional study. Quality of life was measured with the Philadelphia Geriatric Center Morale Scale (PGCMS) and the Manchester Short Assessment of Quality of Life (MANSA). Mental stability was assessed in terms of rehospitalizations, adjustments in medication because of symptom exacerbation, and 6-month prevalence of psychotic symptoms. RESULTS: After adjustment for patient characteristics, the supported-living participants experienced a significantly lower quality of life than the hospital patients, as indicated by two of the three PGCMS subscales and by the MANSA. Disparities were greatest in the subgroup of patients with psychotic disorders. No significant differences in mental stability were found between the two conditions. Eleven of the 96 supported-living participants had undergone temporary rehospitalization since their entry into the program. CONCLUSIONS: Supported living in residential homes for elderly persons is an attractive model, but it does not automatically guarantee the participants a better quality of life. Further research is needed to determine which program characteristics can improve results.

Aged↗
PubMed2005

Development and implementation of a public health workforce training needs assessment survey in North Carolina.

Assessing the training needs of local public health workers is an important step toward providing appropriate training programs in emergency preparedness and core public health competencies. The North Carolina Public Health Workforce Training Needs Assessment survey was implemented through the collaboration of several organizations, including the North Carolina Center for Public Health Preparedness at the North Carolina Institute for Public Health, the outreach and service unit of the University of North Carolina School of Public Health, the Office of Public Health Preparedness and Response in the North Carolina Division of Public Health Epidemiology Section, and local health departments across the state.

Data Collection↗
PubMedDate not supplied

A community diabetes education and gardening project to improve diabetes care in a Northwest American Indian tribe.

PURPOSE: The purpose of this study was to design a culturally appropriate education program for a Northwest American Indian tribe. METHODS: Needs assessment revealed that a community approach rather than clinic-based education would address multiple barriers to diabetes care. Both process and outcome information are described for community and individual level evaluations. RESULTS: This intervention design consisted of community diabetes workshops called "How Healthy Am I?--Treating the Whole Person." The workshops represented a traditional view of health and included 4 specific themes: (1) taking care of the body, with an emphasis on diabetes care and physical activity; (2) mental health needs; (3) foods for healthy living; and (4) spirituality and healing the whole person. Workshops were designed to be social and informational, and involve all community members. A community garden was established to improve access to fresh produce and encourage exercise. CONCLUSIONS: Prior to implementation of the community workshops and evaluations, the tribal government chose to discontinue receiving the federal funding for this project. Elements of a mutually respectful collaboration are outlined and discussed based on the experiences of this project.

Adult↗
PubMed2005

Peroneus longus muscle activation pattern during gait cycle in athletes affected by functional ankle instability: a surface electromyographic study.

BACKGROUND: Functional ankle instability is a clinical syndrome that may develop after acute lateral ankle sprain. Although several causes of this functional instability have been suggested, it is still unclear what the activation pattern of the peroneus longus muscle is in patients with functional ankle instability. HYPOTHESIS: Peroneus longus activation patterns differ in the injured side and the uninjured side in subjects with functional ankle instability. STUDY DESIGN: Descriptive laboratory study. METHODS: The authors examined 14 subjects with functional ankle instability by using surface electromyography during walking. Activation time of the peroneus longus muscle was expressed as a percentage of the stance phase of the gait cycle. RESULTS: A statistically significant decrease in peroneus longus muscle activity was found in the injured side compared with the uninjured side (22.8% +/- 4.25% vs 37.6% +/- 3.5%, respectively). CONCLUSIONS: Results obtained in this study show a change in peroneus longus muscle activation time after injury. Independent of the origin of this change, which could only be surmised, the decrease in peroneus longus muscle activity may result in reduced protection against lateral sprains. CLINICAL RELEVANCE: The assessment of peroneus longus activation pattern during gait is useful to design an appropriate rehabilitation program in athletes suffering from functional ankle instability.

Adolescent↗
PubMedDate not supplied

Injuries in recreational adult fitness activities.

Volunteers (986) from fitness clubs and studios were recruited and followed for a 3-month period to document the injury consequences of adult recreational fitness participation. Participants were telephoned each week and their activities as well as any injuries that occurred were recorded. Of the 525 injuries and complaints reported during 60,629 hours of activity, 475 occurred as a result of sports participation for an overall rate of 7.83 per 1000 hours of participation. Seventy-six percent of these episodes caused the patient to alter or miss 1 or more activities, while 9.5% involved a physician visit. The rate for time-loss injuries was less than 2 per person per year (1.76 per 298 hours) or 5.92 per 1000 hours. Running had a higher risk of injury compared with most other individual sports. Cardiovascular fitness activities had low to medium rates, as did weight work; competitive sports were higher. For 6 of the most commonly injured areas, the reinjury rate was about twice that reported for those with no history of previous injury. The risks of injury from most recreational fitness activities were relatively modest, particularly if the activities were not competitive. Physicians might help patients reduce their risks of injury by encouraging suitable activities and by reducing the risks of reinjury by implementing appropriate rehabilitation programs.

Adult↗
PubMed1996

Vancomycin-resistant enterococci.

OBJECTIVE: To review vancomycin resistance in enterococci (Enterococcus faecalis and Enterococcus faecium) with respect to history, epidemiology, mechanism of resistance, and management. DATA SOURCES: A MEDLINE, IDIS, and current journal search of English-language articles on vancomycin-resistant enterococci (VRE) published between 1982 and 1994 was conducted. STUDY SELECTION: Studies and reports pertaining to vancomycin-resistant E. faecalis and E. faecium were evaluated. Case reports, cohort, epidemiologic, in vitro and in vivo studies were evaluated. DATA EXTRACTION: Reports in which vancomycin minimum inhibitory concentrations were 32 micrograms/mL or more were evaluated. DATA SYNTHESIS: Large outbreaks of VRE infection have occurred as a result of nosocomial spread. Such outbreaks have required intensive infection control procedures to limit the spread of VRE. Vancomycin resistance in E. faecalis and E. faecium has been subdivided into phenotypes, VanA and VanB. The mechanism of vancomycin resistance is caused by the production of depsipeptide D-Ala-D-Lac, which replaces D-Ala-D-Ala in the peptidoglycan pathway, thereby preventing the binding of vancomycin to D-Ala-D-Ala in the peptidoglycan cell wall. The vanA gene is associated with a transpositional element (Tn1546) that can be transferred via conjugation while most data suggest that vanB has an endogenous origin. Education, aggressive infection control practices. surveillance programs, and appropriate use of vancomycin are necessary to respond to the VRE problem. CONCLUSIONS: The prevalence of VRE has increased significantly in recent years and has become a worldwide problem. Several factors, such as prior exposure to vancomycin and antibotics (e.g., cephalosporins, antianaerobic agents), physical location in the hospital, immunosuppression, prolonged hospital stay, and VRE gastrointestinal colonization are associated with VRE infection and colonization. Antibiotic treatment of serious VRE infection depends on the phenotype. Optimal treatment of the VanA phenotype is unknown; the VanB phenotype may be treated with teicoplanin and an aminoglycoside.

Animals↗
PubMed1997

Infant Methemoglobinemia in the Transylvania Region of Romania.

The incidence of infant methemoglobinemia reported in three counties of Transylvania, Romania, was evaluated from medical records, field visits, and interviews. Well water was the main source of nitrate for induction of acquired infant methemoglobinemia, which occurred post-breast-feeding when the infants consumed nitrate-contaminated water used in mixing formula. The average age of reported infants with methemoglobinemia was 39 days, supporting earlier observations that infants less than 4 months old are the most susceptible segment of the population. Vitamin C, rather than methylene blue, was the main medical intervention in the Transylvania region. The mean incidence rates of methemoglobinemia in the three counties (Saut-Mare, Mures, and Bistrita-Nasaud) ranged from 24 to 363 per 100,000 live births over a five-year period (1990-1994). These rates are below earlier reported incidence rates of up to 13% (13,000 per 100,000 live births). Three selected case reports are presented to describe hospital/clinic data, well-water data, and infant feeding practices. Recommendations for appropriate intervention programs are described. The significances of possible physical and neuropsychological effects on the development of children following methemoglobinemia are discussed and the need for further investigations is outlined.

Journal Article↗
PubMed2006

Sebaceous gland tumors and internal malignancy in the context of Muir-Torre syndrome. A case report and review of the literature.

BACKGROUND: The Muir-Torre syndrome is a rare autosomal dominant condition and is currently considered a subtype of the more common hereditary nonpolyposis colorectal cancer syndrome, in which multiple primary malignancies occur together with sebaceous gland tumors. CASE PRESENTATION: We describe a case of a 62-year-old woman with three primary colorectal tumors, genital tumor, and sebaceous adenomas and present her family history of three generations. Our case represents the first case reported from Greece in the international literature. CONCLUSION: Recognition of the syndrome in patients with sebaceous gland tumors should facilitate early detection of subsequent malignancies if the patient is entered into appropriate screening programs.

Journal Article↗
PubMed2026

Chromosome-level assembly and annotation of the Jaguar (Panthera onca) genome.

OBJECTIVES: The Jaguar (Panthera onca) is a large cat species native to the Americas. Despite being successful predators, jaguar populations have declined due to habitat loss. Genome resources can help in conservation efforts as well as in understanding the interesting biology of these Felids. Beside contiguity, a well annotated reference genome provides contextual information for variants that will benefit the design of appropriate conservation programs. DATA DESCRIPTION: We sequenced material from two individuals using a combination of ONT reads and Illumina PE. The resulting nuclear genome assembly has a larger contig N50 (48.04&#xa0;Mb) compared with the existing annotated chromosome-level assembly published by the DNA Zoo project. Using public Hi-C data, we obtained an improved chromosome-level assembly of the Jaguar genome (mPanOnc3.5) with larger contigs, 99.85% of the sequence assigned to chromosomes and 25,267 protein coding genes annotated. Overall, this improved assembly provides a better reference to study this threatened species.

Animals↗
PubMed1992

Evaluation of a program to prevent head and spinal cord injuries: a comparison between middle school and high school.

This study was designed to test whether the Oregon THINK FIRST-Head and Spinal Cord Injury Prevention Program, developed for the high school audience and previously shown to have a beneficial effect, would have the same effect on students in middle school. During the spring of 1989, four schools (two high schools and two middle schools) participated. Two weeks before and after the presentation of the THINK FIRST program, 830 student questionnaires were distributed in classrooms. Questionnaire items were designed to measure knowledge, attitude, behavior, and demographic features. There was a significant difference between high school and middle school students on pretest knowledge (P = 0.0001). The average knowledge increase among all students was 0.81 correct responses (95% confidence interval: +/- 0.22) among 15 questions. The increment in knowledge did not differ significantly (P = 0.37) between high school and middle school students. One-way analysis of variance revealed no significant differences in pretest knowledge or knowledge increase associated with membership in Students Against Drunk Driving or acquaintance with someone having sustained a head or spinal cord injury. After the program, students were more likely to believe that there were actions they could take to keep from getting injured (P less than 0.0001). However, there was no change in self-reported seat belt use and most students reported that they "never" wore a bike helmet. The findings suggest that the THINK FIRST program is appropriate and beneficial for viewing by middle school-aged students.

Adolescent↗
PubMed1983

Medical treatment of infective endocarditis and its limitations.

In an attempt to establish an appropriate management program for patients with active infective endocarditis, 30 patients treated during the past 20 years were studied retrospectively. Microorganisms were confirmed in 27 of the 30 patients (90%) (86.7% by culture and 3.3% at surgery). Among these 27 patients, viridans streptococci were confirmed in 23 (85.2%), aureus staphylococci in 2 (7.4%), epidermidis staphylococci in one (3.7%) and candida albicans in one (3.7%). Twenty of the 23 patients (87%) with viridans streptococcal endocarditis were treated medically with good success, but 2 patients (8.7%), who developed severe congestive heart failure (NYHA 3-4 degrees), underwent emergency surgery, and one of them (4.3%) died from severe heart failure. The synergistic effects of the combined antibiotic therapy were not ascertained in the present series. It was noteworthy that a bolus intravenous administration of penicillin was more effective than its continuous drip infusion. Both patients with aureus staphylococcal endocarditis died before surgery. One patient with prosthetic valve endocarditis due to candida died after a second operation. It is concluded that most patients with active infective endocarditis can be medically treated successfully, but surgery should be performed urgently for patients with severe heart failure, poor response to antibiotics, aureus staphylococcal and candida endocarditis and prosthetic valve endocarditis.

Adolescent↗